The hprK gene of Enterococcus faecalis encodes a novel bifunctional enzyme: the HPr kinase/phosphatase.

abstract：:Many types of microorganisms, including both prokaryotes and eukaryotes, have developed mechanisms to adapt to severe osmotic stress. In this study, we isolated multicopy suppressor genes for a Schizosaccharomyces pombe mutant, which exhibited the clear phenotype of being osmosensitive for growth (Osms) on agar plates...

journal_title：Molecular microbiology

authors： Ohmiya R,Yamada H,Nakashima K,Aiba H,Mizuno T

更新日期：1995-12-01 00:00:00

abstract：:The two-component regulatory system PhoPQ has been shown to regulate the expression of virulence factors in a number of bacterial species. For one such virulence factor, lipopolysaccharide (LPS), the PhoPQ system has been shown to regulate structural modifications in Salmonella enterica var Typhimurium. In Yersinia pe...

journal_title：Molecular microbiology

authors： Hitchen PG,Prior JL,Oyston PC,Panico M,Wren BW,Titball RW,Morris HR,Dell A

更新日期：2002-06-01 00:00:00

abstract：:Mycobacterial genomes contain large sets of loci encoding membrane proteins that belong to a family of multidrug resistance pumps designated Resistance-Nodulation-Cell Division (RND) permeases. Mycobacterial membrane protein Large (MmpL) transporters represent a subclass of RND transporters known to participate in the...

journal_title：Molecular microbiology

authors： Viljoen A,Dubois V,Girard-Misguich F,Blaise M,Herrmann JL,Kremer L

更新日期：2017-06-01 00:00:00

abstract：:A family of nine Salmonella typhimurium type III secretion effectors with a conserved amino-terminus have been defined. Three family members (SifA, SifB and SseJ) have previously been demonstrated to localize to the Salmonella-containing vacuole and to Salmonella-induced filaments. In contrast, we demonstrate that two...

journal_title：Molecular microbiology

authors： Miao EA,Brittnacher M,Haraga A,Jeng RL,Welch MD,Miller SI

更新日期：2003-04-01 00:00:00

abstract：:Regulation of polar development and cell division in Caulobacter crescentus relies on the dynamic localization of several proteins to cell poles at specific stages of the cell cycle. The polar organelle development protein, PodJ, is required for the synthesis of the adhesive holdfast and pili. Here we show the cell cy...

journal_title：Molecular microbiology

authors： Hinz AJ,Larson DE,Smith CS,Brun YV

更新日期：2003-02-01 00:00:00

abstract：:We found that mutations that increased the transcription of the mgtCBR (Mg2+ transport-related) operon conferred increased thermotolerance on this organism. The 5' leader of the mgtCBR mRNA contains two short open reading frames (ORFs), mgtM and mgtP, whose translation regulates the expression of the mgtCBR operon by ...

journal_title：Molecular microbiology

authors： Gall AR,Hegarty AE,Datsenko KA,Westerman RP,SanMiguel P,Csonka LN

更新日期：2018-08-01 00:00:00

abstract：:The fungal pathogen Candida albicans can transition from budding to hyphal growth, which promotes biofilm formation and invasive growth into tissues. Stimulation of adenylyl cyclase to form cAMP induces hyphal morphogenesis. The failure of cells lacking adenylyl cyclase (cyr1Δ) to form hyphae has suggested that cAMP s...

journal_title：Molecular microbiology

authors： Parrino SM,Si H,Naseem S,Groudan K,Gardin J,Konopka JB

更新日期：2017-03-01 00:00:00

abstract：:A challenge common to all bacterial pathogens is to acquire nutrients from hostile host environments. Iron is an important cofactor required for essential cellular processes such as DNA repair, energy production and redox balance. Within a mammalian host, most iron is sequestered within heme, which in turn is predomin...

journal_title：Molecular microbiology

authors： Clark J,Terwilliger A,Nguyen C,Green S,Nobles C,Maresso A

更新日期：2019-08-01 00:00:00

abstract：UNLABELLED:Haem Nitric oxide/OXygen (H-NOX) binding domains are a family of haemoprotein sensors that are widespread in bacterial genomes, but limited information is available on their function. Legionella pneumophila is the only prokaryote found, thus far, to encode two H-NOX proteins. This paper presents data support...

journal_title：Molecular microbiology

authors： Carlson HK,Vance RE,Marletta MA

更新日期：2010-08-01 00:00:00

abstract：:The rotA gene of Escherichia coli encodes a peptidyl-prolyl cis/trans isomerase (PPIase), which is supposed to catalyse protein folding in the periplasm. To investigate the importance of the enzyme, the rotA gene was cloned and a chromosomal deletion mutant was created. The rotA mutant was normally viable. No residual...

journal_title：Molecular microbiology

authors： Kleerebezem M,Heutink M,Tommassen J

更新日期：1995-10-01 00:00:00

abstract：:Chlamydiae are bacterial parasites that carry out a distinct developmental cycle within host cells; however, the mechanisms by which these organisms regulate stage-specific gene expression are not known. We identified a DNA element located between nucleotide (nt) -135 and -90 upstream from the transcription start poin...

journal_title：Molecular microbiology

authors： Zhong J,Douglas AL,Hatch TP

更新日期：2001-07-01 00:00:00

abstract：:Listeria monocytogenes is a Gram-positive intracellular bacterium responsible for severe opportunistic infections in humans and animals. Signature-tagged mutagenesis (STM) was used to identify a gene named fbpA, required for efficient liver colonization of mice inoculated intravenously. FbpA was also shown to be requi...

journal_title：Molecular microbiology

authors： Dramsi S,Bourdichon F,Cabanes D,Lecuit M,Fsihi H,Cossart P

更新日期：2004-07-01 00:00:00

abstract：:Mechanisms of hydrogen peroxide generation in Escherichia coli were investigated using a strain lacking scavenging enzymes. Surprisingly, the deletion of many abundant flavoenzymes that are known to autoxidize in vitro did not substantially lessen overall H(2)O(2) formation. However, H(2)O(2) production diminished by ...

journal_title：Molecular microbiology

authors： Korshunov S,Imlay JA

更新日期：2010-03-01 00:00:00

abstract：:We used in vivo oxidative cross-linking of engineered cysteine pairs to assess conformational changes in the four-helix transmembrane domain of chemoreceptor Trg. Extending previous work, we searched for and found a fourth cross-linking pair that spanned the intrasubunit interface between transmembrane helix 1 (TM1) a...

journal_title：Molecular microbiology

authors： Beel BD,Hazelbauer GL

更新日期：2001-05-01 00:00:00

abstract：:Infection of a murine-spleen dendritic cell line by Listeria monocytogenes was found to induce cell death through apoptosis. To characterize the bacterial product(s) involved in induction of apoptosis, dendritic cells were infected with the L. monocytogenes EGD strain and several isogenic mutants deficient in the prod...

journal_title：Molecular microbiology

authors： Guzmán CA,Domann E,Rohde M,Bruder D,Darji A,Weiss S,Wehland J,Chakraborty T,Timmis KN

更新日期：1996-04-01 00:00:00

abstract：:Malaria-causing parasites are transmitted from humans to mosquitoes when developmentally arrested gametocytes are taken up by a female Anopheles during a blood meal. The changes in environment from human to mosquito activate gametogenesis, including a drop in temperature, a rise in pH, and a mosquito-derived molecule,...

journal_title：Molecular microbiology

authors： Brochet M,Balestra AC,Brusini L

更新日期：2020-10-28 00:00:00

abstract：:Two-component regulatory proteins function in bacteria as sensory and adaptive factors in response to a wide range of environmental stimuli. Some two-component systems, such as PhoP/PhoQ, control transcription of key virulence genes essential for survival in host cells in diverse intracellular bacterial pathogens, inc...

journal_title：Molecular microbiology

authors： Pérez E,Samper S,Bordas Y,Guilhot C,Gicquel B,Martín C

更新日期：2001-07-01 00:00:00

abstract：:DNA polymerases of the X family have been implicated in a variety of DNA repair processes in eukaryotes. Here we show that Deinococcus radiodurans, a highly radioresistant bacterium able to mend hundreds of radiation-induced double-stranded DNA breaks, expresses a DNA polymerase belonging to the X family. This novel b...

journal_title：Molecular microbiology

authors： Lecointe F,Shevelev IV,Bailone A,Sommer S,Hübscher U

更新日期：2004-09-01 00:00:00

abstract：:Like other bacterial species, Mycobacterium tuberculosis has multiple sigma (sigma) factors encoded in its genome. In previously published work, we and others have shown that mutations in some of these transcriptional activators render M. tuberculosis sensitive to various environmental stresses and, in some cases, cau...

journal_title：Molecular microbiology

authors： Manganelli R,Voskuil MI,Schoolnik GK,Dubnau E,Gomez M,Smith I

更新日期：2002-07-01 00:00:00

abstract：:Borrelia hermsii, an agent of relapsing fever, avoids the host's immune response by means of multiphasic antigenic variation. Serotype specificity is determined by variable antigens called the Vmp lipoproteins. Through recombination between linear plasmids a formerly silent vmp gene replaces another vmp gene at a telo...

journal_title：Molecular microbiology

authors： Barbour AG,Burman N,Carter CJ,Kitten T,Bergström S

更新日期：1991-02-01 00:00:00

abstract：:Summary Successful malaria transmission from the mosquito vector to the mammalian host depends crucially on active sporozoite motility. Sporozoite locomotion and host cell invasion are driven by the parasite's own actin/myosin motor. A unique feature of this motor machinery is the presence of very short subpellicular ...

journal_title：Molecular microbiology

authors： Ganter M,Schüler H,Matuschewski K

更新日期：2009-12-01 00:00:00

abstract：:Protein kinase C constitutes a family of serine-threonine kinases found in all eukaryotes and implicated in a wide range of cellular functions, including regulation of cell growth, cellular differentiation and immunity. Here, we present three independent lines of evidence which indicate that protein kinase C is essent...

journal_title：Molecular microbiology

authors： Penn TJ,Wood ME,Soanes DM,Csukai M,Corran AJ,Talbot NJ

更新日期：2015-10-01 00:00:00

abstract：:In mammalian cells RACK1 serves as a scaffold protein that has a role in integrating inputs from different signalling pathways and affects translation through association with ribosomes. Ustilago maydis contains a seven-WD40 repeat motif protein designated Rak1, which shows 68% identity to RACK1 and 51% identity to As...

journal_title：Molecular microbiology

authors： Wang L,Berndt P,Xia X,Kahnt J,Kahmann R

更新日期：2011-09-01 00:00:00

abstract：:A region of 7.8 kb of the plasmid pMB2 from Enterococcus faecalis S-48 carrying the information necessary for production and immunity of the peptide antibiotic AS-48 has been cloned and sequenced. It contains the as-48A structural gene plus five open reading frames (as-48B, as-48C, as-48C1, as-48D and as-48D1). Beside...

journal_title：Molecular microbiology

authors： Martínez-Bueno M,Valdivia E,Gálvez A,Coyette J,Maqueda M

更新日期：1998-01-01 00:00:00

abstract：:Corynebacterium glutamicum is a Gram-positive soil bacterium that prefers the simultaneous catabolism of different carbon sources rather than their sequential utilization. This type of metabolism requires an adaptation of the utilization rates to the overall metabolic capacity. Here we show how two functionally redund...

journal_title：Molecular microbiology

authors： Frunzke J,Engels V,Hasenbein S,Gätgens C,Bott M

更新日期：2008-01-01 00:00:00

abstract：:Early diverged extant organisms, which may serve as convenient laboratory models to look for and study evolutionary ancient features of eukaryotic cell biology, are rare. The diplomonad Giardia intestinalis, a protozoan parasite known to cause diarrhoeal disease, has become an increasingly popular object of basic rese...

journal_title：Molecular microbiology

authors： Hehl AB,Marti M

更新日期：2004-07-01 00:00:00

abstract：:Aspergillus fumigatus, an important human nosocomial pathogen, is resistant to sordarin derivatives, a new family of antifungals that inhibit protein synthesis by interaction with the EF-2-ribosomal stalk complex. To explore the role of the A. fumigatus ribosome in the resistance mechanism, the fungal stalk proteins w...

journal_title：Molecular microbiology

authors： Santos C,Ballesta JP

更新日期：2002-01-01 00:00:00

abstract：:Fungal 1,8-dihydroxynaphthalene (DHN) melanin plays important roles in UV protection, oxidative stress and pathogenesis. However, knowledge of the regulatory mechanisms of its biosynthesis is limited. Previous studies showed two transcription factors, PfmaF and PfmaH, located in the DHN melanin biosynthetic gene clust...

journal_title：Molecular microbiology

authors： Zhang P,Zhou S,Wang G,An Z,Liu X,Li K,Yin WB

更新日期：2019-08-01 00:00:00

abstract：:Oxidative stress serves as an important host/environmental signal that triggers a wide range of responses from the human pathogen Staphylococcus aureus. Among these, a thiol-based oxidation sensing pathway through a global regulator MgrA controls the virulence and antibiotic resistance of the bacterium. Herein, we rep...

journal_title：Molecular microbiology

authors： Chen PR,Nishida S,Poor CB,Cheng A,Bae T,Kuechenmeister L,Dunman PM,Missiakas D,He C

更新日期：2009-01-01 00:00:00

abstract：:A new class of Bacillus thuringiensis delta-endotoxins, or insecticidal control proteins (ICPs), is defined by an apparently cryptic protein with a unique primary structure and novel entomocidal specificity for certain coleopteran and lepidopteran species. The discovery of a new group of ICPs will extend the use of th...

journal_title：Molecular microbiology

authors： Tailor R,Tippett J,Gibb G,Pells S,Pike D,Jordan L,Ely S

更新日期：1992-05-01 00:00:00