Nitric oxide-sensitive and -insensitive interaction of Bacillus subtilis NsrR with a ResDE-controlled promoter.

abstract：:Quorum-sensing control of luminescence in Vibrio harveyi, which involves an indirect autoinducer-mediated phosphorelay signal transduction system, contrasts with the prototypical quorum-sensing system of Vibrio fischeri, in which the autoinducer and the transcriptional activator LuxR directly activate lux operon expre...

journal_title：Molecular microbiology

authors： Miyamoto CM,Dunlap PV,Ruby EG,Meighen EA

更新日期：2003-04-01 00:00:00

abstract：:The polA gene of Escherichia coli encodes DNA polymerase I that is involved in DNA replication and repair. Despite the wide knowledge about structure and function of DNA polymerase I, there is little insight into the regulatory mechanisms involved in polA expression. DnaA is the initiator protein for DNA replication i...

journal_title：Molecular microbiology

authors： Quiñones A,Wandt G,Kleinstäuber S,Messer W

更新日期：1997-03-01 00:00:00

abstract：:The chromosome of Escherichia coli K-12 contains a putative gene, yheB (chiA), at centisome 74.7, whose product shows sequence similarity with chitinases of bacterial and viral origin. We cloned the chiA (yheB) gene and demonstrated that it codes for a 94.5 kDa periplasmic protein with endochitinase/lysozyme activity....

journal_title：Molecular microbiology

authors： Francetic O,Badaut C,Rimsky S,Pugsley AP

更新日期：2000-03-01 00:00:00

abstract：:The surface of Trypanosoma brucei is covered by a dense coat of glycosylphosphatidylinositol-anchored glycoproteins. The major component is the variant surface glycoprotein (VSG) which is glycosylated by both paucimannose and oligomannose N-glycans. Surface glycans are poorly accessible and killing mediated by peptide...

journal_title：Molecular microbiology

authors： Castillo-Acosta VM,Vidal AE,Ruiz-Pérez LM,Van Damme EJ,Igarashi Y,Balzarini J,González-Pacanowska D

更新日期：2013-11-01 00:00:00

abstract：:The O-antigen of Salmonella lipopolysaccharide is a major antigenic determinant and its chemical composition forms the basis for Salmonella serotyping. Modifications of the O-antigen that can affect the serotype include those carried out by the products of glycosyltransferase operons (gtr), which are present on specif...

journal_title：Molecular microbiology

authors： Broadbent SE,Davies MR,van der Woude MW

更新日期：2010-07-01 00:00:00

abstract：:Natural competence in Streptococcus pneumoniae is regulated by a quorum-sensing mechanism consisting of a competence-stimulating peptide (CSP), its dedicated secretion apparatus (ComAB), its histidine kinase receptor (ComD) and a response regulator (ComE). In this report, we show that ComE is a DNA-binding protein tha...

journal_title：Molecular microbiology

authors： Ween O,Gaustad P,Håvarstein LS

更新日期：1999-08-01 00:00:00

abstract：:Polyadenylation is a universal post-transcriptional modification involved in degradation and quality control of bacterial RNAs. In Escherichia coli, it is admitted that any accessible RNA 3' end can be tagged by a poly(A) tail for decay. However, we do not have yet an overall view of the population of polyadenylated m...

journal_title：Molecular microbiology

authors： Maes A,Gracia C,Hajnsdorf E,Régnier P

更新日期：2012-01-01 00:00:00

abstract：:Escherichia coli RnlA-RnlB is a newly identified toxin-antitoxin (TA) system that plays a role in bacteriophage resistance. RnlA functions as a toxin with mRNA endoribonuclease activity and the cognate antitoxin RnlB inhibits RnlA toxicity in E. coli cells. Interestingly, T4 phage encodes the antitoxin Dmd, which acts...

journal_title：Molecular microbiology

authors： Wei Y,Gao ZQ,Otsuka Y,Naka K,Yonesaki T,Zhang H,Dong YH

更新日期：2013-12-01 00:00:00

abstract：:Enteropathogenic Escherichia coli (EPEC) elicit changes in host cell morphology and cause actin rearrangement, a phenotype that has commonly been referred to as attaching/effacing (AE) lesions. The ability of EPEC to induce AE lesions is dependent upon a type III protein secretion/translocation system that is encoded ...

journal_title：Molecular microbiology

authors： Friedberg D,Umanski T,Fang Y,Rosenshine I

更新日期：1999-12-01 00:00:00

abstract：:The haemolytic activity of Serratia marcescens is determined by two proteins, ShlA and ShlB. ShlA integrates into the erythrocyte membrane and causes osmotic lysis through channel formation. The conformation of ShlA and its interaction with erythrocyte membranes were studied by determining the cleavage of ShlA by adde...

journal_title：Molecular microbiology

authors： Schiebel E,Braun V

更新日期：1989-03-01 00:00:00

abstract：:Ail, a multifunctional outer membrane protein of Yersinia pestis, confers cell binding, Yop delivery and serum resistance activities. Resistance to complement proteins in serum is critical for the survival of Y. pestis during the septicemic stage of plague infections. Bacteria employ a variety of tactics to evade the ...

journal_title：Molecular microbiology

authors： Thomson JJ,Plecha SC,Krukonis ES

更新日期：2019-01-01 00:00:00

abstract：:A region of 7.8 kb of the plasmid pMB2 from Enterococcus faecalis S-48 carrying the information necessary for production and immunity of the peptide antibiotic AS-48 has been cloned and sequenced. It contains the as-48A structural gene plus five open reading frames (as-48B, as-48C, as-48C1, as-48D and as-48D1). Beside...

journal_title：Molecular microbiology

authors： Martínez-Bueno M,Valdivia E,Gálvez A,Coyette J,Maqueda M

更新日期：1998-01-01 00:00:00

abstract：:During a normal cell cycle, chromosomes are exposed to many biochemical reactions that require specific types of DNA movement. Separation forces move replicated chromosomes into separate sister cell compartments during cell division, and the contemporaneous acts of DNA replication, RNA transcription and cotranscriptio...

journal_title：Molecular microbiology

authors： Deng S,Stein RA,Higgins NP

更新日期：2005-09-01 00:00:00

abstract：:Protein quality control and proteolysis are involved in cell maintenance and environmental acclimatization in bacteria and eukaryotes. The AAA protease FtsH2 of the cyanobacterium Synechocystis sp. PCC 6803 was identified during a screening for mutants impaired in osmoregulation. The ftsH2(-) mutant was salt sensitive...

journal_title：Molecular microbiology

authors： Stirnberg M,Fulda S,Huckauf J,Hagemann M,Krämer R,Marin K

更新日期：2007-01-01 00:00:00

abstract：:The group A streptococcus (GAS) causes a variety of human diseases, including toxic shock syndrome and necrotizing fasciitis, which are both associated with significant mortality. Even the superficial self-limiting diseases caused by GAS, such as pharyngitis, impose a significant economic burden on society. GAS can ca...

journal_title：Molecular microbiology

authors： Churchward G

更新日期：2007-04-01 00:00:00

abstract：:Elevated expression of the plasma membrane drug efflux pump proteins Cdr1p and Cdr2p was shown to accompany decreased azole susceptibility in Candida albicans clinical isolates. DNA sequence analysis revealed extensive allelic heterozygosity, particularly of CDR2. Cdr2p alleles showed different abilities to transport ...

journal_title：Molecular microbiology

authors： Holmes AR,Tsao S,Ong SW,Lamping E,Niimi K,Monk BC,Niimi M,Kaneko A,Holland BR,Schmid J,Cannon RD

更新日期：2006-10-01 00:00:00

abstract：:The conserved cAMP-dependent protein kinase (PKA) plays critical roles in the regulation of morphological transitions and virulence in the human fungal pathogen Candida albicans. It has long been thought that the PKA catalytic subunit is essential for cell viability in this fungus. Paradoxically, the single adenylyl c...

journal_title：Molecular microbiology

authors： Cao C,Wu M,Bing J,Tao L,Ding X,Liu X,Huang G

更新日期：2017-07-01 00:00:00

abstract：:A number of strains of the widespread aerobic soil bacterium, Bacillus sphaericus, possess crystalline inclusions of a toxin lethal to a variety of insect (larvae) which are vectors of major tropical diseases. Partial amino acid sequence data from one strain, B. sphaericus 2362 have permitted us to design oligonucleot...

journal_title：Molecular microbiology

authors： Hindley J,Berry C

更新日期：1987-09-01 00:00:00

abstract：:Bacterial autotransporters consist of an N-terminal 'passenger domain' that is transported into the extracellular space by an unknown mechanism and a C-terminal 'beta-domain' that forms a beta-barrel in the outer membrane. Recent studies have revealed that fully assembled autotransporters have an unusual architecture ...

journal_title：Molecular microbiology

authors： Ieva R,Skillman KM,Bernstein HD

更新日期：2008-01-01 00:00:00

abstract：:Glutaredoxins and thioredoxins are small heat-stable oxidoreductases that have been conserved throughout evolution. The yeast Saccharomyces cerevisiae contains two gene pairs encoding cytoplasmic glutaredoxins (GRX1, GRX2) and thioredoxins (TRX1, TRX2). We report here that the quadruple trx1 trx2 grx1 grx2 mutant is i...

journal_title：Molecular microbiology

authors： Draculic T,Dawes IW,Grant CM

更新日期：2000-06-01 00:00:00

abstract：:Factors that enhance the transmission of pathogens are poorly understood. We show that Vibrio cholerae shed in human 'rice-water' stools have a 10-fold lower oral infectious dose in an animal model than in vitro grown V. cholerae, which may aid in transmission during outbreaks. Furthermore, we identify a bacterial fac...

journal_title：Molecular microbiology

authors： Butler SM,Nelson EJ,Chowdhury N,Faruque SM,Calderwood SB,Camilli A

更新日期：2006-04-01 00:00:00

abstract：:The Escherichia coli nusG gene product is required for transcription termination by phage HK022 Nun protein at the lambda nutR site in vivo. We show that it is also essential for Nun termination at lambda nutL. Three recessive mis-sense nusG mutations have been isolated that inhibit termination by Nun at lambda nutR. ...

journal_title：Molecular microbiology

authors： Burova E,Hung SC,Chen J,Court DL,Zhou JG,Mogilnitskiy G,Gottesman ME

更新日期：1999-03-01 00:00:00

abstract：:A complete understanding of host-parasite interactions must necessarily include the identification and characterization of gene products expressed by both parties during the infectious process. We have developed a new screen to identify bacterial genes that are transcriptionally induced during infection of a host anim...

journal_title：Molecular microbiology

authors： Camilli A,Mekalanos JJ

更新日期：1995-11-01 00:00:00

abstract：:A challenge common to all bacterial pathogens is to acquire nutrients from hostile host environments. Iron is an important cofactor required for essential cellular processes such as DNA repair, energy production and redox balance. Within a mammalian host, most iron is sequestered within heme, which in turn is predomin...

journal_title：Molecular microbiology

authors： Clark J,Terwilliger A,Nguyen C,Green S,Nobles C,Maresso A

更新日期：2019-08-01 00:00:00

abstract：:The best studied role of ubiquitination is to mark proteins for destruction by the proteasome but, in addition, it has recently been shown to promote macromolecular assembly and function, and alter protein function, thus playing a regulatory role distinct from protein degradation. Deubiquinating enzymes, the ubiquitin...

journal_title：Molecular microbiology

authors： Lockington RA,Kelly JM

更新日期：2001-06-01 00:00:00

abstract：:pAM beta 1 is a low-copy-number, promiscuous plasmid from Gram-positive bacteria that replicates by a unidirectional theta-type mode. Its replication is initiated by an original mechanism, involving the positive rate-limiting RepE protein. Here we show that the pAM beta 1-encoded CopF protein is involved in negative r...

journal_title：Molecular microbiology

authors： Le Chatelier E,Ehrlich SD,Jannière L

更新日期：1994-11-01 00:00:00

abstract：:HM-1:IMSS, a pathogenic strain of Entamoeba histolytica, and its mutant BG-3, identified by resistance to cytochalasin D, were tested for their capacity to: (i) secrete electron-dense granules; (ii) adhere and digest native type I collagen gels; and (iii) produce liver abscesses in new-born hamsters. The results demon...

journal_title：Molecular microbiology

authors： Serrano JJ,de la Garza M,Moreno MA,Tovar R,León G,Tsutsumi V,Muñoz ML

更新日期：1994-02-01 00:00:00

abstract：:Bacteria use quorum-sensing signals or autoinducers to communicate. The signals in Gram-positive bacteria are often peptides activated by proteolytic removal of an N-terminal leader sequence. While investigating stimulation of antimicrobial peptide production by the Streptococcus mutans synthetic competence stimulatin...

journal_title：Molecular microbiology

authors： Petersen FC,Fimland G,Scheie AA

更新日期：2006-09-01 00:00:00

abstract：:Staphylococcus aureus is a leading cause of infective endocarditis (IE). Platelet activation promoted by S. aureus resulting in aggregation and thrombus formation is an important step in the pathogenesis of IE. Here, we report that the fibrinogen/fibronectin-binding proteins FnBPA and FnBPB are major platelet-activati...

journal_title：Molecular microbiology

authors： Fitzgerald JR,Loughman A,Keane F,Brennan M,Knobel M,Higgins J,Visai L,Speziale P,Cox D,Foster TJ

更新日期：2006-01-01 00:00:00

abstract：:In the corn smut fungus Ustilago maydis, pathogenic development is controlled by the b mating type locus that encodes the two homeodomain proteins bE and bW. A heterodimer of bE and bW controls a large set of genes, either directly by binding to cis regulatory sequences or indirectly via a b-dependent regulatory casca...

journal_title：Molecular microbiology

authors： Reichmann M,Jamnischek A,Weinzierl G,Ladendorf O,Huber S,Kahmann R,Kämper J

更新日期：2002-11-01 00:00:00