Abstract:
:Regions close to the replication terminus of the Escherichia coli chromosome are strongly refractory to genomic inversions. Since these regions also harbour polar replication terminator-like sequences or pause sites, we have investigated the possibility that slowing of replication as a result of pausing at inverted pause sites is responsible for inability to isolate stable inversions affecting these regions. A mutation in the tus gene is known to abolish replication pausing at terminators. We show here that the distribution of invertible and noninvertible segments along the chromosome is not affected by tus mutations. This observation eliminates replication pausing as a cause for the reduced fitness of bacteria harbouring certain chromosomal inversions.
journal_name
Mol Microbioljournal_title
Molecular microbiologyauthors
François V,Louarn J,Patte J,Rebollo JE,Louarn JMdoi
10.1111/j.1365-2958.1990.tb00621.xsubject
Has Abstractpub_date
1990-04-01 00:00:00pages
537-42issue
4eissn
0950-382Xissn
1365-2958journal_volume
4pub_type
杂志文章abstract::The PhaF is a nucleoid-associated like protein of Pseudomonas putida KT2442 involved in the polyhydroxyalkanoate (PHA) metabolism. Its primary structure shows two modular domains; the N-terminal PHA granule-binding domain (phasin domain) and the C-terminal half containing AAKP-like tandem repeats characteristic of the...
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pub_type: 杂志文章
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journal_title:Molecular microbiology
pub_type: 杂志文章
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更新日期:1990-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:1990-07-01 00:00:00
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journal_title:Molecular microbiology
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