Use of rare-earth elements in the phyllosphere colonizer Methylobacterium extorquens PA1.

abstract：:Recent studies examining the molecular mechanisms of isoniazid (INH) resistance in Mycobacterium tuberculosis have demonstrated that a significant percentage of drug-resistant strains are mutated in the katG gene which encodes a catalase-peroxidase, and the majority of these alterations are missense mutations which re...

journal_title：Molecular microbiology

authors： Rouse DA,DeVito JA,Li Z,Byer H,Morris SL

更新日期：1996-11-01 00:00:00

abstract：:A novel growth phase-associated two-component-type regulator, Fas (fibronectin/fibrinogen binding/haemolytic activity/streptokinase regulator), of Streptococcus pyogenes was identified in the M1 genome sequence, based on homologies to the histidine protein kinase (HPK) and response regulator (RR) part of the Staphyloc...

journal_title：Molecular microbiology

authors： Kreikemeyer B,Boyle MD,Buttaro BA,Heinemann M,Podbielski A

更新日期：2001-01-01 00:00:00

abstract：:The ability of a bacterial pathogen to monitor available carbon sources in host tissues provides a clear fitness advantage. In the group A streptococcus (GAS), the virulence regulator Mga contains homology to phosphotransferase system (PTS) regulatory domains (PRDs) found in sugar operon regulators. Here we show that ...

journal_title：Molecular microbiology

authors： Hondorp ER,Hou SC,Hause LL,Gera K,Lee CE,McIver KS

更新日期：2013-06-01 00:00:00

abstract：:Reversible protein acetylation is established as a modification of major regulatory significance. In particular, histone acetylation regulates access to genetic information in eukaryotes. For example, class I and class II histone deacetylases are regulatory components of corepressor complexes involved in cell cycle pr...

journal_title：Molecular microbiology

authors： Ingram AK,Horn D

更新日期：2002-07-01 00:00:00

abstract：:DNA polymerases of the X family have been implicated in a variety of DNA repair processes in eukaryotes. Here we show that Deinococcus radiodurans, a highly radioresistant bacterium able to mend hundreds of radiation-induced double-stranded DNA breaks, expresses a DNA polymerase belonging to the X family. This novel b...

journal_title：Molecular microbiology

authors： Lecointe F,Shevelev IV,Bailone A,Sommer S,Hübscher U

更新日期：2004-09-01 00:00:00

abstract：:Through trans-splicing of a 39-nt spliced leader (SL) onto each protein-coding transcript, mature kinetoplastid mRNA acquire a hypermethylated 5'-cap structure, but its function has been unclear. Gene deletions for three Trypanosoma brucei cap 2'-O-ribose methyltransferases, TbMTr1, TbMTr2 and TbMTr3, reveal distinct ...

journal_title：Molecular microbiology

authors： Zamudio JR,Mittra B,Campbell DA,Sturm NR

更新日期：2009-06-01 00:00:00

abstract：:Antigenic variation in Trypanosoma brucei has selected for the evolution of a massive archive of silent Variant Surface Glycoprotein (VSG) genes, which are activated by recombination into specialized expression sites. Such VSG switching can occur at rates substantially higher than background mutation and is dependent ...

journal_title：Molecular microbiology

authors： Hartley CL,McCulloch R

更新日期：2008-06-01 00:00:00

abstract：:In Escherichia coli, RecA protein regulates the DNA damage-inducible survival-enhancing SOS response. Mutant allele recA730, which causes constitutive SOS expression, is lethal at high temperatures in B/r, a derivative of wild-type B, but not in K-12 or in certain B/r--K-12 hybrids. We present evidence that killing is...

journal_title：Molecular microbiology

authors： Kirchner J,Lim D,Witkin EM,Garvey N,Roegner-Maniscalco V

更新日期：1992-10-01 00:00:00

abstract：:LeuO is a quiescent LysR-type regulator belonging to the H-NS regulon. Activation of leuO transcription represses expression of pathogenicity island 1 (SPI-1) in Salmonella enterica serovar Typhimurium and inhibits invasion of epithelial cells. Loss of HilE suppresses LeuO-mediated downregulation of SPI-1. Activation ...

journal_title：Molecular microbiology

authors： Espinosa E,Casadesús J

更新日期：2014-03-01 00:00:00

abstract：:Expression of the 987P gene cluster is activated by the adjacent IS1 element of an STpa transposon. Nucleotide sequence analysis of the 987P-DNA region contiguous with this IS1 element revealed the presence of an open reading frame designated fapR, encoding a basic protein of 260 amino acid residues with a molecular m...

journal_title：Molecular microbiology

authors： Klaasen P,de Graaf FK

更新日期：1990-10-01 00:00:00

abstract：:Francisella tularensis are the causative agent of the zoonotic disease, tularaemia. Among four F. tularensis subspecies, ssp. novicida (F. novicida) is pathogenic only for immunocompromised individuals, while all four subspecies are pathogenic for mice. This study utilized proteomic and bioinformatic approaches to ide...

journal_title：Molecular microbiology

authors： Hager AJ,Bolton DL,Pelletier MR,Brittnacher MJ,Gallagher LA,Kaul R,Skerrett SJ,Miller SI,Guina T

更新日期：2006-10-01 00:00:00

abstract：:Poly(A) polymerase I (PAP I) of Escherichia coli is a member of the nucleotidyltransferase (Ntr) superfamily that includes the eukaryotic PAPs and all the known tRNA CCA-adding enzymes. Five highly conserved aspartic acids in the putative catalytic site of PAP I were changed to either alanine or proline, demonstrating...

journal_title：Molecular microbiology

authors： Raynal LC,Carpousis AJ

更新日期：1999-05-01 00:00:00

abstract：:Trypanosoma cruzi, the etiologic agent of Chagas disease, has a complex life cycle in which four distinct developmental forms alternate between the insect vector and the mammalian host. It is assumed that replicating epimastigotes present in the insect gut are not infective to mammalian host, a paradigm corroborated b...

journal_title：Molecular microbiology

authors： Kessler RL,Contreras VT,Marliére NP,Aparecida Guarneri A,Villamizar Silva LH,Mazzarotto GACA,Batista M,Soccol VT,Krieger MA,Probst CM

更新日期：2017-06-01 00:00:00

abstract：:Small GTP-binding proteins of the highly conserved Rho family act as molecular switches regulating cell signalling, cytoskeletal organization and vesicle trafficking in eukaryotic cells. Here we show that in the dimorphic plant pathogenic fungus Ustilago maydis deletion of either cdc42 or rac1 results in loss of virul...

journal_title：Molecular microbiology

authors： Mahlert M,Leveleki L,Hlubek A,Sandrock B,Bölker M

更新日期：2006-01-01 00:00:00

abstract：:Iron-sulfur (Fe-S) clusters are prosthetic groups on proteins that function in a range of enzymatic and electron transfer reactions. Fe-S cluster synthesis is essential for the survival of all eukaryotes. Independent Fe-S cluster biosynthesis pathways occur in the mitochondrion, plastid, and cytosolic compartments of ...

journal_title：Molecular microbiology

authors： Aw YTV,Seidi A,Hayward JA,Lee J,Makota FV,Rug M,van Dooren GG

更新日期：2020-11-22 00:00:00

abstract：:Various features of the regulation of pathways for biodegradation of recalcitrant compounds by Pseudomonas provide insights into the mechanisms by which operons evolve to acquire conditionally active promoters that permit the corresponding genes to be transcribed only when required. The "regulatory noise hypothesis' p...

journal_title：Molecular microbiology

authors： de Lorenzo V,Pérez-Martín J

更新日期：1996-03-01 00:00:00

abstract：:Infections with the azole-refractory yeast Candida glabrata are now commonly treated with the echinocandins caspofungin (CSF) or micafungin (MCF). True resistance (>  32-fold decreased susceptibility) to these lipopeptide inhibitors of cell wall synthesis is rare and strictly associated with mutations in integral memb...

journal_title：Molecular microbiology

authors： Healey KR,Katiyar SK,Raj S,Edlind TD

更新日期：2012-10-01 00:00:00

abstract：:The recent emergence of indolent and rapidly fatal drug-resistant strains of Mycobacterium tuberculosis has renewed interest in defining the molecular mechanisms of drug resistance in the tubercle bacilli. In this report, we have examined the mechanism of resistance to streptomycin (Sm) in M. tuberculosis through the ...

journal_title：Molecular microbiology

authors： Nair J,Rouse DA,Bai GH,Morris SL

更新日期：1993-11-01 00:00:00

abstract：:A number of strains of the widespread aerobic soil bacterium, Bacillus sphaericus, possess crystalline inclusions of a toxin lethal to a variety of insect (larvae) which are vectors of major tropical diseases. Partial amino acid sequence data from one strain, B. sphaericus 2362 have permitted us to design oligonucleot...

journal_title：Molecular microbiology

authors： Hindley J,Berry C

更新日期：1987-09-01 00:00:00

abstract：:An essential early event in Shigella and Salmonella pathogenesis is invasion of non-phagocytic intestinal epithelial cells. Pathogen entry is triggered by the delivery of multiple bacterial effector proteins into target mammalian cells. The Shigella invasion plasmid antigen B (IpaB), which inserts into the host plasma...

journal_title：Molecular microbiology

authors： Hume PJ,McGhie EJ,Hayward RD,Koronakis V

更新日期：2003-07-01 00:00:00

abstract：:Staphylococcal LukF and Hlg2 are water-soluble monomers of gamma-haemolysin that assemble into oligomeric pores on the erythrocyte membranes. Here, we have created double-cysteine LukF mutants, in which single disulphide bonds connect either the prestem domain and the cap domain (V12C-T136C, Cap-Stem), or two beta-str...

journal_title：Molecular microbiology

authors： Nguyen VT,Higuchi H,Kamio Y

更新日期：2002-09-01 00:00:00

abstract：:The cyanobacterium Anabaena responds to nitrogen deprivation by producing heterocysts, cells specialized for nitrogen fixation, at well-spaced intervals along its filaments. The gene hepA, required for heterocyst maturation, is expressed in response to nitrogen deprivation, prior to visible differentiation. A spatial ...

journal_title：Molecular microbiology

authors： Wolk CP,Elhai J,Kuritz T,Holland D

更新日期：1993-02-01 00:00:00

abstract：:Natural sequence variation was investigated among serogroup A subgroup IV-1 Neisseria meningitidis isolated from diseased patients and healthy carriers in The Gambia, West Africa. The frequencies of DNA import were analysed by sequencing fragments of four linked genes encoding the immunogenic outer membrane proteins T...

journal_title：Molecular microbiology

authors： Linz B,Schenker M,Zhu P,Achtman M

更新日期：2000-06-01 00:00:00

abstract：:To investigate the determining factors in the selection of the transcription start points (tsp) by RNA polymerase of Escherichia coli, we systematically deleted or substituted single base pairs (bps) at 25 putative critical positions in the two extended -10 promoters, P1 and P2, of the gal operon. These changes extend...

journal_title：Molecular microbiology

authors： Lewis DE,Adhya S

更新日期：2004-11-01 00:00:00

abstract：:Legionella pneumophila, the causative agent of Legionnaires' disease, survives in macrophages by altering the endocytic pathway of its host cell. To accomplish this, the bacterium utilizes a type IVB secretion system to deliver effector molecules into the host cell cytoplasm. In a previous report, we performed an exte...

journal_title：Molecular microbiology

authors： Vincent CD,Friedman JR,Jeong KC,Sutherland MC,Vogel JP

更新日期：2012-07-01 00:00:00

abstract：:In response to discrete environmental cues, Saccharomyces cerevisiae cells adjust patterns of gene expression and protein activity to optimize metabolism. Nutrient-sensing systems situated in the plasma membrane (PM) of yeast have only recently been discovered. Ssy1p is one of three identified components of the Ssy1p-...

journal_title：Molecular microbiology

authors： Forsberg H,Gilstring CF,Zargari A,Martínez P,Ljungdahl PO

更新日期：2001-10-01 00:00:00

abstract：:Ureaplasma urealyticum (U. urealyticum), belonging to the class Mollicutes, is a human pathogen colonizing the urogenital tract and causes among other things respiratory diseases in premature infants. We have studied the salvage of pyrimidine deoxynucleosides in U. urealyticum and cloned a key salvage enzyme, thymidin...

journal_title：Molecular microbiology

authors： Carnrot C,Wehelie R,Eriksson S,Bölske G,Wang L

更新日期：2003-11-01 00:00:00

abstract：:The inv locus of Yersinia enterocolitica is sufficient to convert a non-invasive Escherichia coli K12 strain into a microorganism that is able to penetrate cultured mammalian cells. The nucleotide sequence of inv reveals an open reading frame corresponding to an 835-amino-acid protein that is homologous to the invasin...

journal_title：Molecular microbiology

authors： Young VB,Miller VL,Falkow S,Schoolnik GK

更新日期：1990-07-01 00:00:00

abstract：:To identify Rhodobacter capsulatus nif genes necessary for the alternative nitrogenase, strains carrying defined mutations in 32 genes and open reading frames of nif region A, B or C were constructed. The ability of these mutants to grow on nitrogen-free medium with molybdenum (Nif phenotype) or in a nifHDK deletion b...

journal_title：Molecular microbiology

authors： Schüddekopf K,Hennecke S,Liese U,Kutsche M,Klipp W

更新日期：1993-05-01 00:00:00

abstract：:The Salmonella flagellar motor consists of a rotor and about a dozen stator elements. Each stator element, consisting of MotA and MotB, acts as a proton channel to couple proton flow with torque generation. A highly conserved Asp33 residue of MotB is directly involved in the energy coupling mechanism, but it remains u...

journal_title：Molecular microbiology

authors： Che YS,Nakamura S,Morimoto YV,Kami-Ike N,Namba K,Minamino T

更新日期：2014-01-01 00:00:00