Lytic transglycosylases RlpA and MltC assist in Vibrio cholerae daughter cell separation.

abstract：:Peptidoglycan (PG), the major component of the bacterial cell wall, is one large macromolecule. To allow for the different curvatures of PG at cell poles and division sites, there must be local differences in PG architecture and eventually also chemistry. Here we report such local differences in the Gram-positive rod-...

journal_title：Molecular microbiology

authors： Morales Angeles D,Liu Y,Hartman AM,Borisova M,de Sousa Borges A,de Kok N,Beilharz K,Veening JW,Mayer C,Hirsch AK,Scheffers DJ

更新日期：2017-04-01 00:00:00

abstract：:CS1 pili are filamentous proteinaceous appendages found on many enterotoxigenic Escherichia coli (ETEC) strains isolated from human diarrhoeal disease. They are thought to effect colonization of the upper intestine by facilitating binding to human ileal epithelial cells. We have identified a gene, cooB, which lies dir...

journal_title：Molecular microbiology

authors： Scott JR,Wakefield JC,Russell PW,Orndorff PE,Froehlich BJ

更新日期：1992-02-01 00:00:00

abstract：:Carbapenems such as meropenem are being investigated for their potential therapeutic utility against highly drug-resistant tuberculosis. These β-lactams target the transpeptidases that introduce interpeptide cross-links into bacterial peptidoglycan thereby controlling rigidity of the bacterial envelope. Treatment of M...

journal_title：Molecular microbiology

authors： Kumar P,Arora K,Lloyd JR,Lee IY,Nair V,Fischer E,Boshoff HI,Barry CE 3rd

更新日期：2012-10-01 00:00:00

abstract：:A histidine kinase, Hik33, appears to sense decreases in temperature and to regulate the expression of certain cold-inducible genes in the cyanobacterium Synechocystis sp. PCC6803. To examine the role of Hik33 in the regulation of gene expression, we analysed a DeltaHik33 mutant using the DNA microarray technique. In ...

journal_title：Molecular microbiology

authors： Suzuki I,Kanesaki Y,Mikami K,Kanehisa M,Murata N

更新日期：2001-04-01 00:00:00

abstract：:Ustilago maydis is able to initiate pathogenic development after fusion of two haploid cells with different mating type. On the maize leaf surface, the resulting dikaryon switches to filamentous growth, differentiates appressoria and penetrates the host. Here, we report on the plant signals required for filament forma...

journal_title：Molecular microbiology

authors： Mendoza-Mendoza A,Berndt P,Djamei A,Weise C,Linne U,Marahiel M,Vranes M,Kämper J,Kahmann R

更新日期：2009-02-01 00:00:00

abstract：:The TonB system of Escherichia coli (TonB/ExbB/ExbD) transduces the protonmotive force (pmf) of the cytoplasmic membrane to drive active transport by high-affinity outer membrane transporters. In this study, chromosomally encoded ExbD formed formaldehyde-linked complexes with TonB, ExbB and itself (homodimers) in vivo...

journal_title：Molecular microbiology

authors： Ollis AA,Manning M,Held KG,Postle K

更新日期：2009-08-01 00:00:00

abstract：:The bacterium Burkholderia glumae causes rice grain rot by producing toxoflavin, whose expression is regulated by quorum sensing (QS). We report a major deviation from the current paradigm for the regulation of bacterial polar flagellum genes. The N-octanoyl homoserine lactone (C8-HSL)-deficient mutant of B. glumae is...

journal_title：Molecular microbiology

authors： Kim J,Kang Y,Choi O,Jeong Y,Jeong JE,Lim JY,Kim M,Moon JS,Suga H,Hwang I

更新日期：2007-04-01 00:00:00

abstract：:A bioassay was developed to identify stimuli that promote the transcriptional induction of the algD operon for alginate biosynthesis in Pseudomonas aeruginosa. Strain PAO1 carried the algD promoter fused to a chloramphenicol acetyl-transferase cartridge (PalgD-cat), and > 50 compounds were tested for promoting chloram...

journal_title：Molecular microbiology

authors： Wood LF,Leech AJ,Ohman DE

更新日期：2006-10-01 00:00:00

abstract：:Silent information regulator 2 (Sir2)-related proteins or sirtuins function as NAD(+)-dependent deacetylases or ADP ribosylases that target a range of substrates, thereby influencing chromatin structure and a diverse range of other biological functions. Genes encoding three Sir2-related proteins (SIR2rp1-3) have been ...

journal_title：Molecular microbiology

authors： Alsford S,Kawahara T,Isamah C,Horn D

更新日期：2007-02-01 00:00:00

abstract：:Bordetella bronchiseptica is a pathogen that can acquire iron using its native alcaligin siderophore system, but can also use the catechol xenosiderophore enterobactin via the BfeA outer membrane receptor. Transcription of bfeA is positively controlled by a regulator that requires induction by enterobactin. Catecholam...

journal_title：Molecular microbiology

authors： Armstrong SK,Brickman TJ,Suhadolc RJ

更新日期：2012-05-01 00:00:00

abstract：:Long-term antibiotic treatment offers a rare opportunity to study the evolution of bacteria within the same individual. The appearance of new variants has been suggested to take place via the selection of enhanced resistance in compartments of the body in which the antibiotic concentration is low. Laboratory models of...

journal_title：Molecular microbiology

authors： Low AS,MacKenzie FM,Gould IM,Booth IR

更新日期：2001-11-01 00:00:00

abstract：:In the multicellular bacterium Streptomyces coelicolor, functions of developmental (bald) genes are required for the biosynthesis of SapB, a hydrophobic peptidic morphogen that facilitates aerial hyphae formation. Here, we show that aerial hyphal growth and SapB biosynthesis could be activated independently from the n...

journal_title：Molecular microbiology

authors： Nguyen KT,Willey JM,Nguyen LD,Nguyen LT,Viollier PH,Thompson CJ

更新日期：2002-12-01 00:00:00

abstract：:Streptomyces lividans has a novel DNA modification, which sensitises its DNA to degradation during electrophoresis (the Dnd phenotype). The entire gene cluster (dnd) involved in this modification was localized on an 8 kb DNA fragment and was expressed in a S. lividans deletion mutant (dnd) and in several heterologous ...

journal_title：Molecular microbiology

authors： Zhou X,He X,Liang J,Li A,Xu T,Kieser T,Helmann JD,Deng Z

更新日期：2005-09-01 00:00:00

abstract：:A complete understanding of host-parasite interactions must necessarily include the identification and characterization of gene products expressed by both parties during the infectious process. We have developed a new screen to identify bacterial genes that are transcriptionally induced during infection of a host anim...

journal_title：Molecular microbiology

authors： Camilli A,Mekalanos JJ

更新日期：1995-11-01 00:00:00

abstract：:DnaA protein (a trans-acting element) and its binding sequence, DnaA-box: (a cis-acting element) are two elements essential for the initiation of chromosomal replication in Escherichia coli and other enteric bacteria. Recently these two elements have been found to be conserved in three Gram-positive bacteria (Bacillus...

journal_title：Molecular microbiology

authors： Yoshikawa H,Ogasawara N

更新日期：1991-11-01 00:00:00

abstract：:Candida albicans is an opportunistic fungal pathogen. In immunocompromised individuals, it can cause bloodstream infections with high mortality rates. The ability to switch between yeast and hyphal morphologies is a critical virulence factor of C. albicans. In response to diverse environmental cues, several signaling ...

journal_title：Molecular microbiology

authors： Chen C,Zeng G,Wang Y

更新日期：2018-10-01 00:00:00

abstract：:The type III secretion system (TTSS) is a modular apparatus assembled by many pathogenic Gram-negative bacteria and is designed to translocate proteins through the bacterial cell wall into the eukaryotic host cell. The conserved components of the TTSS comprise stacks of rings spanning the inner and outer bacterial mem...

journal_title：Molecular microbiology

authors： Daniell SJ,Kocsis E,Morris E,Knutton S,Booy FP,Frankel G

更新日期：2003-07-01 00:00:00

abstract：:Protein phosphatases 2C are a family of conserved enzymes involved in many aspects of the cell biology. We reported that, in the yeast Saccharomyces cerevisiae, overexpression of the Ptc3p isoform resulted in increased lithium tolerance in the hypersensitive hal3 background. We have found that the tolerance induced by...

journal_title：Molecular microbiology

authors： Ruiz A,González A,García-Salcedo R,Ramos J,Ariño J

更新日期：2006-10-01 00:00:00

abstract：:Despite their high genomic synteny, the Leishmania major and Leishmania infantum species exhibit extensive differences in mRNA expression patterns throughout the parasite's development. Yet, the underlying mechanisms for this species-specific differential gene expression are largely unknown. Here we report that Short ...

journal_title：Molecular microbiology

authors： Müller M,Padmanabhan PK,Papadopoulou B

更新日期：2010-07-01 00:00:00

abstract：:Myxococcus xanthus is a Gram-negative, soil-dwelling bacterium with a complex life cycle which includes fruiting body formation and sporulation in response to starvation. This developmental process is slow, requiring a minimum of 24-48 h, and requires cells to be at high cell density on a solid surface. It is known th...

journal_title：Molecular microbiology

authors： O'Connor KA,Zusman DR

更新日期：1997-05-01 00:00:00

abstract：:Lactose is an abundant dietary carbohydrate metabolized by the dental pathogen Streptococcus mutans. Lactose metabolism presents both classic diauxic behaviors and long-term memory, where the bacteria can pause for >11 h before initiating growth on lactose. Here, we explored mechanisms contributing to unusual aspects ...

journal_title：Molecular microbiology

authors： Zeng L,Burne RA

更新日期：2020-09-03 00:00:00

abstract：:The bacterial actin homologue MreB forms a helix underneath the cytoplasmic membrane and was shown to be essential in the morphogenesis of the rod-shaped cells. Additionally, MreB was implicated to be involved in DNA segregation. However, in our hands the mreBCD deletion strain (PA340-678) grew without apparent DNA se...

journal_title：Molecular microbiology

authors： Karczmarek A,Martínez-Arteaga R,Alexeeva S,Hansen FG,Vicente M,Nanninga N,den Blaauwen T

更新日期：2007-07-01 00:00:00

abstract：:Listeriolysin O (LLO) binds to cholesterol-containing membranes in which it oligomerizes to form pores. Preincubation of the toxin with cholesterol is known to inhibit haemolysis, whereas the oxidized form of cholesterol has no inhibitory effect. Using immunoblot analyses and flow cytometry we demonstrate that preincu...

journal_title：Molecular microbiology

authors： Jacobs T,Darji A,Frahm N,Rohde M,Wehland J,Chakraborty T,Weiss S

更新日期：1998-06-01 00:00:00

abstract：:Avermectins produced by Streptomyces avermitilis are effective anthelmintic agents. The autoregulatory signalling molecule that triggers avermectin biosynthesis is a novel butenolide-type molecule, avenolide, rather than common γ-butyrolactones (GBLs). We identified AvaR2, a pseudo GBL receptor homologue, as an import...

journal_title：Molecular microbiology

authors： Zhu J,Sun D,Liu W,Chen Z,Li J,Wen Y

更新日期：2016-11-01 00:00:00

abstract：:An essential early event in Shigella and Salmonella pathogenesis is invasion of non-phagocytic intestinal epithelial cells. Pathogen entry is triggered by the delivery of multiple bacterial effector proteins into target mammalian cells. The Shigella invasion plasmid antigen B (IpaB), which inserts into the host plasma...

journal_title：Molecular microbiology

authors： Hume PJ,McGhie EJ,Hayward RD,Koronakis V

更新日期：2003-07-01 00:00:00

abstract：:We recently identified a gene (FTN_0818) required for Francisella virulence that seemed likely involved in biotin metabolism. However, the molecular function of this virulence determinant was unclear. Here we show that this protein named BioJ is the enzyme of the biotin biosynthesis pathway that determines the chain l...

journal_title：Molecular microbiology

authors： Feng Y,Napier BA,Manandhar M,Henke SK,Weiss DS,Cronan JE

更新日期：2014-01-01 00:00:00

abstract：:Aspergillus fumigatus, an important human nosocomial pathogen, is resistant to sordarin derivatives, a new family of antifungals that inhibit protein synthesis by interaction with the EF-2-ribosomal stalk complex. To explore the role of the A. fumigatus ribosome in the resistance mechanism, the fungal stalk proteins w...

journal_title：Molecular microbiology

authors： Santos C,Ballesta JP

更新日期：2002-01-01 00:00:00

abstract：:In cell-free Yersinia pseudotuberculosis culture supernatants, we have chemically characterized three N-acyl homoserine lactone (AHL) molecules, N-octanoyl homoserine lactone (C8-HSL), N-(3-oxohexanoyl)homoserine lactone (3-oxo-C6-HSL) and N-hexanoyl homoserine lactone (C6-HSL). We have identified, cloned and sequence...

journal_title：Molecular microbiology

authors： Atkinson S,Throup JP,Stewart GS,Williams P

更新日期：1999-09-01 00:00:00

abstract：:The sequence of phi Ch1 contains an open reading frame (int1) in the central part of its genome that belongs to the lambda integrase family of site-specific recombinases. Sequence similarities to known integrases include the highly conserved tetrad R-H-R-Y. The flanking sequences of int1 contain several direct repeats...

journal_title：Molecular microbiology

authors： Rössler N,Klein R,Scholz H,Witte A

更新日期：2004-04-01 00:00:00

abstract：:Chemotactic adaptation to persisting stimulation involves reversible methylation of the chemoreceptors that form complexes with the histidine kinase CheA at a cell pole. The methyltransferase CheR targets to the C-terminal NWETF sequence of the chemoreceptor. In contrast, localization of the methylesterase CheB is lar...

journal_title：Molecular microbiology

authors： Banno S,Shiomi D,Homma M,Kawagishi I

更新日期：2004-08-01 00:00:00