A Francisella virulence factor catalyses an essential reaction of biotin synthesis.

abstract：:Caulobacter crescentus chromosome replication is precisely coupled to a developmental cell cycle. Like most eubacteria, C. crescentus has a DnaA homologue that is presumed to initiate chromosome replication. However, the C. crescentus replication origin (Cori) lacks perfect consensus Escherichia coli DnaA boxes. Inste...

journal_title：Molecular microbiology

authors： Gorbatyuk B,Marczynski GT

更新日期：2001-04-01 00:00:00

abstract：:Replication fork arrest can cause DNA double-strand breaks (DSBs). These DSBs are caused by the action of the Holliday junction resolvase RuvABC, indicating that they are made by resolution of Holliday junctions formed at blocked forks. In this work, we study the homologous recombination functions required for RuvABC-...

journal_title：Molecular microbiology

authors： Seigneur M,Ehrlich SD,Michel B

更新日期：2000-11-01 00:00:00

abstract：:A locust within chromosome XIII of Saccharomyces cerevisiae containing four genes upregulated by osmotic stress has been characterized. Two of the genes, but not their osmotic induction, were already described: the DNA damage-inducible gene DDR48 and the protease inhibitor gene PAI3. The two novel genes encode a cytop...

journal_title：Molecular microbiology

authors： Miralles VJ,Serrano R

更新日期：1995-08-01 00:00:00

abstract：:Many types of microorganisms, including both prokaryotes and eukaryotes, have developed mechanisms to adapt to severe osmotic stress. In this study, we isolated multicopy suppressor genes for a Schizosaccharomyces pombe mutant, which exhibited the clear phenotype of being osmosensitive for growth (Osms) on agar plates...

journal_title：Molecular microbiology

authors： Ohmiya R,Yamada H,Nakashima K,Aiba H,Mizuno T

更新日期：1995-12-01 00:00:00

abstract：:Transmission of Plasmodium species from a mammalian host to the mosquito vector requires the uptake, during an infected blood meal, of gametocytes, the precursor cells of the gametes. Relatively little is known about the molecular mechanisms involved in the developmental switch from asexual development to sexual diffe...

journal_title：Molecular microbiology

authors： Boisson B,Lacroix C,Bischoff E,Gueirard P,Bargieri DY,Franke-Fayard B,Janse CJ,Ménard R,Baldacci P

更新日期：2011-09-01 00:00:00

abstract：:To identify Rhodobacter capsulatus nif genes necessary for the alternative nitrogenase, strains carrying defined mutations in 32 genes and open reading frames of nif region A, B or C were constructed. The ability of these mutants to grow on nitrogen-free medium with molybdenum (Nif phenotype) or in a nifHDK deletion b...

journal_title：Molecular microbiology

authors： Schüddekopf K,Hennecke S,Liese U,Kutsche M,Klipp W

更新日期：1993-05-01 00:00:00

abstract：:The sex pheromone cAM373 of Enterococcus faecalis and the related staph-cAM373 of Staphylococcus aureus were found to correspond to heptapeptides located within the C-termini of the signal sequences of putative prelipoproteins. The deduced mature forms of the lipoproteins share no detectable homology and presumably se...

journal_title：Molecular microbiology

authors： Flannagan SE,Clewell DB

更新日期：2002-05-01 00:00:00

abstract：:Bacterial cell division requires the assembly of FtsZ protofilaments into a dynamic structure called the 'Z-ring'. The Z-ring recruits the division machinery and directs local cell wall remodeling for constriction. The organization and dynamics of protofilaments within the Z-ring coordinate local cell wall synthesis d...

journal_title：Molecular microbiology

authors： Sundararajan K,Vecchiarelli A,Mizuuchi K,Goley ED

更新日期：2018-10-01 00:00:00

abstract：:Cell-cell and cell-surface adherence represents initial steps in forming multicellular aggregates or in establishing cell-surface interactions. The commonly used Saccharomyces cerevisiae laboratory strain S288c carries a flo8 mutation, and is only able to express the flocculin-encoding genes FLO1 and FLO11, when FLO8 ...

journal_title：Molecular microbiology

authors： Fichtner L,Schulze F,Braus GH

更新日期：2007-12-01 00:00:00

abstract：:Phosphorylcholine (ChoP) is a common surface feature of many mucosal organisms, including Neisseria spp., in which it is present exclusively on pili of pathogenic Neisseria and on the lipopolysaccharide (LPS) of commensal Neisseria (Cn). Its presence in Cn has been confirmed by nuclear magnetic resonance. It appears t...

journal_title：Molecular microbiology

authors： Serino L,Virji M

更新日期：2002-01-01 00:00:00

abstract：:The csiD-ygaF-gabDTP region in the Escherichia coli genome represents a cluster of sigma S-controlled genes. Here, we investigated promoter structures, sigma factor dependencies, potential co-regulation and environmental regulatory patterns for all of these genes. We find that this region constitutes a complex operon ...

journal_title：Molecular microbiology

authors： Metzner M,Germer J,Hengge R

更新日期：2004-02-01 00:00:00

abstract：:The Leishmania major aquaglyceroporin, LmAQP1, is responsible for the transport of trivalent metalloids, arsenite and antimonite. We have earlier shown that downregulation of LmAQP1 provides resistance to trivalent antimony compounds whereas increased expression of LmAQP1 in drug-resistant parasites can reverse the re...

journal_title：Molecular microbiology

authors： Figarella K,Uzcategui NL,Zhou Y,LeFurgey A,Ouellette M,Bhattacharjee H,Mukhopadhyay R

更新日期：2007-08-01 00:00:00

abstract：:Rpc25 is a strongly conserved subunit of RNA polymerase III with homology to Rpa43 in RNA polymerase I, Rpb7 in RNA polymerase II and the archaeal RpoE subunit. A central domain of Rpc25 can replaced the corresponding region of Rpb7 with little or no growth defect, underscoring the functional relatedness of these prot...

journal_title：Molecular microbiology

authors： Zaros C,Thuriaux P

更新日期：2005-01-01 00:00:00

abstract：:The Staphylococcus epidermidis genes icaABC are involved in the synthesis of the polysaccharide intercellular adhesin (PIA), which is located mainly on the cell surface, as shown by immunofluorescence studies with PIA-specific antiserum. PIA was shown to be a linear beta-1,6-linked glucosaminoglycan composed of at lea...

journal_title：Molecular microbiology

authors： Heilmann C,Schweitzer O,Gerke C,Vanittanakom N,Mack D,Götz F

更新日期：1996-06-01 00:00:00

abstract：:The diffusible factor synthase XanB2, originally identified in Xanthomonas campestris pv. campestris (Xcc), is highly conserved across a wide range of bacterial species, but its substrate and catalytic mechanism have not yet been investigated. Here, we show that XanB2 is a unique bifunctional chorismatase that hydroly...

journal_title：Molecular microbiology

authors： Zhou L,Wang JY,Wu J,Wang J,Poplawsky A,Lin S,Zhu B,Chang C,Zhou T,Zhang LH,He YW

更新日期：2013-01-01 00:00:00

abstract：:A bioassay was developed to identify stimuli that promote the transcriptional induction of the algD operon for alginate biosynthesis in Pseudomonas aeruginosa. Strain PAO1 carried the algD promoter fused to a chloramphenicol acetyl-transferase cartridge (PalgD-cat), and > 50 compounds were tested for promoting chloram...

journal_title：Molecular microbiology

authors： Wood LF,Leech AJ,Ohman DE

更新日期：2006-10-01 00:00:00

abstract：:Four outer-membrane proteins of Aeromonas hydrophila were purified and their N-terminal sequences and channel-forming properties were determined. Three could be matched with proteins from other species. One was a maltoporin, as its level increased when cells were grown in maltose-containing media, and the channel it f...

journal_title：Molecular microbiology

authors： Jeanteur D,Gletsu N,Pattus F,Buckley JT

更新日期：1992-11-01 00:00:00

abstract：:The RusA protein of Escherichia coli is a DNA structure-specific endonuclease that resolves Holliday junction intermediates formed during DNA replication, recombination and repair by introducing symmetrically paired incisions 5' to CC dinucleotides. It is encoded by the defective prophage DLP12, which raises the possi...

journal_title：Molecular microbiology

authors： Sharples GJ,Bolt EL,Lloyd RG

更新日期：2002-04-01 00:00:00

abstract：:Bacterial cell shapes are manifestations of programs carried out by multi-protein machines that synthesize and remodel the resilient peptidoglycan (PG) mesh and other polymers surrounding cells. GpsB protein is conserved in low-GC Gram-positive bacteria and is not essential in rod-shaped Bacillus subtilis, where it pl...

journal_title：Molecular microbiology

authors： Land AD,Tsui HC,Kocaoglu O,Vella SA,Shaw SL,Keen SK,Sham LT,Carlson EE,Winkler ME

更新日期：2013-12-01 00:00:00

abstract：:LamB glycoporin has an important general role in carbohydrate uptake during growth at low extracellular sugar concentrations. lamB and mal regulon induction during glucose starvation and glucose-limited continuous culture was investigated using lacZ fusions. A low-level burst of lamB induction occurred upon entry into...

journal_title：Molecular microbiology

authors： Notley L,Ferenci T

更新日期：1995-04-01 00:00:00

abstract：:In Candida glabrata, the sirtuins Sir2 and Hst1 control the expression of a wide number of genes including adhesins required for host colonization and niacin transporters needed for growth. Given that these sirtuins can be inactivated during infection, we asked if their inhibition could modify the response of C. glabr...

journal_title：Molecular microbiology

authors： Orta-Zavalza E,Guerrero-Serrano G,Gutiérrez-Escobedo G,Cañas-Villamar I,Juárez-Cepeda J,Castaño I,De Las Peñas A

更新日期：2013-06-01 00:00:00

abstract：:Like many other bacteria, Burkholderia sp. take up iron in its ferric form via siderophore-dependent transporters. We observed that mutant strains of B. cenocepacia H111 unable to synthesize siderophores did not exhibit any growth defect under iron limited conditions. This finding suggested that this opportunistic pat...

journal_title：Molecular microbiology

authors： Mathew A,Eberl L,Carlier AL

更新日期：2014-02-01 00:00:00

abstract：:Lipid metabolism in Trypanosoma brucei, the causative agent of African sleeping sickness, differs from its human host in several fundamental ways. This has lead to the validation of a plethora of novel drug targets, giving hope of novel chemical intervention against this neglected disease. Cytidine diphosphate diacylg...

journal_title：Molecular microbiology

authors： Lilley AC,Major L,Young S,Stark MJ,Smith TK

更新日期：2014-05-01 00:00:00

abstract：:The stringent response is important for bacterial survival under stressful conditions, such as amino acid starvation, and is characterized by the accumulation of ppGpp and pppGpp. ObgE (CgtA, YhbZ) is an essential conserved GTPase in Escherichia coli and several observations have implicated the protein in the control ...

journal_title：Molecular microbiology

authors： Persky NS,Ferullo DJ,Cooper DL,Moore HR,Lovett ST

更新日期：2009-07-01 00:00:00

abstract：:The GATA factor AreA is a wide-domain regulator in Aspergillus nidulans with transcriptional activation and chromatin remodelling functions. AreA interacts with the nitrate-specific Zn(2)-C(6) cluster protein NirA and both proteins cooperate to synergistically activate nitrate-responsive genes. We have previously esta...

journal_title：Molecular microbiology

authors： Berger H,Pachlinger R,Morozov I,Goller S,Narendja F,Caddick M,Strauss J

更新日期：2006-01-01 00:00:00

abstract：:Laboratory-based evolution and whole-genome sequencing can link genotype and phenotype. We used evolution of acid resistance in exponential phase Escherichia coli to study resistance to a lethal stress. Iterative selection at pH 2.5 generated five populations that were resistant to low pH in early exponential phase. G...

journal_title：Molecular microbiology

authors： Johnson MD,Bell J,Clarke K,Chandler R,Pathak P,Xia Y,Marshall RL,Weinstock GM,Loman NJ,Winn PJ,Lund PA

更新日期：2014-09-01 00:00:00

abstract：:Gram-negative bacteria possess several envelope stress responses that detect and respond to damage to this critical cellular compartment. The σ(E) envelope stress response senses the misfolding of outer membrane proteins (OMPs), while the Cpx two-component system is believed to detect the misfolding of periplasmic and...

journal_title：Molecular microbiology

authors： Vogt SL,Raivio TL

更新日期：2014-05-01 00:00:00

abstract：:The major anionic phospholipids of Escherichia coli, phosphatidylglycerol (PG) and cardiolipin (CL), have been considered to be indispensable for essential cellular functions, such as the initiation of DNA replication and translocation of proteins across the cytoplasmic membrane. However, we successfully constructed a...

journal_title：Molecular microbiology

authors： Matsumoto K

更新日期：2001-03-01 00:00:00

abstract：:The exosporium is the outermost layer of the Bacillus anthracis spore. The predominant protein on the exosporium surface is BclA, a collagen-like glycoprotein. BclA is incorporated on the spore surface late in the B. anthracis sporulation pathway. A second collagen-like protein, BclB, has been shown to be surface-expo...

journal_title：Molecular microbiology

authors： Thompson BM,Stewart GC

更新日期：2008-10-01 00:00:00

abstract：:Histidine kinases (HK) sense and transduce via phosphorylation events many intra- and extracellular signals in bacteria, archaea, slime moulds and plants. HK are also widespread in the fungal kingdom, but their precise roles in the regulation of physiological processes remain largely obscure. Expanding genomic resourc...

journal_title：Molecular microbiology

authors： Defosse TA,Sharma A,Mondal AK,Dugé de Bernonville T,Latgé JP,Calderone R,Giglioli-Guivarc'h N,Courdavault V,Clastre M,Papon N

更新日期：2015-03-01 00:00:00