Abstract:
:A search with the proposed amino acid translation product from the new 'candidate gene' for human Menkes disease against protein sequence libraries showed a remarkable similarity to that for the cadmium efflux ATPase from Staphylococcus aureus resistance plasmids. The Menkes sequence appears closer to the CadA Cd2+ sequence than to P-type ATPases from animal sources. Menkes syndrome is an X-chromosome invariably fatal disease that results from aberrant copper metabolism. The gene that is defective in Menkes patients, i.e. the Menkes candidate gene, encodes a P-type ATPase, whose properties satisfactorily explain the phenotype of the disease. P-type ATPases are all cation pumps, either for uptake (e.g. the bacterial Kdp K+ ATPase), for efflux (e.g. the muscle sarcoplasmic reticulum Ca2+ ATPase), or for cation exchange (e.g. the animal cell Na+/K+ ATPase). These enzymes have a conserved aspartate residue that is transiently phosphorylated from ATP during the transport cycle, hence the name 'P-type' ATPase. The Menkes sequence shares with the staphylococcal CadA ATPase those regions common to all P-type ATPases and also an N-terminal dithiol region that was proposed to be a 'metal-binding motif'. There are one or two copies of this motif in the available CadA sequences and six copies in the Menkes sequence.
journal_name
Mol Microbioljournal_title
Molecular microbiologyauthors
Silver S,Nucifora G,Phung LTdoi
10.1111/j.1365-2958.1993.tb00898.xsubject
Has Abstractpub_date
1993-10-01 00:00:00pages
7-12issue
1eissn
0950-382Xissn
1365-2958journal_volume
10pub_type
杂志文章,评审abstract::A locust within chromosome XIII of Saccharomyces cerevisiae containing four genes upregulated by osmotic stress has been characterized. Two of the genes, but not their osmotic induction, were already described: the DNA damage-inducible gene DDR48 and the protease inhibitor gene PAI3. The two novel genes encode a cytop...
journal_title:Molecular microbiology
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abstract::We used DNA macroarray analysis to identify genes that respond to the status of the intracellular acetyl phosphate (acP) pool. Genes whose expression correlated negatively with the ability to synthesize acP (i.e. negatively regulated genes) function primarily in flagella biosynthesis, a result consistent with observat...
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更新日期:1998-03-01 00:00:00
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pub_type: 杂志文章
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journal_title:Molecular microbiology
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doi:10.1111/j.1365-2958.1993.tb01611.x
更新日期:1993-05-01 00:00:00
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pub_type: 杂志文章
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更新日期:2001-04-01 00:00:00
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pub_type: 杂志文章
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更新日期:1994-05-01 00:00:00
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更新日期:2010-11-01 00:00:00
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更新日期:2010-01-01 00:00:00
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更新日期:2008-06-01 00:00:00
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更新日期:2001-01-01 00:00:00
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journal_title:Molecular microbiology
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pub_type: 杂志文章,评审
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更新日期:1993-06-01 00:00:00
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