Abstract:
:This study examined the role of P fimbriae in the establishment of bacteriuria. Patients (n = 17) were subjected to intravesical inoculation with an asymptomatic bacteriuria strain, Escherichia coli 83972, or its P-fimbriated (pap+/prs+) transformants. As shown by groupwise analysis, the pap+/prs+ transformants established bacteriuria more rapidly than E. coli 83972 (P = 0.021) and required a lower number of inoculations to reach 105 cfu ml-1 (P = 0.018). Intraindividual analysis showed that the pap+/prs+ transformants established bacteriuria more rapidly than E. coli 83972 in the patients who subsequently became carriers of both strains. Finally, bacterial establishment was shown to vary with the in vivo expression of P fimbriae. Bacterial counts were higher when P-fimbrial expression was detected than when the pap+/prs+ strain showed a negative phenotype. The results suggested that P fimbriae enhance the establishment of bacteriuria and fulfil the molecular Koch postulates as a colonization factor in the human urinary tract.
journal_name
Mol Microbioljournal_title
Molecular microbiologyauthors
Wullt B,Bergsten G,Connell H,Röllano P,Gebretsadik N,Hull R,Svanborg Cdoi
10.1046/j.1365-2958.2000.02165.xsubject
Has Abstractpub_date
2000-11-01 00:00:00pages
456-64issue
3eissn
0950-382Xissn
1365-2958pii
mmi2165journal_volume
38pub_type
杂志文章abstract::Nitrogen metabolism genes of Bacillus subtilis are regulated by the availability of rapidly metabolizable nitrogen sources, but not by any mechanism analogous to the two-component Ntr regulatory system found in enteric bacteria. Instead, at least three regulatory proteins independently control the expression of gene p...
journal_title:Molecular microbiology
pub_type: 杂志文章,评审
doi:10.1046/j.1365-2958.1999.01333.x
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doi:10.1111/j.1365-2958.2008.06515.x
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pub_type: 评论,杂志文章
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pub_type: 杂志文章,评审
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更新日期:2003-11-01 00:00:00
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journal_title:Molecular microbiology
pub_type: 杂志文章
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