Cdv-based cell division and cell cycle organization in the thaumarchaeon Nitrosopumilus maritimus.

abstract：:In vivo and in vitro analyses indicate that transcription of the argO gene coding for an arginine exporter is regulated by the global transcriptional regulator Lrp, an effect that went by unnoticed in previous genome-scale screenings of the Lrp regulatory network in Escherichia coli. Lrp activates the argO promoter fo...

journal_title：Molecular microbiology

authors： Peeters E,Nguyen Le Minh P,Foulquié-Moreno M,Charlier D

更新日期：2009-12-01 00:00:00

abstract：:The haemolysin of Haemophilus ducreyi is the newest member of the Proteus/Serratia family of pore-forming toxins. In order to assess the role of the haemolysin in virulence, we constructed an isogenic haemolysin-deficient mutant of H. ducreyi strain 35000 This strain, designated 35000-3, lacks detectable haemolytic ac...

journal_title：Molecular microbiology

authors： Palmer KL,Goldman WE,Munson RS Jr

更新日期：1996-07-01 00:00:00

abstract：:The flow of information from the outside to the inside of bacterial cells is largely directed by protein kinases. In addition to histidine/aspartate phosphorelays of two-component response regulators, recent work in Mycobacterium tuberculosis (Mtb) reinforces the idea that phosphorylation on serine (Ser), threonine (T...

journal_title：Molecular microbiology

authors： Sherman DR,Grundner C

更新日期：2014-10-01 00:00:00

abstract：:Crs5 is a Saccharomyces cerevisiae Metallothionein (MT), non-homologous to the paradigmatic Cu-thionein Cup1. Although considered a secondary copper-resistance agent, we show here that it determines survival under zinc overload in a CUP1-null background. Its overexpression prevents the deleterious effects exhibited by...

journal_title：Molecular microbiology

authors： Pagani A,Villarreal L,Capdevila M,Atrian S

更新日期：2007-01-01 00:00:00

abstract：:Members of the bacterial genus Brucella are facultative intracellular pathogens that reside predominantly within membrane-bound compartments within two host cell types, macrophages and placental trophoblasts. Within macrophages, the brucellae route themselves to an intracellular compartment that is favourable for surv...

journal_title：Molecular microbiology

authors： Roop RM 2nd,Bellaire BH,Valderas MW,Cardelli JA

更新日期：2004-05-01 00:00:00

abstract：:Klebsiella pneumoniae strain PAP996 was previously shown to secrete fatty acylated, aggregated (micellar) pullulanase only after the end of exponential growth. Here we show that the closely related strain K21 secretes large amounts of unacylated, non-aggregated (monomeric) pullulanase during exponential growth. Only a...

journal_title：Molecular microbiology

authors： Kornacker MG,Boyd A,Pugsley AP,Plastow GS

更新日期：1989-04-01 00:00:00

abstract：:Virstatin is a previously described small molecule inhibitor of Vibrio cholerae virulence. We have demonstrated that the molecule inhibits the activity of the transcriptional activator ToxT, thereby preventing elaboration of the toxin co-regulated pilus (TCP) and cholera toxin in vitro and in vivo in O1 strains of V. ...

journal_title：Molecular microbiology

authors： Shakhnovich EA,Sturtevant D,Mekalanos JJ

更新日期：2007-12-01 00:00:00

abstract：:A hallmark of the biofilm architecture is the presence of microcolonies. However, little is known about the underlying mechanisms governing microcolony formation. In the pathogen Pseudomonas aeruginosa, microcolony formation is dependent on the two-component regulator MifR, with mifR mutant biofilms exhibiting an over...

journal_title：Molecular microbiology

authors： Petrova OE,Schurr JR,Schurr MJ,Sauer K

更新日期：2012-11-01 00:00:00

abstract：:The identification, isolation and characterization of a new Aspergillus nidulans positive-acting gene metR, which encodes a transcriptional activator of sulphur metabolism, is reported. metR mutants are tight auxotrophs requiring methionine or homocysteine for growth. Mutations in the metR gene are epistatic to mutati...

journal_title：Molecular microbiology

authors： Natorff R,Sieńko M,Brzywczy J,Paszewski A

更新日期：2003-08-01 00:00:00

abstract：:The plant pathogen Pseudomonas syringae pv. phaseolicola, which causes halo blight disease of beans, contains a 106 kb genomic island PPHGI-1. PPHGI-1 carries a gene, avrPphB, which encodes an effector protein that triggers a resistance response in certain bean cultivars. Previous studies have shown that when PPHGI-1 ...

journal_title：Molecular microbiology

authors： Neale HC,Jackson RW,Preston GM,Arnold DL

更新日期：2018-11-01 00:00:00

abstract：:Red cell invasion by Plasmodium merozoites involves multiple steps such as attachment, apical reorientation, junction formation and entry into a parasitophorous vacuole. These steps are mediated by specific molecular interactions. P. vivax and the simian parasite P. knowlesi require interaction with the Duffy blood gr...

journal_title：Molecular microbiology

authors： Singh AP,Ozwara H,Kocken CH,Puri SK,Thomas AW,Chitnis CE

更新日期：2005-03-01 00:00:00

abstract：:The genes of nicotine dehydrogenase (NDH) were identified, cloned and sequenced from the catabolic plasmid pAO1 of Arthrobacter nicotinovorans. In immediate proximity to this gene cluster is the beginning of the 6-hydroxy-L-niotine oxidase (6-HLNO) gene. NDH is composed of three subunits (A, B and C) of M(r) 30,011, 1...

journal_title：Molecular microbiology

authors： Grether-Beck S,Igloi GL,Pust S,Schilz E,Decker K,Brandsch R

更新日期：1994-09-01 00:00:00

abstract：:In many streptococci, quorum sensing utilizes secreted, linear peptides that engage cognate receptors to coordinate gene expression among members of a local population. Streptococcus mutans employs the secreted peptides CSP and XIP to stimulate production of antimicrobial bacteriocins and to induce development of comp...

journal_title：Molecular microbiology

authors： Federle MJ,Morrison DA

更新日期：2012-10-01 00:00:00

abstract：:This past January, in Cuernavaca Mexico, a conglomerate of scientists met to discuss the contemporary view of Bacterial Locomotion and Signal Transduction (BLAST). The BLAST meetings represent a field that has its roots in chemotaxis and the flagellum-based motility but now encompass all types of cellular movement and...

journal_title：Molecular microbiology

authors： Scharf BE,Aldridge PD,Kirby JR,Crane BR

更新日期：2009-07-01 00:00:00

abstract：:Bacterial cell division requires the assembly of FtsZ protofilaments into a dynamic structure called the 'Z-ring'. The Z-ring recruits the division machinery and directs local cell wall remodeling for constriction. The organization and dynamics of protofilaments within the Z-ring coordinate local cell wall synthesis d...

journal_title：Molecular microbiology

authors： Sundararajan K,Vecchiarelli A,Mizuuchi K,Goley ED

更新日期：2018-10-01 00:00:00

abstract：:Glutaredoxins and thioredoxins are small heat-stable oxidoreductases that have been conserved throughout evolution. The yeast Saccharomyces cerevisiae contains two gene pairs encoding cytoplasmic glutaredoxins (GRX1, GRX2) and thioredoxins (TRX1, TRX2). We report here that the quadruple trx1 trx2 grx1 grx2 mutant is i...

journal_title：Molecular microbiology

authors： Draculic T,Dawes IW,Grant CM

更新日期：2000-06-01 00:00:00

abstract：:A method of insertional mutagenesis for naturally transformable organisms has been adapted from Haemophilus influenzae and applied to the study of the pathogenesis of Campylobacter jejuni. A series of kanamycin-resistant insertional mutants of C. jejuni 81-176 has been generated and screened for loss of ability to inv...

journal_title：Molecular microbiology

authors： Yao R,Burr DH,Doig P,Trust TJ,Niu H,Guerry P

更新日期：1994-12-01 00:00:00

abstract：:Enteropathogenic Escherichia coli (EPEC) is a leading cause of infant diarrhoea. EPEC mediates several effects on host epithelial cells, including activation of signal-transduction pathways, cytoskeletal rearrangement along with pedestal and attaching/effacing lesion formation. It has been previously shown that the EP...

journal_title：Molecular microbiology

authors： Kenny B,Lai LC,Finlay BB,Donnenberg MS

更新日期：1996-04-01 00:00:00

abstract：:Saccharomyces cerevisiae responds to environ-mental stimuli such as an exposure to pheromone or to hexoses after carbon source limitation with a transient elevation of cytosolic calcium (TECC) response. In this study, we examined whether hexose transport and phosphorylation are necessary for the TECC response. We foun...

journal_title：Molecular microbiology

authors： Tökés-Füzesi M,Bedwell DM,Repa I,Sipos K,Sümegi B,Rab A,Miseta A

更新日期：2002-06-01 00:00:00

abstract：:Bacteria harbour both ferrous and ferric iron transporters. We now report that infection of macrophages and mice with a Salmonella enterica Typhimurium strain containing an inactivated feoB-encoded ferrous iron transporter results in increased bacterial replication, compared to infection with wild type. Inactivation o...

journal_title：Molecular microbiology

authors： Nagy TA,Moreland SM,Detweiler CS

更新日期：2014-09-01 00:00:00

abstract：:GPI-anchoring is a universal and critical post-translational protein modification in eukaryotes. In fungi, many cell wall proteins are GPI-anchored, and disruption of GPI-anchored proteins impairs cell wall integrity. After being synthesized and attached to target proteins, GPI anchors undergo modification on lipid mo...

journal_title：Molecular microbiology

authors： Chung D,Thammahong A,Shepardson KM,Blosser SJ,Cramer RA

更新日期：2014-06-01 00:00:00

abstract：:Proteinaceous, hair-like appendages known as fimbriae or pili commonly extend from the surface of prokaryotic cells and serve important functions such as cell adhesion, biofilm formation, motility and DNA transfer. Here we show that a novel group of archaea from cold, sulphidic springs has developed cell surface appen...

journal_title：Molecular microbiology

authors： Moissl C,Rachel R,Briegel A,Engelhardt H,Huber R

更新日期：2005-04-01 00:00:00

abstract：:The cereal pathogen Fusarium graminearum threatens food and feed production worldwide. It reduces the yield and poisons the remaining kernels with mycotoxins, notably deoxynivalenol (DON). We analyzed the importance of gamma-aminobutanoic acid (GABA) metabolism for the life cycle of this fungal pathogen. GABA metaboli...

journal_title：Molecular microbiology

authors： Bönnighausen J,Gebhard D,Kröger C,Hadeler B,Tumforde T,Lieberei R,Bergemann J,Schäfer W,Bormann J

更新日期：2015-12-01 00:00:00

abstract：:Although diminutive in size, bacteria possess highly diverse and spatially confined cellular structures. Two related alphaproteobacteria, Sinorhizobium meliloti and Caulobacter crescentus, serve as models for investigating the genetic basis of morphological variations. S. meliloti, a symbiont of leguminous plants, syn...

journal_title：Molecular microbiology

authors： Fields AT,Navarrete CS,Zare AZ,Huang Z,Mostafavi M,Lewis JC,Rezaeihaghighi Y,Brezler BJ,Ray S,Rizzacasa AL,Barnett MJ,Long SR,Chen EJ,Chen JC

更新日期：2012-06-01 00:00:00

abstract：:The important human pathogen Streptococcus pyogenes (the group A streptococcus or GAS) causes diseases ranging from mild, self-limiting pharyngitis to severe invasive infections. Regulation of the expression of GAS genes in response to specific environmental differences within the host is probably key in determining t...

journal_title：Molecular microbiology

authors： Opdyke JA,Scott JR,Moran CP Jr

更新日期：2001-10-01 00:00:00

abstract：:Protein kinase C constitutes a family of serine-threonine kinases found in all eukaryotes and implicated in a wide range of cellular functions, including regulation of cell growth, cellular differentiation and immunity. Here, we present three independent lines of evidence which indicate that protein kinase C is essent...

journal_title：Molecular microbiology

authors： Penn TJ,Wood ME,Soanes DM,Csukai M,Corran AJ,Talbot NJ

更新日期：2015-10-01 00:00:00

abstract：:Listeria monocytogenes FrvA (Lmo0641) is critical for virulence in the mouse model and is an ortholog of the Bacillus subtilis Fur- and PerR-regulated Fe(II) efflux P1B4 -type ATPase PfeT. Previously, FrvA was suggested to protect against heme toxicity. Here, we demonstrate that an frvA mutant is sensitive to iron int...

journal_title：Molecular microbiology

authors： Pi H,Patel SJ,Argüello JM,Helmann JD

更新日期：2016-06-01 00:00:00

abstract：:We report here the formation of symbiotic plasmids (pSyms), by genetic recombination between rearranged pSyms, which lack symbiotic information, and resistance plasmids carrying parts of different symbiotic plasmids (R's). This recombination was found to occur both between plasmids derived from different Rhizobium pha...

journal_title：Molecular microbiology

authors： Soberón-Chávez G,Nájera R,Espín G,Moreno S

更新日期：1991-04-01 00:00:00

abstract：:The carboxyl-terminal region of diphtheria toxin (DT) has been analysed in order to determine regions of receptor recognition. Biochemical cleavage of the toxin with hydroxylamine (HA) was used to generate the peptides HA9DT (residues 454-535), HA6DT (residues 482-535), and HA3DT (residues 454-481). Characterization o...

journal_title：Molecular microbiology

authors： Rolf JM,Eidels L

更新日期：1993-02-01 00:00:00

abstract：:A series of plasmids carrying an IRL-kan-IRR transposable cassette, in which IRL and IRR are the left- and right-terminal sequences of IS91, have been constructed. These cassettes could be complemented for transposition with similar efficiency when IS91 transposase was provided either in cis or in trans. A total of 87...

journal_title：Molecular microbiology

authors： Bernales I,Mendiola MV,de la Cruz F

更新日期：1999-07-01 00:00:00