Trypanosoma brucei BRCA2 acts in antigenic variation and has undergone a recent expansion in BRC repeat number that is important during homologous recombination.

abstract：:This past January, in Cuernavaca Mexico, a conglomerate of scientists met to discuss the contemporary view of Bacterial Locomotion and Signal Transduction (BLAST). The BLAST meetings represent a field that has its roots in chemotaxis and the flagellum-based motility but now encompass all types of cellular movement and...

journal_title：Molecular microbiology

authors： Scharf BE,Aldridge PD,Kirby JR,Crane BR

更新日期：2009-07-01 00:00:00

abstract：:The response regulator/histidine kinase pair LiaRS of Bacillus subtilis, together with its membrane-bound inhibitor protein LiaF, constitutes an envelope stress-sensing module that is conserved in Firmicutes bacteria. LiaR positively autoregulates the expression of the liaIH-liaGFSR operon from a strictly LiaR-depende...

journal_title：Molecular microbiology

authors： Schrecke K,Jordan S,Mascher T

更新日期：2013-02-01 00:00:00

abstract：:Microtubules are key players in the biology of Trypanosomatid parasites, not only as classical components of the mitotic spindle, microtubule-organizing centres and flagellum but also as the essential constituent of the cytoskeleton. Their length dynamics are regulated by, among others, microtubule-severing proteins. ...

journal_title：Molecular microbiology

authors： Casanova M,Crobu L,Blaineau C,Bourgeois N,Bastien P,Pagès M

更新日期：2009-03-01 00:00:00

abstract：:In this issue of Molecular Microbiology, Rugarabamu and colleagues investigate the role of rhomboid proteases responsible for adhesin shedding during invasion of the apicomplexan parasite Toxoplasma gondii. This study, together with several other recent publications, raises new questions about the function of these rh...

journal_title：Molecular microbiology

authors： Stewart RJ,Tonkin CJ

更新日期：2015-07-01 00:00:00

abstract：:The invasive phenotype of Shigella flexneri is conferred by a 220 kb virulence plasmid, pWR100, that encodes both the lpa proteins, which are involved in the entry process, and factors which are required for the export and correct localization of the lpa proteins. We have characterized the mxiD gene, whose expression,...

journal_title：Molecular microbiology

authors： Allaoui A,Sansonetti PJ,Parsot C

更新日期：1993-01-01 00:00:00

abstract：:Bacteria can respond to a variety of environmental stimuli by means of systems generally composed of two proteins. The first protein (sensor or transmitter) is usually a transmembrane protein with cytoplasmic and extracytoplasmic domains. The extracytoplasmic domain (sensor) senses the environment and transfers the si...

journal_title：Molecular microbiology

authors： Gross R,Aricò B,Rappuoli R

更新日期：1989-11-01 00:00:00

abstract：:Members of the IS3 family of insertion sequences are found in a wide range of bacteria. At least 10 members of this family carry two major open reading frames: a small upstream frame (0 phase), and a longer downstream frame in the -1 phase. The downstream frame shows significant similarity at the amino acid level. A h...

journal_title：Molecular microbiology

authors： Fayet O,Ramond P,Polard P,Prère MF,Chandler M

更新日期：1990-10-01 00:00:00

abstract：:VP4, the major structural protein of the haloarchaeal pleomorphic virus, HRPV-1, is glycosylated. To define the glycan structure attached to this protein, oligosaccharides released by β-elimination were analysed by mass spectrometry and nuclear magnetic resonance spectroscopy. Such analyses showed that the major VP4-d...

journal_title：Molecular microbiology

authors： Kandiba L,Aitio O,Helin J,Guan Z,Permi P,Bamford DH,Eichler J,Roine E

更新日期：2012-05-01 00:00:00

abstract：:Sequence determination of a region downstream from the vanXYc gene in Enterococcus gallinarum BM4174 revealed an open reading frame, designated vanT, that encodes a 698-amino-acid polypeptide with an amino-terminal domain containing 10 predicted transmembrane segments. The protein contained a highly conserved pyridoxa...

journal_title：Molecular microbiology

authors： Arias CA,Martín-Martinez M,Blundell TL,Arthur M,Courvalin P,Reynolds PE

更新日期：1999-03-01 00:00:00

abstract：:Ribosome-tethered chaperones that interact with nascent polypeptide chains have been identified in both prokaryotic and eukaryotic systems. However, these ribosome-associated chaperones share no sequence similarity: bacterial trigger factors (TF) form an independent protein family while the yeast machinery is Hsp70-ba...

journal_title：Molecular microbiology

authors： Rauch T,Hundley HA,Pfund C,Wegrzyn RD,Walter W,Kramer G,Kim SY,Craig EA,Deuerling E

更新日期：2005-07-01 00:00:00

abstract：:In Escherichia coli, initiation of chromosome replication requires that DnaA binds to R boxes (9-mer repeats) in oriC, the unique chromosomal replication origin. At the time of initiation, integration host factor (IHF) also binds to a specific site in oriC. IHF stimulates open complex formation by DnaA on supercoiled ...

journal_title：Molecular microbiology

authors： Grimwade JE,Ryan VT,Leonard AC

更新日期：2000-02-01 00:00:00

abstract：:Ribonucleotide reductases supply cells with their deoxyribonucleotides. Three enzyme types are known, classes I, II and III. Class II enzymes are anaerobic whereas class I enzymes are aerobic, and so class I and II enzymes are often produced by the same organism under opposing oxygen regimes. Escherichia coli contains...

journal_title：Molecular microbiology

authors： Andrews SC

更新日期：2011-04-01 00:00:00

abstract：:Despite their high genomic synteny, the Leishmania major and Leishmania infantum species exhibit extensive differences in mRNA expression patterns throughout the parasite's development. Yet, the underlying mechanisms for this species-specific differential gene expression are largely unknown. Here we report that Short ...

journal_title：Molecular microbiology

authors： Müller M,Padmanabhan PK,Papadopoulou B

更新日期：2010-07-01 00:00:00

abstract：:Long-term antibiotic treatment offers a rare opportunity to study the evolution of bacteria within the same individual. The appearance of new variants has been suggested to take place via the selection of enhanced resistance in compartments of the body in which the antibiotic concentration is low. Laboratory models of...

journal_title：Molecular microbiology

authors： Low AS,MacKenzie FM,Gould IM,Booth IR

更新日期：2001-11-01 00:00:00

abstract：:This review assembles data from three bodies of literature (bacterial genetics, plastid biogenesis and parasitology) that seldom have much direct cross-talk. After overcoming terminological complications to sort out microbial nifS from sufS genes, we connect a bacterial operon, recently found to be involved in iron me...

journal_title：Molecular microbiology

authors： Ellis KE,Clough B,Saldanha JW,Wilson RJ

更新日期：2001-09-01 00:00:00

abstract：:The cell wall mycolyl-arabinogalactan-peptidoglycan complex is essential in mycobacterial species, such as Mycobacterium tuberculosis and is the target of several antitubercular drugs. For instance, ethambutol targets arabinogalactan biosynthesis through inhibition of the arabinofuranosyltransferases Mt-EmbA and Mt-Em...

journal_title：Molecular microbiology

authors： Birch HL,Alderwick LJ,Bhatt A,Rittmann D,Krumbach K,Singh A,Bai Y,Lowary TL,Eggeling L,Besra GS

更新日期：2008-09-01 00:00:00

abstract：:Peptidoglycan (PG), the major component of the bacterial cell wall, is one large macromolecule. To allow for the different curvatures of PG at cell poles and division sites, there must be local differences in PG architecture and eventually also chemistry. Here we report such local differences in the Gram-positive rod-...

journal_title：Molecular microbiology

authors： Morales Angeles D,Liu Y,Hartman AM,Borisova M,de Sousa Borges A,de Kok N,Beilharz K,Veening JW,Mayer C,Hirsch AK,Scheffers DJ

更新日期：2017-04-01 00:00:00

abstract：:FlhD and FlhC are the transcriptional activators of the flagellar regulon. The heterotetrameric complex formed by these two proteins activates the transcription of the class II flagellar genes. The flagellar regulon consists not only of flagellar genes, but also of the chemotactic genes and some receptor proteins. Rec...

journal_title：Molecular microbiology

authors： Campos A,Matsumura P

更新日期：2001-02-01 00:00:00

abstract：:Streptococcus pyogenes interacts with host fibronectin via distinct surface components. One of these components is the Sfbl protein (streptococcal fibronectin-binding protein, now specified as class I), an adhesin that represents a protein family with characteristic features. Here we present the complete structure of ...

journal_title：Molecular microbiology

authors： Kreikemeyer B,Talay SR,Chhatwal GS

更新日期：1995-07-01 00:00:00

abstract：:Copy-number mutants of Staphylococcus aureus macrolide-lincosamide-streptogramin B (MLS) resistance plasmid pT48 were isolated by their resistance to the non-inducing macrolide, tylosin. One mutant plasmid, pcopD3, showed a three- to five-fold cis-dominant increase in copy number, and nucleotide sequence analysis reve...

journal_title：Molecular microbiology

authors： Catchpole I,Dyke KG

更新日期：1991-04-01 00:00:00

abstract：:Cell morphogenesis is a complex process that depends on cytoskeleton and membrane organization, intracellular signalling and vesicular trafficking. The rod shape of the fission yeast Schizosaccharomyces pombe and the availability of powerful genetic tools make this species an excellent model to study cell morphology. ...

journal_title：Molecular microbiology

authors： Cadou A,Couturier A,Le Goff C,Soto T,Miklos I,Sipiczki M,Xie L,Paulson JR,Cansado J,Le Goff X

更新日期：2010-09-01 00:00:00

abstract：:Human gut bifidobacteria rely on ATP-binding cassette (ABC) transporters for oligosaccharide uptake. Multiple oligosaccharide-specific solute-binding protein (SBP) genes are occasionally associated with a single ABC transporter, but the significance of this multiplicity remains unclear. Here, we characterize BlMnBP1 a...

journal_title：Molecular microbiology

authors： Ejby M,Guskov A,Pichler MJ,Zanten GC,Schoof E,Saburi W,Slotboom DJ,Abou Hachem M

更新日期：2019-07-01 00:00:00

abstract：:Strains of Escherichia coli have been produced which express very high levels of the tRNA(1Leu) isoacceptor. This was accomplished by transforming cells with plasmids containing the leuV operon which encodes three copies of the tRNA(1Leu) gene. Most transformants grew very slowly and exhibited a 15-fold increase in ce...

journal_title：Molecular microbiology

authors： Wahab SZ,Rowley KO,Holmes WM

更新日期：1993-01-01 00:00:00

abstract：:Bacteroides fragilis toxin (BFT) is a protein secreted by enterotoxigenic (ETBF) strains of B. fragilis. BFT is synthesized as a proprotein (proBFT) that is predicted to be a lipoprotein and that is cleaved into two discrete fragments by a clostripain-like protease called fragipain (Fpn). In this study, we obtained ev...

journal_title：Molecular microbiology

authors： Pierce JV,Fellows JD,Anderson DE,Bernstein HD

更新日期：2020-09-29 00:00:00

abstract：:Viable mutations affecting the 5'-phosphate sensor of RNase E, including R169Q or T170A, become lethal when combined with deletions removing part of the non-catalytic C-terminal domain of RNase E. The phosphate sensor is required for efficient autoregulation of RNase E synthesis as RNase E R169Q is strongly overexpres...

journal_title：Molecular microbiology

authors： Garrey SM,Mackie GA

更新日期：2011-06-01 00:00:00

abstract：:The Escherichia coli rodA and ftsW genes and the spoVE gene of Bacillus subtilis encode membrane proteins that control peptidoglycan synthesis during cellular elongation, division and sporulation respectively. While rodA and ftsW are essential genes in E. coli, the B. subtilis spoVE gene is dispensable for growth and ...

journal_title：Molecular microbiology

authors： Henriques AO,Glaser P,Piggot PJ,Moran CP Jr

更新日期：1998-04-01 00:00:00

abstract：:Manganese has emerged as an important trace element in bacterial physiology. The correlation between manganese accumulation and resistance to oxidative stress has led to the suggestion that, in addition to a role as a prosthetic group in superoxide dismutase, manganese could exert its antioxidant effect via non-enzyma...

journal_title：Molecular microbiology

authors： McEwan AG

更新日期：2009-05-01 00:00:00

abstract：:The plant pathogen Pseudomonas syringae pv. phaseolicola, which causes halo blight disease of beans, contains a 106 kb genomic island PPHGI-1. PPHGI-1 carries a gene, avrPphB, which encodes an effector protein that triggers a resistance response in certain bean cultivars. Previous studies have shown that when PPHGI-1 ...

journal_title：Molecular microbiology

authors： Neale HC,Jackson RW,Preston GM,Arnold DL

更新日期：2018-11-01 00:00:00

abstract：:The td group I intron interrupting the thymidylate synthase (TS) gene of phage T4 is a mobile intron that encodes the homing endonuclease I-TevI. Efficient RNA splicing of the intron is required to restore function of the TS gene, while expression of I-TevI from within the intron is required to initiate intron mobilit...

journal_title：Molecular microbiology

authors： Gibb EA,Edgell DR

更新日期：2010-10-01 00:00:00

abstract：:A novel two-component system (TCS) designated as DraR-K (sco3063/sco3062) was identified to be involved in differential regulation of antibiotic biosynthesis in Streptomyces coelicolor. The S. coelicolor mutants with deletion of either or both of draR and draK exhibited significantly reduced actinorhodin (ACT) but inc...

journal_title：Molecular microbiology

authors： Yu Z,Zhu H,Dang F,Zhang W,Qin Z,Yang S,Tan H,Lu Y,Jiang W

更新日期：2012-08-01 00:00:00