Abstract：
:Protein degradation is required for homeostasis of all living organisms. Self-compartmentalized ATP-dependent proteases are required for virulence of several pathogenic bacteria. Among the proteases implicated are ClpP and Lon, as well as the more recently identified bacterial proteasome. It is generally assumed that when a pathogen invades a host, microbial proteins become irreversibly damaged and need to be degraded. However, recent data suggest that proteolysis is also essential for virulence gene regulation. In this review, we will discuss what is known about the relationship between ATP-dependent proteolysis and pathogenesis. In addition, we will propose other potential roles these chambered proteases may have in bacterial virulence. Importantly, these proteases show promise as targets for antimicrobial therapy.
journal_name
Mol Microbioljournal_title
Molecular microbiologyauthors
Butler SM,Festa RA,Pearce MJ,Darwin KHdoi
10.1111/j.1365-2958.2006.05128.xsubject
Has Abstractpub_date
2006-05-01 00:00:00pages
553-62issue
3eissn
0950-382Xissn
1365-2958pii
MMI5128journal_volume
60pub_type
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