Abstract:
:We show that Yersinia pestis and pesticin-sensitive isolates of Y. pseudotuberculosis possess a common 34 kbp DNA region that has all the hallmarks of a pathogenicity island and is inserted into different asparaginyl tRNA genes at different chromosomal locations in each species. This pathogenicity island (YP-HPI) is marked by IS100, has a G + C content different from its host, is flanked by 24 bp direct repeats, encodes a putative, P4-like integrase and contains the iron uptake virulence genes from the pgm locus of Y. pestis. These findings indicate independent horizontal acquisition of this island by Y. pestis and Y. pseudotuberculosis. The two YP-HPI locations and their possession of an integrase gene support a model of site-specific integration of the YP-HPI into these bacteria.
journal_name
Mol Microbioljournal_title
Molecular microbiologyauthors
Hare JM,Wagner AK,McDonough KAdoi
10.1046/j.1365-2958.1999.01172.xsubject
Has Abstractpub_date
1999-01-01 00:00:00pages
291-303issue
1eissn
0950-382Xissn
1365-2958journal_volume
31pub_type
杂志文章abstract::A transposon mutant of Escherichia coli 5K was isolated which reduced 10- to 50-fold the secreted extracellular haemolytic activity of cells carrying the complete hlyCABD operon while leaving unaffected the intracellular haemolytic activity and the levels of intracellular and extracellular haemolysin protein, HlyA. Th...
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journal_title:Molecular microbiology
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更新日期:1996-02-01 00:00:00
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