A new piperidinol derivative targeting mycolic acid transport in Mycobacterium abscessus.

abstract：:Genetic exchange by natural transformation in Streptococcus pneumoniae occurs in a cell-density dependent process and is initiated by a small extracellular signalling molecule, the competence-stimulating peptide (CSP). comC, the gene for this peptide, has previously been identified and encodes a 44 amino acid pre-pept...

journal_title：Molecular microbiology

authors： Cheng Q,Campbell EA,Naughton AM,Johnson S,Masure HR

更新日期：1997-02-01 00:00:00

abstract：:The Dot/Icm system is a type IVb secretion system used by Legionella pneumophila to modulate vesicular transport in both protozoan and mammalian host cells. It has been shown that proteins and processes that are highly conserved in all eukaryotic cells are targets for some of the proteins injected by the Dot/Icm syste...

journal_title：Molecular microbiology

authors： Campodonico EM,Chesnel L,Roy CR

更新日期：2005-05-01 00:00:00

abstract：:Nodularia spumigena is a filamentous nitrogen-fixing cyanobacterium that forms toxic blooms in brackish water bodies worldwide. Spumigins are serine protease inhibitors reported from a single strain of N. spumigena isolated from the Baltic Sea. These linear tetrapeptides contain non-proteinogenic amino acids including...

journal_title：Molecular microbiology

authors： Fewer DP,Jokela J,Rouhiainen L,Wahlsten M,Koskenniemi K,Stal LJ,Sivonen K

更新日期：2009-09-01 00:00:00

abstract：:The AMA1 sequence is an efficient plasmid replicator and transformation enhancer in Aspergillus nidulans. It comprises two long perfect inverted repeats (MATE elements) flanking a short, unique, central spacer. Subclone analysis indicates that the complete inverted duplication, but not the unique central spacer, is ne...

journal_title：Molecular microbiology

authors： Aleksenko A,Gems D,Clutterbuck J

更新日期：1996-04-01 00:00:00

abstract：:Interactions between domains of ATP-binding cassette (ABC) transporters are of great functional importance and yet are poorly understood. To gain further knowledge of these protein-protein interactions, we studied the inner membrane complex of the maltose transporter of Escherichia coli. We focused on interactions bet...

journal_title：Molecular microbiology

authors： Mourez M,Jéhanno M,Schneider E,Dassa E

更新日期：1998-10-01 00:00:00

abstract：:Arsenic is the most ubiquitous environmental toxin. Here, we demonstrate that bacteria have evolved the ability to use arsenic to gain a competitive advantage over other bacteria at least twice. Microbes generate toxic methylarsenite (MAs(III)) by methylation of arsenite (As(III)) or reduction of methylarsenate (MAs(V...

journal_title：Molecular microbiology

authors： Chen J,Yoshinaga M,Rosen BP

更新日期：2019-02-01 00:00:00

abstract：:Molecular analyses were applied to the genes encoding variants of the serosubtyping antigen, the class 1 outer membrane protein (PorA), from 55 serogroup A Neisseria meningitidis strains. These genes were evolutionarily stable and exhibited a limited range of genetic variation, primarily generated by recombination. Tr...

journal_title：Molecular microbiology

authors： Suker J,Feavers IM,Achtman M,Morelli G,Wang JF,Maiden MC

更新日期：1994-04-01 00:00:00

abstract：:Pseudomonas aeruginosa can express two distinct forms of lipopolysaccharide (LPS), called A-band and B-band. As an attempt to understand the molecular biology of the synthesis and regulation of these LPS antigens, a recombinant plasmid, pFV3, containing genes for A-band expression was isolated previously. In the prese...

journal_title：Molecular microbiology

authors： Lightfoot J,Lam JS

更新日期：1993-05-01 00:00:00

abstract：:Reversible phase variation between the rugose and smooth colony variants is predicted to be important for the survival of Vibrio cholerae in natural aquatic habitats. Microarray expression profiling studies of the rugose and smooth variants of the same strain led to the identification of 124 differentially regulated g...

journal_title：Molecular microbiology

authors： Yildiz FH,Liu XS,Heydorn A,Schoolnik GK

更新日期：2004-07-01 00:00:00

abstract：:The phenomenon of cell-density-dependent control of gene expression, called autoinduction, has long been a subject of interest and investigation in bioluminescent marine bacteria. It is now becoming clear that many other bacteria, including animal and plant pathogens, use an autoinduction mechanism to regulate a varie...

journal_title：Molecular microbiology

authors： Sitnikov DM,Schineller JB,Baldwin TO

更新日期：1995-09-01 00:00:00

abstract：:Deprivation of FtsN, the last protein in the hierarchy of divisome assembly, causes the disassembly of other elements from the division ring, even extending to already assembled proto-ring proteins. Therefore the stability and function of the divisome to produce rings active in septation is not guaranteed until FtsN i...

journal_title：Molecular microbiology

authors： Rico AI,García-Ovalle M,Palacios P,Casanova M,Vicente M

更新日期：2010-05-01 00:00:00

abstract：:We report the construction and the expression in Escherichia coli of three different fusion genes encoding the extended human IgG3 hinge region (Hi) fused in-phase to the C-terminal end of bacterial TEM1 beta-lactamase (Bla). In the first fusion gene blahi, TEM1 beta-lactamase (Bla). In the first fusion gene blahi, th...

journal_title：Molecular microbiology

authors： De Sutter K,Remaut E,Fiers W

更新日期：1992-08-01 00:00:00

abstract：:The threonine dehydratase IlvA is part of the isoleucine biosynthesis pathway in the Gram-positive model bacterium Bacillus subtilis. Consequently, deletion of ilvA causes isoleucine auxotrophy. It has been reported that ilvA pseudo-revertants having a derepressed hom-thrCB operon appear in the presence of threonine. ...

journal_title：Molecular microbiology

authors： Rosenberg J,Müller P,Lentes S,Thiele MJ,Zeigler DR,Tödter D,Paulus H,Brantl S,Stülke J,Commichau FM

更新日期：2016-09-01 00:00:00

abstract：:The endoribonuclease RNase E plays an important role in RNA processing and degradation in Escherichia coli. The construction of an E. coli strain in which the cellular concentration of RNase E can be precisely controlled has made it possible to examine and quantify the effect of RNase E scarcity on RNA decay, gene reg...

journal_title：Molecular microbiology

authors： Jain C,Deana A,Belasco JG

更新日期：2002-02-01 00:00:00

abstract：:Chromalveolates like the diatom Phaeodactylum tricornutum arose through the uptake of a red alga by a phagotrophic protist, a process termed secondary endosymbiosis. In consequence, the plastids are surrounded by two additional membranes compared with primary plastids. This plastid morphology poses additional barriers...

journal_title：Molecular microbiology

authors： Hempel F,Felsner G,Maier UG

更新日期：2010-05-01 00:00:00

abstract：:We describe a chemotactic-like response of Escherichia coli strains lacking most of the known chemotaxis machinery but containing high levels of the response regulator CheY. The bacteria accumulated in aspartate-containing capillaries, they formed rings on tryptone-containing semisolid agar, and the probability of cou...

journal_title：Molecular microbiology

authors： Barak R,Eisenbach M

更新日期：1999-02-01 00:00:00

abstract：:The predatory bacterium Bdellovibrio bacteriovorus swims rapidly by rotation of a single, polar flagellum comprised of a helical filament of flagellin monomers, contained within a membrane sheath and powered by a basal motor complex. Bdellovibrio collides with, enters and replicates within bacterial prey, a process pr...

journal_title：Molecular microbiology

authors： Lambert C,Evans KJ,Till R,Hobley L,Capeness M,Rendulic S,Schuster SC,Aizawa S,Sockett RE

更新日期：2006-04-01 00:00:00

abstract：:Fungal secondary metabolites are important bioactive compounds but the conditions leading to expression of most of the putative secondary metabolism (SM) genes predicted by fungal genomics are unknown. Here we describe a novel mechanism involved in SM-gene regulation based on the finding that, in Aspergillus nidulans,...

journal_title：Molecular microbiology

authors： Reyes-Dominguez Y,Bok JW,Berger H,Shwab EK,Basheer A,Gallmetzer A,Scazzocchio C,Keller N,Strauss J

更新日期：2010-06-01 00:00:00

abstract：:During persistent infection, the intracellular bacterial pathogen Chlamydia trachomatis is viable but severely attenuates the production of new, infectious elementary bodies (EBs). To investigate the reasons for this lack of new EB output, we analysed the expression of chlamydial genes encoding products required for D...

journal_title：Molecular microbiology

authors： Gérard HC,Krausse-Opatz B,Wang Z,Rudy D,Rao JP,Zeidler H,Schumacher HR,Whittum-Hudson JA,Köhler L,Hudson AP

更新日期：2001-08-01 00:00:00

abstract：:We demonstrate that disruption of the htrA (high temperature requirement A) gene in either the virulent Bacillus anthracis Vollum (pXO1(+) , pXO2(+) ), or in the ΔVollum (pXO1(-), pXO2(-), nontoxinogenic and noncapsular) strains, affect significantly the ability of the resulting mutants to withstand heat, oxidative, e...

journal_title：Molecular microbiology

authors： Chitlaru T,Zaide G,Ehrlich S,Inbar I,Cohen O,Shafferman A

更新日期：2011-09-01 00:00:00

abstract：:Deletions or substitutions of amino acids at the carboxyl-terminus of the heat-labile enterotoxin B subunit (EtxB) affect its assembly into pentamers in a temperature-dependent manner. At 42 degrees C, the mutations prevent the B subunits from achieving their final pentameric structure resulting in membrane associatio...

journal_title：Molecular microbiology

authors： Sandkvist M,Bagdasarian M

更新日期：1993-11-01 00:00:00

abstract：:Although diminutive in size, bacteria possess highly diverse and spatially confined cellular structures. Two related alphaproteobacteria, Sinorhizobium meliloti and Caulobacter crescentus, serve as models for investigating the genetic basis of morphological variations. S. meliloti, a symbiont of leguminous plants, syn...

journal_title：Molecular microbiology

authors： Fields AT,Navarrete CS,Zare AZ,Huang Z,Mostafavi M,Lewis JC,Rezaeihaghighi Y,Brezler BJ,Ray S,Rizzacasa AL,Barnett MJ,Long SR,Chen EJ,Chen JC

更新日期：2012-06-01 00:00:00

abstract：:Until recently, rare-earth elements (REEs) had been thought to be biologically inactive. This view changed with the discovery of the methanol dehydrogenase XoxF that strictly relies on REEs for its activity. Some methylotrophs only contain xoxF, while others, including the model phyllosphere colonizer Methylobacterium...

journal_title：Molecular microbiology

authors： Ochsner AM,Hemmerle L,Vonderach T,Nüssli R,Bortfeld-Miller M,Hattendorf B,Vorholt JA

更新日期：2019-05-01 00:00:00

abstract：:Cytoadhesion of infected red blood cells (iRBC) is mediated through parasite-encoded, clonally variant surface antigens (VSA) and is a central process in the pathogenesis of Plasmodium falciparum malaria. Pregnancy-associated malaria (PAM) has been linked to VSA-mediated adhesion of iRBC to the glycosaminoglycan chond...

journal_title：Molecular microbiology

authors： Salanti A,Staalsoe T,Lavstsen T,Jensen AT,Sowa MP,Arnot DE,Hviid L,Theander TG

更新日期：2003-07-01 00:00:00

abstract：:In nature, organic acids are a commonly used source of carbon and energy. Many bacteria use AMP-forming acid:CoA ligases to convert organic acids into their corresponding acyl-CoA derivatives, which can then enter metabolism. The soil environment contains a broad diversity of organic acids, so it is not surprising tha...

journal_title：Molecular microbiology

authors： Burckhardt RM,VanDrisse CM,Tucker AC,Escalante-Semerena JC

更新日期：2020-01-01 00:00:00

abstract：:In trying to identify genetic loci involved in the regulation of cap5 genes in Staphylococcus aureus, we isolated a transposon mutant that exhibited a growth defect, enhanced autolysis and increased sensitivity to Triton X-100 and penicillin, attributable in part to increased murein hydrolase activity. Analysis of the...

journal_title：Molecular microbiology

authors： Ingavale SS,Van Wamel W,Cheung AL

更新日期：2003-06-01 00:00:00

abstract：:Sphingomyelin is the main sphingolipid in Trypanosoma brucei, the causative agent of African sleeping sickness. In vitro and in vivo characterization of the T. brucei neutral sphingomyelinase demonstrates that it is directly involved in sphingomyelin catabolism. Gene knockout studies in the bloodstream form of the par...

journal_title：Molecular microbiology

authors： Young SA,Smith TK

更新日期：2010-06-01 00:00:00

abstract：:An 18 633 bp region containing the replicon from the approximately 53 kb pBM400 plasmid of Bacillus megaterium QM B1551 has been sequenced and characterized. This region contained a complete rRNA operon plus 10 other potential open reading frames (ORFs). The replicon consisted of an upstream promoter and three contigu...

journal_title：Molecular microbiology

authors： Kunnimalaiyaan M,Stevenson DM,Zhou Y,Vary PS

更新日期：2001-02-01 00:00:00

abstract：:The efficiency of beta-lactam antibiotics, which are among our most useful chemotherapeutic weapons, is continuously challenged by the emergence of resistant bacterial strains. This is most often due to the production of beta-lactamases by the resistant cells. These enzymes inactivate the antibiotics by hydrolysing th...

journal_title：Molecular microbiology

authors： Frère JM

更新日期：1995-05-01 00:00:00

abstract：:Sphingosine-1-phosphate (S1P), a bioactive sphingolipid metabolite, plays a critical role in the orchestration of immune responses. S1P levels within the mammalian host are tightly regulated, in part through the activity of S1P lyase (S1PL) which catalyses its irreversible degradation. Herein, we describe the identifi...

journal_title：Molecular microbiology

authors： Custódio R,McLean CJ,Scott AE,Lowther J,Kennedy A,Clarke DJ,Campopiano DJ,Sarkar-Tyson M,Brown AR

更新日期：2016-12-01 00:00:00