Abstract:
:Manganese has emerged as an important trace element in bacterial physiology. The correlation between manganese accumulation and resistance to oxidative stress has led to the suggestion that, in addition to a role as a prosthetic group in superoxide dismutase, manganese could exert its antioxidant effect via non-enzymatic redox reactions. The article by Anjem et al. in the current issue of Molecular Microbiology investigates the role of manganese ions in the defence against hydrogen peroxide in Escherichia coli. The results indicate that the redox activity of manganese is not linked to its protective effect. Instead, it is suggested that manganese replaces ferrous iron in enzymes that contain divalent cations at their active site. This enables the cell to avoid oxidative stress associated with iron release in the presence of hydrogen peroxide.
journal_name
Mol Microbioljournal_title
Molecular microbiologyauthors
McEwan AGdoi
10.1111/j.1365-2958.2009.06700.xsubject
Has Abstractpub_date
2009-05-01 00:00:00pages
812-4issue
4eissn
0950-382Xissn
1365-2958pii
MMI6700journal_volume
72pub_type
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