Direct MinE-membrane interaction contributes to the proper localization of MinDE in E. coli.

abstract：:Crop destruction by the hemibiotrophic rice pathogen Magnaporthe oryzae requires plant defence suppression to facilitate extensive biotrophic growth in host cells before the onset of necrosis. How this is achieved at the genetic level is not well understood. Here, we report that a M. oryzae sirtuin, MoSir2, plays an e...

journal_title：Molecular microbiology

authors： Fernandez J,Marroquin-Guzman M,Nandakumar R,Shijo S,Cornwell KM,Li G,Wilson RA

更新日期：2014-10-01 00:00:00

abstract：:In the corn smut fungus Ustilago maydis, pathogenic development is controlled by the b mating type locus that encodes the two homeodomain proteins bE and bW. A heterodimer of bE and bW controls a large set of genes, either directly by binding to cis regulatory sequences or indirectly via a b-dependent regulatory casca...

journal_title：Molecular microbiology

authors： Reichmann M,Jamnischek A,Weinzierl G,Ladendorf O,Huber S,Kahmann R,Kämper J

更新日期：2002-11-01 00:00:00

abstract：:Bacteriophages recognize and bind to their hosts with the help of receptor-binding proteins (RBPs) that emanate from the phage particle in the form of fibers or tailspikes. RBPs show a great variability in their shapes, sizes, and location on the particle. Some RBPs are known to depolymerize surface polysaccharides of...

journal_title：Molecular microbiology

authors： Prokhorov NS,Riccio C,Zdorovenko EL,Shneider MM,Browning C,Knirel YA,Leiman PG,Letarov AV

更新日期：2017-08-01 00:00:00

abstract：:Viable mutations affecting the 5'-phosphate sensor of RNase E, including R169Q or T170A, become lethal when combined with deletions removing part of the non-catalytic C-terminal domain of RNase E. The phosphate sensor is required for efficient autoregulation of RNase E synthesis as RNase E R169Q is strongly overexpres...

journal_title：Molecular microbiology

authors： Garrey SM,Mackie GA

更新日期：2011-06-01 00:00:00

abstract：:The esg locus is required for the formation of multicellular fruiting bodies and spores by the developmental bacterium Myxococcus xanthus. Studies have suggested that esg mutants are defective in the production of an essential signal (E-signal) used in cell-cell communication and that E-signalling is required for the ...

journal_title：Molecular microbiology

authors： Downard J,Toal D

更新日期：1995-04-01 00:00:00

abstract：:Proteins with LytM (Peptidase_M23) domains are broadly distributed in bacteria and have been implicated in a variety of important processes, including cell division and cell-shape determination. Most LytM-like proteins that have been structurally and/or biochemically characterized are metallo-endopeptidases that cleav...

journal_title：Molecular microbiology

authors： Peters NT,Morlot C,Yang DC,Uehara T,Vernet T,Bernhardt TG

更新日期：2013-08-01 00:00:00

abstract：:The genetic and biochemical mechanisms by which Mycobacterium tuberculosis senses and responds to the complex environment that it encounters during infection and persistence within the host remain unknown. In a number of bacterial species, the Kdp signal transduction pathway appears to be the primary response to envir...

journal_title：Molecular microbiology

authors： Steyn AJ,Joseph J,Bloom BR

更新日期：2003-02-01 00:00:00

abstract：:Lipids are essential structural constituents of bacterial cell membranes and walls, and their biosynthetic pathways are stringently regulated at both biochemical and genetic levels. The recent surge of new information about transcriptional regulation of bacterial lipid metabolism is highlighted by two studies in this ...

journal_title：Molecular microbiology

authors： Zhang YM,Rock CO

更新日期：2010-10-01 00:00:00

abstract：:Pathogenic strains of Yersinia deploy a type III secretion system to inject the potent tyrosine phosphatase YopH into host cells, where it dephosphorylates focal adhesion-associated substrates. The amino-terminal, non-catalytic domain of YopH is bifunctional; it is essential for the secretion and binding of the specif...

journal_title：Molecular microbiology

authors： Smith CL,Khandelwal P,Keliikuli K,Zuiderweg ER,Saper MA

更新日期：2001-11-01 00:00:00

abstract：:Chromalveolates like the diatom Phaeodactylum tricornutum arose through the uptake of a red alga by a phagotrophic protist, a process termed secondary endosymbiosis. In consequence, the plastids are surrounded by two additional membranes compared with primary plastids. This plastid morphology poses additional barriers...

journal_title：Molecular microbiology

authors： Hempel F,Felsner G,Maier UG

更新日期：2010-05-01 00:00:00

abstract：:In almost all bacteria, cell division is co-ordinated by the essential tubulin homologue FtsZ and represents an attractive but as yet unexploited target for new antibiotics. The benzamides, e.g. PC190723, are potent FtsZ inhibitors that have the potential to yield an important new class of antibiotic. However, the evo...

journal_title：Molecular microbiology

authors： Adams DW,Wu LJ,Errington J

更新日期：2016-03-01 00:00:00

abstract：:In Escherichia coli, after DNA damage, the SOS response increases the transcription (and protein levels) of approximately 50 genes. As DNA repair ensues, the level of transcription returns to homeostatic levels. ClpXP and other proteases return the high levels of several SOS proteins to homeostasis. When all SOS genes...

journal_title：Molecular microbiology

authors： Warr AR,Klimova AN,Nwaobasi AN,Sandler SJ

更新日期：2019-02-01 00:00:00

abstract：:Ail, a multifunctional outer membrane protein of Yersinia pestis, confers cell binding, Yop delivery and serum resistance activities. Resistance to complement proteins in serum is critical for the survival of Y. pestis during the septicemic stage of plague infections. Bacteria employ a variety of tactics to evade the ...

journal_title：Molecular microbiology

authors： Thomson JJ,Plecha SC,Krukonis ES

更新日期：2019-01-01 00:00:00

abstract：:Overexpression of the MDR1 gene, encoding a multi-drug efflux pump of the major facilitator superfamily, is a major cause of resistance to the widely used antifungal agent fluconazole and other toxic substances in the fungal pathogen Candida albicans. We found that all tested clinical and in vitro generated C. albican...

journal_title：Molecular microbiology

authors： Dunkel N,Blass J,Rogers PD,Morschhäuser J

更新日期：2008-08-01 00:00:00

abstract：:CoiA is a transient protein expressed specifically during competence and required for genetic transformation in Streptococcus pneumoniae, but not for DNA uptake. It is widely conserved among Gram-positive bacteria but its function is unknown. Here we report that although the rate of DNA uptake was not affected in a co...

journal_title：Molecular microbiology

authors： Desai BV,Morrison DA

更新日期：2007-02-01 00:00:00

abstract：:A number of strains of the widespread aerobic soil bacterium, Bacillus sphaericus, possess crystalline inclusions of a toxin lethal to a variety of insect (larvae) which are vectors of major tropical diseases. Partial amino acid sequence data from one strain, B. sphaericus 2362 have permitted us to design oligonucleot...

journal_title：Molecular microbiology

authors： Hindley J,Berry C

更新日期：1987-09-01 00:00:00

abstract：:We have shown previously that deletion of the Saccharomyces cerevisiae UMP1 gene encoding the 20S proteasome maturase causes sensitivity to UV radiation. In the current report, we have extended this finding to show that mutations specifically compromising chymotrypsin-like or trypsin-like activity of 20S proteasome pe...

journal_title：Molecular microbiology

authors： Podlaska A,McIntyre J,Skoneczna A,Sledziewska-Gojska E

更新日期：2003-09-01 00:00:00

abstract：:A promoter controlling expression of the pristinamycin multidrug resistance gene (ptr), originally isolated from Streptomyces pristinaespiralis, is inducible by many toxic compounds in various Streptomyces species. Studies of ptr promoter control were carried out in the heterologous host, Streptomyces lividans. In S. ...

journal_title：Molecular microbiology

authors： Salah-Bey K,Thompson CJ

更新日期：1995-09-01 00:00:00

abstract：:In the past, ultrastructural investigations of Leishmania mexicana amastigotes revealed structures that were tentatively identified as autophagosomes. This study has now provided definitive data that autophagy occurs in the parasite during differentiation both to metacyclic promastigotes and to amastigotes, autophagos...

journal_title：Molecular microbiology

authors： Williams RA,Tetley L,Mottram JC,Coombs GH

更新日期：2006-08-01 00:00:00

abstract：:Histidine kinases function as dimers. The kinase domain of the osmosensing histidine kinase EnvZ of Escherichia coli consists of two domains: domain A (67 residues) responsible for histidine phosphotransfer and dimerization, and domain B (161 residues) responsible for the catalytic and ATP-binding function. The indivi...

journal_title：Molecular microbiology

authors： Qin L,Dutta R,Kurokawa H,Ikura M,Inouye M

更新日期：2000-04-01 00:00:00

abstract：:Small repeat sequences in bacterial genomes, which represent non-autonomous mobile elements, have close similarities to archaeon and eukaryotic miniature inverted repeat transposable elements. These repeat elements are found in both intergenic and intragenic chromosomal regions, and contain an array of diverse motifs....

journal_title：Molecular microbiology

authors： Delihas N

更新日期：2008-02-01 00:00:00

abstract：:Hybrid genes were constructed to express bifunctional hybrid proteins in which staphyloccal nuclease A with or without an amino-terminal OmpA signal sequence was fused with TEM beta-lactamase (at the carboxyl terminal side) using the signal peptide of the major outer membrane lipoprotein of Escherichia coli as an inte...

journal_title：Molecular microbiology

authors： Kim H,Paul S,Gennity J,Jennity J corrected to Gennity J,Inouye M

更新日期：1994-03-01 00:00:00

abstract：:Copy-number mutants of Staphylococcus aureus macrolide-lincosamide-streptogramin B (MLS) resistance plasmid pT48 were isolated by their resistance to the non-inducing macrolide, tylosin. One mutant plasmid, pcopD3, showed a three- to five-fold cis-dominant increase in copy number, and nucleotide sequence analysis reve...

journal_title：Molecular microbiology

authors： Catchpole I,Dyke KG

更新日期：1991-04-01 00:00:00

abstract：:Virstatin is a previously described small molecule inhibitor of Vibrio cholerae virulence. We have demonstrated that the molecule inhibits the activity of the transcriptional activator ToxT, thereby preventing elaboration of the toxin co-regulated pilus (TCP) and cholera toxin in vitro and in vivo in O1 strains of V. ...

journal_title：Molecular microbiology

authors： Shakhnovich EA,Sturtevant D,Mekalanos JJ

更新日期：2007-12-01 00:00:00

abstract：:The nucleotide sequence of trkA, a gene encoding a surface component of the constitutive K(+)-uptake systems TrkG and TrkH from Escherichia coli, was determined. The structure of the TrkA protein deduced from the nucleotide sequence accords with the view that TrkA is peripherally bound to the inner side of the cytopla...

journal_title：Molecular microbiology

authors： Schlösser A,Hamann A,Bossemeyer D,Schneider E,Bakker EP

更新日期：1993-08-01 00:00:00

abstract：:The gene encoding a Lon protease homologue has been cloned from Brucella abortus. The putative Brucella abortus Lon shares > 60% amino acid identity with its Escherichia coli counterpart and the recombinant form of this protein restores the capacity of an Escherichia coli lon mutant to resist killing by ultraviolet ir...

journal_title：Molecular microbiology

authors： Robertson GT,Kovach ME,Allen CA,Ficht TA,Roop RM 2nd

更新日期：2000-02-01 00:00:00

abstract：:Mismatch repair (MMR) corrects DNA polymerase errors occurring during genome replication. MMR is critical for genome maintenance, and its loss increases mutation rates several hundred fold. Recent work has shown that the interaction between the mismatch recognition protein MutS and the replication processivity clamp i...

journal_title：Molecular microbiology

authors： Klocko AD,Schroeder JW,Walsh BW,Lenhart JS,Evans ML,Simmons LA

更新日期：2011-11-01 00:00:00

abstract：:Regions close to the replication terminus of the Escherichia coli chromosome are strongly refractory to genomic inversions. Since these regions also harbour polar replication terminator-like sequences or pause sites, we have investigated the possibility that slowing of replication as a result of pausing at inverted pa...

journal_title：Molecular microbiology

authors： François V,Louarn J,Patte J,Rebollo JE,Louarn JM

更新日期：1990-04-01 00:00:00

abstract：:Ustilago maydis is able to initiate pathogenic development after fusion of two haploid cells with different mating type. On the maize leaf surface, the resulting dikaryon switches to filamentous growth, differentiates appressoria and penetrates the host. Here, we report on the plant signals required for filament forma...

journal_title：Molecular microbiology

authors： Mendoza-Mendoza A,Berndt P,Djamei A,Weise C,Linne U,Marahiel M,Vranes M,Kämper J,Kahmann R

更新日期：2009-02-01 00:00:00

abstract：:The shdA gene is the only determinant known to be required for persistence of Salmonella enterica serotype Typhimurium (S. Typhimurium) in the murine caecum and for efficient and prolonged shedding of the organism with the faeces. To study the biological activity of the ShdA protein, we examined its expression and bin...

journal_title：Molecular microbiology

authors： Kingsley RA,Santos RL,Keestra AM,Adams LG,Bäumler AJ

更新日期：2002-02-01 00:00:00