Abstract:
:The human fungal pathogen Candida albicans switches its morphology from yeast to hyphal forms. The morphological transition may render C. albicans virulent. Several signaling cascades, including those of the cyclic AMP-protein kinase A and mitogen-activated protein kinase pathways, are responsible for morphogenesis. In this study, we observed a reduction in gene transcription of ribosomal proteins during true hyphae formation. Moreover, morphogenesis-dependent decrease in ribosomal protein gene transcription was confirmed in constitutive yeast or filamentous growing strains. We consistently observed that polysome and monosome levels were decreased by hyphal stimuli through TORC1 and Sch9 kinases. Taken together, these results provide several lines of evidence to show that the Tor1-Sch9 kinase cascade, which stimulates transcription of ribosomal protein genes, exists in C. albicans. Thus, the present study revealed a novel link between ribosome biogenesis and morphogenesis in C. albicans that is mediated by Tor1 and Sch9.
journal_name
Mol Microbioljournal_title
Molecular microbiologyauthors
Kim SW,Joo YJ,Chun YJ,Park YK,Kim Jdoi
10.1111/mmi.14346subject
Has Abstractpub_date
2019-09-01 00:00:00pages
1041-1057issue
3eissn
0950-382Xissn
1365-2958journal_volume
112pub_type
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