Abstract:
:Bottlenecks reduce the size of the gene pool within populations of all life forms with implications for their subsequent survival. Here, we examine the effects of bottlenecks on bacterial commensal-pathogens during transmission between, and dissemination within, hosts. By reducing genetic diversity, bottlenecks may alter individual or population-wide adaptive potential. A diverse range of hypermutable mechanisms have evolved in infectious agents that allow for rapid generation of genetic diversity in specific genomic loci as opposed to the variability arising from increased genome-wide mutation rates. These localised hypermutable mechanisms include multi-gene phase variation (PV) of outer membrane components, multi-allele PV of restriction systems and recombination-driven antigenic variation. We review selected experimental and theoretical (mathematical) models pertaining to the hypothesis that localised hypermutation (LH) compensates for fitness losses caused by bottlenecks and discuss whether bottlenecks have driven the evolution of hypermutable loci.
journal_name
Mol Microbioljournal_title
Molecular microbiologyauthors
De Ste Croix M,Holmes J,Wanford JJ,Moxon ER,Oggioni MR,Bayliss CDdoi
10.1111/mmi.14453subject
Has Abstractpub_date
2020-03-01 00:00:00pages
672-681issue
3eissn
0950-382Xissn
1365-2958journal_volume
113pub_type
杂志文章,评审abstract::MexAB-OprM is a multidrug efflux system that contributes to intrinsic and acquired multidrug resistance in Pseudomonas aeruginosa, the latter as a result of mutational hyperexpression of the mexAB-oprM operon. While efflux gene hyperexpression typically results from mutations in the linked mexR repressor gene, it also...
journal_title:Molecular microbiology
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journal_title:Molecular microbiology
pub_type: 杂志文章
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更新日期:1994-01-01 00:00:00
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journal_title:Molecular microbiology
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journal_title:Molecular microbiology
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journal_title:Molecular microbiology
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journal_title:Molecular microbiology
pub_type: 杂志文章
doi:10.1111/j.1365-2958.1993.tb01104.x
更新日期:1993-01-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2004-08-01 00:00:00
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journal_title:Molecular microbiology
pub_type: 杂志文章
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更新日期:1989-05-01 00:00:00
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journal_title:Molecular microbiology
pub_type: 杂志文章
doi:10.1111/j.1365-2958.2007.05646.x
更新日期:2007-04-01 00:00:00
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journal_title:Molecular microbiology
pub_type: 杂志文章
doi:10.1111/j.1365-2958.2010.07520.x
更新日期:2011-03-01 00:00:00
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journal_title:Molecular microbiology
pub_type: 杂志文章
doi:10.1111/j.1365-2958.1989.tb00166.x
更新日期:1989-12-01 00:00:00
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pub_type: 杂志文章
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更新日期:1998-07-01 00:00:00
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pub_type: 杂志文章
doi:10.1111/j.1365-2958.2011.07597.x
更新日期:2011-04-01 00:00:00
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pub_type: 评论,杂志文章
doi:10.1111/j.1365-2958.2009.06660.x
更新日期:2009-04-01 00:00:00
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pub_type: 杂志文章
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更新日期:2004-06-01 00:00:00
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journal_title:Molecular microbiology
pub_type: 杂志文章
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journal_title:Molecular microbiology
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pub_type: 杂志文章
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更新日期:2008-08-01 00:00:00
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更新日期:2013-03-01 00:00:00
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journal_title:Molecular microbiology
pub_type: 杂志文章
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更新日期:1994-05-01 00:00:00
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journal_title:Molecular microbiology
pub_type: 杂志文章
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更新日期:1994-03-01 00:00:00
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pub_type: 杂志文章
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更新日期:2008-10-01 00:00:00