Abstract:
:Cell-cell communication via the production and detection of chemical signal molecules has been the focus of a great deal of research over the past decade. One class of chemical signals widely used by proteobacteria consists of N-acyl-homoserine lactones, which are synthesized by proteins related to LuxI of Vibrio fischeri and are detected by proteins related to the V. fischeri LuxR protein. A related marine bacterium, Vibrio harveyi, communicates using two chemical signals, one of which, autoinducer-2 (AI-2), is a furanone borate diester that is synthesized by the LuxS protein and detected by a periplasmic protein called LuxP. Evidence from a number of laboratories suggests that AI-2 may be used as a signal by diverse groups of bacteria, and might permit intergeneric signalling. These two families of signalling systems have been studied from the perspectives of physiology, ecology, biochemistry, and more recently, structural biology. Here, we review the biochemistry and structural biology of both acyl-homoserine-lactone-dependent and AI-2-dependent signalling systems.
journal_name
Mol Microbioljournal_title
Molecular microbiologyauthors
Pappas KM,Weingart CL,Winans SCdoi
10.1111/j.1365-2958.2004.04212.xsubject
Has Abstractpub_date
2004-08-01 00:00:00pages
755-69issue
3eissn
0950-382Xissn
1365-2958pii
MMI4212journal_volume
53pub_type
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journal_title:Molecular microbiology
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