Vital role for the Plasmodium actin capping protein (CP) beta-subunit in motility of malaria sporozoites.

abstract：:Mycoplasma agalactiae, an important pathogen of small ruminants, exhibits antigenic diversity by switching the expression of multiple surface lipoproteins called Vpmas (Variable proteins of M. agalactiae). Although phase variation has been shown to play important roles in many host-pathogen interactions, the biologica...

journal_title：Molecular microbiology

authors： Chopra-Dewasthaly R,Citti C,Glew MD,Zimmermann M,Rosengarten R,Jechlinger W

更新日期：2008-03-01 00:00:00

abstract：:Platelet binding by Streptococcus gordonii strain M99 is strongly correlated with the expression of the large surface glycoprotein GspB. A 14 kb chromosomal region downstream of gspB was previously shown to be required for the expression of this protein. The region encodes SecA2 and SecY2, which are components of an a...

journal_title：Molecular microbiology

authors： Takamatsu D,Bensing BA,Sullam PM

更新日期：2004-04-01 00:00:00

abstract：:Despite their high genomic synteny, the Leishmania major and Leishmania infantum species exhibit extensive differences in mRNA expression patterns throughout the parasite's development. Yet, the underlying mechanisms for this species-specific differential gene expression are largely unknown. Here we report that Short ...

journal_title：Molecular microbiology

authors： Müller M,Padmanabhan PK,Papadopoulou B

更新日期：2010-07-01 00:00:00

abstract：:In nitrogen-poor soils, rhizobia elicit nodule formation on legume roots, within which they differentiate into bacteroids that fix atmospheric nitrogen. Protection against reactive oxygen species (ROS) was anticipated to play an important role in Rhizobium-legume symbiosis because nitrogenase is extremely oxygen sensi...

journal_title：Molecular microbiology

authors： Santos R,Hérouart D,Puppo A,Touati D

更新日期：2000-11-01 00:00:00

abstract：:The expression of the structural genes for lysine (LYS) biosynthesis is controlled by a pathway-specific regulation mediated by the transcriptional activator Lys14 in the presence of alpha-aminoadipate semialdehyde, an intermediate of the pathway acting as a co-inducer. Owing to end product inhibition of the first ste...

journal_title：Molecular microbiology

authors： Becker B,Feller A,el Alami M,Dubois E,Piérard A

更新日期：1998-07-01 00:00:00

abstract：:An 18 633 bp region containing the replicon from the approximately 53 kb pBM400 plasmid of Bacillus megaterium QM B1551 has been sequenced and characterized. This region contained a complete rRNA operon plus 10 other potential open reading frames (ORFs). The replicon consisted of an upstream promoter and three contigu...

journal_title：Molecular microbiology

authors： Kunnimalaiyaan M,Stevenson DM,Zhou Y,Vary PS

更新日期：2001-02-01 00:00:00

abstract：:Arginine auxotrophs of the dinitrogen-fixing cyanobacterium Anabaena species strain PCC 7120 were isolated after ultraviolet light mutagenesis and penicillin enrichment. Two of these auxotrophs were complemented by a cosmid gene library of the wild-type strain established in Escherichia coli that was transferred en ma...

journal_title：Molecular microbiology

authors： Floriano B,Herrero A,Flores E

更新日期：1992-08-01 00:00:00

abstract：:Because the ferric uptake regulator (fur) appears to be an essential gene in Pseudomonas aeruginosa, resistance to manganese was used as an enrichment to isolate strains carrying point mutations in the fur gene in order to assess its role in the co-ordinate expression of siderophores and exotoxin A (ETA). This report ...

journal_title：Molecular microbiology

authors： Barton HA,Johnson Z,Cox CD,Vasil AI,Vasil ML

更新日期：1996-09-01 00:00:00

abstract：:In prokaryotes, the principal signal transduction systems operating at the level of protein phosphorylation are the two-component systems. A number of hybrid histidine protein kinases in these systems contain several receiver domains, however, the function of these receiver domains is unknown. The RodK kinase in Myxoc...

journal_title：Molecular microbiology

authors： Rasmussen AA,Wegener-Feldbrügge S,Porter SL,Armitage JP,Søgaard-Andersen L

更新日期：2006-04-01 00:00:00

abstract：:Pseudomonas aeruginosa is an opportunistic pathogen that is notorious for its intrinsic drug resistance. We have used chemical and genetic techniques to characterize three putative kinase genes that are involved in the addition of phosphate to the inner core region of P. aeruginosa lipopolysaccharide. The first gene i...

journal_title：Molecular microbiology

authors： Walsh AG,Matewish MJ,Burrows LL,Monteiro MA,Perry MB,Lam JS

更新日期：2000-02-01 00:00:00

abstract：:The pathogen Vibrio cholerae modulates the expression of many genes in order to transition from its environmental reservoir to its niche in the human host. Among these are genes encoding two related Type IV pili, the mannose-sensitive haemagglutinin (MSHA) pilus, which aids V. cholerae persistence in aquatic environme...

journal_title：Molecular microbiology

authors： Hsiao A,Toscano K,Zhu J

更新日期：2008-02-01 00:00:00

abstract：:The glycopeptide antibiotic-producing bacterium, Streptomyces toyocaensis NRRL 15009, has proteins phosphorylated on Ser, Thr, Tyr and His, implying the presence of a battery of associated kinases. We have identified the Ser/Thr protein kinase gene fragments stoPK-1, stoPK-2, stoPK-3 and stoPK-4 from S. toyocaensis NR...

journal_title：Molecular microbiology

authors： Neu JM,MacMillan SV,Nodwell JR,Wright GD

更新日期：2002-04-01 00:00:00

abstract：:Phase variation of the major ureaplasma surface membrane protein, the multiple-banded antigen (MBA), with its counterpart, the UU376 protein, was recently discussed as a result of DNA inversion occurring at specific inverted repeats. Two similar inverted repeats to the ones within the mba locus were found in the genom...

journal_title：Molecular microbiology

authors： Zimmerman CU,Rosengarten R,Spergser J

更新日期：2011-02-01 00:00:00

abstract：:Prior to the discovery of a minimal ATP-dependent DNA ligase in Haemophilus influenzae, bacteria were thought to only possess a NAD-dependent ligase, which was involved in sealing of Okazaki fragments. We now know that a diverse range of bacterial species possess up to six of these accessory bacterial ATP-dependent DN...

journal_title：Molecular microbiology

authors： Williamson A,Hjerde E,Kahlke T

更新日期：2016-01-01 00:00:00

abstract：:BldD generally functions as a repressor controlling morphological development of Streptomyces. In this work, evidences that BldD also activates antibiotic production are provided. In Streptomyces roseosporus (which produces daptomycin widely used for treatment of human infections), deletion of bldD notably reduced dap...

journal_title：Molecular microbiology

authors： Yan H,Lu X,Sun D,Zhuang S,Chen Q,Chen Z,Li J,Wen Y

更新日期：2020-01-01 00:00:00

abstract：:Listeria monocytogenes is a Gram-positive intracellular parasite and the causative organism of human listeriosis. In this article we demonstrate that L. monocytogenes encodes a functional member of the CodY family of global regulatory proteins that is responsive to both GTP and branched chain amino acids. By transcrip...

journal_title：Molecular microbiology

authors： Bennett HJ,Pearce DM,Glenn S,Taylor CM,Kuhn M,Sonenshein AL,Andrew PW,Roberts IS

更新日期：2007-03-01 00:00:00

abstract：:Myxococcus xanthus is a Gram-negative bacterium capable of complex developmental processes involving vegetative swarming and fruiting body formation. Social (S-) gliding motility, one of the two motility systems used by M. xanthus, requires at least two cell surface structures: type IV pili (TFP) and extracellular pol...

journal_title：Molecular microbiology

authors： Yang Z,Lux R,Hu W,Hu C,Shi W

更新日期：2010-06-01 00:00:00

abstract：:The Myxococcus xanthus gene, pkn9, encodes a protein that contains significant homology with eukaryotic Ser/Thr protein kinases. The pkn9 gene was singled out of a previously identified family of kinase genes by amplification techniques that displayed differences in kinase gene expression during selected periods of th...

journal_title：Molecular microbiology

authors： Hanlon WA,Inouye M,Inouye S

更新日期：1997-02-01 00:00:00

abstract：:The esg locus is required for the formation of multicellular fruiting bodies and spores by the developmental bacterium Myxococcus xanthus. Studies have suggested that esg mutants are defective in the production of an essential signal (E-signal) used in cell-cell communication and that E-signalling is required for the ...

journal_title：Molecular microbiology

authors： Downard J,Toal D

更新日期：1995-04-01 00:00:00

abstract：:RNase protection experiments show that the sizes of the two R100 finP molecules are 74 and 135 nucleotides. In an RNase III mutant, finP transcripts form stable double-stranded hybrids of 108 bp and 68 bp with traJ transcripts. RNase protection experiments also show that most R100-1 transcripts originating in traM cro...

journal_title：Molecular microbiology

authors： Dempsey WB

更新日期：1994-07-01 00:00:00

abstract：:Listeria monocytogenes is a facultative intracellular pathogen which secretes a pore-forming cytolysin, listeriolysin O (LLO), necessary for intracellular growth. Clostridium perfringens is an extracellular pathogen which secretes a related cytolysin, perfringolysin O (PFO). When PFO is secreted by intracellular L. mo...

journal_title：Molecular microbiology

authors： Jones S,Preiter K,Portnoy DA

更新日期：1996-09-01 00:00:00

abstract：:Salmonella translocate a group of type III effectors into the host cells to induce entry, promote survival and cause intestinal inflammation. Although the biochemical and cellular mechanisms of how bacterial effectors function inside host cells remain largely unknown, studies have indicated that a likely strategy is t...

journal_title：Molecular microbiology

authors： Zhang Y,Higashide WM,McCormick BA,Chen J,Zhou D

更新日期：2006-11-01 00:00:00

abstract：:Summary Spore formation in the Gram-positive bacterium Bacillus subtilis is a last resort adaptive response to starvation. To initiate sporulation, the key regulator in this process, Spo0A, needs to be activated by the so-called phosphorelay. Within a sporulating culture of B. subtilis, some cells initiate this develo...

journal_title：Molecular microbiology

authors： Veening JW,Hamoen LW,Kuipers OP

更新日期：2005-06-01 00:00:00

abstract：:We have previously shown that in the human pathogen Neisseria meningitidis group B (MenB) more than 200 genes are regulated in response to growth with iron. Among the Fur-dependent, upregulated genes identified by microarray analysis was a putative operon constituted by three genes, annotated as NMB1436, NMB1437 and N...

journal_title：Molecular microbiology

authors： Grifantini R,Frigimelica E,Delany I,Bartolini E,Giovinazzi S,Balloni S,Agarwal S,Galli G,Genco C,Grandi G

更新日期：2004-11-01 00:00:00

abstract：:The nucleotide sequence of a 2711bp DNA segment which contains the N-terminal coding sequence and the 5' flanking region of a crystal protein gene (bta) from Bacillus thuringiensis subsp. aizawai 7.29 has been determined. The coding region encodes an 824 amino-acid polypeptide corresponding to a carboxy-terminally tru...

journal_title：Molecular microbiology

authors： Sanchis V,Lereclus D,Menou G,Chaufaux J,Guo S,Lecadet MM

更新日期：1989-02-01 00:00:00

abstract：:The PhaF is a nucleoid-associated like protein of Pseudomonas putida KT2442 involved in the polyhydroxyalkanoate (PHA) metabolism. Its primary structure shows two modular domains; the N-terminal PHA granule-binding domain (phasin domain) and the C-terminal half containing AAKP-like tandem repeats characteristic of the...

journal_title：Molecular microbiology

authors： Galán B,Dinjaski N,Maestro B,de Eugenio LI,Escapa IF,Sanz JM,García JL,Prieto MA

更新日期：2011-01-01 00:00:00

abstract：:Fourteen Rhodobacter capsulatus mutants unable to grow with xanthine as sole nitrogen source were isolated by random Tn5 mutagenesis. Five of these Tn5 insertions were mapped within two adjacent chromosomal EcoRI fragments hybridizing to oligonucleotides synthesized according to conserved amino acid sequences of eukar...

journal_title：Molecular microbiology

authors： Leimkühler S,Kern M,Solomon PS,McEwan AG,Schwarz G,Mendel RR,Klipp W

更新日期：1998-02-01 00:00:00

abstract：:We used DNA macroarray analysis to identify genes that respond to the status of the intracellular acetyl phosphate (acP) pool. Genes whose expression correlated negatively with the ability to synthesize acP (i.e. negatively regulated genes) function primarily in flagella biosynthesis, a result consistent with observat...

journal_title：Molecular microbiology

authors： Wolfe AJ,Chang DE,Walker JD,Seitz-Partridge JE,Vidaurri MD,Lange CF,Prüss BM,Henk MC,Larkin JC,Conway T

更新日期：2003-05-01 00:00:00

abstract：:Biofilm formation is a social behaviour that generates favourable conditions for sustained survival in the natural environment. For the Gram-positive bacterium Bacillus subtilis the process involves the differentiation of cell fate within an isogenic population and the production of communal goods that form the biofil...

journal_title：Molecular microbiology

authors： Cairns LS,Hobley L,Stanley-Wall NR

更新日期：2014-08-01 00:00:00

abstract：:Chlamydia is predicted to encode two alternative sigma factors that could provide a mechanism for the regulation of gene expression via alternative forms of RNA polymerase. We have demonstrated that sigma 28, one of these alternative sigma factors, is transcriptionally active. Chlamydial sigma 28 RNA polymerase was re...

journal_title：Molecular microbiology

authors： Yu HH,Tan M

更新日期：2003-10-01 00:00:00