Apoptosis in yeast--mechanisms and benefits to a unicellular organism.

Abstract:

:Initial observations that the budding yeast Saccharomyces cerevisiae can be induced to undergo a form of cell death exhibiting typical markers of apoptosis has led to the emergence of a thriving new field of research. Since this discovery, a number of conserved pro- and antiapoptotic proteins have been identified in yeast. Indeed, early experiments have successfully validated yeasts as a powerful genetic tool with which to investigate mechanisms of apoptosis. However, we still have little understanding as to why programmes of cell suicide exist in unicellular organisms and how they may be benefit such organisms. Recent research has begun to elucidate pathways that regulate yeast apoptosis in response to environmental stimuli. These reports strengthen the idea that physiologically relevant mechanisms of programmed cell death are present, and that these function as important regulators of yeast cell populations.

journal_name

Mol Microbiol

journal_title

Molecular microbiology

authors

Gourlay CW,Du W,Ayscough KR

doi

10.1111/j.1365-2958.2006.05486.x

subject

Has Abstract

pub_date

2006-12-01 00:00:00

pages

1515-21

issue

6

eissn

0950-382X

issn

1365-2958

pii

MMI5486

journal_volume

62

pub_type

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