What is Vipp1 good for?

abstract：:This study examined the role of P fimbriae in the establishment of bacteriuria. Patients (n = 17) were subjected to intravesical inoculation with an asymptomatic bacteriuria strain, Escherichia coli 83972, or its P-fimbriated (pap+/prs+) transformants. As shown by groupwise analysis, the pap+/prs+ transformants establ...

journal_title：Molecular microbiology

authors： Wullt B,Bergsten G,Connell H,Röllano P,Gebretsadik N,Hull R,Svanborg C

更新日期：2000-11-01 00:00:00

abstract：:To establish a lysogenic lifestyle, the temperate bacteriophage φC31 integrates its genome into the chromosome of its Streptomyces host, by site-specific recombination between attP (the attachment site in the phage DNA) and attB (the chromosomal attachment site). This reaction is promoted by a phage-encoded serine rec...

journal_title：Molecular microbiology

authors： Stark WM

更新日期：2011-06-01 00:00:00

abstract：:The expression of the structural genes for lysine (LYS) biosynthesis is controlled by a pathway-specific regulation mediated by the transcriptional activator Lys14 in the presence of alpha-aminoadipate semialdehyde, an intermediate of the pathway acting as a co-inducer. Owing to end product inhibition of the first ste...

journal_title：Molecular microbiology

authors： Becker B,Feller A,el Alami M,Dubois E,Piérard A

更新日期：1998-07-01 00:00:00

abstract：:CS1 pili are filamentous proteinaceous appendages found on many enterotoxigenic Escherichia coli (ETEC) strains isolated from human diarrhoeal disease. They are thought to effect colonization of the upper intestine by facilitating binding to human ileal epithelial cells. We have identified a gene, cooB, which lies dir...

journal_title：Molecular microbiology

authors： Scott JR,Wakefield JC,Russell PW,Orndorff PE,Froehlich BJ

更新日期：1992-02-01 00:00:00

abstract：:The Helicobacter pylori genome contains a gene (hp1338 or nikR) that encodes a nickel-dependent regulator that is homologous to the Escherichia coli nickel-responsive regulator, NikR. The H. pylori nikR product acts as a pleiotropic metal-dependent regulator. We constructed a non-polar isogenic mutant deleted for the ...

journal_title：Molecular microbiology

authors： Contreras M,Thiberge JM,Mandrand-Berthelot MA,Labigne A

更新日期：2003-08-01 00:00:00

abstract：:RpoS, an alternative primary sigma factor, has been shown to be regulated at multiple levels, including transcription, translation and protein stability. Here, we present evidence that suggests that RpoS is regulated at yet another level by the product of the crl gene. The crl gene was first thought to encode the majo...

journal_title：Molecular microbiology

authors： Pratt LA,Silhavy TJ

更新日期：1998-09-01 00:00:00

abstract：:We have cloned the rpoD gene encoding the principal sigma (sigma) factor of Helicobacter pylori. The deduced amino acid sequence reveals a predicted polypeptide of 676 residues that has amino acid homology with the principal sigma factors of a number of divergent prokaryotes. We have designated this factor sigma80. Am...

journal_title：Molecular microbiology

authors： Beier D,Spohn G,Rappuoli R,Scarlato V

更新日期：1998-10-01 00:00:00

abstract：:Histidine kinases function as dimers. The kinase domain of the osmosensing histidine kinase EnvZ of Escherichia coli consists of two domains: domain A (67 residues) responsible for histidine phosphotransfer and dimerization, and domain B (161 residues) responsible for the catalytic and ATP-binding function. The indivi...

journal_title：Molecular microbiology

authors： Qin L,Dutta R,Kurokawa H,Ikura M,Inouye M

更新日期：2000-04-01 00:00:00

abstract：:mscL encodes a channel in Escherichia coli that is opened by membrane stretch force, probably serving as an osmotic gauge. Sequences more or less similar to mscL are found in other bacteria, but the degree of conserved function has been unclear. We subcloned and expressed these putative homologues in E. coli and exami...

journal_title：Molecular microbiology

authors： Moe PC,Blount P,Kung C

更新日期：1998-05-01 00:00:00

abstract：:Salmonella enterica subspecies I serotypes are responsible for the vast majority of salmonellosis in mammals and birds, yet only a few factors specific to this group that allow them to persist in this niche have been identified. We show that STM0557, a S. enterica subspecies I-specific gene encoding an inner membrane ...

journal_title：Molecular microbiology

authors： Bogomolnaya LM,Santiviago CA,Yang HJ,Baumler AJ,Andrews-Polymenis HL

更新日期：2008-12-01 00:00:00

abstract：:Lipid metabolism in Trypanosoma brucei, the causative agent of African sleeping sickness, differs from its human host in several fundamental ways. This has lead to the validation of a plethora of novel drug targets, giving hope of novel chemical intervention against this neglected disease. Cytidine diphosphate diacylg...

journal_title：Molecular microbiology

authors： Lilley AC,Major L,Young S,Stark MJ,Smith TK

更新日期：2014-05-01 00:00:00

abstract：:The nucleotide sequence of the ugp genes of Escherichia coli K-12, which encode a phosphate-limitation inducible uptake system for sn-glycerol-3-phosphate and glycerophosphoryl diesters, was determined. The genetic organization of the operon differed from previously published results. A single promoter, containing a p...

journal_title：Molecular microbiology

authors： Overduin P,Boos W,Tommassen J

更新日期：1988-11-01 00:00:00

abstract：:Periplasmic Cu,Zn-superoxide dismutases (Cu,Zn-SODs) are implicated in bacterial virulence. It has been proposed that some bacterial P(1B)-type ATPases supply copper to periplasmic cupro-proteins and such transporters have also been implicated in virulence. Here we show that either of two P(1B)-type ATPases, CopA or G...

journal_title：Molecular microbiology

authors： Osman D,Patterson CJ,Bailey K,Fisher K,Robinson NJ,Rigby SE,Cavet JS

更新日期：2013-02-01 00:00:00

abstract：:In all eukaryotic organisms, messenger RNA (mRNA) is synthesized in the nucleus and then exported to the cytoplasm for translation. The export reaction requires the concerted action of a large number of protein components, including a set of shuttle proteins that can exit and re-enter the nucleus through the nuclear p...

journal_title：Molecular microbiology

authors： Gratzer S,Beilharz T,Beddoe T,Henry MF,Lithgow T

更新日期：2000-03-01 00:00:00

abstract：:Bacterial secretion systems often employ molecular chaperones to recognize and facilitate export of their substrates. Recent work demonstrated that a secreted component of the type VI secretion system (T6SS), haemolysin co-regulated protein (Hcp), binds directly to effectors, enhancing their stability in the bacterial...

journal_title：Molecular microbiology

authors： Whitney JC,Beck CM,Goo YA,Russell AB,Harding BN,De Leon JA,Cunningham DA,Tran BQ,Low DA,Goodlett DR,Hayes CS,Mougous JD

更新日期：2014-05-01 00:00:00

abstract：:Establishment of an axis of cell polarity and differentiation of the cell poles are fundamental aspects of cellular development in many organisms. We compared the effects of two bacterial cytoskeletal-like systems, the MreB and MinCDE systems, on these processes in Escherichia coli. We report that the Min proteins are...

journal_title：Molecular microbiology

authors： Shih YL,Kawagishi I,Rothfield L

更新日期：2005-11-01 00:00:00

abstract：:In the multicellular bacterium Streptomyces coelicolor, functions of developmental (bald) genes are required for the biosynthesis of SapB, a hydrophobic peptidic morphogen that facilitates aerial hyphae formation. Here, we show that aerial hyphal growth and SapB biosynthesis could be activated independently from the n...

journal_title：Molecular microbiology

authors： Nguyen KT,Willey JM,Nguyen LD,Nguyen LT,Viollier PH,Thompson CJ

更新日期：2002-12-01 00:00:00

abstract：:A library of genomic DNA fragments from Haemophilus influenzae type b (Hib) DL42 was constructed in plasmid pBR322, transformed into Escherichia coli strain RR1, and screened for recombinant clones with haemin-binding activity by plating onto haemin-containing agar. Expression of haemin-binding activity by clones corr...

journal_title：Molecular microbiology

authors： Hanson MS,Hansen EJ

更新日期：1991-02-01 00:00:00

abstract：:Plasmodium vivax is one of four Plasmodium species that cause human malaria. P. vivax and a related simian malaria parasite, Plasmodium knowlesi, invade erythrocytes by binding the Duffy antigen/receptor for chemokines (DARC) through their respective Duffy binding proteins. Here we show that tyrosines 30 and 41 of DAR...

journal_title：Molecular microbiology

authors： Choe H,Moore MJ,Owens CM,Wright PL,Vasilieva N,Li W,Singh AP,Shakri R,Chitnis CE,Farzan M

更新日期：2005-03-01 00:00:00

abstract：:We determined the genome-wide environmental stress response (ESR) expression profile of Candida glabrata, a human pathogen related to Saccharomyces cerevisiae. Despite different habitats, C. glabrata, S. cerevisiae, Schizosaccharomyces pombe and Candida albicans have a qualitatively similar ESR. We investigate the fun...

journal_title：Molecular microbiology

authors： Roetzer A,Gregori C,Jennings AM,Quintin J,Ferrandon D,Butler G,Kuchler K,Ammerer G,Schüller C

更新日期：2008-08-01 00:00:00

abstract：:Cells invest a significant amount of their energy synthesizing proteins, and a large portion of the energy expenditure goes into making ribosomes, the RNA-protein machines at the centre of translation. When ribosomes are damaged in a cell, i.e. during stressful conditions, cells must first recognize the damage and the...

journal_title：Molecular microbiology

authors： Cate JH

更新日期：2010-02-01 00:00:00

abstract：:In this work we present the localization and characterization of the repl promoter (Prepl) and show aspects of the regulation. Comparison of Prepl with other autoregulated replication protein gene promoters revealed similarities, but Prepl differs from some of these characterized promoters in not being regulated by th...

journal_title：Molecular microbiology

authors： Gammie AE,Crosa JH

更新日期：1991-12-01 00:00:00

abstract：:A two-hybrid approach was applied to screen for proteins with the ability to interact with PHB synthase (PhaC1) of Ralstonia eutropha. The H16_A0141 gene (phaM) was identified in the majority of positive clones. PhaM (26.6 kDa) strongly interacted with PhaC1 and with phasin PhaP5 but not with PhaP1 or other PHB granul...

journal_title：Molecular microbiology

authors： Pfeiffer D,Wahl A,Jendrossek D

更新日期：2011-11-01 00:00:00

abstract：:Toxin-antitoxin (TA) systems on the chromosomes of free-living bacteria appear to facilitate cell survival during intervals of stress by inducing a state of reversible growth arrest. However, upon prolonged stress, TA toxin action leads to cell death. They have been implicated in several clinically important phenomena...

journal_title：Molecular microbiology

authors： Prysak MH,Mozdzierz CJ,Cook AM,Zhu L,Zhang Y,Inouye M,Woychik NA

更新日期：2009-03-01 00:00:00

abstract：:Iron-sulfur (Fe-S) clusters are prosthetic groups on proteins that function in a range of enzymatic and electron transfer reactions. Fe-S cluster synthesis is essential for the survival of all eukaryotes. Independent Fe-S cluster biosynthesis pathways occur in the mitochondrion, plastid, and cytosolic compartments of ...

journal_title：Molecular microbiology

authors： Aw YTV,Seidi A,Hayward JA,Lee J,Makota FV,Rug M,van Dooren GG

更新日期：2020-11-22 00:00:00

abstract：:The osteolytic toxin of Pasteurella multocida induces bone resorption in vivo and in vitro (Foged et al., 1988; Kimman et al., 1987). In this report the toxin-encoding toxA gene is sequenced, and the deduced primary structure of the toxin shows a protein of 1285 amino acids, containing a striking homology to a metal-b...

journal_title：Molecular microbiology

authors： Petersen SK

更新日期：1990-05-01 00:00:00

abstract：:We have shown previously that deletion of the Saccharomyces cerevisiae UMP1 gene encoding the 20S proteasome maturase causes sensitivity to UV radiation. In the current report, we have extended this finding to show that mutations specifically compromising chymotrypsin-like or trypsin-like activity of 20S proteasome pe...

journal_title：Molecular microbiology

authors： Podlaska A,McIntyre J,Skoneczna A,Sledziewska-Gojska E

更新日期：2003-09-01 00:00:00

abstract：:The analysis of the not well understood composition of the stalk, a key ribosomal structure, in eukaryotes having multiple 12 kDa P1/P2 acidic protein components has been approached using these proteins tagged with a histidine tail at the C-terminus. Tagged Saccharomyces cerevisiae ribosomes, which contain two P1 prot...

journal_title：Molecular microbiology

authors： Guarinos E,Santos C,Sánchez A,Qiu DY,Remacha M,Ballesta JP

更新日期：2003-10-01 00:00:00

abstract：:Polyadenylation is a universal post-transcriptional modification involved in degradation and quality control of bacterial RNAs. In Escherichia coli, it is admitted that any accessible RNA 3' end can be tagged by a poly(A) tail for decay. However, we do not have yet an overall view of the population of polyadenylated m...

journal_title：Molecular microbiology

authors： Maes A,Gracia C,Hajnsdorf E,Régnier P

更新日期：2012-01-01 00:00:00

abstract：:VP4, the major structural protein of the haloarchaeal pleomorphic virus, HRPV-1, is glycosylated. To define the glycan structure attached to this protein, oligosaccharides released by β-elimination were analysed by mass spectrometry and nuclear magnetic resonance spectroscopy. Such analyses showed that the major VP4-d...

journal_title：Molecular microbiology

authors： Kandiba L,Aitio O,Helin J,Guan Z,Permi P,Bamford DH,Eichler J,Roine E

更新日期：2012-05-01 00:00:00