Characterization of the pathway for transport of the cytoadherence-mediating protein, PfEMP1, to the host cell surface in malaria parasite-infected erythrocytes.

abstract：:Type IV pili (T4P) are surface structures that undergo extension/retraction oscillations to generate cell motility. In Myxococcus xanthus, T4P are unipolarly localized and undergo pole-to-pole oscillations synchronously with cellular reversals. We investigated the mechanisms underlying these oscillations. We show that...

journal_title：Molecular microbiology

authors： Bulyha I,Schmidt C,Lenz P,Jakovljevic V,Höne A,Maier B,Hoppert M,Søgaard-Andersen L

更新日期：2009-11-01 00:00:00

abstract：:Numerous eukaryotes have developed specific metabolic traits that are not present in extensively studied model organisms. For instance, the procyclic insect form of Trypanosoma brucei, a parasite responsible for sleeping sickness in its mammalian-specific bloodstream form, metabolizes glucose into excreted succinate a...

journal_title：Molecular microbiology

authors： Bringaud F,Biran M,Millerioux Y,Wargnies M,Allmann S,Mazet M

更新日期：2015-06-01 00:00:00

abstract：:Escherichia coli and Salmonella can use chitin-derived oligosaccharides as carbon and nitrogen sources. Chitosugars traverse the outer membrane through a dedicated chitoporin, ChiP, and are transported across the cytoplasmic membrane by the chitobiose transporter (ChbBCA). Previous work revealed that synthesis of the ...

journal_title：Molecular microbiology

authors： Plumbridge J,Bossi L,Oberto J,Wade JT,Figueroa-Bossi N

更新日期：2014-05-01 00:00:00

abstract：:Borrelia hermsii, an agent of relapsing fever, avoids the host's immune response by means of multiphasic antigenic variation. Serotype specificity is determined by variable antigens called the Vmp lipoproteins. Through recombination between linear plasmids a formerly silent vmp gene replaces another vmp gene at a telo...

journal_title：Molecular microbiology

authors： Barbour AG,Burman N,Carter CJ,Kitten T,Bergström S

更新日期：1991-02-01 00:00:00

abstract：:In general, wild Escherichia coli strains can grow effectively under moderately acidic organic acid-rich conditions. We found that the Shiga Toxin-producing E. coli (STEC) O157:H7 NGY9 grows more quickly than a K-12 strain in Luria-Bertani (LB)-2-morpholinoethanesulphonic acid (MES) broth supplemented with acetic acid...

journal_title：Molecular microbiology

authors： Barua S,Yamashino T,Hasegawa T,Yokoyama K,Torii K,Ohta M

更新日期：2002-02-01 00:00:00

abstract：:The plant pathogen Pseudomonas syringae pv. phaseolicola, which causes halo blight disease of beans, contains a 106 kb genomic island PPHGI-1. PPHGI-1 carries a gene, avrPphB, which encodes an effector protein that triggers a resistance response in certain bean cultivars. Previous studies have shown that when PPHGI-1 ...

journal_title：Molecular microbiology

authors： Neale HC,Jackson RW,Preston GM,Arnold DL

更新日期：2018-11-01 00:00:00

abstract：:The chromosome ends of human malaria parasites harbour many genes encoding proteins that are exported to the surface of infected red cells, often being involved in host-parasite interactions and immune evasion. Unlike other murine malaria parasites Plasmodium chabaudi undergoes antigenic variation during passage in th...

journal_title：Molecular microbiology

authors： Fischer K,Chavchich M,Huestis R,Wilson DW,Kemp DJ,Saul A

更新日期：2003-06-01 00:00:00

abstract：:Bacteria use quorum-sensing signals or autoinducers to communicate. The signals in Gram-positive bacteria are often peptides activated by proteolytic removal of an N-terminal leader sequence. While investigating stimulation of antimicrobial peptide production by the Streptococcus mutans synthetic competence stimulatin...

journal_title：Molecular microbiology

authors： Petersen FC,Fimland G,Scheie AA

更新日期：2006-09-01 00:00:00

abstract：:Plasmodium falciparum erythrocyte membrane protein-1 (PfEMP-1) is exposed on the surface of infected erythrocytes where it both acts as an important pathogenicity factor in malaria and undergoes antigenic variation as a means of immune evasion. Because the mammalian erythrocyte lacks a protein secretory machinery ther...

journal_title：Molecular microbiology

authors： Papakrivos J,Newbold CI,Lingelbach K

更新日期：2005-02-01 00:00:00

abstract：:Choline-binding proteins (CBPs) from Streptococcus pneumoniae are involved in several important processes. Inactivation of zmpB, a gene that encodes a surface-located putative zinc metalloprotease, in a S. pneumoniae serotype 4 strain was recently reported to reveal a composite phenotype, including extensive chain for...

journal_title：Molecular microbiology

authors： Bergé M,García P,Iannelli F,Prère MF,Granadel C,Polissi A,Claverys JP

更新日期：2001-03-01 00:00:00

abstract：:Translating ribosomes require elongation factor P (EF-P) to incorporate consecutive prolines (XPPX) into nascent peptide chains. The proteome of Corynebacterium glutamicum ATCC 13032 contains a total of 1,468 XPPX motifs, many of which are found in proteins involved in primary and secondary metabolism. We show here th...

journal_title：Molecular microbiology

authors： Pinheiro B,Petrov DP,Guo L,Martins GB,Bramkamp M,Jung K

更新日期：2020-10-04 00:00:00

abstract：:Cholesterol catabolism is widespread in actinobacteria and is critical for Mycobacterium tuberculosis (Mtb) virulence. Catabolism of steroid nucleus rings C and D is poorly understood: it is initiated by the CoA thioesterification of 3aα-H-4α(3'-propanoate)-7aβ-methylhexahydro-1,5-indanedione (HIP) by FadD3, whose gen...

journal_title：Molecular microbiology

authors： Casabon I,Zhu SH,Otani H,Liu J,Mohn WW,Eltis LD

更新日期：2013-09-01 00:00:00

abstract：:Metabolic adaptations are critical to the ability of bacterial pathogens to grow within host cells and are normally preceded by sensing of host-specific metabolic signals, which in turn can influence the pathogen's virulence state. Previously, we reported that the intracellular bacterial pathogen Listeria monocytogene...

journal_title：Molecular microbiology

authors： Lobel L,Sigal N,Borovok I,Belitsky BR,Sonenshein AL,Herskovits AA

更新日期：2015-02-01 00:00:00

abstract：:The Leishmania major aquaglyceroporin, LmAQP1, is responsible for the transport of trivalent metalloids, arsenite and antimonite. We have earlier shown that downregulation of LmAQP1 provides resistance to trivalent antimony compounds whereas increased expression of LmAQP1 in drug-resistant parasites can reverse the re...

journal_title：Molecular microbiology

authors： Figarella K,Uzcategui NL,Zhou Y,LeFurgey A,Ouellette M,Bhattacharjee H,Mukhopadhyay R

更新日期：2007-08-01 00:00:00

abstract：:Burkholderia mallei, the aetiologic agent of glanders, causes a variety of illnesses in animals and humans ranging from occult infections to acute fulminating septicaemias. To better understand the role of lipopolysaccharide (LPS) in the pathogenesis of these diseases, studies were initiated to characterize the struct...

journal_title：Molecular microbiology

authors： Brett PJ,Burtnick MN,Snyder DS,Shannon JG,Azadi P,Gherardini FC

更新日期：2007-01-01 00:00:00

abstract：:Regulation of polar development and cell division in Caulobacter crescentus relies on the dynamic localization of several proteins to cell poles at specific stages of the cell cycle. The polar organelle development protein, PodJ, is required for the synthesis of the adhesive holdfast and pili. Here we show the cell cy...

journal_title：Molecular microbiology

authors： Hinz AJ,Larson DE,Smith CS,Brun YV

更新日期：2003-02-01 00:00:00

abstract：:The cell envelope of mycobacteria is a complex multilaminar structure that protects the cell from stresses encountered in the environment, and plays an important role against the bactericidal activity of immune system cells. The outermost layer of the mycobacterial envelope typically contains species-specific glycolip...

journal_title：Molecular microbiology

authors： Sondén B,Kocíncová D,Deshayes C,Euphrasie D,Rhayat L,Laval F,Frehel C,Daffé M,Etienne G,Reyrat JM

更新日期：2005-10-01 00:00:00

abstract：:Two papers in this issue of Molecular Microbiology from Carol Gross and colleagues describe experiments that investigate how two alternative Escherichia coli sigma proteins recognize target promoter -10 regions. A combination of genetics, biochemistry and bioinformatics is used to show that determinants in two adjacen...

journal_title：Molecular microbiology

authors： Busby SJ

更新日期：2009-05-01 00:00:00

abstract：:Bordetella bronchiseptica is a pathogen that can acquire iron using its native alcaligin siderophore system, but can also use the catechol xenosiderophore enterobactin via the BfeA outer membrane receptor. Transcription of bfeA is positively controlled by a regulator that requires induction by enterobactin. Catecholam...

journal_title：Molecular microbiology

authors： Armstrong SK,Brickman TJ,Suhadolc RJ

更新日期：2012-05-01 00:00:00

abstract：:Experimental evidence suggests that apicomplexan parasites possess bipartite promoters with basal and regulated cis-elements similar to other eukaryotes. Using a dual luciferase model adapted for recombinational cloning and use in Toxoplasma gondii, we show that genomic regions flanking 16 parasite genes, which encomp...

journal_title：Molecular microbiology

authors： Behnke MS,Radke JB,Smith AT,Sullivan WJ Jr,White MW

更新日期：2008-06-01 00:00:00

abstract：:The malaria parasite Plasmodium falciparum is highly adapted to cope with the oxidative stress to which it is exposed during the erythrocytic stages of its life cycle. This includes the defence against oxidative insults arising from the parasite's metabolism of haemoglobin which results in the formation of reactive ox...

journal_title：Molecular microbiology

authors： Müller S

更新日期：2004-09-01 00:00:00

abstract：:Borrelia burgdorferi survives in an enzootic cycle, and Dps proteins protect DNA against damage during starvation or oxidative stress. The role of a Dps homologue encoded by Borrelia in spirochaete survival was assessed. Dps-deficient spirochaetes were infectious in mice via needle-inoculation at the dose of 10(5) spi...

journal_title：Molecular microbiology

authors： Li X,Pal U,Ramamoorthi N,Liu X,Desrosiers DC,Eggers CH,Anderson JF,Radolf JD,Fikrig E

更新日期：2007-02-01 00:00:00

abstract：:Folate metabolism in malaria parasites is a long-standing, clinical target for chemotherapy and prophylaxis. However, despite determination of the complete genome sequence of the lethal species Plasmodium falciparum, the pathway of de novo folate biosynthesis remains incomplete, as no candidate gene for dihydroneopter...

journal_title：Molecular microbiology

authors： Dittrich S,Mitchell SL,Blagborough AM,Wang Q,Wang P,Sims PF,Hyde JE

更新日期：2008-02-01 00:00:00

abstract：:The AppA protein of Rhodobacter sphaeroides is unique in its ability to sense and transmit redox signals as well as light signals. By functioning as antagonist to the PpsR transcriptional repressor, it regulates the expression of photosynthesis genes in response to these environmental stimuli. Here we show binding of ...

journal_title：Molecular microbiology

authors： Han Y,Meyer MH,Keusgen M,Klug G

更新日期：2007-05-01 00:00:00

abstract：:Virulence factors secreted by Listeria monocytogenes are known to interfere with host cellular signalling pathways. We investigated whether L. monocytogenes modulates T-cell receptor signalling by examining surface expression of proteins known to be upregulated on activated T cells. In vitro culture of murine splenocy...

journal_title：Molecular microbiology

authors： Zenewicz LA,Skinner JA,Goldfine H,Shen H

更新日期：2004-03-01 00:00:00

abstract：:9 alpha-Hydroxylation of 4-androstene-3,17-dione (AD) and 1,4-androstadiene-3,17-dione (ADD) is catalysed by 3-ketosteroid 9 alpha-hydroxylase (KSH), a key enzyme in microbial steroid catabolism. Very limited knowledge is presently available on the KSH enzyme. Here, we report for the first time the identification and ...

journal_title：Molecular microbiology

authors： van der Geize R,Hessels GI,van Gerwen R,van der Meijden P,Dijkhuizen L

更新日期：2002-08-01 00:00:00

abstract：:Transcription in vitro of two osmoregulated promoters, for the Escherichia coli osmB and osmY genes, was analysed using two species of RNA polymerase holoenzyme reconstituted from purified core enzyme and either sigma D (sigma 70, the major sigma in exponentially growing cells) or sigma S (sigma 38, the principal sigm...

journal_title：Molecular microbiology

authors： Ding Q,Kusano S,Villarejo M,Ishihama A

更新日期：1995-05-01 00:00:00

abstract：:A 2 kb DNA fragment isolated from a cosmid library of Aquaspirillum magnetotacticum strain MS-1 complements the aromatic-metabolite requirements and iron-uptake deficiencies of Escherichia coli and Salmonella typhimurium strains that lack a functional aroD (biosynthetic dehydrodquinase) sequence. All recombinant cosmi...

journal_title：Molecular microbiology

authors： Berson AE,Hudson DV,Waleh NS

更新日期：1991-09-01 00:00:00

abstract：:We have previously described HpuAB, a two-component receptor that mediates binding to haemoglobin (Hb), haemoglobin-haptoglobin (Hb-Hp) and apo-haptoglobin (Hp). In this communication, we constructed non-polar mutations in the hpuA and hpuB loci to examine the individual roles of HpuA and HpuB. Our results indicate th...

journal_title：Molecular microbiology

authors： Lewis LA,Gipson M,Hartman K,Ownbey T,Vaughn J,Dyer DW

更新日期：1999-06-01 00:00:00

abstract：:The export of large negatively charged capsular polysaccharides across the outer membrane represents a significant challenge to Gram negative bacteria. In the case of Escherichia coli group 2 capsular polysaccharides, the mechanism of export across the outer membrane was unknown, with no identified candidate outer mem...

journal_title：Molecular microbiology

authors： McNulty C,Thompson J,Barrett B,Lord L,Andersen C,Roberts IS

更新日期：2006-02-01 00:00:00