Abstract:
:During a normal cell cycle, chromosomes are exposed to many biochemical reactions that require specific types of DNA movement. Separation forces move replicated chromosomes into separate sister cell compartments during cell division, and the contemporaneous acts of DNA replication, RNA transcription and cotranscriptional translation of membrane proteins cause specific regions of DNA to twist, writhe and expand or contract. Recent experiments indicate that a dynamic and stochastic mechanism creates supercoil DNA domains soon after DNA replication. Domain structure is subsequently reorganized by RNA transcription. Examples of transcription-dependent chromosome remodelling are also emerging from eukaryotic cell systems.
journal_name
Mol Microbioljournal_title
Molecular microbiologyauthors
Deng S,Stein RA,Higgins NPdoi
10.1111/j.1365-2958.2005.04796.xsubject
Has Abstractpub_date
2005-09-01 00:00:00pages
1511-21issue
6eissn
0950-382Xissn
1365-2958pii
MMI4796journal_volume
57pub_type
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