Abstract:
:Expression of the 987P gene cluster is activated by the adjacent IS1 element of an STpa transposon. Nucleotide sequence analysis of the 987P-DNA region contiguous with this IS1 element revealed the presence of an open reading frame designated fapR, encoding a basic protein of 260 amino acid residues with a molecular mass of 30,349 Daltons. The gene product, FapR, possesses similarity to a number of positive regulators of gene expression: VirF, Rns, AppY and EnvY. Moreover, a 43-amino-acid residue sequence in the C-terminal part of FapR is similar to the C-terminal domain of AraC, RhaR, and RhaS. Expression of fapR is dependent on the adjacent IS1 element. The FapR protein appears to be required for activation of the silent promoter of the fimbrial subunit gene, fapC.
journal_name
Mol Microbioljournal_title
Molecular microbiologyauthors
Klaasen P,de Graaf FKdoi
10.1111/j.1365-2958.1990.tb00556.xsubject
Has Abstractpub_date
1990-10-01 00:00:00pages
1779-83issue
10eissn
0950-382Xissn
1365-2958journal_volume
4pub_type
杂志文章abstract::The de novo purine biosynthetic enzymes 5-amino-4-imidazolecarboxamide-ribonucleotide (AICAR) transformylase (EC 2.1.2.3), IMP cyclohydrolase (EC 3.5.4.10) and glycineamide-ribonucleotide (GAR) synthetase (EC 2.1.2.2) are encoded by the purHD locus of Escherichia coli. The DNA sequence of this locus revealed two open ...
journal_title:Molecular microbiology
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pub_type: 杂志文章
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更新日期:1998-02-01 00:00:00
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pub_type: 评论,杂志文章
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journal_title:Molecular microbiology
pub_type: 杂志文章
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更新日期:1994-06-01 00:00:00
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