Abstract：
:Bacteria use quorum-sensing signals or autoinducers to communicate. The signals in Gram-positive bacteria are often peptides activated by proteolytic removal of an N-terminal leader sequence. While investigating stimulation of antimicrobial peptide production by the Streptococcus mutans synthetic competence stimulating peptide signal (21-CSP), we found a peptide similar to the 21-CSP, but lacking the three C-terminal amino acid residues (18-CSP). The 18-CSP was more potent in inducing competence, biofilm formation, and antimicrobial activity than the 21-CSP. Our results indicate that cleavage of the three C-terminal residues occurred post export, and was not regulated by the CSP-signalling system. Deletion of comD encoding the CSP receptor abolished the competence and biofilm responses to the 21-CSP and the 18-CSP, suggesting that signal transduction via the ComD receptor is involved in the responses to both CSPs. In S. mutans GS5, beside the 18-CSP we also purified to homogeneity a two-peptide bacteriocin which production was stimulated by the 18-CSP and the 21-CSP. Partial sequence of the two-peptide bacteriocin revealed the product of the smbAB genes recently described. We found that the peptide SmbB was slightly different from the deduced sequence, and confirmed the prediction that both peptides constituting SmbAB bacteriocin are post-translationally modified. SmbAB exhibited antimicrobial activity against 11 species of streptococci, Enterococcus faecalis and Staphylocococcus epidermidis. Taken together, the findings support the involvement of the CSP response in bacteriocin production by streptococci and suggest a novel strategy to potentiate autoinducer activity.
journal_name
Mol Microbioljournal_title
Molecular microbiologyauthors
Petersen FC,Fimland G,Scheie AAdoi
10.1111/j.1365-2958.2006.05312.xsubject
Has Abstractpub_date
2006-09-01 00:00:00pages
1322-34issue
5eissn
0950-382Xissn
1365-2958pii
MMI5312journal_volume
61pub_type
杂志文章abstract：:RNA secondary structure is important in a wide variety of biological processes, but relatively little is known about the pathways and kinetics of RNA folding. When the IS10 transposase (tnp) gene is transcribed from a promoter outside the element, little increase in tnp expression is observed. This protection from out...
journal_title：Molecular microbiology
pub_type： 杂志文章
doi：10.1111/j.1365-2958.1994.tb01337.x
更新日期：1994-12-01 00:00:00
abstract：:Interactions between domains of ATP-binding cassette (ABC) transporters are of great functional importance and yet are poorly understood. To gain further knowledge of these protein-protein interactions, we studied the inner membrane complex of the maltose transporter of Escherichia coli. We focused on interactions bet...
journal_title：Molecular microbiology
pub_type： 杂志文章
doi：10.1046/j.1365-2958.1998.01070.x
更新日期：1998-10-01 00:00:00
abstract：:Photoregulation of pigmentation during complementary chromatic acclimation (CCA) is well studied in Fremyella diplosiphon; however, mechanistic insights into the CCA-associated morphological changes are still emerging. F. diplosiphon cells are rectangular under green light (GL), whereas cells are smaller and spherical...
journal_title：Molecular microbiology
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journal_title：Molecular microbiology
pub_type： 杂志文章
doi：10.1111/j.1365-2958.2006.05417.x
更新日期：2006-11-01 00:00:00
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journal_title：Molecular microbiology
pub_type： 杂志文章
doi：10.1111/j.1365-2958.2007.06020.x
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journal_title：Molecular microbiology
pub_type： 杂志文章
doi：10.1111/mmi.12885
更新日期：2015-03-01 00:00:00
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journal_title：Molecular microbiology
pub_type： 杂志文章,评审
doi：10.1111/j.1365-2958.2012.08131.x
更新日期：2012-08-01 00:00:00
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journal_title：Molecular microbiology
pub_type： 杂志文章
doi：10.1046/j.1365-2958.1998.00968.x
更新日期：1998-07-01 00:00:00
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journal_title：Molecular microbiology
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更新日期：1997-09-01 00:00:00
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pub_type： 杂志文章
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更新日期：1999-07-01 00:00:00
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journal_title：Molecular microbiology
pub_type： 杂志文章
doi：10.1111/j.1365-2958.2005.04740.x
更新日期：2005-08-01 00:00:00
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journal_title：Molecular microbiology
pub_type： 杂志文章
doi：10.1111/mmi.13071
更新日期：2015-09-01 00:00:00
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journal_title：Molecular microbiology
pub_type： 杂志文章
doi：10.1111/j.1365-2958.2004.04154.x
更新日期：2004-07-01 00:00:00
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journal_title：Molecular microbiology
pub_type： 杂志文章
doi：10.1046/j.1365-2958.1998.00797.x
更新日期：1998-05-01 00:00:00
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pub_type： 杂志文章
doi：10.1046/j.1365-2958.2002.03147.x
更新日期：2002-10-01 00:00:00
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journal_title：Molecular microbiology
pub_type： 杂志文章
doi：10.1111/j.1365-2958.1991.tb00738.x
更新日期：1991-03-01 00:00:00
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journal_title：Molecular microbiology
pub_type： 杂志文章,评审
doi：10.1111/j.1365-2958.1989.tb00264.x
更新日期：1989-08-01 00:00:00
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pub_type： 杂志文章
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journal_title：Molecular microbiology
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journal_title：Molecular microbiology
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更新日期：2012-04-01 00:00:00
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journal_title：Molecular microbiology
pub_type： 杂志文章,评审
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journal_title：Molecular microbiology
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journal_title：Molecular microbiology
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更新日期：1997-10-01 00:00:00
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journal_title：Molecular microbiology
pub_type： 杂志文章
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更新日期：2008-06-01 00:00:00
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journal_title：Molecular microbiology
pub_type： 杂志文章,评审
doi：10.1046/j.1365-2958.1998.00652.x
更新日期：1998-01-01 00:00:00
