Cell-cell communication in filamentous cyanobacteria.


:Although cytoplasmic bridges between adjacent cells in the filaments of nitrogen-fixing cyanobacteria have been known for decades, the existence also of a continuous periplasm along the filaments raised the possibility that alternative modes of communication between cells could be utilized. The latter hypothesis was investigated by using GFP fusions to proteins whose expression is cell-specific and engineered to be transported into the periplasm. Two groups have recently obtained contradictory results, one supporting periplasmic transport of GFP from cell to cell, the other not. A third effort, involving members of the first group, used a smaller, soluble fluorophore and found rapid communication via the cytoplasmic bridges between cells. The dilemma of periplasmic diffusion remains unresolved.


Mol Microbiol


Molecular microbiology


Haselkorn R




Has Abstract


2008-11-01 00:00:00














  • Neisseria gonorrhoeae acquires mutations in analogous regions of gyrA and parC in fluoroquinolone-resistant isolates.

    abstract::Neisseria gonorrhoeae homologues of gyrA and parC have been identified using hybridization probes generated from conserved regions of diverse gyrA genes. These genes have been tentatively identified as gyrA and parC, based on predicted amino acid sequence homologies to known GyrA homologues from numerous bacterial spe...

    journal_title:Molecular microbiology

    pub_type: 杂志文章


    authors: Belland RJ,Morrison SG,Ison C,Huang WM

    更新日期:1994-10-01 00:00:00

  • Regulated transcription of Clostridium difficile toxin genes.

    abstract::The Clostridium difficile toxA and toxB genes, encoding cytotoxic and enterotoxic proteins responsible for antibiotic-associated colitis and pseudomembranous colitis, were shown to be transcribed both from gene-specific promoters and from promoters of upstream genes. However, the gene-specific transcripts represented ...

    journal_title:Molecular microbiology

    pub_type: 杂志文章


    authors: Dupuy B,Sonenshein AL

    更新日期:1998-01-01 00:00:00

  • Reduced polysialic acid capsule expression in Escherichia coli K1 mutants with chromosomal defects in kpsF.

    abstract::Neuroinvasive Escherichia coli K1 synthesizes and assembles a polysialic acid capsule virulence factor on the external leaflet of the outer membrane. This capsule functions in pathogenesis by blocking non-immune host defence mechanisms and acting as a relatively non-immunogenic molecular mimic of the polysialic acid c...

    journal_title:Molecular microbiology

    pub_type: 杂志文章


    authors: Cieslewicz M,Vimr E

    更新日期:1997-10-01 00:00:00

  • Identification of competence pheromone responsive genes in Streptococcus pneumoniae by use of DNA microarrays.

    abstract::Natural genetic transformation in Streptococcus pneumoniae is controlled in part by a quorum-sensing system mediated by a peptide pheromone called competence-stimulating peptide (CSP), which acts to coordinate transient activation of genes required for competence. To characterize the transcriptional response and regul...

    journal_title:Molecular microbiology

    pub_type: 杂志文章


    authors: Peterson SN,Sung CK,Cline R,Desai BV,Snesrud EC,Luo P,Walling J,Li H,Mintz M,Tsegaye G,Burr PC,Do Y,Ahn S,Gilbert J,Fleischmann RD,Morrison DA

    更新日期:2004-02-01 00:00:00

  • Autoregulation of the Escherichia coli replication initiator protein, DnaA, is indirect.

    abstract::The expression of dnaA is autoregulated, in that transcription of the gene increases when DnaA is inactivated (and initiation of replication prevented) and decreases when DnaA is supplied in excess. However, the inactivation of DnaA does not necessarily lead to increased DnaA production, as dnaA(Ts; temperature sensit...

    journal_title:Molecular microbiology

    pub_type: 杂志文章


    authors: Smith RW,McAteer S,Masters M

    更新日期:1997-03-01 00:00:00

  • Identification of novel virulence factors associated with signal transduction pathways in Alternaria brassicicola.

    abstract::Alternaria brassicicola is an important, necrotrophic fungal pathogen that causes black spot disease on Brassicas. In order to study pathogenicity mechanisms, gene deletion mutants were generated for 21 putative regulatory genes including kinases and transcription factors subjectively selected from the annotated A. br...

    journal_title:Molecular microbiology

    pub_type: 杂志文章


    authors: Cho Y,Kim KH,La Rota M,Scott D,Santopietro G,Callihan M,Mitchell TK,Lawrence CB

    更新日期:2009-06-01 00:00:00

  • Identification of the DotL coupling protein subcomplex of the Legionella Dot/Icm type IV secretion system.

    abstract::Legionella pneumophila, the causative agent of Legionnaires' disease, survives in macrophages by altering the endocytic pathway of its host cell. To accomplish this, the bacterium utilizes a type IVB secretion system to deliver effector molecules into the host cell cytoplasm. In a previous report, we performed an exte...

    journal_title:Molecular microbiology

    pub_type: 杂志文章


    authors: Vincent CD,Friedman JR,Jeong KC,Sutherland MC,Vogel JP

    更新日期:2012-07-01 00:00:00

  • Burkholderia mallei expresses a unique lipopolysaccharide mixture that is a potent activator of human Toll-like receptor 4 complexes.

    abstract::Burkholderia mallei, the aetiologic agent of glanders, causes a variety of illnesses in animals and humans ranging from occult infections to acute fulminating septicaemias. To better understand the role of lipopolysaccharide (LPS) in the pathogenesis of these diseases, studies were initiated to characterize the struct...

    journal_title:Molecular microbiology

    pub_type: 杂志文章


    authors: Brett PJ,Burtnick MN,Snyder DS,Shannon JG,Azadi P,Gherardini FC

    更新日期:2007-01-01 00:00:00

  • CPMK2, an SLT2-homologous mitogen-activated protein (MAP) kinase, is essential for pathogenesis of Claviceps purpurea on rye: evidence for a second conserved pathogenesis-related MAP kinase cascade in phytopathogenic fungi.

    abstract::Cpmk2, encoding a mitogen-activated protein (MAP) kinase from the ascomycete Claviceps purpurea, is an orthologue of SLT2 from Saccharomyces cerevisiae, the first isolated from a biotrophic, non-appressorium-forming pathogen. Deletion mutants obtained by a gene replacement approach show impaired vegetative properties ...

    journal_title:Molecular microbiology

    pub_type: 杂志文章


    authors: Mey G,Held K,Scheffer J,Tenberge KB,Tudzynski P

    更新日期:2002-10-01 00:00:00

  • Membrane protein insertase YidC in bacteria and archaea.

    abstract::The insertion of proteins into the prokaryotic plasma membrane is catalyzed by translocases and insertases. On one hand, the Sec translocase operates as a transmembrane channel that can open laterally to first bind and then release the hydrophobic segments of a substrate protein into the lipid bilayer. On the other ha...

    journal_title:Molecular microbiology

    pub_type: 杂志文章,评审


    authors: Kuhn A,Kiefer D

    更新日期:2017-02-01 00:00:00

  • Buffering of stable RNA promoter activity against DNA relaxation requires a far upstream sequence.

    abstract::The stable RNA promoters of Escherichia coli are exquisitely sensitive to variations in the superhelical density of DNA. Previously, we have shown that binding of the DNA architectural protein FIS at the upstream activating sequences (UASs) of stable RNA promoters prevents the transcription complexes from inactivation...

    journal_title:Molecular microbiology

    pub_type: 杂志文章


    authors: Rochman M,Blot N,Dyachenko M,Glaser G,Travers A,Muskhelishvili G

    更新日期:2004-07-01 00:00:00

  • Identification and characterization of two families of F420 H2-dependent reductases from Mycobacteria that catalyse aflatoxin degradation.

    abstract::Aflatoxins are polyaromatic mycotoxins that contaminate a range of food crops as a result of fungal growth and contribute to serious health problems in the developing world because of their toxicity and mutagenicity. Although relatively resistant to biotic degradation, aflatoxins can be metabolized by certain species ...

    journal_title:Molecular microbiology

    pub_type: 杂志文章


    authors: Taylor MC,Jackson CJ,Tattersall DB,French N,Peat TS,Newman J,Briggs LJ,Lapalikar GV,Campbell PM,Scott C,Russell RJ,Oakeshott JG

    更新日期:2010-11-01 00:00:00

  • The cephamycin biosynthetic genes pcbAB, encoding a large multidomain peptide synthetase, and pcbC of Nocardia lactamdurans are clustered together in an organization different from the same genes in Acremonium chrysogenum and Penicillium chrysogenum.

    abstract::A 34 kb fragment of the Nocardia lactamdurans DNA carrying the cluster of early cephamycin biosynthetic genes was cloned in lambda EMBL3 by hybridization with probes internal to the pcbAB and pcbC genes of Penicillium chrysogenum and Streptomyces griseus. The pcbAB and pcbC genes were found to be closely linked togeth...

    journal_title:Molecular microbiology

    pub_type: 杂志文章


    authors: Coque JJ,Martín JF,Calzada JG,Liras P

    更新日期:1991-05-01 00:00:00

  • FtsA reshapes membrane architecture and remodels the Z-ring in Escherichia coli.

    abstract::Cell division in prokaryotes initiates with assembly of the Z-ring at midcell, which, in Escherichia coli, is tethered to the inner leaflet of the cytoplasmic membrane through a direct interaction with FtsA, a widely conserved actin homolog. The Z-ring is comprised of polymers of tubulin-like FtsZ and has been suggest...

    journal_title:Molecular microbiology

    pub_type: 杂志文章


    authors: Conti J,Viola MG,Camberg JL

    更新日期:2018-02-01 00:00:00

  • Reverse transcriptase in bacteria.

    abstract::Reverse transcriptase, discovered in 1970 in retroviruses, has until recently been found only in eukaryotic organisms. Recently it was shown to occur in two groups of bacteria: myxobacteria and Escherichia coli. The gene for reverse transcriptase is part of a chromosomal genetic element that codes for the production o...

    journal_title:Molecular microbiology

    pub_type: 杂志文章,评审


    authors: Lim D,Maas WK

    更新日期:1989-08-01 00:00:00

  • Structure-function analysis of the LytM domain of EnvC, an activator of cell wall remodelling at the Escherichia coli division site.

    abstract::Proteins with LytM (Peptidase_M23) domains are broadly distributed in bacteria and have been implicated in a variety of important processes, including cell division and cell-shape determination. Most LytM-like proteins that have been structurally and/or biochemically characterized are metallo-endopeptidases that cleav...

    journal_title:Molecular microbiology

    pub_type: 杂志文章


    authors: Peters NT,Morlot C,Yang DC,Uehara T,Vernet T,Bernhardt TG

    更新日期:2013-08-01 00:00:00

  • Iron-reducing bacteria unravel novel strategies for the anaerobic catabolism of aromatic compounds.

    abstract::Although the aerobic degradation of aromatic compounds has been extensively studied in many microorganisms, the anaerobic mineralization of the aromatic ring is a more recently discovered microbial capacity on which very little information is available from facultative anaerobic bacteria. In this issue of Molecular Mi...

    journal_title:Molecular microbiology

    pub_type: 杂志文章


    authors: Carmona M,Díaz E

    更新日期:2005-12-01 00:00:00

  • Organization and regulation of the Corynebacterium glutamicum hom-thrB and thrC loci.

    abstract::The genes encoding the three terminal enzymes in the threonine biosynthetic pathway, homoserine dehydrogenase (hom), homoserine kinase (thrB) and threonine synthase (thrC) have been isolated from Corynebacterium glutamicum. The C. glutamicum hom and thrB genes were subcloned on a 3.6 kb SalI-generated chromosomal frag...

    journal_title:Molecular microbiology

    pub_type: 杂志文章


    authors: Follettie MT,Shin HK,Sinskey AJ

    更新日期:1988-01-01 00:00:00

  • A new piperidinol derivative targeting mycolic acid transport in Mycobacterium abscessus.

    abstract::The natural resistance of Mycobacterium abscessus to most commonly available antibiotics seriously limits chemotherapeutic treatment options, which is particularly challenging for cystic fibrosis patients infected with this rapid-growing mycobacterium. New drugs with novel molecular targets are urgently needed against...

    journal_title:Molecular microbiology

    pub_type: 杂志文章


    authors: Dupont C,Viljoen A,Dubar F,Blaise M,Bernut A,Pawlik A,Bouchier C,Brosch R,Guérardel Y,Lelièvre J,Ballell L,Herrmann JL,Biot C,Kremer L

    更新日期:2016-08-01 00:00:00

  • Characterization of a membrane-linked Ser/Thr protein kinase in Bacillus subtilis, implicated in developmental processes.

    abstract::PrkC was shown to be a eukaryotic-like (Hanks-type) protein kinase from Bacillus subtilis with a structural organization similar to that of the eukaryotic sensor Ser/Thr or Tyr kinases (e.g. the TGF beta or PDGF receptors). The molecule consists of a catalytic domain located in the cytoplasm, joined by a single transm...

    journal_title:Molecular microbiology

    pub_type: 杂志文章


    authors: Madec E,Laszkiewicz A,Iwanicki A,Obuchowski M,Séror S

    更新日期:2002-10-01 00:00:00

  • Streptomyces lividans 66 contains a gene for phage resistance which is similar to the phage lambda ea59 endonuclease gene.

    abstract::The DNA of wild-type Streptomyces lividans 66 is degraded during electrophoresis in buffers containing traces of ferrous iron. S. lividans ZX1, a mutant selected for resistance to DNA degradation, simultaneously became sensitive to phi HAU3, a wide-host-range temperate bacteriophage. A DNA fragment conferring phi HAU3...

    journal_title:Molecular microbiology

    pub_type: 杂志文章


    authors: Zhou X,Deng Z,Hopwood DA,Kieser T

    更新日期:1994-06-01 00:00:00

  • Structural and functional diversity among bacterial interspersed mosaic elements (BIMEs).

    abstract::Palindromic units (PU or REP) were defined as 40-nucleotide DNA sequences which are highly repeated in the genome of several members of the Enterobacteriaceae. They were shown to be a constituent of the bacterial interspersed mosaic element (BIME), in which they are associated with other repetitive sequences. We repor...

    journal_title:Molecular microbiology

    pub_type: 杂志文章


    authors: Bachellier S,Saurin W,Perrin D,Hofnung M,Gilson E

    更新日期:1994-04-01 00:00:00

  • Critical protective role of bacterial superoxide dismutase in rhizobium-legume symbiosis.

    abstract::In nitrogen-poor soils, rhizobia elicit nodule formation on legume roots, within which they differentiate into bacteroids that fix atmospheric nitrogen. Protection against reactive oxygen species (ROS) was anticipated to play an important role in Rhizobium-legume symbiosis because nitrogenase is extremely oxygen sensi...

    journal_title:Molecular microbiology

    pub_type: 杂志文章


    authors: Santos R,Hérouart D,Puppo A,Touati D

    更新日期:2000-11-01 00:00:00

  • Differential regulation of antibiotic biosynthesis by DraR-K, a novel two-component system in Streptomyces coelicolor.

    abstract::A novel two-component system (TCS) designated as DraR-K (sco3063/sco3062) was identified to be involved in differential regulation of antibiotic biosynthesis in Streptomyces coelicolor. The S. coelicolor mutants with deletion of either or both of draR and draK exhibited significantly reduced actinorhodin (ACT) but inc...

    journal_title:Molecular microbiology

    pub_type: 杂志文章


    authors: Yu Z,Zhu H,Dang F,Zhang W,Qin Z,Yang S,Tan H,Lu Y,Jiang W

    更新日期:2012-08-01 00:00:00

  • The purified Shigella IpaB and Salmonella SipB translocators share biochemical properties and membrane topology.

    abstract::An essential early event in Shigella and Salmonella pathogenesis is invasion of non-phagocytic intestinal epithelial cells. Pathogen entry is triggered by the delivery of multiple bacterial effector proteins into target mammalian cells. The Shigella invasion plasmid antigen B (IpaB), which inserts into the host plasma...

    journal_title:Molecular microbiology

    pub_type: 杂志文章


    authors: Hume PJ,McGhie EJ,Hayward RD,Koronakis V

    更新日期:2003-07-01 00:00:00

  • An atypical orthologue of 6-pyruvoyltetrahydropterin synthase can provide the missing link in the folate biosynthesis pathway of malaria parasites.

    abstract::Folate metabolism in malaria parasites is a long-standing, clinical target for chemotherapy and prophylaxis. However, despite determination of the complete genome sequence of the lethal species Plasmodium falciparum, the pathway of de novo folate biosynthesis remains incomplete, as no candidate gene for dihydroneopter...

    journal_title:Molecular microbiology

    pub_type: 杂志文章


    authors: Dittrich S,Mitchell SL,Blagborough AM,Wang Q,Wang P,Sims PF,Hyde JE

    更新日期:2008-02-01 00:00:00

  • The proper folding of a long C-terminal segment of the yeast Lys14p regulator is required for activation of LYS genes in response to the metabolic effector.

    abstract::Transcription of lysine genes in Saccharomyces cerevisiae is dependent on Lys14p and on alpha-aminoadipate semialdehyde (alphaAASA), an intermediate of the pathway. The two-thirds C-terminal end of Lys14p is sufficient to ensure the activation function of the protein and its modulation by alphaAASA. Here, we show that...

    journal_title:Molecular microbiology

    pub_type: 杂志文章


    authors: El Alami M,Feller A,Piérard A,Dubois E

    更新日期:2002-03-01 00:00:00

  • NAD+ binding to the Escherichia coli K(+)-uptake protein TrkA and sequence similarity between TrkA and domains of a family of dehydrogenases suggest a role for NAD+ in bacterial transport.

    abstract::The nucleotide sequence of trkA, a gene encoding a surface component of the constitutive K(+)-uptake systems TrkG and TrkH from Escherichia coli, was determined. The structure of the TrkA protein deduced from the nucleotide sequence accords with the view that TrkA is peripherally bound to the inner side of the cytopla...

    journal_title:Molecular microbiology

    pub_type: 杂志文章


    authors: Schlösser A,Hamann A,Bossemeyer D,Schneider E,Bakker EP

    更新日期:1993-08-01 00:00:00

  • Multicopy plasmid instability: the dimer catastrophe hypothesis.

    abstract::Multimer formation reduces plasmid copy number and is an established cause of segregational instability. Nevertheless, it is difficult to rationalize observations that low levels of dimers can cause severe instability, if we assume they are distributed evenly in cell populations. We report here that dimer distribution...

    journal_title:Molecular microbiology

    pub_type: 杂志文章


    authors: Summers DK,Beton CW,Withers HL

    更新日期:1993-06-01 00:00:00

  • Dual modes of membrane binding direct pore formation by Streptolysin O.

    abstract::Effector translocation is central to the virulence of many bacterial pathogens, including Streptococcus pyogenes, which utilizes the cholesterol-dependent cytolysin Streptolysin O (SLO) to translocate the NAD(+) glycohydrolase SPN into host cells during infection. SLO's translocation activity does not require host cel...

    journal_title:Molecular microbiology

    pub_type: 杂志文章


    authors: Mozola CC,Caparon MG

    更新日期:2015-09-01 00:00:00