Abstract:
:Various features of the regulation of pathways for biodegradation of recalcitrant compounds by Pseudomonas provide insights into the mechanisms by which operons evolve to acquire conditionally active promoters that permit the corresponding genes to be transcribed only when required. The "regulatory noise hypothesis' proposes that transcriptional control systems develop responsiveness to new signals due to the leakiness and lack of specificity of preexisting promoters and regulators. When needed, these may become more specific through suppression of undesirable signals and further fine-tuning of the recruited proteins to interact with distinct chemicals. This hypothesis is supported by the sophisticated regulation of sigma 54-dependent promoters of the TOL (toluene biodegradation) operons, which can be activated to various degrees by heterologous proteins. Such "illegitimate' activation is suppressed by bent DNA structures, either static or protein induced, between promoter core elements. Therefore, not only the regulators but also the DNA sequences participate in the process that gives rise to novel specificities.
journal_name
Mol Microbioljournal_title
Molecular microbiologyauthors
de Lorenzo V,Pérez-Martín Jdoi
10.1111/j.1365-2958.1996.tb02463.xsubject
Has Abstractpub_date
1996-03-01 00:00:00pages
1177-84issue
6eissn
0950-382Xissn
1365-2958journal_volume
19pub_type
杂志文章,评审abstract::Proteic toxin-antitoxin (TA) loci were first identified in bacterial plasmids, and they were regarded as involved in stable plasmid maintenance by a so-called 'addiction' mechanism. Later, chromosomally encoded TA loci were identified and their function ascribed to survival mechanisms when bacteria were subjected to s...
journal_title:Molecular microbiology
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更新日期:1999-12-01 00:00:00
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更新日期:2003-07-01 00:00:00
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更新日期:1993-08-01 00:00:00
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更新日期:2004-03-01 00:00:00
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journal_title:Molecular microbiology
pub_type: 杂志文章
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更新日期:1992-12-01 00:00:00
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更新日期:1992-08-01 00:00:00
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更新日期:2003-11-01 00:00:00
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journal_title:Molecular microbiology
pub_type: 杂志文章
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更新日期:1995-11-01 00:00:00
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更新日期:2011-11-01 00:00:00
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journal_title:Molecular microbiology
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journal_title:Molecular microbiology
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更新日期:2002-02-01 00:00:00
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journal_title:Molecular microbiology
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更新日期:1991-06-01 00:00:00
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更新日期:1999-10-01 00:00:00
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更新日期:2004-09-01 00:00:00
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journal_title:Molecular microbiology
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更新日期:1999-01-01 00:00:00
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journal_title:Molecular microbiology
pub_type: 杂志文章
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更新日期:2010-08-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2007-01-01 00:00:00