Abstract:
:We investigated the function and transcriptional regulation of ywcG. The protein is essential for Bacillus subtilis. Biochemical characterization of the protein revealed that it is an FMN-containing NADPH oxidase. ywcG is transcribed throughout the whole life cycle of B. subtilis. The start point of transcription is preceded by potential promoter sequences for sigmaA, sigmaB and sigmaD. A boost in transcription occurs at the beginning of stationary phase in complex media containing glutamate and glucose. The induction of transcription at the beginning of stationary phase needs the activity of a different alternative sigma-factor sigmaD. ywcG is, therefore, the first gene with a putative role in energy metabolism from B. subtilis that is transcribed in a sigmaD-dependent fashion, but its regulation is unique and the reverse of that described for all other sigmaD-dependent genes.
journal_name
Mol Microbioljournal_title
Molecular microbiologyauthors
Moch C,Schrögel O,Allmansberger Rdoi
10.1046/j.1365-2958.1998.00734.xsubject
Has Abstractpub_date
1998-03-01 00:00:00pages
889-98issue
5eissn
0950-382Xissn
1365-2958journal_volume
27pub_type
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