Abstract:
:Mycobacterial genomes contain large sets of loci encoding membrane proteins that belong to a family of multidrug resistance pumps designated Resistance-Nodulation-Cell Division (RND) permeases. Mycobacterial membrane protein Large (MmpL) transporters represent a subclass of RND transporters known to participate in the export of lipid components across the cell envelope. These surface-exposed lipids with unusual structures play key roles in the physiology of mycobacteria and/or can act as virulence factors and immunomodulators. Defining the substrate specificity of MmpLs and their mechanisms of regulation helps understanding how mycobacteria elaborate their complex cell wall. This review describes the diversity of MmpL proteins in mycobacteria, emphasising their high abundance in a few opportunistic rapid-growing mycobacteria. It reports the conservation of mmpL loci between Mycobacterium tuberculosis and non-tuberculous mycobacteria, useful in predicting the role of MmpLs with unknown functions. Paradoxically, whereas MmpLs participate in drug resistance mechanisms, they represent also attractive pharmacological targets, opening the way for exciting translational applications. The most recent advances regarding structural/functional information are also provided to explain the molecular basis underlying the proton-motive force driven lipid transport. Overall, this review emphasises the Janus-face nature of MmpLs at the crossroads between antibiotic resistance mechanisms and exquisite vulnerability to drugs.
journal_name
Mol Microbioljournal_title
Molecular microbiologyauthors
Viljoen A,Dubois V,Girard-Misguich F,Blaise M,Herrmann JL,Kremer Ldoi
10.1111/mmi.13675subject
Has Abstractpub_date
2017-06-01 00:00:00pages
889-904issue
6eissn
0950-382Xissn
1365-2958journal_volume
104pub_type
杂志文章,评审abstract::The F factor traY gene product (TraYp) is a site-specific DNA-binding protein involved in initiation of DNA transfer during bacterial conjugation. The sequence of TraYp exhibits a unique direct-repeat structure predicted to have a ribbon-helix-helix DNA-binding motif in each repeat unit. The stoichiometry of TraYp bin...
journal_title:Molecular microbiology
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journal_title:Molecular microbiology
pub_type: 杂志文章
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更新日期:2006-11-01 00:00:00
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pub_type: 杂志文章
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更新日期:2009-09-01 00:00:00
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更新日期:1998-07-01 00:00:00
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更新日期:2001-10-01 00:00:00
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更新日期:2004-05-01 00:00:00
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journal_title:Molecular microbiology
pub_type: 杂志文章
doi:10.1046/j.1365-2958.2001.02627.x
更新日期:2001-10-01 00:00:00
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更新日期:2008-05-01 00:00:00
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journal_title:Molecular microbiology
pub_type: 杂志文章
doi:10.1046/j.1365-2958.2003.03501.x
更新日期:2003-05-01 00:00:00
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journal_title:Molecular microbiology
pub_type: 杂志文章
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更新日期:2013-02-01 00:00:00
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pub_type: 杂志文章
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journal_title:Molecular microbiology
pub_type: 杂志文章,评审
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pub_type: 评论,杂志文章
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pub_type: 评论,杂志文章
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