Local silencing controls the oxidative stress response and the multidrug resistance in Candida glabrata.

abstract：:Bacteria utilize phosphorelay systems to respond to environmental or intracellular stimuli. Salmonella enterica encodes a four-step phosphorelay system that involves two sensor kinase proteins, RcsC and RcsD, and a response regulator, RcsB. The physiological stimulus for Rcs phosphorelay activation is unknown; however...

journal_title：Molecular microbiology

authors： Erickson KD,Detweiler CS

更新日期：2006-11-01 00:00:00

abstract：:On the basis of the published N-terminal amino acid sequence of the soluble lytic transglycosylase 35 (Slt35) of Escherichia coli, an open reading frame (ORF) was cloned from the 60.8 min region of the E. coli chromosome. The nucleotide sequence of the ORF, containing a putative lipoprotein-processing site, was shown ...

journal_title：Molecular microbiology

authors： Ehlert K,Höltje JV,Templin MF

更新日期：1995-05-01 00:00:00

abstract：:The cheA gene encodes two overlapping polypeptides with a common carboxyl terminus: CheAL and CheAS. CheAL plays a central role in the Escherichia coli chemotaxis signalling pathway by autophosphorylation and transferring the phosphate to both CheY and CheB. On the other hand, the physiological functions of CheAS rema...

journal_title：Molecular microbiology

authors： Wang H,Matsumura P

更新日期：1996-02-01 00:00:00

abstract：:Cellulosomes are key for lignocellulosic biomass degradation in cellulolytic Clostridia. Better understanding of the mechanism of cellulosome regulation would allow us to improve lignocellulose hydrolysis. It is hypothesized that cellulosomal protease inhibitors would regulate cellulosome architecture and then lignoce...

journal_title：Molecular microbiology

authors： Xu T,Li Y,He Z,Zhou J

更新日期：2014-02-01 00:00:00

abstract：:Bacillus subtilis SpoIIE is a Ser protein phosphatase whose action on the phosphoprotein SpoIIAA triggers the cell type-specific activation of a sporulation transcription factor. Here we report that SpoIIE displays sequence similarity to the PP2C family of eukaryotic Ser/Thr protein phosphatases, and that residues com...

journal_title：Molecular microbiology

authors： Adler E,Donella-Deana A,Arigoni F,Pinna LA,Stragler P

更新日期：1997-01-01 00:00:00

abstract：:Mismatch repair (MMR) corrects DNA polymerase errors occurring during genome replication. MMR is critical for genome maintenance, and its loss increases mutation rates several hundred fold. Recent work has shown that the interaction between the mismatch recognition protein MutS and the replication processivity clamp i...

journal_title：Molecular microbiology

authors： Klocko AD,Schroeder JW,Walsh BW,Lenhart JS,Evans ML,Simmons LA

更新日期：2011-11-01 00:00:00

abstract：:Disulfide bonds are found in many proteins associated with the cell wall of Escherichia coli, and for some of these proteins the disulfide bond is critical to their stability and function. One protein found to contain a disulfide bond is the essential cell division protein FtsN, but the importance of this bond to the ...

journal_title：Molecular microbiology

authors： Meehan BM,Landeta C,Boyd D,Beckwith J

更新日期：2017-02-01 00:00:00

abstract：:Transcription in vitro of two osmoregulated promoters, for the Escherichia coli osmB and osmY genes, was analysed using two species of RNA polymerase holoenzyme reconstituted from purified core enzyme and either sigma D (sigma 70, the major sigma in exponentially growing cells) or sigma S (sigma 38, the principal sigm...

journal_title：Molecular microbiology

authors： Ding Q,Kusano S,Villarejo M,Ishihama A

更新日期：1995-05-01 00:00:00

abstract：:The nucleotide sequence of the proximal half of the rfb region of Shigella flexneri has been determined, and the genes encoding enzymes involved in the biosynthesis of dTDP-rhamnose have been identified. These genes show strong homology to the rfb genes encoding dTDP-rhamnose biosynthesis in Salmonella enterica serova...

journal_title：Molecular microbiology

authors： Macpherson DF,Manning PA,Morona R

更新日期：1994-01-01 00:00:00

abstract：:A simplified system using bacterial insertion sequence IS911 has been developed to investigate targeted insertion next to DNA sequences resembling IS ends. We show here that these IR-targeted events occur by an unusual mechanism. In the circular IS911 transposition intermediate the two IRs are abutted to form an IR/IR...

journal_title：Molecular microbiology

authors： Loot C,Turlan C,Chandler M

更新日期：2004-01-01 00:00:00

abstract：:Chromosomal rearrangements are common in both clinical isolates and spontaneous mutants of Candida albicans. It appears that many of these rearrangements are caused by translocations around the major sequence repeat (MSR) that is present in all chromosomes except chromosome 3, suggesting that homologous recombination ...

journal_title：Molecular microbiology

authors： Ciudad T,Andaluz E,Steinberg-Neifach O,Lue NF,Gow NA,Calderone RA,Larriba G

更新日期：2004-08-01 00:00:00

abstract：:Several Fusarium species produce the polyketide mycotoxin zearalenone (ZEA), a causative agent of hyperestrogenic syndrome in animals that is often found in F. graminearum-infected cereals in temperate regions. The ZEA biosynthetic cluster genes PKS4, PKS13, ZEB1 and ZEB2 encode a reducing polyketide synthase, a non-r...

journal_title：Molecular microbiology

authors： Park AR,Son H,Min K,Park J,Goo JH,Rhee S,Chae SK,Lee YW

更新日期：2015-09-01 00:00:00

abstract：:Bacteroides fragilis toxin (BFT) is a protein secreted by enterotoxigenic (ETBF) strains of B. fragilis. BFT is synthesized as a proprotein (proBFT) that is predicted to be a lipoprotein and that is cleaved into two discrete fragments by a clostripain-like protease called fragipain (Fpn). In this study, we obtained ev...

journal_title：Molecular microbiology

authors： Pierce JV,Fellows JD,Anderson DE,Bernstein HD

更新日期：2020-09-29 00:00:00

abstract：:In cell-free Yersinia pseudotuberculosis culture supernatants, we have chemically characterized three N-acyl homoserine lactone (AHL) molecules, N-octanoyl homoserine lactone (C8-HSL), N-(3-oxohexanoyl)homoserine lactone (3-oxo-C6-HSL) and N-hexanoyl homoserine lactone (C6-HSL). We have identified, cloned and sequence...

journal_title：Molecular microbiology

authors： Atkinson S,Throup JP,Stewart GS,Williams P

更新日期：1999-09-01 00:00:00

abstract：:Klebsiella pneumoniae strain PAP996 was previously shown to secrete fatty acylated, aggregated (micellar) pullulanase only after the end of exponential growth. Here we show that the closely related strain K21 secretes large amounts of unacylated, non-aggregated (monomeric) pullulanase during exponential growth. Only a...

journal_title：Molecular microbiology

authors： Kornacker MG,Boyd A,Pugsley AP,Plastow GS

更新日期：1989-04-01 00:00:00

abstract：:The replication-initiator protein DnaA is ubiquitous in the eubacterial world. It binds to an asymmetric 9 bp consensus DNA sequence, the DnaA box. Besides its primary function as an initiator, it acts as a transcription factor that represses or activates several genes, or terminates transcription, depending on the lo...

journal_title：Molecular microbiology

authors： Messer W,Weigel C

更新日期：1997-04-01 00:00:00

abstract：:The syrD gene of Pseudomonas syringae pathovar syringae strain B301D-R was characterized and sequenced. The syrD open reading frame is 1695 bp long and encodes a predicted protein, SyrD, of approximately 63 kDa. Database searches revealed that SyrD shares a high degree of similarity with the ATP-binding cassette (ABC)...

journal_title：Molecular microbiology

authors： Quigley NB,Mo YY,Gross DC

更新日期：1993-08-01 00:00:00

abstract：:Heteroduplexes between the DNA molecules of 12 lambdoid phages were analysed by electron microscopy. The positions of the regions of base sequence homology between the DNA molecules divide them into 35 segments, most of which have a number of alternative forms (alleles), which in general must be functionally homologou...

journal_title：Molecular microbiology

authors： Highton PJ,Chang Y,Myers RJ

更新日期：1990-08-01 00:00:00

abstract：:In spite of displaying the most extreme dormancy and resistance properties known among living systems, bacterial endospores retain an alert environment-sensing mechanism that can respond within seconds to the presence of specific germinants. This germination response is triggered in the absence of both germinant and g...

journal_title：Molecular microbiology

authors： Foster SJ,Johnstone K

更新日期：1990-01-01 00:00:00

abstract：:Gram-negative bacteria have evolved numerous pathways to secrete proteins across their complex cell envelopes. Here, we describe a protein secretion system that uses a holin membrane protein in tandem with a cell wall-editing enzyme to mediate the secretion of substrate proteins from the periplasm to the cell exterior...

journal_title：Molecular microbiology

authors： Palmer T,Finney AJ,Saha CK,Atkinson GC,Sargent F

更新日期：2020-09-04 00:00:00

abstract：:The malaria parasite Plasmodium falciparum is highly adapted to cope with the oxidative stress to which it is exposed during the erythrocytic stages of its life cycle. This includes the defence against oxidative insults arising from the parasite's metabolism of haemoglobin which results in the formation of reactive ox...

journal_title：Molecular microbiology

authors： Müller S

更新日期：2004-09-01 00:00:00

abstract：:Leishmania parasites target macrophages in their mammalian hosts and proliferate within the mature phagolysosome compartment of these cells. Intracellular amastigote stages are dependent on sugars as a major carbon source in vivo, but retain the capacity to utilize other carbon sources. To investigate whether amastigo...

journal_title：Molecular microbiology

authors： Saunders EC,Naderer T,Chambers J,Landfear SM,McConville MJ

更新日期：2018-04-01 00:00:00

abstract：:In May 2004, over 100 bacteriologists from 19 different countries discussed recent progress in identification and understanding of individual signal transfer mechanisms in bacteria and in the mutual interactions between these systems to form a functional living cell. The meeting was held in San Feliu and supported by ...

journal_title：Molecular microbiology

authors： Hellingwerf KJ

更新日期：2004-10-01 00:00:00

abstract：:A reputed iron-responsive region, which contains multiple nuclear protein-binding DNA sequences, was shown previously to regulate iron-inducible transcription of the ap65-1 gene in the protozoan pathogen, Trichomonas vaginalis. These DNA sequences include two overlapping MYB recognition elements (MRE-1/MRE-2r) and thr...

journal_title：Molecular microbiology

authors： Ong SJ,Huang SC,Liu HW,Tai JH

更新日期：2004-06-01 00:00:00

abstract：:Overexpression of the MDR1 gene, encoding a multi-drug efflux pump of the major facilitator superfamily, is a major cause of resistance to the widely used antifungal agent fluconazole and other toxic substances in the fungal pathogen Candida albicans. We found that all tested clinical and in vitro generated C. albican...

journal_title：Molecular microbiology

authors： Dunkel N,Blass J,Rogers PD,Morschhäuser J

更新日期：2008-08-01 00:00:00

abstract：:The archaeal transcription apparatus is chimeric: its core components (RNA polymerase and basal factors) closely resemble those of eukaryotic RNA polymerase II, but the putative archaeal transcriptional regulators are overwhelmingly of bacterial type. Particular interest attaches to how these bacterial-type effectors,...

journal_title：Molecular microbiology

authors： Ouhammouch M,Langham GE,Hausner W,Simpson AJ,El-Sayed NM,Geiduschek EP

更新日期：2005-05-01 00:00:00

abstract：:In order to identify molecules that might be responsible for the difference in pathogenicity between the two closely related protozoan parasites Entamoeba histolytica and Entamoeba dispar, we focussed on cysteine proteinases because this class of enzymes has been considered important for pathogenic tissue destruction....

journal_title：Molecular microbiology

authors： Bruchhaus I,Jacobs T,Leippe M,Tannich E

更新日期：1996-10-01 00:00:00

abstract：:Quinone-based compounds have been exploited to treat infectious diseases and cancer, with such chemicals often functioning as inhibitors of key metabolic pathways or as prodrugs. Here, we screened an aziridinyl 1,4-benzoquinone (ABQ) library against the causative agents of trypanosomiasis, and cutaneous leishmaniasis,...

journal_title：Molecular microbiology

authors： Meredith EL,Kumar A,Konno A,Szular J,Alsford S,Seifert K,Horn D,Wilkinson SR

更新日期：2017-10-01 00:00:00

abstract：:Penicillium marneffei is a thermally dimorphic opportunistic human pathogen with a saprophytic filamentous hyphal form at 25 degrees C and a pathogenic unicellular yeast form at 37 degrees C. During infection. P. marneffei yeast cells exist intracellularly in macrophages. To cope with nutrient deprivation during the i...

journal_title：Molecular microbiology

authors： Cánovas D,Andrianopoulos A

更新日期：2006-12-01 00:00:00

abstract：:Burkholderia mallei, the aetiologic agent of glanders, causes a variety of illnesses in animals and humans ranging from occult infections to acute fulminating septicaemias. To better understand the role of lipopolysaccharide (LPS) in the pathogenesis of these diseases, studies were initiated to characterize the struct...

journal_title：Molecular microbiology

authors： Brett PJ,Burtnick MN,Snyder DS,Shannon JG,Azadi P,Gherardini FC

更新日期：2007-01-01 00:00:00