Specificity and selectivity determinants of peptide transport in Lactococcus lactis and other microorganisms.

abstract：:Osmoregulatory mutants of Saccharomyces cerevisiae with a defect in their capacity to readjust the cell volume/buoyant density after osmotically induced dehydration were enriched by density gradient centrifugation. Colonies derived from cells that remained dense after dehydration were screened for sensitivity to high ...

journal_title：Molecular microbiology

authors： Larsson K,Ansell R,Eriksson P,Adler L

更新日期：1993-12-01 00:00:00

abstract：:The Escherichia coli treA gene encodes an osmotically inducible periplasmic trehalase. A strain carrying a treA-lacZ transcriptional fusion was constructed. The beta-galactosidase activity produced in this strain growing exponentially in a medium of high osmotic pressure was 10-fold higher than that produced in a medi...

journal_title：Molecular microbiology

authors： Repoila F,Gutierrez C

更新日期：1991-03-01 00:00:00

abstract：:The lipoprotein Lpp is the most numerically abundant protein in Escherichia coli, has been investigated for over 40 years, and has served as the paradigmatic bacterial lipoprotein since its initial discovery. It exists in two distinct forms: a 'bound-form', which is covalently bound to the cell's peptidoglycan layer, ...

journal_title：Molecular microbiology

authors： Cowles CE,Li Y,Semmelhack MF,Cristea IM,Silhavy TJ

更新日期：2011-03-01 00:00:00

abstract：:CTXphi is a filamentous phage that encodes cholera toxin, one of the principal virulence factors of Vibrio cholerae. CTXphi is unusual among filamentous phages because it can either replicate as a plasmid or integrate into the V. cholerae chromosome at a specific site. The CTXphi genome has two regions, the 'core' and...

journal_title：Molecular microbiology

authors： Waldor MK,Rubin EJ,Pearson GD,Kimsey H,Mekalanos JJ

更新日期：1997-06-01 00:00:00

abstract：:The Pseudomonas aeruginosa algD gene is the first gene of an operon encoding most of the enzymes necessary for biosynthesis of the exopolysaccharide alginate. Transcriptional activation of algD results in the high-level synthesis of alginate, an important P. aeruginosa virulence factor with antiphagocytic and adherenc...

journal_title：Molecular microbiology

authors： Baynham PJ,Brown AL,Hall LL,Wozniak DJ

更新日期：1999-09-01 00:00:00

abstract：:SigD and SigE (Salmonella invasion gene) are proteins needed for optimal invasion of Salmonella typhimurium into eukaryotic cells in vitro. SigD is a secreted protein and SigE is a putative chaperone required for SigD stability and/or secretion. SigD is secreted by a type III secretion apparatus encoded within a patho...

journal_title：Molecular microbiology

authors： Darwin KH,Miller VL

更新日期：2000-02-01 00:00:00

abstract：:The regulation of gene expression by the two-component regulatory system PhoP/PhoQ is necessary for Salmonella typhimurium survival within macrophages, defensin resistance, acid resistance, and murine typhoid fever pathogenesis. Salmonella experience multiple environments during mammalian infection and survival requir...

journal_title：Molecular microbiology

authors： Miller SI

更新日期：1991-09-01 00:00:00

abstract：:The polA gene of Escherichia coli encodes DNA polymerase I that is involved in DNA replication and repair. Despite the wide knowledge about structure and function of DNA polymerase I, there is little insight into the regulatory mechanisms involved in polA expression. DnaA is the initiator protein for DNA replication i...

journal_title：Molecular microbiology

authors： Quiñones A,Wandt G,Kleinstäuber S,Messer W

更新日期：1997-03-01 00:00:00

abstract：:The major anionic phospholipids of Escherichia coli, phosphatidylglycerol (PG) and cardiolipin (CL), have been considered to be indispensable for essential cellular functions, such as the initiation of DNA replication and translocation of proteins across the cytoplasmic membrane. However, we successfully constructed a...

journal_title：Molecular microbiology

authors： Matsumoto K

更新日期：2001-03-01 00:00:00

abstract：:Photorhabdus are bacteria found colonizing the gut of a specialized stage of the nematode Heterorhabditis, called the infective juvenile (IJ). The IJ is a free-living stage of the nematode that seeks out and infects insect larvae. Once inside the insect the IJ release Photorhabdus into the haemolymph where the bacteri...

journal_title：Molecular microbiology

authors： Watson RJ,Joyce SA,Spencer GV,Clarke DJ

更新日期：2005-05-01 00:00:00

abstract：:Motile bacteria sense their physical and chemical environment through highly cooperative, ordered arrays of chemoreceptors. These signalling complexes phosphorylate a response regulator which in turn governs flagellar motor reversals, driving cells towards favourable environments. The structural changes that translate...

journal_title：Molecular microbiology

authors： Briegel A,Ames P,Gumbart JC,Oikonomou CM,Parkinson JS,Jensen GJ

更新日期：2013-09-01 00:00:00

abstract：:Conjugative transfer of toxin and antibiotic resistance plasmids in Clostridium perfringens is mediated by the tcp conjugation locus. Surprisingly, neither a relaxase gene nor an origin of transfer (oriT) has been identified on these plasmids, which are typified by the 47 kb tetracycline resistance plasmid pCW3. The t...

journal_title：Molecular microbiology

authors： Wisniewski JA,Traore DA,Bannam TL,Lyras D,Whisstock JC,Rood JI

更新日期：2016-03-01 00:00:00

abstract：:Various features of the regulation of pathways for biodegradation of recalcitrant compounds by Pseudomonas provide insights into the mechanisms by which operons evolve to acquire conditionally active promoters that permit the corresponding genes to be transcribed only when required. The "regulatory noise hypothesis' p...

journal_title：Molecular microbiology

authors： de Lorenzo V,Pérez-Martín J

更新日期：1996-03-01 00:00:00

abstract：:Cytoadhesion of infected red blood cells (iRBC) is mediated through parasite-encoded, clonally variant surface antigens (VSA) and is a central process in the pathogenesis of Plasmodium falciparum malaria. Pregnancy-associated malaria (PAM) has been linked to VSA-mediated adhesion of iRBC to the glycosaminoglycan chond...

journal_title：Molecular microbiology

authors： Salanti A,Staalsoe T,Lavstsen T,Jensen AT,Sowa MP,Arnot DE,Hviid L,Theander TG

更新日期：2003-07-01 00:00:00

abstract：:Quinone-based compounds have been exploited to treat infectious diseases and cancer, with such chemicals often functioning as inhibitors of key metabolic pathways or as prodrugs. Here, we screened an aziridinyl 1,4-benzoquinone (ABQ) library against the causative agents of trypanosomiasis, and cutaneous leishmaniasis,...

journal_title：Molecular microbiology

authors： Meredith EL,Kumar A,Konno A,Szular J,Alsford S,Seifert K,Horn D,Wilkinson SR

更新日期：2017-10-01 00:00:00

abstract：:Having no known environmental reservoir, Streptococcus pyogenes, a bacterium responsible for a wider variety of human diseases than any other bacterial species, must rely on its host for metabolic substrates. Although a streptococcal aldolase, LacD.1, has been adapted to virulence gene regulation, both LacD.1 and a pa...

journal_title：Molecular microbiology

authors： Loughman JA,Caparon MG

更新日期：2007-04-01 00:00:00

abstract：:We have isolated RNA polymerase from Mycobacterium smegmatis and established conditions for specific transcription initiation in vitro. The M. smegmatis enzyme has a strong dependence on supercoiling of the DNA substrate for transcription from mycobacterial promoters. We also show that RNA polymerase is the target for...

journal_title：Molecular microbiology

authors： Levin ME,Hatfull GF

更新日期：1993-04-01 00:00:00

abstract：:In mammalian cells RACK1 serves as a scaffold protein that has a role in integrating inputs from different signalling pathways and affects translation through association with ribosomes. Ustilago maydis contains a seven-WD40 repeat motif protein designated Rak1, which shows 68% identity to RACK1 and 51% identity to As...

journal_title：Molecular microbiology

authors： Wang L,Berndt P,Xia X,Kahnt J,Kahmann R

更新日期：2011-09-01 00:00:00

abstract：:Dimerization and inactivation of ribosomes in Escherichia coli is a two-step process that involves the binding of ribosome modulation factor (RMF) and hibernation promotion factor (HPF). Lactococcus lactis MG1363 expresses a protein, YfiA(L) (l) , which associates with ribosomes in the stationary phase of growth and i...

journal_title：Molecular microbiology

authors： Puri P,Eckhardt TH,Franken LE,Fusetti F,Stuart MC,Boekema EJ,Kuipers OP,Kok J,Poolman B

更新日期：2014-01-01 00:00:00

abstract：:In this study, we followed the genomic, lipidomic and metabolomic changes associated with the selection of miltefosine (MIL) resistance in two clinically derived Leishmania donovani strains with different inherent resistance to antimonial drugs (antimony sensitive strain Sb-S; and antimony resistant Sb-R). MIL-R was e...

journal_title：Molecular microbiology

authors： Shaw CD,Lonchamp J,Downing T,Imamura H,Freeman TM,Cotton JA,Sanders M,Blackburn G,Dujardin JC,Rijal S,Khanal B,Illingworth CJ,Coombs GH,Carter KC

更新日期：2016-03-01 00:00:00

abstract：:In Escherichia coli the flagellar regulon consists of more than 60 genes organized in three hierarchically and temporally regulated transcriptional classes. The flagellar sigma factor FliA (sigma(28)) is responsible for class 3 expression and, in the early phase of flagellar assembly, is inhibited by its anti-sigma fa...

journal_title：Molecular microbiology

authors： Barembruch C,Hengge R

更新日期：2007-07-01 00:00:00

abstract：:The pathogenicity of Plasmodium falciparum is partly due to parasite-induced host cell modifications. These modifications are facilitated by exported P. falciparum proteins, collectively referred to as the exportome. Export of several hundred proteins is mediated by the PEXEL/HT, a protease cleavage site. The PEXEL/HT...

journal_title：Molecular microbiology

authors： Schulze J,Kwiatkowski M,Borner J,Schlüter H,Bruchhaus I,Burmester T,Spielmann T,Pick C

更新日期：2015-07-01 00:00:00

abstract：:RpoS, an alternative primary sigma factor, has been shown to be regulated at multiple levels, including transcription, translation and protein stability. Here, we present evidence that suggests that RpoS is regulated at yet another level by the product of the crl gene. The crl gene was first thought to encode the majo...

journal_title：Molecular microbiology

authors： Pratt LA,Silhavy TJ

更新日期：1998-09-01 00:00:00

abstract：:The translational roles of the Shine-Dalgarno sequence, the initiation codon, the space between them, and the second codon have been studied. The Shine-Dalgarno sequence UAAGGAGG initiated translation roughly four times more efficiently than did the shorter AAGGA sequence. Each Shine-Dalgarno sequence required a minim...

journal_title：Molecular microbiology

authors： Ringquist S,Shinedling S,Barrick D,Green L,Binkley J,Stormo GD,Gold L

更新日期：1992-05-01 00:00:00

abstract：:Photorhabdus and Xenorhabdus bacteria colonize the intestines of the infective soil-dwelling stage of entomophagous nematodes, Heterorhabditis and Steinernema, respectively. These nematodes infect susceptible insect larvae and release the bacteria into the insect blood. The bacteria kill the insect larvae and convert ...

journal_title：Molecular microbiology

authors： Goodrich-Blair H,Clarke DJ

更新日期：2007-04-01 00:00:00

abstract：:Strains of Rhizobium leguminosarum biovar viciae specifically make an abundant protein (Rhi) in free-living culture but not in bacteroids. Genes needed for Rhi synthesis are on a Sym plasmid and here we show that one of these genes, rhiA, is the structural gene that specifies this polypeptide. Transcription of rhiA re...

journal_title：Molecular microbiology

authors： Economou A,Hawkins FK,Downie JA,Johnston AW

更新日期：1989-01-01 00:00:00

abstract：:The tetA(L) gene of Bacillus subtilis encodes a transmembrane protein that can function as a Tc-metal/H+ antiporter, conferring low-level resistance to tetracycline. The TetA(L) coding sequence is preceded by a leader region that contains a 20-amino-acid open reading frame and an appropriately spaced ribosome binding ...

journal_title：Molecular microbiology

authors： Stasinopoulos SJ,Farr GA,Bechhofer DH

更新日期：1998-12-01 00:00:00

abstract：:The best studied role of ubiquitination is to mark proteins for destruction by the proteasome but, in addition, it has recently been shown to promote macromolecular assembly and function, and alter protein function, thus playing a regulatory role distinct from protein degradation. Deubiquinating enzymes, the ubiquitin...

journal_title：Molecular microbiology

authors： Lockington RA,Kelly JM

更新日期：2001-06-01 00:00:00

abstract：:Francisella tularensis are the causative agent of the zoonotic disease, tularaemia. Among four F. tularensis subspecies, ssp. novicida (F. novicida) is pathogenic only for immunocompromised individuals, while all four subspecies are pathogenic for mice. This study utilized proteomic and bioinformatic approaches to ide...

journal_title：Molecular microbiology

authors： Hager AJ,Bolton DL,Pelletier MR,Brittnacher MJ,Gallagher LA,Kaul R,Skerrett SJ,Miller SI,Guina T

更新日期：2006-10-01 00:00:00

abstract：:The cytokinetic apparatus of bacteria is initially formed by the polymerization of the tubulin-like FtsZ protein into a ring structure at midcell. This so-called Z-ring facilitates the recruitment of many additional proteins to the division site to form the mature divisome machine. Although the assembly pathway leadin...

journal_title：Molecular microbiology

authors： Tsang MJ,Bernhardt TG

更新日期：2015-03-01 00:00:00