Reversible non-genetic phenotypic heterogeneity in bacterial quorum sensing.

abstract：:Escherichia coli has two heat shock regulons under the transcriptional control of Esigma32 and EsigmaE RNA polymerases. These polymerases control the expression of genes, the products of which are needed for correct folding of proteins in the cytoplasm and the extracytoplasm respectively. In this study, we report that...

journal_title：Molecular microbiology

authors： Klein G,Dartigalongue C,Raina S

更新日期：2003-04-01 00:00:00

abstract：:Stable RNA maturation is a key process in the generation of functional RNAs, and failure to correctly process these RNAs can lead to their elimination through quality control mechanisms. Studies of the maturation pathways of ribosomal RNA and transfer RNA in Bacillus subtilis showed they were radically different from ...

journal_title：Molecular microbiology

authors： Gilet L,DiChiara JM,Figaro S,Bechhofer DH,Condon C

更新日期：2015-01-01 00:00:00

abstract：:A novel growth phase-associated two-component-type regulator, Fas (fibronectin/fibrinogen binding/haemolytic activity/streptokinase regulator), of Streptococcus pyogenes was identified in the M1 genome sequence, based on homologies to the histidine protein kinase (HPK) and response regulator (RR) part of the Staphyloc...

journal_title：Molecular microbiology

authors： Kreikemeyer B,Boyle MD,Buttaro BA,Heinemann M,Podbielski A

更新日期：2001-01-01 00:00:00

abstract：:We report here the cloning of the arginine repressor gene argR of Bacillus stearothermophilus and the characterization and purification to homogeneity of its product. The deduced amino acid sequence of the 16.8-kDa ArgR subunit shares 72% identity with its mesophilic homologue AhrC of Bacilus subtilis. Sequence analys...

journal_title：Molecular microbiology

authors： Dion M,Charlier D,Wang H,Gigot D,Savchenko A,Hallet JN,Glansdorff N,Sakanyan V

更新日期：1997-07-01 00:00:00

abstract：:Bacterial cytochrome cbb3 oxidases are members of the haeme-copper oxidase superfamily that are important for energy conservation by a variety of proteobacteria under oxygen-limiting conditions. The opportunistic pathogen Pseudomonas aeruginosa is unusual in possessing two operons that each potentially encode a cbb3 o...

journal_title：Molecular microbiology

authors： Comolli JC,Donohue TJ

更新日期：2004-02-01 00:00:00

abstract：:Bactericidal/permeability-increasing protein (BPI) of neutrophils is a lipopolysaccharide (LPS)-binding antibacterial protein with specificity for Gram negative bacteria. BPI binding to the bacterial surface rapidly triggers potentially reversible bacterial growth inhibition and alterations of the outer membrane and, ...

journal_title：Molecular microbiology

authors： Prohinar P,Forst SA,Reed D,Mandic-Mulec I,Weiss J

更新日期：2002-03-01 00:00:00

abstract：:Caulobacter crescentus chromosome replication is precisely coupled to a developmental cell cycle. Like most eubacteria, C. crescentus has a DnaA homologue that is presumed to initiate chromosome replication. However, the C. crescentus replication origin (Cori) lacks perfect consensus Escherichia coli DnaA boxes. Inste...

journal_title：Molecular microbiology

authors： Gorbatyuk B,Marczynski GT

更新日期：2001-04-01 00:00:00

abstract：:The Crp/Fnr family of transcriptional regulators play central roles in transcriptional control of diverse physiological responses, and are activated by a surprising diversity of mechanisms. MrpC is a Crp/Fnr homolog that controls the Myxococcus xanthus developmental program. A long-standing model proposed that MrpC ac...

journal_title：Molecular microbiology

authors： Feeley BE,Bhardwaj V,McLaughlin PT,Diggs S,Blaha GM,Higgs PI

更新日期：2019-11-01 00:00:00

abstract：:While bacteria such as Escherichia coli and Bacillus subtilis harbour a single circular chromosome, some freshwater cyanobacteria have multiple chromosomes p er cell. The detailed mechanism(s) of cyanobacterialreplication remains unclear. To elucidate the replication origin (ori ), form and synchrony of the multi-copy...

journal_title：Molecular microbiology

authors： Watanabe S,Ohbayashi R,Shiwa Y,Noda A,Kanesaki Y,Chibazakura T,Yoshikawa H

更新日期：2012-02-01 00:00:00

abstract：:The cell wall mycolyl-arabinogalactan-peptidoglycan complex is essential in mycobacterial species, such as Mycobacterium tuberculosis and is the target of several antitubercular drugs. For instance, ethambutol targets arabinogalactan biosynthesis through inhibition of the arabinofuranosyltransferases Mt-EmbA and Mt-Em...

journal_title：Molecular microbiology

authors： Birch HL,Alderwick LJ,Bhatt A,Rittmann D,Krumbach K,Singh A,Bai Y,Lowary TL,Eggeling L,Besra GS

更新日期：2008-09-01 00:00:00

abstract：:The type III secretion system (TTSS) is a modular apparatus assembled by many pathogenic Gram-negative bacteria and is designed to translocate proteins through the bacterial cell wall into the eukaryotic host cell. The conserved components of the TTSS comprise stacks of rings spanning the inner and outer bacterial mem...

journal_title：Molecular microbiology

authors： Daniell SJ,Kocsis E,Morris E,Knutton S,Booy FP,Frankel G

更新日期：2003-07-01 00:00:00

abstract：:In F. graminearum, the transcription factor TRI6 positively regulates the trichothecene biosynthetic gene cluster (BGC) leading to the production of the secondary metabolite 15-acetyl deoxynivalenol. Secondary metabolites are not essential for survival, instead, they enable the pathogen to successfully infect its host...

journal_title：Molecular microbiology

authors： Shostak K,Bonner C,Sproule A,Thapa I,Shields SWJ,Blackwell B,Vierula J,Overy D,Subramaniam R

更新日期：2020-10-01 00:00:00

abstract：:Prokaryotes protect their genomes from foreign DNA with a diversity of defence mechanisms, including a widespread restriction-modification (R-M) system involving phosphorothioate (PT) modification of the DNA backbone. Unlike classical R-M systems, highly partial PT modification of consensus motifs in bacterial genomes...

journal_title：Molecular microbiology

authors： Cao B,Cheng Q,Gu C,Yao F,DeMott MS,Zheng X,Deng Z,Dedon PC,You D

更新日期：2014-08-01 00:00:00

abstract：:We have used a targeted gene deletion event to remove the coding region for the bgl1 gene encoding an extracellular beta-glucosidase from the genome of the cellulolytic fungus Trichoderma reesei. The bgl1 null mutants were used to investigate the role of beta-glucosidase in the hydrolysis of cellulose and induction of...

journal_title：Molecular microbiology

authors： Fowler T,Brown RD Jr

更新日期：1992-11-01 00:00:00

abstract：:Chromosomes are divided into topologically independent regions, called domains, by the action of uncharacterized barriers. With the goal of identifying domain barrier components, we designed a genetic selection for mutants with reduced negative supercoiling of the Escherichia coli chromosome. We employed a strain that...

journal_title：Molecular microbiology

authors： Hardy CD,Cozzarelli NR

更新日期：2005-09-01 00:00:00

abstract：:Cells require a sensory system and a motility structure to achieve directed movement. Bacteria and archaea possess rotating filamentous motility structures that work in concert with the sensory chemotaxis system. This allows microorganisms to move along chemical gradients. The central response regulator protein CheY c...

journal_title：Molecular microbiology

authors： Li Z,Rodriguez-Franco M,Albers SV,Quax TEF

更新日期：2020-09-01 00:00:00

abstract：:clpC of Bacillus subtilis is part of an operon containing six genes. Northern blot analysis suggested that all genes are co-transcribed and encode stress-inducible proteins. Two promoters (PA and PB) were mapped upstream of the first gene. PA resembles promoters recognized by the vegetative RNA polymerase E sigma A. T...

journal_title：Molecular microbiology

authors： Krüger E,Msadek T,Hecker M

更新日期：1996-05-01 00:00:00

abstract：:A respiratory quinol oxidase complex that is encoded by the soxABCD operon has been purified from the thermoacidophilic archaeon Sulfolobus acidocaldarius. The enzyme was solubilized with dodecyl maltoside and purified in the presence of this detergent and ethylene glycol. The complex is hydrodynamically homogeneous a...

journal_title：Molecular microbiology

authors： Lübben M,Warne A,Albracht SP,Saraste M

更新日期：1994-07-01 00:00:00

abstract：:In matings between Lactococcus lactis strains, the conjugative transposons Tn916 and Tn919 are found in the chromosome of the transconjugants in the same place as in the chromosome of the donor, indicating that no transposition has occurred. In agreement with this, the frequency of L. lactis transconjugants from intra...

journal_title：Molecular microbiology

authors： Bringel F,Van Alstine GL,Scott JR

更新日期：1991-12-01 00:00:00

abstract：:A gene conferring low-level isoniazid (INH) resistance on Mycobacterium smegmatis was isolated from a cosmid library of the genome of an INH-resistant Mycobacterium bovis strain. The gene had good homology with ahpC, the product of which is a subunit of alkyl hydroperoxide reductase, and also with a family of thiol-sp...

journal_title：Molecular microbiology

authors： Wilson TM,Collins DM

更新日期：1996-03-01 00:00:00

abstract：:The 9.5 kb virB operon is the largest of the six major operons in the Ti plasmid vir region. This operon contains eleven genes, the largest of which is virB4. This gene encodes an 84 kDa protein whose function has not been identified. Its roles in conferring virulence on Agrobacterium tumefaciens and in the T-DNA tran...

journal_title：Molecular microbiology

authors： Shirasu K,Koukolíková-Nicola Z,Hohn B,Kado CI

更新日期：1994-02-01 00:00:00

abstract：:Cytochrome c biogenesis describes the posttranslational pathway for the conversion of pre-apocytochrome c into the mature holocytochrome c. It involves an unknown number of consecutive biochemical steps, including translocation of the precursor polypeptide and haem into the periplasm and the covalent linkage between t...

journal_title：Molecular microbiology

authors： Thöny-Meyer L,Ritz D,Hennecke H

更新日期：1994-04-01 00:00:00

abstract：:DNA processing reactions often involve multiple components acting in concert to achieve the desired outcome. However, it is usually difficult to know how the components communicate and cooperate to orchestrate an ordered series of events. We address this question in the context of the Tn 10 transposition reaction, in ...

journal_title：Molecular microbiology

authors： Liu D,Sewitz S,Crellin P,Chalmers R

更新日期：2006-12-01 00:00:00

abstract：:The rfb (O antigen) gene cluster of group C2 Salmonella differs from that of group B in a central region of 12.4 kb: we report the sequencing of this region of strain M67 (group C2) and a subsequent comparison with the central region of strain LT2 (group B). We find a block of seven open reading frames unique to group...

journal_title：Molecular microbiology

authors： Brown PK,Romana LK,Reeves PR

更新日期：1992-05-01 00:00:00

abstract：:Type VI secretion is critical for Vibrio cholerae to successfully combat phagocytic eukaryotes and to survive in the presence of competing bacterial species. V. cholerae type VI secretion system genes are encoded in one large and two small clusters. In V. cholerae, type VI secretion is controlled by quorum sensing, th...

journal_title：Molecular microbiology

authors： Shao Y,Bassler BL

更新日期：2014-06-01 00:00:00

abstract：:In response to genotoxic stress (GS), Candida albicans can undergo polarized growth and massive genome rearrangements including loss-of-heterozygosity (LOH) events. We evaluated the contribution of the CaRad53p and CaDun1p kinases of the DNA damage checkpoint (DDCP) in these processes. Characterization of C. albicans ...

journal_title：Molecular microbiology

authors： Loll-Krippleber R,d'Enfert C,Feri A,Diogo D,Perin A,Marcet-Houben M,Bougnoux ME,Legrand M

更新日期：2014-02-01 00:00:00

abstract：:We have determined the sizes of the chromosomes of six Bacillus cereus strains (range 2.4-4.3 Mb) and constructed a physical map of the smallest B. cereus chromosome (2.4 Mb). This map was compared to those of the chromosomes of four B. cereus strains and one B. thuringiensis strain previously determined to be 5.4-6.3...

journal_title：Molecular microbiology

authors： Carlson CR,Kolstø AB

更新日期：1994-07-01 00:00:00

abstract：:The Escherichia coli DNA glycosylase Mug excises 3,N(4)-ethenocytosines (epsilon C) and uracils from DNA, but its biological function is obscure. This is because epsilon C is not found in E. coli DNA, and uracil-DNA glycosylase (Ung), a distinct enzyme, is much more efficient at removing uracils from DNA than Mug. We ...

journal_title：Molecular microbiology

authors： Mokkapati SK,Fernández de Henestrosa AR,Bhagwat AS

更新日期：2001-09-01 00:00:00

abstract：:The Escherichia coli dam gene and upstream sequences were cloned from the Kohara phage 4D4. Five promoters were found to contribute to dam gene transcription. P1 and P2 (the major promoter) were situated approximately 3.5 kb upstream of the structural gene, P3 was within the aroB gene, P4 was within the urf74.3 gene, ...

journal_title：Molecular microbiology

authors： Løbner-Olesen A,Boye E,Marinus MG

更新日期：1992-07-01 00:00:00

abstract：:The esg locus is required for the formation of multicellular fruiting bodies and spores by the developmental bacterium Myxococcus xanthus. Studies have suggested that esg mutants are defective in the production of an essential signal (E-signal) used in cell-cell communication and that E-signalling is required for the ...

journal_title：Molecular microbiology

authors： Downard J,Toal D

更新日期：1995-04-01 00:00:00