Maturation of the 5' end of Bacillus subtilis 16S rRNA by the essential ribonuclease YkqC/RNase J1.

abstract：:Phospholipases C play a role in the pathogenesis of several bacteria. Mycobacterium tuberculosis, the causative agent of tuberculosis, possesses four genes encoding putative phospholipases C, plcA, plcB, plcC and plcD. However, the contribution of these genes to virulence is unknown. We constructed four single mutants...

journal_title：Molecular microbiology

authors： Raynaud C,Guilhot C,Rauzier J,Bordat Y,Pelicic V,Manganelli R,Smith I,Gicquel B,Jackson M

更新日期：2002-07-01 00:00:00

abstract：:The Escherichia coli nusG gene product is required for transcription termination by phage HK022 Nun protein at the lambda nutR site in vivo. We show that it is also essential for Nun termination at lambda nutL. Three recessive mis-sense nusG mutations have been isolated that inhibit termination by Nun at lambda nutR. ...

journal_title：Molecular microbiology

authors： Burova E,Hung SC,Chen J,Court DL,Zhou JG,Mogilnitskiy G,Gottesman ME

更新日期：1999-03-01 00:00:00

abstract：:Changes in the mRNA levels of two Mycobacterium tuberculosis genes (fbpB known as antigen 85B, and hspX known as Acr) were studied in infected human monocytes. Antigen 85B is an enzyme involved in cell wall biosynthesis and is also a major target of the immune response. Acr is a stress protein believed to be involved ...

journal_title：Molecular microbiology

authors： Wilkinson RJ,DesJardin LE,Islam N,Gibson BM,Kanost RA,Wilkinson KA,Poelman D,Eisenach KD,Toossi Z

更新日期：2001-02-01 00:00:00

abstract：:Natural competence in Streptococcus pneumoniae is regulated by a quorum-sensing mechanism consisting of a competence-stimulating peptide (CSP), its dedicated secretion apparatus (ComAB), its histidine kinase receptor (ComD) and a response regulator (ComE). In this report, we show that ComE is a DNA-binding protein tha...

journal_title：Molecular microbiology

authors： Ween O,Gaustad P,Håvarstein LS

更新日期：1999-08-01 00:00:00

abstract：:Superoxide dismutase, catalase, glutathione peroxidase and peroxiredoxins form an antioxidant network protecting cells against reactive oxygen species (ROS). Catalase is a potent H2O2-detoxifying enzyme, which is unexpectedly absent in some members of the Kinetoplastida and Apicomplexa, but present in Toxoplasma gondi...

journal_title：Molecular microbiology

authors： Ding M,Kwok LY,Schlüter D,Clayton C,Soldati D

更新日期：2004-01-01 00:00:00

abstract：:An essential early event in Shigella and Salmonella pathogenesis is invasion of non-phagocytic intestinal epithelial cells. Pathogen entry is triggered by the delivery of multiple bacterial effector proteins into target mammalian cells. The Shigella invasion plasmid antigen B (IpaB), which inserts into the host plasma...

journal_title：Molecular microbiology

authors： Hume PJ,McGhie EJ,Hayward RD,Koronakis V

更新日期：2003-07-01 00:00:00

abstract：:The product of the codY gene is required for nutritional repression of the Bacillus subtillis dipeptide permease operon (dpp), an operon expressed at early stationary phase in nutrient-rich medium. Though unrelated to any known DNA-binding protein, CodY was shown to bind specifically to the dpp promoter region. DNase ...

journal_title：Molecular microbiology

authors： Serror P,Sonenshein AL

更新日期：1996-05-01 00:00:00

abstract：:The heterotrimeric G-protein pathway is a ubiquitous eukaryotic signalling module that is known to regulate growth and differentiation in many plant pathogens. We previously identified Pigpa1, a gene encoding a G-protein alpha subunit from the potato late blight pathogen Phytophthora infestans. P. infestans belongs to...

journal_title：Molecular microbiology

authors： Latijnhouwers M,Ligterink W,Vleeshouwers VG,van West P,Govers F

更新日期：2004-02-01 00:00:00

abstract：:Salmonella enterica subspecies I serotypes are responsible for the vast majority of salmonellosis in mammals and birds, yet only a few factors specific to this group that allow them to persist in this niche have been identified. We show that STM0557, a S. enterica subspecies I-specific gene encoding an inner membrane ...

journal_title：Molecular microbiology

authors： Bogomolnaya LM,Santiviago CA,Yang HJ,Baumler AJ,Andrews-Polymenis HL

更新日期：2008-12-01 00:00:00

abstract：:Cells require a sensory system and a motility structure to achieve directed movement. Bacteria and archaea possess rotating filamentous motility structures that work in concert with the sensory chemotaxis system. This allows microorganisms to move along chemical gradients. The central response regulator protein CheY c...

journal_title：Molecular microbiology

authors： Li Z,Rodriguez-Franco M,Albers SV,Quax TEF

更新日期：2020-09-01 00:00:00

abstract：:RelA and SpoT of Gram-negative organisms critically regulate cellular levels of (p)ppGpp. Here, we have dissected the spoT gene function of the cholera pathogen Vibrio cholerae by extensive genetic analysis. Unlike Escherichia coli, V. choleraeDeltarelADeltaspoT cells accumulated (p)ppGpp upon fatty acid or glucose st...

journal_title：Molecular microbiology

authors： Das B,Pal RR,Bag S,Bhadra RK

更新日期：2009-04-01 00:00:00

abstract：:Prokaryotic toxin - antitoxin (TA) loci encode mRNA interferases that inhibit translation, either by cleaving mRNA codons at the ribosomal A site or by cleaving any RNA site-specifically. So far, seven mRNA interferases of Escherichia coli have been identified, four of which cleave mRNA by a translation-dependent mech...

journal_title：Molecular microbiology

authors： Christensen-Dalsgaard M,Jørgensen MG,Gerdes K

更新日期：2010-01-01 00:00:00

abstract：:Interpretation of the constantly expanding body of genomic information requires that the function of each gene be established. Here we report the genomic analysis and structural modelling of a previously uncharacterized redox-metabolism protein UrdA (SO_4620) of Shewanella oneidensis MR-1, which led to a discovery of ...

journal_title：Molecular microbiology

authors： Bogachev AV,Bertsova YV,Bloch DA,Verkhovsky MI

更新日期：2012-12-01 00:00:00

abstract：:We have found a simple relationship between bacterial growth rate and the translation elongation rate. Thus, for a set of defined ribosomal protein S12 mutations which reduce the efficiency of the ternary complex ribosome interaction (and restrict the frequency of translational errors) there is a linear relationship b...

journal_title：Molecular microbiology

authors： Tubulekas I,Hughes D

更新日期：1993-01-01 00:00:00

abstract：:Retinal and its derivatives represent essential compounds in many biological systems. In animals, they are synthesized through a symmetrical cleavage of beta-carotene catalysed by a monooxygenase. Here, we demonstrate that the open reading frame sll1541 from the cyanobacterium Synechocystis sp. PCC 6803 encodes the fi...

journal_title：Molecular microbiology

authors： Ruch S,Beyer P,Ernst H,Al-Babili S

更新日期：2005-02-01 00:00:00

abstract：:Helicobacter pylori is a human gastric pathogen that colonizes ∼ 50% of the world's population. It can cause gastritis, gastric or duodenal ulcers and also gastric cancer. The numerous side effects of available treatments and the emergence of antibiotic resistant strains are severe concerns that justify further resear...

journal_title：Molecular microbiology

authors： Lester J,Kichler S,Oickle B,Fairweather S,Oberc A,Chahal J,Ratnayake D,Creuzenet C

更新日期：2015-04-01 00:00:00

abstract：:The pathogenic fungus Candida albicans commonly causes mucosal surface infections. In immunocompromised patients, C. albicans may penetrate into deeper tissue, enter the bloodstream and disseminate within the host causing life-threatening systemic infections. In order to elucidate how C. albicans responds to the chall...

journal_title：Molecular microbiology

authors： Fradin C,Kretschmar M,Nichterlein T,Gaillardin C,d'Enfert C,Hube B

更新日期：2003-03-01 00:00:00

abstract：:RepA, the initiator protein of plasmid P1, binds to multiple sites (iterons) in the origin. The binding normally requires participation of chaperones, DnaJ, DnaK and GrpE. When purified, RepA appears dimeric and is inactive in iteron binding. On reaction with chaperones, a species active in iteron binding is formed an...

journal_title：Molecular microbiology

authors： Dibbens JA,Muraiso K,Chattoraj DK

更新日期：1997-10-01 00:00:00

abstract：:Oxidative stress serves as an important host/environmental signal that triggers a wide range of responses from the human pathogen Staphylococcus aureus. Among these, a thiol-based oxidation sensing pathway through a global regulator MgrA controls the virulence and antibiotic resistance of the bacterium. Herein, we rep...

journal_title：Molecular microbiology

authors： Chen PR,Nishida S,Poor CB,Cheng A,Bae T,Kuechenmeister L,Dunman PM,Missiakas D,He C

更新日期：2009-01-01 00:00:00

abstract：:Biofilm formation of Staphylococcus epidermidis on smooth polymer surfaces has been shown to be mediated by the ica operon. Upon activation of this operon, a polysaccharide intercellular adhesin (PIA) is synthesized that supports bacterial cell-to-cell contacts and triggers the production of thick, multilayered biofil...

journal_title：Molecular microbiology

authors： Ziebuhr W,Krimmer V,Rachid S,Lössner I,Götz F,Hacker J

更新日期：1999-04-01 00:00:00

abstract：:Members of the bacterial genus Brucella are facultative intracellular pathogens that reside predominantly within membrane-bound compartments within two host cell types, macrophages and placental trophoblasts. Within macrophages, the brucellae route themselves to an intracellular compartment that is favourable for surv...

journal_title：Molecular microbiology

authors： Roop RM 2nd,Bellaire BH,Valderas MW,Cardelli JA

更新日期：2004-05-01 00:00:00

abstract：:Iron is a member of a small group of nutrients that limits aquatic primary production. Mechanisms for utilizing iron have to be efficient and adapted according to the ecological niche. In respect to iron acquisition cyanobacteria, prokaryotic oxygen evolving photosynthetic organisms can be divided into siderophore- an...

journal_title：Molecular microbiology

authors： Rudolf M,Kranzler C,Lis H,Margulis K,Stevanovic M,Keren N,Schleiff E

更新日期：2015-08-01 00:00:00

abstract：:In prokaryotes, the principal signal transduction systems operating at the level of protein phosphorylation are the two-component systems. A number of hybrid histidine protein kinases in these systems contain several receiver domains, however, the function of these receiver domains is unknown. The RodK kinase in Myxoc...

journal_title：Molecular microbiology

authors： Rasmussen AA,Wegener-Feldbrügge S,Porter SL,Armitage JP,Søgaard-Andersen L

更新日期：2006-04-01 00:00:00

abstract：:The osteolytic toxin of Pasteurella multocida induces bone resorption in vivo and in vitro (Foged et al., 1988; Kimman et al., 1987). In this report the toxin-encoding toxA gene is sequenced, and the deduced primary structure of the toxin shows a protein of 1285 amino acids, containing a striking homology to a metal-b...

journal_title：Molecular microbiology

authors： Petersen SK

更新日期：1990-05-01 00:00:00

abstract：:Ammonium movement across biological membranes is facilitated by a class of ubiquitous channel proteins from the Amt/Rh family. Amt proteins have also been implicated in cellular responses to ammonium availability in many organisms. Ammonium sensing by Amt in bacteria is mediated by complex formation with cytosolic pro...

journal_title：Molecular microbiology

authors： Huergo LF,Merrick M,Pedrosa FO,Chubatsu LS,Araujo LM,Souza EM

更新日期：2007-12-01 00:00:00

abstract：:Translating ribosomes require elongation factor P (EF-P) to incorporate consecutive prolines (XPPX) into nascent peptide chains. The proteome of Corynebacterium glutamicum ATCC 13032 contains a total of 1,468 XPPX motifs, many of which are found in proteins involved in primary and secondary metabolism. We show here th...

journal_title：Molecular microbiology

authors： Pinheiro B,Petrov DP,Guo L,Martins GB,Bramkamp M,Jung K

更新日期：2020-10-04 00:00:00

abstract：:Strain 1470 is the standard typing strain for serogroup F of Clostridium difficile containing both toxin genes, toxA-1470 and toxB-1470. A polymerase chain reaction (PCR)-based approach to the sequencing of the total toxB-1470 gene identified an open reading frame (ORF) of 7104 nucleotides. In comparison with the prev...

journal_title：Molecular microbiology

authors： von Eichel-Streiber C,Meyer zu Heringdorf D,Habermann E,Sartingen S

更新日期：1995-07-01 00:00:00

abstract：:In Aspergillus nidulans the global regulatory gene veA is necessary for the biosynthesis of several secondary metabolites, including the mycotoxin sterigmatocystin (ST). In order to identify additional veA-dependent genetic elements involved in regulating ST production, we performed a mutagenesis on a deletion veA (Δv...

journal_title：Molecular microbiology

authors： Ramamoorthy V,Shantappa S,Dhingra S,Calvo AM

更新日期：2012-08-01 00:00:00

abstract：:BldD generally functions as a repressor controlling morphological development of Streptomyces. In this work, evidences that BldD also activates antibiotic production are provided. In Streptomyces roseosporus (which produces daptomycin widely used for treatment of human infections), deletion of bldD notably reduced dap...

journal_title：Molecular microbiology

authors： Yan H,Lu X,Sun D,Zhuang S,Chen Q,Chen Z,Li J,Wen Y

更新日期：2020-01-01 00:00:00

abstract：:Plasmodium vivax is one of four Plasmodium species that cause human malaria. P. vivax and a related simian malaria parasite, Plasmodium knowlesi, invade erythrocytes by binding the Duffy antigen/receptor for chemokines (DARC) through their respective Duffy binding proteins. Here we show that tyrosines 30 and 41 of DAR...

journal_title：Molecular microbiology

authors： Choe H,Moore MJ,Owens CM,Wright PL,Vasilieva N,Li W,Singh AP,Shakri R,Chitnis CE,Farzan M

更新日期：2005-03-01 00:00:00