Abstract:
:The Streptomyces wild-type chromosome is linear in all examples studied. The ends of the chromosome or telomeres consist of terminal inverted repeats of various sizes with proteins covalently bound to their 5' ends. The chromosome is very unstable and undergoes very large deletions spontaneously at rates higher than 0.1% of spores. Frequently, the telomeres are included in the deletions. Loss of both telomeres leads to circularization of the chromosome. The wild-type chromosome can also be circularized artificially by targeted recombination. Spontaneously or artificially circularized chromosomes are even more unstable than the linear ones. High-copy-number tandem amplifications of specific chromosomal regions are frequently associated with the deletions. RecA seems to be involved in the amplification mechanism and control of genetic instability.
journal_name
Mol Microbioljournal_title
Molecular microbiologyauthors
Volff JN,Altenbuchner Jdoi
10.1046/j.1365-2958.1998.00652.xsubject
Has Abstractpub_date
1998-01-01 00:00:00pages
239-46issue
2eissn
0950-382Xissn
1365-2958journal_volume
27pub_type
杂志文章,评审abstract::Almost all bacterial genomes contain DNA of viral origin, including functional prophages or degenerated phage elements. A frequent but often unnoted phenomenon is the spontaneous induction of prophage elements (SPI) even in the absence of an external stimulus. In this study, we have analyzed SPI of the large, degenera...
journal_title:Molecular microbiology
pub_type: 杂志文章
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更新日期:2004-04-01 00:00:00
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更新日期:1990-11-01 00:00:00
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更新日期:1993-11-01 00:00:00
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journal_title:Molecular microbiology
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更新日期:1998-08-01 00:00:00
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更新日期:2002-02-01 00:00:00
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更新日期:1994-03-01 00:00:00
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更新日期:2001-03-01 00:00:00
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