Quorum regulatory small RNAs repress type VI secretion in Vibrio cholerae.

abstract：:Poly(A) polymerase I (PAP I) of Escherichia coli is a member of the nucleotidyltransferase (Ntr) superfamily that includes the eukaryotic PAPs and all the known tRNA CCA-adding enzymes. Five highly conserved aspartic acids in the putative catalytic site of PAP I were changed to either alanine or proline, demonstrating...

journal_title：Molecular microbiology

authors： Raynal LC,Carpousis AJ

更新日期：1999-05-01 00:00:00

abstract：:Trans-acting small regulatory RNAs (sRNAs) are key players in the regulation of gene expression in bacteria. There are hundreds of different sRNAs in a typical bacterium, which in contrast to eukaryotic microRNAs are more heterogeneous in length, sequence composition, and secondary structure. The vast majority of sRNA...

journal_title：Molecular microbiology

authors： Georg J,Lalaouna D,Hou S,Lott SC,Caldelari I,Marzi S,Hess WR,Romby P

更新日期：2020-03-01 00:00:00

abstract：:Mycoplasma hyopneumoniae induces respiratory disease in swine by colonizing cilia causing ciliostasis, cilial loss and epithelial cell death. Heparin binds to M. hyopneumoniae cells in a dose-dependent manner and blocks its ability to adhere to porcine cilia. We show here that Mhp493 (P216), a paralogue of the cilium ...

journal_title：Molecular microbiology

authors： Wilton J,Jenkins C,Cordwell SJ,Falconer L,Minion FC,Oneal DC,Djordjevic MA,Connolly A,Barchia I,Walker MJ,Djordjevic SP

更新日期：2009-02-01 00:00:00

abstract：:Escherichia coli FtsN is a bitopic membrane protein that is essential for triggering active cell constriction. A small periplasmic subdomain ((E) FtsN) is required and sufficient for function, but its mechanism of action is unclear. We isolated extragenic (E) FtsN*-suppressing mutations that restore division in cells ...

journal_title：Molecular microbiology

authors： Liu B,Persons L,Lee L,de Boer PA

更新日期：2015-03-01 00:00:00

abstract：:Recently, we identified a novel disulfide oxidoreductase, SdbA, in the oral bacterium Streptococcus gordonii. Disulfide oxidoreductases form disulfide bonds in nascent proteins using a CXXC catalytic motif. Typically, the N-terminal cysteine interacts with substrates, whereas the C-terminal cysteine is buried and only...

journal_title：Molecular microbiology

authors： Davey L,Cohen A,LeBlanc J,Halperin SA,Lee SF

更新日期：2016-01-01 00:00:00

abstract：:The earliest event in bacterial cell division is the formation of a Z ring, composed of the tubulin-like FtsZ protein, at the division site at midcell. This ring then recruits several other division proteins and together they drive the formation of a division septum between two replicated chromosomes. Here we show tha...

journal_title：Molecular microbiology

authors： Peters PC,Migocki MD,Thoni C,Harry EJ

更新日期：2007-04-01 00:00:00

abstract：:Francisella tularensis are the causative agent of the zoonotic disease, tularaemia. Among four F. tularensis subspecies, ssp. novicida (F. novicida) is pathogenic only for immunocompromised individuals, while all four subspecies are pathogenic for mice. This study utilized proteomic and bioinformatic approaches to ide...

journal_title：Molecular microbiology

authors： Hager AJ,Bolton DL,Pelletier MR,Brittnacher MJ,Gallagher LA,Kaul R,Skerrett SJ,Miller SI,Guina T

更新日期：2006-10-01 00:00:00

abstract：:5'-nucleotidases (5'-NTs) are enzymes that catalyze the hydrolysis of nucleoside monophosphates to produce nucleosides and phosphate. Since the identification of adenosine synthase A (AdsA) in Staphylococcus aureus in 2009, several other 5'-NTs have been discovered in Gram-positive cocci, mainly in streptococci. Despi...

journal_title：Molecular microbiology

authors： Soh KY,Loh JMS,Proft T

更新日期：2020-04-01 00:00:00

abstract：:Schizosaccharomyces pombe Rho1p regulates (1,3)beta-d-glucan synthesis and is required for cell integrity maintenance and actin cytoskeleton organization, but nothing is known about the regulation of this protein. At least nine different S. pombe genes code for proteins predicted to act as Rho GTPase-activating protei...

journal_title：Molecular microbiology

authors： Calonge TM,Arellano M,Coll PM,Perez P

更新日期：2003-01-01 00:00:00

abstract：:Interpretation of the constantly expanding body of genomic information requires that the function of each gene be established. Here we report the genomic analysis and structural modelling of a previously uncharacterized redox-metabolism protein UrdA (SO_4620) of Shewanella oneidensis MR-1, which led to a discovery of ...

journal_title：Molecular microbiology

authors： Bogachev AV,Bertsova YV,Bloch DA,Verkhovsky MI

更新日期：2012-12-01 00:00:00

abstract：:When fungi grow on plant or insect surfaces coated with wax polyesters that protect against pathogens, the fungi generally form aerial hyphae to contact the surfaces. Aerial structures such as hyphae and conidiophores are coated with hydrophobins, which are surface-active proteins involved in adhesion to hydrophobic s...

journal_title：Molecular microbiology

authors： Takahashi T,Maeda H,Yoneda S,Ohtaki S,Yamagata Y,Hasegawa F,Gomi K,Nakajima T,Abe K

更新日期：2005-09-01 00:00:00

abstract：:The DNA of wild-type Streptomyces lividans 66 is degraded during electrophoresis in buffers containing traces of ferrous iron. S. lividans ZX1, a mutant selected for resistance to DNA degradation, simultaneously became sensitive to phi HAU3, a wide-host-range temperate bacteriophage. A DNA fragment conferring phi HAU3...

journal_title：Molecular microbiology

authors： Zhou X,Deng Z,Hopwood DA,Kieser T

更新日期：1994-06-01 00:00:00

abstract：:Red cell invasion by Plasmodium merozoites involves multiple steps such as attachment, apical reorientation, junction formation and entry into a parasitophorous vacuole. These steps are mediated by specific molecular interactions. P. vivax and the simian parasite P. knowlesi require interaction with the Duffy blood gr...

journal_title：Molecular microbiology

authors： Singh AP,Ozwara H,Kocken CH,Puri SK,Thomas AW,Chitnis CE

更新日期：2005-03-01 00:00:00

abstract：:Although once thought to be unique to bacteria, d-amino acids are also produced by mammals. For example, d-serine is excreted in human urine at concentrations ranging from 3.0 to 40 micro g ml-1. An epidemiological survey demonstrated that urine isolates of E. coli are more likely to catabolise d-serine via expression...

journal_title：Molecular microbiology

authors： Roesch PL,Redford P,Batchelet S,Moritz RL,Pellett S,Haugen BJ,Blattner FR,Welch RA

更新日期：2003-07-01 00:00:00

abstract：:Superoxide dismutase, catalase, glutathione peroxidase and peroxiredoxins form an antioxidant network protecting cells against reactive oxygen species (ROS). Catalase is a potent H2O2-detoxifying enzyme, which is unexpectedly absent in some members of the Kinetoplastida and Apicomplexa, but present in Toxoplasma gondi...

journal_title：Molecular microbiology

authors： Ding M,Kwok LY,Schlüter D,Clayton C,Soldati D

更新日期：2004-01-01 00:00:00

abstract：:The PhaF is a nucleoid-associated like protein of Pseudomonas putida KT2442 involved in the polyhydroxyalkanoate (PHA) metabolism. Its primary structure shows two modular domains; the N-terminal PHA granule-binding domain (phasin domain) and the C-terminal half containing AAKP-like tandem repeats characteristic of the...

journal_title：Molecular microbiology

authors： Galán B,Dinjaski N,Maestro B,de Eugenio LI,Escapa IF,Sanz JM,García JL,Prieto MA

更新日期：2011-01-01 00:00:00

abstract：:Several bacterial genera express proteins that contain collagen-like regions, which are associated with variable (V) non-collagenous regions. The streptococcal collagen-like proteins, Scl1 and Scl2, of group A Streptococcus (GAS) are members of this 'prokaryotic collagen' family, and they too contain an amino-terminal...

journal_title：Molecular microbiology

authors： Han R,Caswell CC,Lukomska E,Keene DR,Pawlowski M,Bujnicki JM,Kim JK,Lukomski S

更新日期：2006-07-01 00:00:00

abstract：:HM-1:IMSS, a pathogenic strain of Entamoeba histolytica, and its mutant BG-3, identified by resistance to cytochalasin D, were tested for their capacity to: (i) secrete electron-dense granules; (ii) adhere and digest native type I collagen gels; and (iii) produce liver abscesses in new-born hamsters. The results demon...

journal_title：Molecular microbiology

authors： Serrano JJ,de la Garza M,Moreno MA,Tovar R,León G,Tsutsumi V,Muñoz ML

更新日期：1994-02-01 00:00:00

abstract：:The UhpA protein is required for expression of the sugar phosphate transporter UhpT in Escherichia coli and is regulated by phosphate transfer from the transmembrane UhpBC sensor kinase complex. UhpA action requires the sensor kinase complex and the site of phosphorylation, Asp-54, under normal conditions, but not whe...

journal_title：Molecular microbiology

authors： Webber CA,Kadner RJ

更新日期：1997-06-01 00:00:00

abstract：:Pneumococcus has been shown to bind to epithelial cells of the nasopharynx and lung, and to endothelial cells of the peripheral vasculature. To characterize bacterial elements required for attachment to these cell types, a library of genetically altered pneumococci with defects in exported proteins was screened for th...

journal_title：Molecular microbiology

authors： Spellerberg B,Cundell DR,Sandros J,Pearce BJ,Idanpaan-Heikkila I,Rosenow C,Masure HR

更新日期：1996-02-01 00:00:00

abstract：:The enteric gamma-proteobacterium Photorhabdus luminescens kills a wide range of insects, whilst also maintaining a mutualistic relationship with soil nematodes from the family Heterorhabditis. Pathogenicity is associated with bacterial exponential growth, whilst mutualism is associated with post-exponential (stationa...

journal_title：Molecular microbiology

authors： Bager R,Roghanian M,Gerdes K,Clarke DJ

更新日期：2016-05-01 00:00:00

abstract：:We have isolated RNA polymerase from Mycobacterium smegmatis and established conditions for specific transcription initiation in vitro. The M. smegmatis enzyme has a strong dependence on supercoiling of the DNA substrate for transcription from mycobacterial promoters. We also show that RNA polymerase is the target for...

journal_title：Molecular microbiology

authors： Levin ME,Hatfull GF

更新日期：1993-04-01 00:00:00

abstract：:In their natural habitats, microorganisms are often exposed to osmolality changes in the environment. The osmotic stress must be sensed and converted into an activity change of specific enzymes and transport proteins and/or it must trigger their synthesis such that the osmotic imbalance can be rapidly restored. On the...

journal_title：Molecular microbiology

authors： Poolman B,Glaasker E

更新日期：1998-07-01 00:00:00

abstract：:The crystal structures of two active forms of dissimilatory sulphite reductase (Dsr) from Desulfovibrio gigas, Dsr-I and Dsr-II, are compared at 1.76 and 2.05 Å resolution respectively. The dimeric α2β2γ2 structure of Dsr-I contains eight [4Fe-4S] clusters, two saddle-shaped sirohaems and two flat sirohydrochlorins. I...

journal_title：Molecular microbiology

authors： Hsieh YC,Liu MY,Wang VC,Chiang YL,Liu EH,Wu WG,Chan SI,Chen CJ

更新日期：2010-12-01 00:00:00

abstract：:FlhD and FlhC are the transcriptional activators of the flagellar regulon. The heterotetrameric complex formed by these two proteins activates the transcription of the class II flagellar genes. The flagellar regulon consists not only of flagellar genes, but also of the chemotactic genes and some receptor proteins. Rec...

journal_title：Molecular microbiology

authors： Campos A,Matsumura P

更新日期：2001-02-01 00:00:00

abstract：:Beta-oxidation (beta-ox) occurs exclusively in the peroxisomes of Saccharomyces cerevisiae and other yeasts, leading to the supposition that fungi lack mitochondrial beta-ox. Here we present unequivocal evidence that the filamentous fungus Aspergillus nidulans houses both peroxisomal and mitochondrial beta-ox. While g...

journal_title：Molecular microbiology

authors： Maggio-Hall LA,Keller NP

更新日期：2004-12-01 00:00:00

abstract：:Release factors RF1 and RF2 are required in bacteria for the cleavage of peptidyl-tRNA. A single sequence motif, GGQ, is conserved in all eubacterial, archaebacterial and eukaryotic release factors and may mimic the CCA end of tRNA, although the position of the motif in the crystal structures of human eRF1 and Escheri...

journal_title：Molecular microbiology

authors： Mora L,Heurgué-Hamard V,Champ S,Ehrenberg M,Kisselev LL,Buckingham RH

更新日期：2003-01-01 00:00:00

abstract：:The importance of methylthioadenosine/S-adenosylhomocysteine (MTA/SAH) nucleosidase in bacteria has started to be appreciated only in the past decade. A comprehensive analysis of its various roles here demonstrates that it is an integral component of the activated methyl cycle, which recycles adenine and methionine th...

journal_title：Molecular microbiology

authors： Parveen N,Cornell KA

更新日期：2011-01-01 00:00:00

abstract：:Site-specific recombination by the Cre recombinase takes place at a simple DNA site (loxP), requires no additional proteins and gives topologically simple recombination products. In contrast, cer and psi sites for Xer recombination contain approximately 150 bp of accessory sequences, require accessory proteins PepA, A...

journal_title：Molecular microbiology

authors： Gourlay SC,Colloms SD

更新日期：2004-04-01 00:00:00

abstract：:A 2.7 kb fragment of Helicobacter pylori UA802 chromosomal DNA was cloned and sequenced. Three open reading frames (designated ORF1, ORF2 and ORF3, respectively) were predicted from the DNA sequence, of which ORF1 and ORF2 appeared to be located within the same operon. The deduced 611-amino-acid sequence of ORF1, a P-...

journal_title：Molecular microbiology

authors： Ge Z,Hiratsuka K,Taylor DE

更新日期：1995-01-01 00:00:00