Pneumococcal zinc metalloproteinase ZmpC cleaves human matrix metalloproteinase 9 and is a virulence factor in experimental pneumonia.

abstract：:Motile bacteria sense their physical and chemical environment through highly cooperative, ordered arrays of chemoreceptors. These signalling complexes phosphorylate a response regulator which in turn governs flagellar motor reversals, driving cells towards favourable environments. The structural changes that translate...

journal_title：Molecular microbiology

authors： Briegel A,Ames P,Gumbart JC,Oikonomou CM,Parkinson JS,Jensen GJ

更新日期：2013-09-01 00:00:00

abstract：:In bacteria, DNA supercoil movement is restricted to subchromosomal regions or 'domains.' To elucidate the nature of domain boundaries, we analysed reaction kinetics for gammadelta site-specific resolution in six chromosomal intervals ranging in size from 14 to 90 kb. In stationary cultures of Salmonella typhimurium, ...

journal_title：Molecular microbiology

authors： Staczek P,Higgins NP

更新日期：1998-09-01 00:00:00

abstract：:The essential proteins DnaB, DnaD and DnaI of Bacillus subtilis are required for initiation, but not elongation, of DNA replication, and for replication restart at stalled forks. The interactions and functions of these proteins have largely been determined in vitro based on their roles in replication restart. During r...

journal_title：Molecular microbiology

authors： Smits WK,Goranov AI,Grossman AD

更新日期：2010-01-01 00:00:00

abstract：:The analysis of the not well understood composition of the stalk, a key ribosomal structure, in eukaryotes having multiple 12 kDa P1/P2 acidic protein components has been approached using these proteins tagged with a histidine tail at the C-terminus. Tagged Saccharomyces cerevisiae ribosomes, which contain two P1 prot...

journal_title：Molecular microbiology

authors： Guarinos E,Santos C,Sánchez A,Qiu DY,Remacha M,Ballesta JP

更新日期：2003-10-01 00:00:00

abstract：:Strains of Neisseria meningitidis express one of two porin proteins. These porins have been identified as the class 2 and class 3 proteins, and express serotype-specific epitopes. The gene for the class 3 protein was amplified by the polymerase chain reaction from the DNA of a serotype 4 strain as a 1025 bp fragment. ...

journal_title：Molecular microbiology

authors： Zapata GA,Vann WF,Rubinstein Y,Frasch CE

更新日期：1992-12-01 00:00:00

abstract：:Ustilago maydis, the causal agent of corn smut disease, displays dimorphic growth in which it alternates between a budding haploid saprophyte and a filamentous dikaryotic pathogen. We are interested in identifying the genetic determinants of filamentous growth and pathogenicity in U. maydis. To do this, we have taken ...

journal_title：Molecular microbiology

authors： Mayorga ME,Gold SE

更新日期：1999-11-01 00:00:00

abstract：:The molecular chaperone Hsp90 is a regulatory component of some key signalling proteins in the cytosol of eukaryotic cells. For some of these functions, its interaction with co-chaperones is required. Limited proteolysis defined stable folded units of Hsp90. Both an N-terminal (N210) and a C-terminal (262C) fragment i...

journal_title：Molecular microbiology

authors： Scheibel T,Weikl T,Rimerman R,Smith D,Lindquist S,Buchner J

更新日期：1999-11-01 00:00:00

abstract：:We have identified a phosphate transporter (TcPho91) localized to the bladder of the contractile vacuole complex (CVC) of Trypanosoma cruzi, the etiologic agent of Chagas disease. TcPho91 has 12 transmembrane domains, an N-terminal regulatory SPX (named after SYG1, Pho81 and XPR1) domain and an anion permease domain. ...

journal_title：Molecular microbiology

authors： Jimenez V,Docampo R

更新日期：2015-09-01 00:00:00

abstract：:In vitro, the sigma(s) subunit of RNA polymerase (RNAP), RpoS, recognizes nearly identical -35 and -10 promoter consensus sequences as the vegetative sigma70. In vivo, promoter selectivity of RNAP holoenzyme containing either sigma(s) (Esigma(s)) or sigma70 (Esigma70) seems to be achieved by the differential ability o...

journal_title：Molecular microbiology

authors： Typas A,Hengge R

更新日期：2006-02-01 00:00:00

abstract：:A Lactobacillus casei BL23 strain defective in an OmpR-family response regulator encoded by LCABL_18980 (PrcR, RR11), showed enhanced proteolytic activity caused by overexpression of the gene encoding the proteinase PrtP. Transcriptomic analysis revealed that, in addition to prtP expression, PrcR regulates genes encod...

journal_title：Molecular microbiology

authors： Alcántara C,Bäuerl C,Revilla-Guarinos A,Pérez-Martínez G,Monedero V,Zúñiga M

更新日期：2016-04-01 00:00:00

abstract：:A series of lipoproteins was detected in the membrane fraction of Yersinia enterocolitica W227, a typical strain from serotype O:9. At least two of them, YlpA and YlpB, are encoded by the pYV plasmid. The sequence of ylpA reveals the presence of a typical lipoprotein signal peptide. The mature YlpA protein would be 22...

journal_title：Molecular microbiology

authors： China B,Michiels T,Cornelis GR

更新日期：1990-09-01 00:00:00

abstract：:Rhamnolipid acts as a virulence factor during Pseudomonas aeruginosa infection. Here, we show that deletion of the catabolite repression control (crc) gene in P. aeruginosa leads to a rhamnolipid-negative phenotype. This effect is mediated by the down-regulation of rhl quorum sensing (QS). We discover that a disruptio...

journal_title：Molecular microbiology

authors： Yang N,Ding S,Chen F,Zhang X,Xia Y,Di H,Cao Q,Deng X,Wu M,Wong CC,Tian XX,Yang CG,Zhao J,Lan L

更新日期：2015-05-01 00:00:00

abstract：:Mycobacterium tuberculosis infects one-third of the world's population and causes two million deaths annually. The unusually low permeability of its cell wall contributes to the ability of M. tuberculosis to grow within host macrophages, a property required for pathogenesis of infection. Mycobacterium marinum is an es...

journal_title：Molecular microbiology

authors： Gao LY,Laval F,Lawson EH,Groger RK,Woodruff A,Morisaki JH,Cox JS,Daffe M,Brown EJ

更新日期：2003-09-01 00:00:00

abstract：:We have demonstrated hypervariability of native short-motif repeats (microsatellites) in Escherichia coli. Twenty-five of the longest microsatellites in the E. coli genome were identified. These were analysed for length variability among 22 wild-type (non-mutator) isolates from the E. coli collection of reference (ECO...

journal_title：Molecular microbiology

authors： Metzgar D,Thomas E,Davis C,Field D,Wills C

更新日期：2001-01-01 00:00:00

abstract：:Chemoreceptors play a central role in chemotaxis, allowing bacteria to detect chemical gradients and bias their swimming behavior in order to navigate toward favorable environments. The genome of the kiwifruit pathogen, Pseudomonas syringae pv. actinidiae (Psa) strain NZ-V13 encodes 43 predicted chemoreceptors, none o...

journal_title：Molecular microbiology

authors： McKellar JL,Minnell JJ,Gerth ML

更新日期：2015-05-01 00:00:00

abstract：:In cyanobacteria and chloroplasts, exposure to HL damages the photosynthetic apparatus, especially the D1 subunit of Photosystem II. To avoid chronic photoinhibition, a PSII repair cycle operates to replace damaged PSII subunits with newly synthesised versions. To determine the sub-cellular location of this process, w...

journal_title：Molecular microbiology

authors： Sacharz J,Bryan SJ,Yu J,Burroughs NJ,Spence EM,Nixon PJ,Mullineaux CW

更新日期：2015-05-01 00:00:00

abstract：:We have identified and characterized three genes, SUT1, SUT2 and SUT3, that encode glucose transporters of the yeast Pichia stipitis. When expressed in a Saccharomyces cerevisiae hxt null mutant strain that is unable to take up monosaccharides, all three proteins restored growth on glucose. Sequencing of the genes rev...

journal_title：Molecular microbiology

authors： Weierstall T,Hollenberg CP,Boles E

更新日期：1999-02-01 00:00:00

abstract：:In this study we show for the first time the intracellular distribution of a K39 kinesin homologue in Leishmania donovani, a medically important parasite of humans. Further, we demonstrated that this motor protein is expressed in both the insect and mammalian developmental forms (i.e. promastigote and amastigotes) of ...

journal_title：Molecular microbiology

authors： Gerald NJ,Coppens I,Dwyer DM

更新日期：2007-02-01 00:00:00

abstract：:The [NiFe]hydrogenase of the photosynthetic bacterium Rhodobacter capsulatus is encoded by the structural hupSLC operon, the expression of which is induced by H2. H2 activation was no longer observable in chromosomal hupR mutants, an indication that HupR is implicated directly in the activation by H2 of hupS gene expr...

journal_title：Molecular microbiology

authors： Toussaint B,de Sury d'Aspremont R,Delic-Attree I,Berchet V,Elsen S,Colbeau A,Dischert W,Lazzaroni Y,Vignais PM

更新日期：1997-12-01 00:00:00

abstract：:Malaria transmission requires that the parasites differentiate into gametocytes prior to ingestion by a mosquito during a blood meal. Once in the mosquito midgut the gametocytes emerge from red blood cells (RBCs), fertilize, develop into ookinetes and finally infectious sporozoites. Gamete surface antigen, Pfs230, is ...

journal_title：Molecular microbiology

authors： Eksi S,Czesny B,van Gemert GJ,Sauerwein RW,Eling W,Williamson KC

更新日期：2006-08-01 00:00:00

abstract：:Bacterial biofilms contain subpopulations of cells that are dormant and highly tolerant to antibiotics. While dormant, the bacteria must maintain the integrity of macromolecules required for resuscitation. Previously, we showed that hibernation promoting factor (HPF) is essential for protecting Pseudomonas aeruginosa ...

journal_title：Molecular microbiology

authors： Akiyama T,Williamson KS,Franklin MJ

更新日期：2018-10-01 00:00:00

abstract：:Pyruvoyl-dependent histidine decarboxylases are produced as proenzymes that mature by cleavage followed by formation of the pyruvoyl prosthetic group. The histidine decarboxylation pathway of Streptococcus thermophilus CHCC1524 that consists of the pyruvoyl-dependent histidine decarboxylase HdcA and the histidine/hist...

journal_title：Molecular microbiology

authors： Trip H,Mulder NL,Rattray FP,Lolkema JS

更新日期：2011-02-01 00:00:00

abstract：:Translating ribosomes require elongation factor P (EF-P) to incorporate consecutive prolines (XPPX) into nascent peptide chains. The proteome of Corynebacterium glutamicum ATCC 13032 contains a total of 1,468 XPPX motifs, many of which are found in proteins involved in primary and secondary metabolism. We show here th...

journal_title：Molecular microbiology

authors： Pinheiro B,Petrov DP,Guo L,Martins GB,Bramkamp M,Jung K

更新日期：2020-10-04 00:00:00

abstract：:Wild strains of Bacillus subtilis are capable of forming architecturally complex communities of cells known as biofilms. Critical to biofilm formation is the eps operon, which is believed to be responsible for the biosynthesis of an exopolysaccharide that binds chains of cells together in bundles. We report that trans...

journal_title：Molecular microbiology

authors： Kearns DB,Chu F,Branda SS,Kolter R,Losick R

更新日期：2005-02-01 00:00:00

abstract：:Pregnancy-associated malaria (PAM) is caused by Plasmodium falciparum-infected erythrocytes (IEs) that bind to chondroitin sulphate A (CSA) in the placenta by PAM-associated clonally variant surface antigens (VSA). Pregnancy-specific VSA (VSA(PAM)), which include the PfEMP1 variant VAR2CSA, are targets of IgG-mediated...

journal_title：Molecular microbiology

authors： Barfod L,Bernasconi NL,Dahlbäck M,Jarrossay D,Andersen PH,Salanti A,Ofori MF,Turner L,Resende M,Nielsen MA,Theander TG,Sallusto F,Lanzavecchia A,Hviid L

更新日期：2007-01-01 00:00:00

abstract：:The K1 killer toxin of Saccharomyces cerevisiae consists of 103- and 83-residue alpha and beta components whose derivation, from a 316-residue precursor preprotoxin, requires processing at the alpha N-terminus (after ProArg-44), the alpha C-terminus (after ArgArg-149) and at the beta N-terminus (after LysArg-233). The...

journal_title：Molecular microbiology

authors： Zhu YS,Zhang XY,Cartwright CP,Tipper DJ

更新日期：1992-02-01 00:00:00

abstract：:Tst, the gene for toxic shock syndrome toxin-1 (TSST-1), is part of a 15.2 kb genetic element in Staphylococcus aureus that is absent in TSST-1-negative strains. The prototype, in RN4282, is flanked by a 17 nucleotide direct repeat and contains genes for a second possible superantigen toxin, a Dichelobacter nodosus Va...

journal_title：Molecular microbiology

authors： Lindsay JA,Ruzin A,Ross HF,Kurepina N,Novick RP

更新日期：1998-07-01 00:00:00

abstract：:Clp ATPases, which include the ubiquitous HSP100 family, are classified according to their structural features and sequence similarities. During the course of the Bacillus subtilis genome sequencing project, we identified a gene encoding a new member of the HSP100 family. We designated this protein ClpE, as it is the ...

journal_title：Molecular microbiology

authors： Derré I,Rapoport G,Devine K,Rose M,Msadek T

更新日期：1999-05-01 00:00:00

abstract：:Structural maintenance of chromosome (SMC) and the SMC-interacting kleisin protein families have key functions in the chromosome organization of most organisms. Here, we report that the Bacillus subtilis kleisin, ScpA, can form a ternary complex with the SMC and ScpB proteins in a yeast tri-hybrid assay, supporting th...

journal_title：Molecular microbiology

authors： Dervyn E,Noirot-Gros MF,Mervelet P,McGovern S,Ehrlich SD,Polard P,Noirot P

更新日期：2004-03-01 00:00:00

abstract：:Type IV secretion systems are increasingly recognized as important virulence determinants of Gram-negative bacterial pathogens. While the examination of several type IV-secreted proteins suggested that their secretion depends on C-terminal signals, the nature of these signals and their conservation among different sys...

journal_title：Molecular microbiology

authors： Hohlfeld S,Pattis I,Püls J,Plano GV,Haas R,Fischer W

更新日期：2006-03-01 00:00:00