Genetic characterization of a Rhizobium meliloti lactose utilization locus.

abstract：:Pneumococcus has been shown to bind to epithelial cells of the nasopharynx and lung, and to endothelial cells of the peripheral vasculature. To characterize bacterial elements required for attachment to these cell types, a library of genetically altered pneumococci with defects in exported proteins was screened for th...

journal_title：Molecular microbiology

authors： Spellerberg B,Cundell DR,Sandros J,Pearce BJ,Idanpaan-Heikkila I,Rosenow C,Masure HR

更新日期：1996-02-01 00:00:00

abstract：:PrkC was shown to be a eukaryotic-like (Hanks-type) protein kinase from Bacillus subtilis with a structural organization similar to that of the eukaryotic sensor Ser/Thr or Tyr kinases (e.g. the TGF beta or PDGF receptors). The molecule consists of a catalytic domain located in the cytoplasm, joined by a single transm...

journal_title：Molecular microbiology

authors： Madec E,Laszkiewicz A,Iwanicki A,Obuchowski M,Séror S

更新日期：2002-10-01 00:00:00

abstract：:Streptococcus mutans, a commensal of the human oral cavity, can survive in the bloodstream and cause infective endocarditis (IE). However, the virulence factors associated with this manifestation of disease are not known. Here, we demonstrate that AtlA, an autolysin of S. mutans is a newly identified fibronectin (Fn) ...

journal_title：Molecular microbiology

authors： Jung CJ,Zheng QH,Shieh YH,Lin CS,Chia JS

更新日期：2009-11-01 00:00:00

abstract：:Clinical strains of Candida albicans are highly tolerant of aneuploidies and other genome rearrangements. We have used comparative genome hybridization (CGH), in an array format, to analyse the copy number of over 6000 open reading frames (ORFs) in the genomic DNA of C. albicans laboratory strains carrying one (CAI-4)...

journal_title：Molecular microbiology

authors： Selmecki A,Bergmann S,Berman J

更新日期：2005-03-01 00:00:00

abstract：:Small GTP-binding proteins of the highly conserved Rho family act as molecular switches regulating cell signalling, cytoskeletal organization and vesicle trafficking in eukaryotic cells. Here we show that in the dimorphic plant pathogenic fungus Ustilago maydis deletion of either cdc42 or rac1 results in loss of virul...

journal_title：Molecular microbiology

authors： Mahlert M,Leveleki L,Hlubek A,Sandrock B,Bölker M

更新日期：2006-01-01 00:00:00

abstract：:The kinetics of initiation of chromosome replication after induction of DnaA protein synthesis was studied in a dnaA(nuII) rnh mutant of Escherichia coli. DnaA protein synthesis was induced to different extents using the wild-type dnaA gene controlled by a lac promoter. Initiation of chromosome replication from oriC, ...

journal_title：Molecular microbiology

authors： Hansen FG,Atlung T

更新日期：1995-01-01 00:00:00

abstract：:The streptococcal antigen I/II (AgI/II)-family polypeptides are cell wall-anchored adhesins expressed by most indigenous oral streptococci. Proteins sharing 30-40% overall amino acid sequence similarities with AgI/II-family proteins are also expressed by Streptococcus pyogenes. The S. pyogenes M28_Spy1325 polypeptide ...

journal_title：Molecular microbiology

authors： Maddocks SE,Wright CJ,Nobbs AH,Brittan JL,Franklin L,Strömberg N,Kadioglu A,Jepson MA,Jenkinson HF

更新日期：2011-08-01 00:00:00

abstract：:Toxin-antitoxin (TA) systems on the chromosomes of free-living bacteria appear to facilitate cell survival during intervals of stress by inducing a state of reversible growth arrest. However, upon prolonged stress, TA toxin action leads to cell death. They have been implicated in several clinically important phenomena...

journal_title：Molecular microbiology

authors： Prysak MH,Mozdzierz CJ,Cook AM,Zhu L,Zhang Y,Inouye M,Woychik NA

更新日期：2009-03-01 00:00:00

abstract：:The endoribonuclease RNase E plays an important role in RNA processing and degradation in Escherichia coli. The construction of an E. coli strain in which the cellular concentration of RNase E can be precisely controlled has made it possible to examine and quantify the effect of RNase E scarcity on RNA decay, gene reg...

journal_title：Molecular microbiology

authors： Jain C,Deana A,Belasco JG

更新日期：2002-02-01 00:00:00

abstract：:RepA, the initiator protein of plasmid P1, binds to multiple sites (iterons) in the origin. The binding normally requires participation of chaperones, DnaJ, DnaK and GrpE. When purified, RepA appears dimeric and is inactive in iteron binding. On reaction with chaperones, a species active in iteron binding is formed an...

journal_title：Molecular microbiology

authors： Dibbens JA,Muraiso K,Chattoraj DK

更新日期：1997-10-01 00:00:00

abstract：:The location of FtsQ, an Escherichia coli protein essential for cell division, is, under physiological conditions, in the cytoplasmic membrane facing towards the periplasmic space. An amino-proximal hydrophobic domain is required for FtsQ to reach its location and for its activity in the cell. Overexpression of modifi...

journal_title：Molecular microbiology

authors： Dopazo A,Palacios P,Sánchez M,Pla J,Vicente M

更新日期：1992-03-01 00:00:00

abstract：:Only one species of Shigella, Shigella dysenteriae 1, has been demonstrated to produce Shiga toxin (Stx). Stx is closely related to the toxins produced by Shiga toxin-producing Escherichia coli (STEC). In STEC, these toxins are often encoded on lambdoid bacteriophages and are major virulence factors for these organism...

journal_title：Molecular microbiology

authors： McDonough MA,Butterton JR

更新日期：1999-12-01 00:00:00

abstract：:Filamentous heterocyst-forming cyanobacteria are a beautiful example of prokaryotic multicellularity. The filaments can achieve simultaneous nitrogen fixation and oxygenic photosynthesis by cooperation between two cell types: the photosynthetic vegetative cells and the nitrogen-fixing heterocysts. The multicellular fe...

journal_title：Molecular microbiology

authors： Mullineaux CW,Nürnberg DJ

更新日期：2014-12-01 00:00:00

abstract：:The F factor traY gene product (TraYp) is a site-specific DNA-binding protein involved in initiation of DNA transfer during bacterial conjugation. The sequence of TraYp exhibits a unique direct-repeat structure predicted to have a ribbon-helix-helix DNA-binding motif in each repeat unit. The stoichiometry of TraYp bin...

journal_title：Molecular microbiology

authors： Nelson WC,Matson SW

更新日期：1996-06-01 00:00:00

abstract：:Prior studies have shown that the catalase-deficient pathogen Streptococcus pyogenes (group A streptococcus) has a robust ability to resist oxidative stress that partially involves the transcriptional regulator PerR. However, the extent of the PerR regulon and the contribution of the members of this regulon to virulen...

journal_title：Molecular microbiology

authors： Brenot A,King KY,Caparon MG

更新日期：2005-01-01 00:00:00

abstract：:Listeria monocytogenes is a Gram-positive intracellular bacterium responsible for severe opportunistic infections in humans and animals. Signature-tagged mutagenesis (STM) was used to identify a gene named fbpA, required for efficient liver colonization of mice inoculated intravenously. FbpA was also shown to be requi...

journal_title：Molecular microbiology

authors： Dramsi S,Bourdichon F,Cabanes D,Lecuit M,Fsihi H,Cossart P

更新日期：2004-07-01 00:00:00

abstract：:The cloned Citrobacter freundii ampC beta-lactamase is inducible in the presence of its regulatory gene ampR in Escherichia coli (Lindberg et al., 1985). The basal level of expression and inducibility are affected by two E. coli proteins encoded by the closely linked ampD and ampE genes. Deletion of both genes led to ...

journal_title：Molecular microbiology

authors： Lindquist S,Galleni M,Lindberg F,Normark S

更新日期：1989-08-01 00:00:00

abstract：:Whereas tetrahydrofolate is an essential cofactor in all bacteria, the gene that encodes the enzyme dihydrofolate reductase (DHFR) could not be identified in many of the bacteria whose genomes have been entirely sequenced. In this communication we show that the halophilic archaea Halobacterium salinarum and Haloarcula...

journal_title：Molecular microbiology

authors： Levin I,Giladi M,Altman-Price N,Ortenberg R,Mevarech M

更新日期：2004-12-01 00:00:00

abstract：:The 29 kDa protein of pathogenic Entamoeba histolytica is a cysteine-rich surface antigen which we recently characterized by cDNA sequencing and by using monoclonal antibodies which differentiated between pathogenic and non-pathogenic clinical isolates. To determine the structure and biochemical attributes of this pro...

journal_title：Molecular microbiology

authors： Flores BM,Batzer MA,Stein MA,Petersen C,Diedrich DL,Torian BE

更新日期：1993-03-01 00:00:00

abstract：:Integrated self-transmissible elements called conjugative transposons have been found in many different bacteria, but little is known about how they excise from the chromosome to form the circular intermediate, which is then transferred by conjugation. We have now identified a gene, exc, which is required for the exci...

journal_title：Molecular microbiology

authors： Cheng Q,Sutanto Y,Shoemaker NB,Gardner JF,Salyers AA

更新日期：2001-08-01 00:00:00

abstract：:The unfolded protein response (UPR) is an important stress signalling pathway involved in the cellular development and environmental adaptation of fungi. We investigated the importance of the UPR pathway in the pathogenicity of the plant necrotrophic fungus Alternaria brassicicola, which causes black spot disease on a...

journal_title：Molecular microbiology

authors： Joubert A,Simoneau P,Campion C,Bataillé-Simoneau N,Iacomi-Vasilescu B,Poupard P,François JM,Georgeault S,Sellier E,Guillemette T

更新日期：2011-03-01 00:00:00

abstract：:NsrR is a nitric oxide (NO)-sensitive transcription repressor that controls NO metabolism in a wide range of bacteria. In Bacillus subtilis, NsrR represses transcription of the nitrite reductase (nasDEF) genes that are under positive control of the ResD-ResE two-component signal transduction system. Derepression is ac...

journal_title：Molecular microbiology

authors： Kommineni S,Yukl E,Hayashi T,Delepine J,Geng H,Moënne-Loccoz P,Nakano MM

更新日期：2010-12-01 00:00:00

abstract：:Protozoan parasites of the phylum Apicomplexa harbour a chloroplast-like organelle, the apicoplast. The biosynthetic pathways localized to this organelle are of cyanobacterial origin and therefore offer attractive targets for the development of new drugs for the treatment of malaria and toxoplasmosis. The apicoplast a...

journal_title：Molecular microbiology

authors： Vaishnava S,Striepen B

更新日期：2006-09-01 00:00:00

abstract：:The Gram-positive pathogen Corynebacterium diphtheriae exports through the Sec apparatus many extracellular proteins that include the key virulence factors diphtheria toxin and the adhesive pili. How these proteins attain their native conformations after translocation as unfolded precursors remains elusive. The fact t...

journal_title：Molecular microbiology

authors： Reardon-Robinson ME,Osipiuk J,Jooya N,Chang C,Joachimiak A,Das A,Ton-That H

更新日期：2015-12-01 00:00:00

abstract：:Protection against maternal malaria has been associated with the acquisition of a specific antibody response that prevents adhesion of Plasmodium falciparum-infected erythrocytes to the glycosaminoglycan chondroitin-4-sulphate (CSA), which is present in the placental intervillous space. These antibodies are directed a...

journal_title：Molecular microbiology

authors： Andrews KT,Pirrit LA,Przyborski JM,Sanchez CP,Sterkers Y,Ricken S,Wickert H,Lépolard C,Avril M,Scherf A,Gysin J,Lanzer M

更新日期：2003-08-01 00:00:00

abstract：:SpsA, a pneumococcal surface protein belonging to the family of choline-binding proteins, interacts specifically with secretory immunglobulin A (SIgA) via the secretory component (SC). SIgA and free SC from mouse, rat, rabbit and guinea-pig failed to interact with SpsA indicating species-specific binding to human SIgA...

journal_title：Molecular microbiology

authors： Hammerschmidt S,Tillig MP,Wolff S,Vaerman JP,Chhatwal GS

更新日期：2000-05-01 00:00:00

abstract：:The repABC replicons contain an operon encoding the initiator protein (RepC) and partitioning proteins (RepA and RepB). The latter two proteins negatively regulate the transcription of the operon. In this article we have identified two novel regulatory elements, located within the conserved repB-repC intergenic sequen...

journal_title：Molecular microbiology

authors： Venkova-Canova T,Soberón NE,Ramírez-Romero MA,Cevallos MA

更新日期：2004-12-01 00:00:00

abstract：:Virulence factors secreted by Listeria monocytogenes are known to interfere with host cellular signalling pathways. We investigated whether L. monocytogenes modulates T-cell receptor signalling by examining surface expression of proteins known to be upregulated on activated T cells. In vitro culture of murine splenocy...

journal_title：Molecular microbiology

authors： Zenewicz LA,Skinner JA,Goldfine H,Shen H

更新日期：2004-03-01 00:00:00

abstract：:Effector translocation is central to the virulence of many bacterial pathogens, including Streptococcus pyogenes, which utilizes the cholesterol-dependent cytolysin Streptolysin O (SLO) to translocate the NAD(+) glycohydrolase SPN into host cells during infection. SLO's translocation activity does not require host cel...

journal_title：Molecular microbiology

authors： Mozola CC,Caparon MG

更新日期：2015-09-01 00:00:00

abstract：:MreB shares a common prokaryotic ancestor with actin and is present in almost all rod-shaped bacteria. MreB proteins have been implicated in a range of important cell processes, including cell morphogenesis, chromosome segregation and cell polarity. The mreB gene frequently lies at the beginning of a cluster of genes,...

journal_title：Molecular microbiology

authors： Formstone A,Errington J

更新日期：2005-03-01 00:00:00