Mismatch repair causes the dynamic release of an essential DNA polymerase from the replication fork.

abstract：:Cyanobacteria respond to changes in light or nutrient availability by modifications in their photosynthetic light harvesting antenna. In unicellular cyanobacteria a small polypeptide (NblA) is required for phycobilisome degradation following environmental stresses. In the filamentous strain Tolypothrix sp. PCC 7601 th...

journal_title：Molecular microbiology

authors： Luque I,Ochoa De Alda JA,Richaud C,Zabulon G,Thomas JC,Houmard J

更新日期：2003-11-01 00:00:00

abstract：:We used the LacO/GFP-LacI system to label and visualize the IncP beta plasmid R751 fluorescently during conjugative transfer between live donor and recipient bacteria. Comparisons of R751 in conjugative and non-conjugative conditions have allowed us to identify key localizations and movements associated with the initi...

journal_title：Molecular microbiology

authors： Lawley TD,Gordon GS,Wright A,Taylor DE

更新日期：2002-05-01 00:00:00

abstract：:The chromosomal DpnII gene cassette of Streptococcus pneumoniae encodes two methyltransferases and an endonuclease. One methyltransferase acts on double-stranded and the other on single-stranded DNA. Two mRNAs are transcribed from the cassette. One, a SigA promoter transcript, includes all three genes; the other inclu...

journal_title：Molecular microbiology

authors： Lacks SA,Ayalew S,de la Campa AG,Greenberg B

更新日期：2000-03-01 00:00:00

abstract：:VP4, the major structural protein of the haloarchaeal pleomorphic virus, HRPV-1, is glycosylated. To define the glycan structure attached to this protein, oligosaccharides released by β-elimination were analysed by mass spectrometry and nuclear magnetic resonance spectroscopy. Such analyses showed that the major VP4-d...

journal_title：Molecular microbiology

authors： Kandiba L,Aitio O,Helin J,Guan Z,Permi P,Bamford DH,Eichler J,Roine E

更新日期：2012-05-01 00:00:00

abstract：:citS and citT genes encoding a new two-component system were identified in the 71 degrees region between the pel and citM loci on the Bacillus subtilis chromosome. citS- and citT-deficient strains were unable to grow on minimal plates including citrate as a sole carbon source. In addition, a strain deficient in citM, ...

journal_title：Molecular microbiology

authors： Yamamoto H,Murata M,Sekiguchi J

更新日期：2000-08-01 00:00:00

abstract：:The marine Gram-negative bacteria Rhodopirellula baltica and Oceanicaulis alexandrii have, in contrast to Escherichia coli, membrane insertases with extended positively charged C-terminal regions similar to the YidC homologues in mitochondria and Gram-positive bacteria. We have found that chimeric forms of E. coli Yid...

journal_title：Molecular microbiology

authors： Seitl I,Wickles S,Beckmann R,Kuhn A,Kiefer D

更新日期：2014-01-01 00:00:00

abstract：:Gram-negative bacteria survive harmful environmental stressors by modifying their outer membrane. Much of this protection is afforded upon remodeling of the lipid A region of the major surface molecule lipopolysaccharide (LPS). For example, the addition of cationic substituents, such as 4-amino-4-deoxy-L-arabinose (L-...

journal_title：Molecular microbiology

authors： Nowicki EM,O'Brien JP,Brodbelt JS,Trent MS

更新日期：2015-07-01 00:00:00

abstract：:The ZmpC zinc metalloproteinase of Streptococcus pneumoniae, annotated in the type 4 genome as SP0071, was found to cleave human matrix metalloproteinase 9 (MMP-9). The previously described IgA protease activity was confirmed to be specifically linked to the IgA1-protease/SP1154 zinc metalloproteinase. MMP-9 is a prot...

journal_title：Molecular microbiology

authors： Oggioni MR,Memmi G,Maggi T,Chiavolini D,Iannelli F,Pozzi G

更新日期：2003-08-01 00:00:00

abstract：:The fimbrial and afimbrial adhesins of the Dr family mediate the adherence of uropathogenic and diarrhoea-associated Escherichia coli to decay-accelerating factor (DAF) present on erythrocytes and other cell types. The Dr haemagglutinin binds type IV collagen and, unlike other members of the Dr family, mediates an adh...

journal_title：Molecular microbiology

authors： Carnoy C,Moseley SL

更新日期：1997-01-01 00:00:00

abstract：:Ustilago maydis is able to initiate pathogenic development after fusion of two haploid cells with different mating type. On the maize leaf surface, the resulting dikaryon switches to filamentous growth, differentiates appressoria and penetrates the host. Here, we report on the plant signals required for filament forma...

journal_title：Molecular microbiology

authors： Mendoza-Mendoza A,Berndt P,Djamei A,Weise C,Linne U,Marahiel M,Vranes M,Kämper J,Kahmann R

更新日期：2009-02-01 00:00:00

abstract：:One often compares cells to computers, and signalling proteins to transistors. Location and wiring of those molecular transistors is paramount in defining the function of the subcellular chips. The bacterial chemotactic sensing apparatus is a large, stable assembly consisting of thousands of receptors, signal transduc...

journal_title：Molecular microbiology

authors： Shimizu TS,Le Novère N

更新日期：2008-07-01 00:00:00

abstract：:In this work, we have studied the in vitro translational features of a bicistronic mRNA of the extremely thermophilic Archaeon Sulfolobus solfataricus, with the aim of determining the nature of the cis-acting signals controlling the recognition of the translation initiation sites in the Archaea. We found that the most...

journal_title：Molecular microbiology

authors： Condò I,Ciammaruconi A,Benelli D,Ruggero D,Londei P

更新日期：1999-10-01 00:00:00

abstract：:In this paper we describe the chromosomal location of various loci in Erwinia chrysanthemi strain 3937. Auxotrophic markers were obtained by chemical mutagenesis, antibiotic resistances were isolated spontaneously and mutations in sugar utilization were obtained by means of Mu insertions. These markers were located on...

journal_title：Molecular microbiology

authors： Hugouvieux-Cotte-Pattat N,Reverchon S,Robert-Baudouy J

更新日期：1989-05-01 00:00:00

abstract：:The virulent phenotype of Shigella requires loci on the chromosome as well as on the large virulence plasmid, and is regulated via a complex web of interactions amongst various chromosomal and large plasmid genes. To further investigate the role of chromosomal loci in virulence, we performed random Tn10 mutagenesis in...

journal_title：Molecular microbiology

authors： Mac Síomóin RA,Nakata N,Murai T,Yoshikawa M,Tsuji H,Sasakawa C

更新日期：1996-02-01 00:00:00

abstract：:Bacteria of Shigella spp. are responsible for shigellosis in humans. They use a type III secretion (TTS) system encoded by a 200 kb virulence plasmid to enter epithelial cells and trigger apoptosis in macrophages. This TTS system comprises a secretion apparatus, translocators and effectors that transit through this ap...

journal_title：Molecular microbiology

authors： Penno C,Sansonetti P,Parsot C

更新日期：2005-04-01 00:00:00

abstract：:Only few small, regulatory RNAs encoded opposite another gene have been identified in bacteria. Here, we report the characterization of a locus where a small RNA (SymR) is encoded in cis to an SOS-induced gene whose product shows homology to the antitoxin MazE (SymE). Synthesis of the SymE protein is tightly repressed...

journal_title：Molecular microbiology

authors： Kawano M,Aravind L,Storz G

更新日期：2007-05-01 00:00:00

abstract：:Dormant bacterial spores are extraordinarily resistant to environmental insults and are vectors of various illnesses. However, spores cannot cause disease unless they germinate and become vegetative cells. The molecular details of initiation of germination are not understood, but proteins essential in early stages of ...

journal_title：Molecular microbiology

authors： Griffiths KK,Zhang J,Cowan AE,Yu J,Setlow P

更新日期：2011-08-01 00:00:00

abstract：:Fungi capable of sexual reproduction use heterothallic (self-sterile) or homothallic (self-fertile) mating strategies. In most ascomycetes, a single mating type locus, MAT, with two alternative forms (MAT1-1 and MAT1-2) called idiomorphs, controls mating ability. In heterothallic ascomycetes, these alternative idiomor...

journal_title：Molecular microbiology

authors： Lee J,Lee T,Lee YW,Yun SH,Turgeon BG

更新日期：2003-10-01 00:00:00

abstract：:The cell wall mycolyl-arabinogalactan-peptidoglycan complex is essential in mycobacterial species, such as Mycobacterium tuberculosis and is the target of several antitubercular drugs. For instance, ethambutol targets arabinogalactan biosynthesis through inhibition of the arabinofuranosyltransferases Mt-EmbA and Mt-Em...

journal_title：Molecular microbiology

authors： Birch HL,Alderwick LJ,Bhatt A,Rittmann D,Krumbach K,Singh A,Bai Y,Lowary TL,Eggeling L,Besra GS

更新日期：2008-09-01 00:00:00

abstract：:Ethionamide (ETH) is an important second-line antitubercular drug used for the treatment of patients infected with multidrug-resistant Mycobacterium tuberculosis. Although ETH is a structural analogue of isoniazid, only little cross-resistance to these two drugs is observed among clinical isolates. Both isoniazid and ...

journal_title：Molecular microbiology

authors： Engohang-Ndong J,Baillat D,Aumercier M,Bellefontaine F,Besra GS,Locht C,Baulard AR

更新日期：2004-01-01 00:00:00

abstract：:The bacterial flagellum contains a specialized secretion apparatus in its base that pumps certain protein subunits through the growing structure to their sites of installation beyond the membrane. A related apparatus functions in the injectisomes of gram-negative pathogens to export virulence factors into host cells. ...

journal_title：Molecular microbiology

authors： Erhardt M,Wheatley P,Kim EA,Hirano T,Zhang Y,Sarkar MK,Hughes KT,Blair DF

更新日期：2017-04-01 00:00:00

abstract：:We report a novel strategy for selecting mutations that mislocalize lipoproteins within the Escherichia coli cell envelope and describe the mutants obtained. A strain carrying a deletion of the chromosomal malE gene, coding for the periplasmic maltose-binding protein (MalE), cannot use maltose unless a wild-type copy ...

journal_title：Molecular microbiology

authors： Seydel A,Gounon P,Pugsley AP

更新日期：1999-11-01 00:00:00

abstract：SUMMARY:The pathogenic fungus Cryptococcus neoformans generally initiates infection in mammalian lung tissue and subsequently disseminates to the brain. We performed serial analysis of gene expression (SAGE) on C. neoformans cells recovered from the lungs of mice and found elevated expression of genes for central carbo...

journal_title：Molecular microbiology

authors： Hu G,Cheng PY,Sham A,Perfect JR,Kronstad JW

更新日期：2008-09-01 00:00:00

abstract：:Bottlenecks reduce the size of the gene pool within populations of all life forms with implications for their subsequent survival. Here, we examine the effects of bottlenecks on bacterial commensal-pathogens during transmission between, and dissemination within, hosts. By reducing genetic diversity, bottlenecks may al...

journal_title：Molecular microbiology

authors： De Ste Croix M,Holmes J,Wanford JJ,Moxon ER,Oggioni MR,Bayliss CD

更新日期：2020-03-01 00:00:00

abstract：:Phaseolotoxin, a phytotoxin of Pseudomonas syringae pv. phaseolicola, is produced at 18 degrees C but not at 28 degrees C. Here we report that a fragment (24.4 kb) cloned from the wild-type strain, which does not harbour a gene(s) involved in phaseolotoxin biosynthesis, abolishes this thermoregulation in the wild type...

journal_title：Molecular microbiology

authors： Rowley KB,Clements DE,Mandel M,Humphreys T,Patil SS

更新日期：1993-05-01 00:00:00

abstract：:Leishmania parasites target macrophages in their mammalian hosts and proliferate within the mature phagolysosome compartment of these cells. Intracellular amastigote stages are dependent on sugars as a major carbon source in vivo, but retain the capacity to utilize other carbon sources. To investigate whether amastigo...

journal_title：Molecular microbiology

authors： Saunders EC,Naderer T,Chambers J,Landfear SM,McConville MJ

更新日期：2018-04-01 00:00:00

abstract：:Protein quality control and proteolysis are involved in cell maintenance and environmental acclimatization in bacteria and eukaryotes. The AAA protease FtsH2 of the cyanobacterium Synechocystis sp. PCC 6803 was identified during a screening for mutants impaired in osmoregulation. The ftsH2(-) mutant was salt sensitive...

journal_title：Molecular microbiology

authors： Stirnberg M,Fulda S,Huckauf J,Hagemann M,Krämer R,Marin K

更新日期：2007-01-01 00:00:00

abstract：:Bacteria attach to their appropriate environmental niche by using adhesins. To maximize their contact with the environment, adhesins are often present on the ends of long hairlike structures called pili. Recently, attention has focused on pili of Gram-positive bacteria because they may be vaccine candidates in importa...

journal_title：Molecular microbiology

authors： Scott JR,Zähner D

更新日期：2006-10-01 00:00:00

abstract：:Polymorphonuclear neutrophils are the most important mammalian host defence cells against infections with Pseudomonas aeruginosa. Screening of a signature tagged mutagenesis library of the non-piliated P. aeruginosa strain TBCF10839 uncovered that transposon inactivation of its pilY1 gene rendered the bacterium more r...

journal_title：Molecular microbiology

authors： Bohn YS,Brandes G,Rakhimova E,Horatzek S,Salunkhe P,Munder A,van Barneveld A,Jordan D,Bredenbruch F,Häussler S,Riedel K,Eberl L,Jensen PØ,Bjarnsholt T,Moser C,Hoiby N,Tümmler B,Wiehlmann L

更新日期：2009-02-01 00:00:00

abstract：:Two-component signal transduction (TCST) pathways are regulatory systems that are highly homologous throughout the bacterial kingdom. Their established role in virulence and absence in vertebrates has made TCST an attractive target for therapeutic intervention. However, such systems have yet to yield success in the de...

journal_title：Molecular microbiology

authors： Hubbard JA,MacLachlan LK,King GW,Jones JJ,Fosberry AP

更新日期：2003-09-01 00:00:00