Nifs and Sufs in malaria.

abstract：:Streptomyces scabies is the best studied of those streptomycetes that cause an economically important disease known as potato scab. The phytotoxin thaxtomin is made exclusively by these pathogens and is required for virulence. Here we describe regulation of thaxtomin biosynthesis by TxtR, a member of the AraC/XylS fam...

journal_title：Molecular microbiology

authors： Joshi MV,Bignell DR,Johnson EG,Sparks JP,Gibson DM,Loria R

更新日期：2007-11-01 00:00:00

abstract：:Of the four Plasmodium species that routinely cause malaria in humans, Plasmodium falciparum is responsible for the majority of malaria mortality and consequently gets most of the headlines. Outside Africa, however, more malaria cases are caused by its distant cousin Plasmodium vivax, resulting in a daunting morbidity...

journal_title：Molecular microbiology

authors： Rayner J

更新日期：2005-03-01 00:00:00

abstract：:We have characterized a number of mutations in fnr that interfere with FNR-dependent transcription activation at two promoters where the FNR-binding site is centred around 41 1/2 bp upstream from the transcription start site. The substituted residues in all but one of these FNR mutants are clustered around a presumed ...

journal_title：Molecular microbiology

authors： Bell A,Busby S

更新日期：1994-01-01 00:00:00

abstract：:Cell differentiation is widespread during the development of multicellular organisms, but rarely observed in prokaryotes. One example of prokaryotic differentiation is the gram-negative bacterium Myxococcus xanthus. In response to starvation, this gliding bacterium initiates a complex developmental programme that resu...

journal_title：Molecular microbiology

authors： Hoiczyk E,Ring MW,McHugh CA,Schwär G,Bode E,Krug D,Altmeyer MO,Lu JZ,Bode HB

更新日期：2009-10-01 00:00:00

abstract：:The flagellar genes of Caulobacter crescentus are expressed under cell-cycle control. Expression is regulated by both flagellar assembly cues and cell-cycle events. In this paper we define the sequences required for the expression of the flgF operon, a new class of sigma 54 flagellar promoter. This promoter type is ex...

journal_title：Molecular microbiology

authors： Marques MV,Gober JW

更新日期：1995-04-01 00:00:00

abstract：:We report here the identification and characterization of a member of the Myxococcus xanthus SdeK signal transduction pathway, BrgE. This protein was identified as an SdeK-interacting component using a yeast two-hybrid screen, and we further confirmed this interaction by the glutathione S-transferase (GST) pulldown as...

journal_title：Molecular microbiology

authors： Pham VD,Shebelut CW,Zumstein EJ,Singer M

更新日期：2005-08-01 00:00:00

abstract：:DivIB, DivIC and FtsL are bacterial proteins essential for cell division, which show interdependencies for their stabilities and localization. We have reconstituted in vitro a trimeric complex consisting of the recombinant extracellular domains of the three proteins from Streptococcus pneumoniae. The extracellular dom...

journal_title：Molecular microbiology

authors： Noirclerc-Savoye M,Le Gouëllec A,Morlot C,Dideberg O,Vernet T,Zapun A

更新日期：2005-01-01 00:00:00

abstract：:In the environment and during infection, the human intestinal pathogen Vibrio cholerae must overcome noxious compounds that damage the bacterial outer membrane. The El Tor and classical biotypes of O1 V. cholerae show striking differences in their resistance to membrane disrupting cationic antimicrobial peptides (CAMP...

journal_title：Molecular microbiology

authors： Herrera CM,Henderson JC,Crofts AA,Trent MS

更新日期：2017-11-01 00:00:00

abstract：:Fungal cellulolytic and hemicellulolytic enzymes are promising tools for industrial hydrolysis of cellulosic biomass; however, the regulatory network underlying their production is not well understood. The recent discovery of the transcriptional activators ClrB and McmA in Aspergillus nidulans implied a novel regulato...

journal_title：Molecular microbiology

authors： Li N,Kunitake E,Aoyama M,Ogawa M,Kanamaru K,Kimura M,Koyama Y,Kobayashi T

更新日期：2016-12-01 00:00:00

abstract：:In response to discrete environmental cues, Saccharomyces cerevisiae cells adjust patterns of gene expression and protein activity to optimize metabolism. Nutrient-sensing systems situated in the plasma membrane (PM) of yeast have only recently been discovered. Ssy1p is one of three identified components of the Ssy1p-...

journal_title：Molecular microbiology

authors： Forsberg H,Gilstring CF,Zargari A,Martínez P,Ljungdahl PO

更新日期：2001-10-01 00:00:00

abstract：:Photorhabdus are bacteria found colonizing the gut of a specialized stage of the nematode Heterorhabditis, called the infective juvenile (IJ). The IJ is a free-living stage of the nematode that seeks out and infects insect larvae. Once inside the insect the IJ release Photorhabdus into the haemolymph where the bacteri...

journal_title：Molecular microbiology

authors： Watson RJ,Joyce SA,Spencer GV,Clarke DJ

更新日期：2005-05-01 00:00:00

abstract：:Escherichia coli RnlA-RnlB is a newly identified toxin-antitoxin (TA) system that plays a role in bacteriophage resistance. RnlA functions as a toxin with mRNA endoribonuclease activity and the cognate antitoxin RnlB inhibits RnlA toxicity in E. coli cells. Interestingly, T4 phage encodes the antitoxin Dmd, which acts...

journal_title：Molecular microbiology

authors： Wei Y,Gao ZQ,Otsuka Y,Naka K,Yonesaki T,Zhang H,Dong YH

更新日期：2013-12-01 00:00:00

abstract：:Differential expression of the genes expressing Pap pili in Escherichia coli was suggested to involve mRNAs with different stabilities. As the result of a post-transcriptional processing event, a papA gene-specific mRNA product (mRNA-A) accumulates in large excess relative to the primary mRNA-BA transcript. Our result...

journal_title：Molecular microbiology

authors： Nilsson P,Uhlin BE

更新日期：1991-07-01 00:00:00

abstract：:Protein degradation is required for homeostasis of all living organisms. Self-compartmentalized ATP-dependent proteases are required for virulence of several pathogenic bacteria. Among the proteases implicated are ClpP and Lon, as well as the more recently identified bacterial proteasome. It is generally assumed that ...

journal_title：Molecular microbiology

authors： Butler SM,Festa RA,Pearce MJ,Darwin KH

更新日期：2006-05-01 00:00:00

abstract：:The stable maintenance of low-copy-number plasmids requires active partitioning, with the most common mechanism in prokaryotes involving the ATPase ParA. ParA proteins undergo intricate spatiotemporal relocations across the nucleoid, dynamics that function to position plasmids at equally spaced intervals. This spacing...

journal_title：Molecular microbiology

authors： Howard M,Gerdes K

更新日期：2010-10-01 00:00:00

abstract：:Avermectins produced by Streptomyces avermitilis are effective anthelmintic agents. The autoregulatory signalling molecule that triggers avermectin biosynthesis is a novel butenolide-type molecule, avenolide, rather than common γ-butyrolactones (GBLs). We identified AvaR2, a pseudo GBL receptor homologue, as an import...

journal_title：Molecular microbiology

authors： Zhu J,Sun D,Liu W,Chen Z,Li J,Wen Y

更新日期：2016-11-01 00:00:00

abstract：:Phosphorylcholine (ChoP) is a common surface feature of many mucosal organisms, including Neisseria spp., in which it is present exclusively on pili of pathogenic Neisseria and on the lipopolysaccharide (LPS) of commensal Neisseria (Cn). Its presence in Cn has been confirmed by nuclear magnetic resonance. It appears t...

journal_title：Molecular microbiology

authors： Serino L,Virji M

更新日期：2002-01-01 00:00:00

abstract：:Understanding the mechanisms of polysialic acid synthesis in Escherichia coli K1 requires a molecular description of the polymerase complex. Since the number of potential models explaining polysialic acid assembly would be constrained if only one sialyltransferase were required for this process, the phenotypes of a si...

journal_title：Molecular microbiology

authors： Steenbergen SM,Vimr ER

更新日期：1990-04-01 00:00:00

abstract：:P1 B -ATPases are among the most common resistance factors to metal-induced stress. Belonging to the superfamily of P-type ATPases, they are capable of exporting transition metal ions at the expense of adenosine triphosphate (ATP) hydrolysis. P1 B -ATPases share a conserved structure of three cytoplasmic domains linke...

journal_title：Molecular microbiology

authors： Drees SL,Beyer DF,Lenders-Lomscher C,Lübben M

更新日期：2015-08-01 00:00:00

abstract：:The development of new drugs for treating Pneumocystis carinii infections in AIDS patients is hampered by the lack of long-term culture systems, and by our generally limited knowledge of this organism. Recently, however, we observed significant activity of various benzimidazoles against growth of this organism in shor...

journal_title：Molecular microbiology

authors： Edlind TD,Bartlett MS,Weinberg GA,Prah GN,Smith JW

更新日期：1992-11-01 00:00:00

abstract：:Mutation of staphylococcal accessory regulator (sarA) results in increased production of extracellular proteases in Staphylococcus aureus, which has been correlated with decreased biofilm formation and decreased accumulation of extracellular toxins. We used murine models of implant-associated biofilm infection and S. ...

journal_title：Molecular microbiology

authors： Zielinska AK,Beenken KE,Mrak LN,Spencer HJ,Post GR,Skinner RA,Tackett AJ,Horswill AR,Smeltzer MS

更新日期：2012-12-01 00:00:00

abstract：:Post-transcriptional repression of porin synthesis has emerged as a major function of Hfq-dependent, small non-coding RNAs (sRNAs). Many enterobacteria express OmpX-like porins, a family of outer membrane proteins whose physiological roles and structural properties have been studied intensively. While regulatory sRNAs...

journal_title：Molecular microbiology

authors： Papenfort K,Pfeiffer V,Lucchini S,Sonawane A,Hinton JC,Vogel J

更新日期：2008-05-01 00:00:00

abstract：:Gyrase-mediated hypernegative supercoiling is one manifestation of R-loop formation, a phenomenon that is normally suppressed by topoisomerase I (topA) in Escherichia coli. Overproduction of RNase HI (rnhA), an enzyme that removes the RNA moiety of R-loops, prevents hypernegative supercoiling and allows growth of topA...

journal_title：Molecular microbiology

authors： Usongo V,Nolent F,Sanscartier P,Tanguay C,Broccoli S,Baaklini I,Drlica K,Drolet M

更新日期：2008-08-01 00:00:00

abstract：:A series of plasmids carrying an IRL-kan-IRR transposable cassette, in which IRL and IRR are the left- and right-terminal sequences of IS91, have been constructed. These cassettes could be complemented for transposition with similar efficiency when IS91 transposase was provided either in cis or in trans. A total of 87...

journal_title：Molecular microbiology

authors： Bernales I,Mendiola MV,de la Cruz F

更新日期：1999-07-01 00:00:00

abstract：:Small regulatory RNAs (sRNAs) are well known to command bacterial protein synthesis by modulating the translation and decay of target mRNAs. Most sRNAs are specifically regulated by a cognate transcription factor under certain growth or stress conditions. Investigations of the conserved Hfq-dependent MicM sRNA in Esch...

journal_title：Molecular microbiology

authors： Vogel J

更新日期：2009-09-01 00:00:00

abstract：:LeuO is a quiescent LysR-type regulator belonging to the H-NS regulon. Activation of leuO transcription represses expression of pathogenicity island 1 (SPI-1) in Salmonella enterica serovar Typhimurium and inhibits invasion of epithelial cells. Loss of HilE suppresses LeuO-mediated downregulation of SPI-1. Activation ...

journal_title：Molecular microbiology

authors： Espinosa E,Casadesús J

更新日期：2014-03-01 00:00:00

abstract：:The plasmid plP1066, harboured by by a methicillin-resistant Staphylococcus aureus strain isolated in France, carries genes specifying beta-lactamase. This plasmid undergoes numerous rearrangements. One of these was insertion, between the genes binR and sin encoding resolvases, of a 16 kb element which displayed the c...

journal_title：Molecular microbiology

authors： Derbise A,Dyke KG,el Solh N

更新日期：1995-08-01 00:00:00

abstract：:Bacteria of the genera Bacillus and Clostridium form highly resistant spores, which in the case of some pathogens act as the infectious agents. An exosporium forms the outermost layer of some spores; it plays roles in protection, adhesion, dissemination, host targeting in pathogens and germination control. The exospor...

journal_title：Molecular microbiology

authors： Terry C,Jiang S,Radford DS,Wan Q,Tzokov S,Moir A,Bullough PA

更新日期：2017-05-01 00:00:00

abstract：:The localization of SeqA, thymidylate synthase, DnaB (helicase) and the DNA polymerase components alpha and tau, has been studied by immunofluorescence microscopy. The origin has been labelled through GFP-LacI bound near oriC. SeqA was located in the cell centre for one replication factory (RF) and at 1/4 and 3/4 posi...

journal_title：Molecular microbiology

authors： den Blaauwen T,Aarsman ME,Wheeler LJ,Nanninga N

更新日期：2006-11-01 00:00:00

abstract：:The Helicobacter pylori genome contains a gene (hp1338 or nikR) that encodes a nickel-dependent regulator that is homologous to the Escherichia coli nickel-responsive regulator, NikR. The H. pylori nikR product acts as a pleiotropic metal-dependent regulator. We constructed a non-polar isogenic mutant deleted for the ...

journal_title：Molecular microbiology

authors： Contreras M,Thiberge JM,Mandrand-Berthelot MA,Labigne A

更新日期：2003-08-01 00:00:00