PKA and Sch9 control a molecular switch important for the proper adaptation to nutrient availability.

abstract：:A 4.0 kb EcoRI fragment of Bacillus subtilis conferring thiostrepton resistance was cloned and characterized. By nucleotide sequencing of the relevant region, six open reading frames were established, which corresponded to a part of spo0H, a ribosomal protein gene (rpmG), an unidentified open reading frame (orfE), a t...

journal_title：Molecular microbiology

authors： Jeong SM,Yoshikawa H,Takahashi H

更新日期：1993-10-01 00:00:00

abstract：:In the corn smut fungus Ustilago maydis, pathogenic development is controlled by the b mating type locus that encodes the two homeodomain proteins bE and bW. A heterodimer of bE and bW controls a large set of genes, either directly by binding to cis regulatory sequences or indirectly via a b-dependent regulatory casca...

journal_title：Molecular microbiology

authors： Reichmann M,Jamnischek A,Weinzierl G,Ladendorf O,Huber S,Kahmann R,Kämper J

更新日期：2002-11-01 00:00:00

abstract：:This review assembles data from three bodies of literature (bacterial genetics, plastid biogenesis and parasitology) that seldom have much direct cross-talk. After overcoming terminological complications to sort out microbial nifS from sufS genes, we connect a bacterial operon, recently found to be involved in iron me...

journal_title：Molecular microbiology

authors： Ellis KE,Clough B,Saldanha JW,Wilson RJ

更新日期：2001-09-01 00:00:00

abstract：:The gltX gene, encoding the glutamyl-tRNA synthetase (GluRS), and the valU operon, whose transcripts contain three tRNAVal/UAC and one tRNALys/UUU, are adjacent and divergently transcribed. It is the only known case of adjacent genes encoding an aminoacyl-tRNA synthetase and a tRNA precursor in Escherichia coli. The g...

journal_title：Molecular microbiology

authors： Champagne N,Lapointe J

更新日期：1998-03-01 00:00:00

abstract：:Staphylococcus aureus strain M produces large amounts of capsular polysaccharide. It produces a non-encapsulated variant at a frequency of 0.01% at 37 degrees C. At high temperature (43 degrees C), the frequency of capsule loss was shown to be 1-38%. A 19 kb plasmid and a prophage were found to be carried by the M str...

journal_title：Molecular microbiology

authors： Lee CY

更新日期：1992-06-01 00:00:00

abstract：:The insertion of proteins into the prokaryotic plasma membrane is catalyzed by translocases and insertases. On one hand, the Sec translocase operates as a transmembrane channel that can open laterally to first bind and then release the hydrophobic segments of a substrate protein into the lipid bilayer. On the other ha...

journal_title：Molecular microbiology

authors： Kuhn A,Kiefer D

更新日期：2017-02-01 00:00:00

abstract：:The rotA gene of Escherichia coli encodes a peptidyl-prolyl cis/trans isomerase (PPIase), which is supposed to catalyse protein folding in the periplasm. To investigate the importance of the enzyme, the rotA gene was cloned and a chromosomal deletion mutant was created. The rotA mutant was normally viable. No residual...

journal_title：Molecular microbiology

authors： Kleerebezem M,Heutink M,Tommassen J

更新日期：1995-10-01 00:00:00

abstract：:Phase variation of the major ureaplasma surface membrane protein, the multiple-banded antigen (MBA), with its counterpart, the UU376 protein, was recently discussed as a result of DNA inversion occurring at specific inverted repeats. Two similar inverted repeats to the ones within the mba locus were found in the genom...

journal_title：Molecular microbiology

authors： Zimmerman CU,Rosengarten R,Spergser J

更新日期：2011-02-01 00:00:00

abstract：:Helicobacter pylori is anomalous among non nitrogen-fixing bacteria in containing an incomplete NIF system for Fe-S cluster assembly comprising two essential proteins, NifS (cysteine desulfurase) and NifU (scaffold protein). Although nifU deletion strains cannot be obtained via the conventional gene replacement, a Nif...

journal_title：Molecular microbiology

authors： Benoit SL,Holland AA,Johnson MK,Maier RJ

更新日期：2018-05-01 00:00:00

abstract：:Three u.v.-induced mutants of the purine-cytosine permease gene of Saccharomyces cerevisiae, with altered apparent Michaelis constant of transport (Kmapp), were cloned and sequenced. One of the mutants had extensive nucleotide replacement, whereas the other two had a single mutation. To evaluate the contribution of th...

journal_title：Molecular microbiology

authors： Bloch JC,Sychrova H,Souciet JL,Jund R,Chevallier MR

更新日期：1992-10-01 00:00:00

abstract：:Microcins are a class of ribosomally synthesized antibacterial peptides produced by Enterobacteriaceae and active against closely related bacterial species. While some microcins are active as unmodified peptides, others are heavily modified by dedicated maturation enzymes. Low-molecular-weight microcins from the post-...

journal_title：Molecular microbiology

authors： Severinov K,Semenova E,Kazakov A,Kazakov T,Gelfand MS

更新日期：2007-09-01 00:00:00

abstract：:Having no known environmental reservoir, Streptococcus pyogenes, a bacterium responsible for a wider variety of human diseases than any other bacterial species, must rely on its host for metabolic substrates. Although a streptococcal aldolase, LacD.1, has been adapted to virulence gene regulation, both LacD.1 and a pa...

journal_title：Molecular microbiology

authors： Loughman JA,Caparon MG

更新日期：2007-04-01 00:00:00

abstract：:In addition to being the major citric acid cycle aconitase in Escherichia coli the aconitase B protein (AcnB) is also a post-transcriptional regulator of gene expression. The AcnB proteins represent a distinct branch of the aconitase superfamily that possess a HEAT-like domain (domain 5). The HEAT domains of other pro...

journal_title：Molecular microbiology

authors： Tang Y,Guest JR,Artymiuk PJ,Green J

更新日期：2005-06-01 00:00:00

abstract：:The secretion of numerous proteins during vegetative growth of Myxococcus xanthus, and the multicellular development cycle induced upon starvation of these bacteria, are partially interrelated in so far as mutants impaired in extracellular protein production are unable to undergo development. We have cloned and sequen...

journal_title：Molecular microbiology

authors： Laval-Favre K,Letouvet-Pawlak B,Friedrich T,Alexandre J,Guespin-Michel JF

更新日期：1997-03-01 00:00:00

abstract：:The recombination of short homologous ends in Escherichia coli has been known for 30 years, and it is often used for both site-directed mutagenesis and in vivo cloning. For cloning, a plasmid and target DNA fragments were converted into linear DNA fragments with short homologous ends, which are joined via recombinatio...

journal_title：Molecular microbiology

authors： Yang Y,Wang T,Yu Q,Liu H,Xun L,Xia Y

更新日期：2020-12-29 00:00:00

abstract：:The influence of low pH on inducible gene expression in Lactobacillus acidophilus was investigated by the use of differential display. Logarithmic phase cultures were exposed to pH 3.5 for various intervals, and RNA was isolated and reverse transcribed. The resultant cDNAs were subjected to PCR and the products were r...

journal_title：Molecular microbiology

authors： Kullen MJ,Klaenhammer TR

更新日期：1999-09-01 00:00:00

abstract：:LeuO is a quiescent LysR-type regulator belonging to the H-NS regulon. Activation of leuO transcription represses expression of pathogenicity island 1 (SPI-1) in Salmonella enterica serovar Typhimurium and inhibits invasion of epithelial cells. Loss of HilE suppresses LeuO-mediated downregulation of SPI-1. Activation ...

journal_title：Molecular microbiology

authors： Espinosa E,Casadesús J

更新日期：2014-03-01 00:00:00

abstract：:Cellulosomes are key for lignocellulosic biomass degradation in cellulolytic Clostridia. Better understanding of the mechanism of cellulosome regulation would allow us to improve lignocellulose hydrolysis. It is hypothesized that cellulosomal protease inhibitors would regulate cellulosome architecture and then lignoce...

journal_title：Molecular microbiology

authors： Xu T,Li Y,He Z,Zhou J

更新日期：2014-02-01 00:00:00

abstract：:The natural resistance of Mycobacterium abscessus to most commonly available antibiotics seriously limits chemotherapeutic treatment options, which is particularly challenging for cystic fibrosis patients infected with this rapid-growing mycobacterium. New drugs with novel molecular targets are urgently needed against...

journal_title：Molecular microbiology

authors： Dupont C,Viljoen A,Dubar F,Blaise M,Bernut A,Pawlik A,Bouchier C,Brosch R,Guérardel Y,Lelièvre J,Ballell L,Herrmann JL,Biot C,Kremer L

更新日期：2016-08-01 00:00:00

abstract：:Cell division is mediated by different mechanisms in different evolutionary lineages. While bacteria and euryarchaea utilize an FtsZ-based mechanism, most crenarchaea divide using the Cdv system, related to the eukaryotic ESCRT-III machinery. Intriguingly, thaumarchaeal genomes encode both FtsZ and Cdv protein homolog...

journal_title：Molecular microbiology

authors： Pelve EA,Lindås AC,Martens-Habbena W,de la Torre JR,Stahl DA,Bernander R

更新日期：2011-11-01 00:00:00

abstract：:The Incl1 conjugative plasmid Collb-P9 carries a psiB gene that prevents induction of the SOS response in host bacteria. This locus is located 2.5 kb downstream of the ssb (single-stranded DNA-binding protein) gene in the leading region. This portion of Collb is strikingly similar to part of the leading region of the ...

journal_title：Molecular microbiology

authors： Jones AL,Barth PT,Wilkins BM

更新日期：1992-03-01 00:00:00

abstract：:In Candida glabrata, the sirtuins Sir2 and Hst1 control the expression of a wide number of genes including adhesins required for host colonization and niacin transporters needed for growth. Given that these sirtuins can be inactivated during infection, we asked if their inhibition could modify the response of C. glabr...

journal_title：Molecular microbiology

authors： Orta-Zavalza E,Guerrero-Serrano G,Gutiérrez-Escobedo G,Cañas-Villamar I,Juárez-Cepeda J,Castaño I,De Las Peñas A

更新日期：2013-06-01 00:00:00

abstract：:Fungi capable of sexual reproduction use heterothallic (self-sterile) or homothallic (self-fertile) mating strategies. In most ascomycetes, a single mating type locus, MAT, with two alternative forms (MAT1-1 and MAT1-2) called idiomorphs, controls mating ability. In heterothallic ascomycetes, these alternative idiomor...

journal_title：Molecular microbiology

authors： Lee J,Lee T,Lee YW,Yun SH,Turgeon BG

更新日期：2003-10-01 00:00:00

abstract：:Among players in neurobiology, ion channels are the demigods that underlie all our senses, behaviour and intelligence. In animals, these 'gated pores' detect ligands, voltage, heat or stretch forces and emit electric or ionic signals. Patch clamp and genome sequencing now show that nearly all microbes also have these ...

journal_title：Molecular microbiology

authors： Kung C,Blount P

更新日期：2004-07-01 00:00:00

abstract：:The Escherichia coli Sm-like host factor I (Hfq) is thought to play direct and indirect roles in post-transcriptional regulation by targeting small regulatory RNAs and mRNAs. In this study, we have used proteomics to identify new mRNA targets of Hfq. We have identified 11 candidate proteins, synthesis of which was dif...

journal_title：Molecular microbiology

authors： Vecerek B,Moll I,Afonyushkin T,Kaberdin V,Bläsi U

更新日期：2003-11-01 00:00:00

abstract：:A transposon mutant of Escherichia coli 5K was isolated which reduced 10- to 50-fold the secreted extracellular haemolytic activity of cells carrying the complete hlyCABD operon while leaving unaffected the intracellular haemolytic activity and the levels of intracellular and extracellular haemolysin protein, HlyA. Th...

journal_title：Molecular microbiology

authors： Stanley PL,Diaz P,Bailey MJ,Gygi D,Juarez A,Hughes C

更新日期：1993-11-01 00:00:00

abstract：:The Myxococcus xanthus gene, pkn9, encodes a protein that contains significant homology with eukaryotic Ser/Thr protein kinases. The pkn9 gene was singled out of a previously identified family of kinase genes by amplification techniques that displayed differences in kinase gene expression during selected periods of th...

journal_title：Molecular microbiology

authors： Hanlon WA,Inouye M,Inouye S

更新日期：1997-02-01 00:00:00

abstract：:The nucleotide sequence of trkA, a gene encoding a surface component of the constitutive K(+)-uptake systems TrkG and TrkH from Escherichia coli, was determined. The structure of the TrkA protein deduced from the nucleotide sequence accords with the view that TrkA is peripherally bound to the inner side of the cytopla...

journal_title：Molecular microbiology

authors： Schlösser A,Hamann A,Bossemeyer D,Schneider E,Bakker EP

更新日期：1993-08-01 00:00:00

abstract：:The exosporium is the outermost layer of the Bacillus anthracis spore. The predominant protein on the exosporium surface is BclA, a collagen-like glycoprotein. BclA is incorporated on the spore surface late in the B. anthracis sporulation pathway. A second collagen-like protein, BclB, has been shown to be surface-expo...

journal_title：Molecular microbiology

authors： Thompson BM,Stewart GC

更新日期：2008-10-01 00:00:00

abstract：:The Staphylococcus epidermidis genes icaABC are involved in the synthesis of the polysaccharide intercellular adhesin (PIA), which is located mainly on the cell surface, as shown by immunofluorescence studies with PIA-specific antiserum. PIA was shown to be a linear beta-1,6-linked glucosaminoglycan composed of at lea...

journal_title：Molecular microbiology

authors： Heilmann C,Schweitzer O,Gerke C,Vanittanakom N,Mack D,Götz F

更新日期：1996-06-01 00:00:00