Abstract:
:Members of the IS3 family of insertion sequences are found in a wide range of bacteria. At least 10 members of this family carry two major open reading frames: a small upstream frame (0 phase), and a longer downstream frame in the -1 phase. The downstream frame shows significant similarity at the amino acid level. A highly conserved region of this frame also exhibits notable similarity with a region of the integrase (endonuclease) domain of retroviruses. Although the overall transposition mechanism of the insertion sequence and retroviral elements is certainly different, the two groups may share additional common features, including a -1 frameshift resulting in the production of a fusion protein.
journal_name
Mol Microbioljournal_title
Molecular microbiologyauthors
Fayet O,Ramond P,Polard P,Prère MF,Chandler Mdoi
10.1111/j.1365-2958.1990.tb00555.xsubject
Has Abstractpub_date
1990-10-01 00:00:00pages
1771-7issue
10eissn
0950-382Xissn
1365-2958journal_volume
4pub_type
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