Heterozygosity of genes on the sex chromosome regulates Candida albicans virulence.

abstract：:The AMA1 sequence is an efficient plasmid replicator and transformation enhancer in Aspergillus nidulans. It comprises two long perfect inverted repeats (MATE elements) flanking a short, unique, central spacer. Subclone analysis indicates that the complete inverted duplication, but not the unique central spacer, is ne...

journal_title：Molecular microbiology

authors： Aleksenko A,Gems D,Clutterbuck J

更新日期：1996-04-01 00:00:00

abstract：:Bacteriophage D3 is capable of lysogenizing Pseudomonas aeruginosa PAO1 (serotype O5), converting the O-antigen from O5 to O16 and O-acetylating the N-acetylfucosamine moiety. To investigate the mechanism of lysogenic conversion, a 3.6 kb fragment from the D3 genome was isolated capable of mediating serotypic conversi...

journal_title：Molecular microbiology

authors： Newton GJ,Daniels C,Burrows LL,Kropinski AM,Clarke AJ,Lam JS

更新日期：2001-03-01 00:00:00

abstract：:Bacterial secretion systems often employ molecular chaperones to recognize and facilitate export of their substrates. Recent work demonstrated that a secreted component of the type VI secretion system (T6SS), haemolysin co-regulated protein (Hcp), binds directly to effectors, enhancing their stability in the bacterial...

journal_title：Molecular microbiology

authors： Whitney JC,Beck CM,Goo YA,Russell AB,Harding BN,De Leon JA,Cunningham DA,Tran BQ,Low DA,Goodlett DR,Hayes CS,Mougous JD

更新日期：2014-05-01 00:00:00

abstract：:TOL plasmid pWW0 of Pseudomonas putida contains two operons that specify a pathway for the degradation of aromatic hydrocarbons. The upper pathway operon encodes the enzymes for the oxidation of toluene/xylenes to benzoate/toluates, and the metacleavage pathway operon encodes the enzymes for the further oxidation of t...

journal_title：Molecular microbiology

authors： Marqués S,Ramos JL

更新日期：1993-09-01 00:00:00

abstract：:The PII protein has been considered pivotal to the dual cascade regulating ammonia assimilation through glutamine synthetase activity. Here we show that PII, encoded by the glnB gene, is not always essential; for instance upon ammonia deprivation of a glnB deletion strain, glutamine synthetase can be deadenylylated as...

journal_title：Molecular microbiology

authors： van Heeswijk WC,Hoving S,Molenaar D,Stegeman B,Kahn D,Westerhoff HV

更新日期：1996-07-01 00:00:00

abstract：:Ammonium movement across biological membranes is facilitated by a class of ubiquitous channel proteins from the Amt/Rh family. Amt proteins have also been implicated in cellular responses to ammonium availability in many organisms. Ammonium sensing by Amt in bacteria is mediated by complex formation with cytosolic pro...

journal_title：Molecular microbiology

authors： Huergo LF,Merrick M,Pedrosa FO,Chubatsu LS,Araujo LM,Souza EM

更新日期：2007-12-01 00:00:00

abstract：:HapR is a quorum sensing-regulated transcription factor that represses the virulence cascade in Vibrio cholerae by binding to a specific site centred at -71 in the aphA promoter, ultimately preventing activation of the tcpPH promoter on the Vibrio pathogenicity island. In an effort to elucidate the mechanism by which ...

journal_title：Molecular microbiology

authors： Lin W,Kovacikova G,Skorupski K

更新日期：2007-05-01 00:00:00

abstract：:In order to identify molecules that might be responsible for the difference in pathogenicity between the two closely related protozoan parasites Entamoeba histolytica and Entamoeba dispar, we focussed on cysteine proteinases because this class of enzymes has been considered important for pathogenic tissue destruction....

journal_title：Molecular microbiology

authors： Bruchhaus I,Jacobs T,Leippe M,Tannich E

更新日期：1996-10-01 00:00:00

abstract：:A number of small, multicopy plasmids from Gram-positive bacteria replicate by an asymmetric rolling-circle mechanism. Previous studies with several of these plasmids have identified a palindromic sequence, SSOA, that acts as the single-strand origin (SSO) for the replication of the lagging-strand DNA. Although not al...

journal_title：Molecular microbiology

authors： Dempsey LA,Zhao AC,Khan SA

更新日期：1995-02-01 00:00:00

abstract：:Transposases mediate transposition first by binding specific DNA end sequences that define a transposable element and then by organizing protein and DNA into a highly structured and stable nucleoprotein 'synaptic' complex. Synaptic complex assembly is a central checkpoint in many transposition mechanisms. The Tn5 syna...

journal_title：Molecular microbiology

authors： Adams CD,Schnurr B,Skoko D,Marko JF,Reznikoff WS

更新日期：2006-12-01 00:00:00

abstract：:Bacteria co-ordinate their social behaviour in a density-dependent manner by production of diffusible signal molecules by a process known as quorum sensing (QS). It is generally assumed that in homogenous environments and at high cell density, QS synchronizes cells in the population to perform collective social tasks ...

journal_title：Molecular microbiology

authors： Pradhan BB,Chatterjee S

更新日期：2014-05-01 00:00:00

abstract：:The chromosome ends of human malaria parasites harbour many genes encoding proteins that are exported to the surface of infected red cells, often being involved in host-parasite interactions and immune evasion. Unlike other murine malaria parasites Plasmodium chabaudi undergoes antigenic variation during passage in th...

journal_title：Molecular microbiology

authors： Fischer K,Chavchich M,Huestis R,Wilson DW,Kemp DJ,Saul A

更新日期：2003-06-01 00:00:00

abstract：:The energy requirement for the second step in pullulanase secretion by the general secretory pathway was studied in Escherichia coli. In order to uncouple the two steps in the secretion pathway (across the cytoplasmic and outer membranes, respectively) and to facilitate kinetic analysis of secretion, a variant form of...

journal_title：Molecular microbiology

authors： Possot OM,Letellier L,Pugsley AP

更新日期：1997-05-01 00:00:00

abstract：:Proteus mirabilis is a common cause of urinary tract infection (UTI) in individuals with structural abnormalities or long-term catheterization. The expression of mannose-resistant/Proteus-like (MR/P) fimbria is phase variable because of the inversion of a 251 bp DNA fragment that carries the promoter for the mrp opero...

journal_title：Molecular microbiology

authors： Li X,Lockatell CV,Johnson DE,Mobley HL

更新日期：2002-08-01 00:00:00

abstract：:The availability of nutrients is a major determinant for the timing of morphogenesis and antibiotic production in the soil-dwelling bacterium Streptomyces coelicolor. Here we show that N-acetylglucosamine transport, the first step of an important nutrient signalling cascade, is mediated by the NagE2 permease of the ph...

journal_title：Molecular microbiology

authors： Nothaft H,Rigali S,Boomsma B,Swiatek M,McDowall KJ,van Wezel GP,Titgemeyer F

更新日期：2010-03-01 00:00:00

abstract：:A series of lipoproteins was detected in the membrane fraction of Yersinia enterocolitica W227, a typical strain from serotype O:9. At least two of them, YlpA and YlpB, are encoded by the pYV plasmid. The sequence of ylpA reveals the presence of a typical lipoprotein signal peptide. The mature YlpA protein would be 22...

journal_title：Molecular microbiology

authors： China B,Michiels T,Cornelis GR

更新日期：1990-09-01 00:00:00

abstract：:9 alpha-Hydroxylation of 4-androstene-3,17-dione (AD) and 1,4-androstadiene-3,17-dione (ADD) is catalysed by 3-ketosteroid 9 alpha-hydroxylase (KSH), a key enzyme in microbial steroid catabolism. Very limited knowledge is presently available on the KSH enzyme. Here, we report for the first time the identification and ...

journal_title：Molecular microbiology

authors： van der Geize R,Hessels GI,van Gerwen R,van der Meijden P,Dijkhuizen L

更新日期：2002-08-01 00:00:00

abstract：:A major obstacle to tuberculosis (TB) control is the problem of chronic TB infection (CTBI). Here we report that 5'-adenosinephosphosulphate reductase (CysH), an enzyme essential for the production of reduced-sulphur-containing metabolites, is critical for Mycobacterium tuberculosis (Mtb) survival in chronic infection...

journal_title：Molecular microbiology

authors： Senaratne RH,De Silva AD,Williams SJ,Mougous JD,Reader JR,Zhang T,Chan S,Sidders B,Lee DH,Chan J,Bertozzi CR,Riley LW

更新日期：2006-03-01 00:00:00

abstract：:A complete understanding of host-parasite interactions must necessarily include the identification and characterization of gene products expressed by both parties during the infectious process. We have developed a new screen to identify bacterial genes that are transcriptionally induced during infection of a host anim...

journal_title：Molecular microbiology

authors： Camilli A,Mekalanos JJ

更新日期：1995-11-01 00:00:00

abstract：:Listeriolysin O (LLO) binds to cholesterol-containing membranes in which it oligomerizes to form pores. Preincubation of the toxin with cholesterol is known to inhibit haemolysis, whereas the oxidized form of cholesterol has no inhibitory effect. Using immunoblot analyses and flow cytometry we demonstrate that preincu...

journal_title：Molecular microbiology

authors： Jacobs T,Darji A,Frahm N,Rohde M,Wehland J,Chakraborty T,Weiss S

更新日期：1998-06-01 00:00:00

abstract：:Atovaquone represents a class of antimicrobial agents with a broad-spectrum activity against various parasitic infections, including malaria, toxoplasmosis and Pneumocystis pneumonia. In malaria parasites, atovaquone inhibits mitochondrial electron transport at the level of the cytochrome bc1 complex and collapses mit...

journal_title：Molecular microbiology

authors： Srivastava IK,Morrisey JM,Darrouzet E,Daldal F,Vaidya AB

更新日期：1999-08-01 00:00:00

abstract：:Pseudomonas aeruginosa, a Gram-negative bacterium, is a significant opportunistic pathogen associated with skin and soft tissue infections, nosocomial pneumonia and sepsis. In addition, it can chronically colonize the lungs of cystic fibrosis (CF) patients. Overproduction of the exopolysaccharide called alginate provi...

journal_title：Molecular microbiology

authors： Damron FH,Goldberg JB

更新日期：2012-05-01 00:00:00

abstract：:The identification, isolation and characterization of a new Aspergillus nidulans positive-acting gene metR, which encodes a transcriptional activator of sulphur metabolism, is reported. metR mutants are tight auxotrophs requiring methionine or homocysteine for growth. Mutations in the metR gene are epistatic to mutati...

journal_title：Molecular microbiology

authors： Natorff R,Sieńko M,Brzywczy J,Paszewski A

更新日期：2003-08-01 00:00:00

abstract：:An operon including two new genes (nasS and nasT) has been defined, cloned and sequenced. The deduced NASS protein is homologous to NRTA from Synechococcus sp. and to NASF from Klebsiella pneumoniae, two proteins involved in nitrate uptake. The predicted NAST polypeptide is homologous to the regulator proteins of the ...

journal_title：Molecular microbiology

authors： Gutierrez JC,Ramos F,Ortner L,Tortolero M

更新日期：1995-11-01 00:00:00

abstract：:The Escherichia coli toxin exporter HlyB comprises an integral membrane domain fused to a cytoplasmic domain of the ATP-binding cassette (ABC) super-family, and it directs translocation of the 110kDa haemolysin protein out of the bacterial cell without using an N-terminal secretion signal peptide. We have exploited th...

journal_title：Molecular microbiology

authors： Koronakis E,Hughes C,Milisav I,Koronakis V

更新日期：1995-04-01 00:00:00

abstract：:Encased within the 280 kb genome in the capsid of the giant myovirus φKZ is an unusual cylindrical proteinaceous 'inner body' of highly ordered structure. We present here mass spectrometry, bioinformatic and biochemical studies that reveal novel information about the φKZ head and the complex inner body. The identifica...

journal_title：Molecular microbiology

authors： Thomas JA,Weintraub ST,Wu W,Winkler DC,Cheng N,Steven AC,Black LW

更新日期：2012-04-01 00:00:00

abstract：:In mid-June, the second Young Microbiologists Symposium took place under the broad title of 'Microbe signalling, organization and pathogenesis' on the picturesque campus of University College Cork, Ireland. The symposium attracted 150 microbiologists from 15 different countries. The key feature of this meeting was tha...

journal_title：Molecular microbiology

authors： Caly DL,Coulthurst SJ,Geoghegan JA,Malone JG,Ryan RP

更新日期：2012-11-01 00:00:00

abstract：:Enhancement of enzyme thermostability by protein engineering gives us information about the thermostabilization mechanism as well as advantages for industrial use of enzymes. In this study, we enhanced the thermostability of endoglucanase EngB, one component of the cellulase complex (cellulosome) from Clostridium cell...

journal_title：Molecular microbiology

authors： Murashima K,Kosugi A,Doi RH

更新日期：2002-08-01 00:00:00

abstract：:Fungal cellulolytic and hemicellulolytic enzymes are promising tools for industrial hydrolysis of cellulosic biomass; however, the regulatory network underlying their production is not well understood. The recent discovery of the transcriptional activators ClrB and McmA in Aspergillus nidulans implied a novel regulato...

journal_title：Molecular microbiology

authors： Li N,Kunitake E,Aoyama M,Ogawa M,Kanamaru K,Kimura M,Koyama Y,Kobayashi T

更新日期：2016-12-01 00:00:00

abstract：:The archaeal transcription apparatus is chimeric: its core components (RNA polymerase and basal factors) closely resemble those of eukaryotic RNA polymerase II, but the putative archaeal transcriptional regulators are overwhelmingly of bacterial type. Particular interest attaches to how these bacterial-type effectors,...

journal_title：Molecular microbiology

authors： Ouhammouch M,Langham GE,Hausner W,Simpson AJ,El-Sayed NM,Geiduschek EP

更新日期：2005-05-01 00:00:00