The frequency of expression of pyelonephritis-associated pili is under regulatory control.

abstract：:Differential gene expression is a key strategy adopted by the Lyme disease spirochaete, Borrelia burgdorferi, for adaptation and survival in the mammalian host and the tick vector. Many B. burgdorferi surface lipoproteins fall into two distinct groups according to their expression patterns: one group primarily express...

journal_title：Molecular microbiology

authors： Wang P,Dadhwal P,Cheng Z,Zianni MR,Rikihisa Y,Liang FT,Li X

更新日期：2013-09-01 00:00:00

abstract：:SpollE is an integral membrane protein that governs the establishment of cell-specific gene transcription during the process of sporulation in Bacillus subtilis. Synthesis of SpollE commences shortly after the onset of sporulation, after which the protein localizes at sites of potential cell division near both ends of...

journal_title：Molecular microbiology

authors： Levin PA,Losick R,Stragier P,Arigoni F

更新日期：1997-09-01 00:00:00

abstract：:Induction of the sugar-phosphate transport system in Escherichia coli by external glucose-6-phosphate is regulated by the UhpABC regulatory proteins. UhpA protein is required for uhpT transcription and is related to response regulators of two-component regulatory systems. UhpA and its homologues appear to be composed ...

journal_title：Molecular microbiology

authors： Webber CA,Kadner RJ

更新日期：1995-03-01 00:00:00

abstract：:9 alpha-Hydroxylation of 4-androstene-3,17-dione (AD) and 1,4-androstadiene-3,17-dione (ADD) is catalysed by 3-ketosteroid 9 alpha-hydroxylase (KSH), a key enzyme in microbial steroid catabolism. Very limited knowledge is presently available on the KSH enzyme. Here, we report for the first time the identification and ...

journal_title：Molecular microbiology

authors： van der Geize R,Hessels GI,van Gerwen R,van der Meijden P,Dijkhuizen L

更新日期：2002-08-01 00:00:00

abstract：:Roughly 10% of all genes in Escherichia coli are controlled by the global transcription factor Lrp, which responds to nutrient availability. Bioinformatically, we identified lrp as one of several putative targets for the sRNA MicF, which is transcriptionally downregulated by Lrp. Deleting micF results in higher Lrp le...

journal_title：Molecular microbiology

authors： Holmqvist E,Unoson C,Reimegård J,Wagner EG

更新日期：2012-05-01 00:00:00

abstract：:The tra operon of the prototypical F plasmid and its relatives enables transfer of a copy of the plasmid to other bacterial cells via the process of conjugation. Tra proteins assemble to form the transferosome, the transmembrane pore through which the DNA is transferred, and the relaxosome, a complex of DNA-binding pr...

journal_title：Molecular microbiology

authors： Wong JJ,Lu J,Glover JN

更新日期：2012-08-01 00:00:00

abstract：:A number of plasmid-encoded gene systems are thought to stabilize plasmids by killing plasmid-free cells (also termed post-segregational killing or plasmid addiction). Here we analyse the mechanisms of plasmid stabilization by ccd of F, parDE of RP4 and parD of R1, and compare them to hok/sok of R1. To induce synchron...

journal_title：Molecular microbiology

authors： Jensen RB,Grohmann E,Schwab H,Díaz-Orejas R,Gerdes K

更新日期：1995-07-01 00:00:00

abstract：:Caulobacter crescentus chromosome replication is precisely coupled to a developmental cell cycle. Like most eubacteria, C. crescentus has a DnaA homologue that is presumed to initiate chromosome replication. However, the C. crescentus replication origin (Cori) lacks perfect consensus Escherichia coli DnaA boxes. Inste...

journal_title：Molecular microbiology

authors： Gorbatyuk B,Marczynski GT

更新日期：2001-04-01 00:00:00

abstract：:Engulfment of the forespore by the mother cell is a universal feature of endosporulation. In Bacillus subtilis, the forespore protein SpoIIQ and the mother cell protein SpoIIIAH form a channel, essential for endosporulation, through which the developing spore is nurtured. The two proteins also form a backup system for...

journal_title：Molecular microbiology

authors： Serrano M,Crawshaw AD,Dembek M,Monteiro JM,Pereira FC,Pinho MG,Fairweather NF,Salgado PS,Henriques AO

更新日期：2016-04-01 00:00:00

abstract：:Calcineurin plays essential roles in virulence and growth of pathogenic fungi and is a target of the natural products FK506 and Cyclosporine A. In the pathogenic mucoralean fungus Mucor circinelloides, calcineurin mutation or inhibition confers a yeast-locked phenotype indicating that calcineurin governs the dimorphic...

journal_title：Molecular microbiology

authors： Lee SC,Li A,Calo S,Inoue M,Tonthat NK,Bain JM,Louw J,Shinohara ML,Erwig LP,Schumacher MA,Ko DC,Heitman J

更新日期：2015-09-01 00:00:00

abstract：:The cell walls of Sulfolobales species consist of proteinaceous S-layers assembled from two polypeptides, SlaA and SlaB. We isolated the large S-layer protein of Acidianus ambivalens and both S-layer subunits of Sulfolobus solfataricus and Metallosphaera sedula, respectively. The slaAB genes, lying adjacently in the c...

journal_title：Molecular microbiology

authors： Veith A,Klingl A,Zolghadr B,Lauber K,Mentele R,Lottspeich F,Rachel R,Albers SV,Kletzin A

更新日期：2009-07-01 00:00:00

abstract：:Fluorescent polyclonal antibodies specific for MukB have been used to study its localization in Escherichia coli. In wild-type cells, the MukB protein appeared as a limited number of oblong shapes embracing the nucleoid. MukB remained associated with the nucleoid in the absence of DNA replication. The centre of gravit...

journal_title：Molecular microbiology

authors： den Blaauwen T,Lindqvist A,Löwe J,Nanninga N

更新日期：2001-12-01 00:00:00

abstract：:In general, wild Escherichia coli strains can grow effectively under moderately acidic organic acid-rich conditions. We found that the Shiga Toxin-producing E. coli (STEC) O157:H7 NGY9 grows more quickly than a K-12 strain in Luria-Bertani (LB)-2-morpholinoethanesulphonic acid (MES) broth supplemented with acetic acid...

journal_title：Molecular microbiology

authors： Barua S,Yamashino T,Hasegawa T,Yokoyama K,Torii K,Ohta M

更新日期：2002-02-01 00:00:00

abstract：:Expression of the 987P gene cluster is activated by the adjacent IS1 element of an STpa transposon. Nucleotide sequence analysis of the 987P-DNA region contiguous with this IS1 element revealed the presence of an open reading frame designated fapR, encoding a basic protein of 260 amino acid residues with a molecular m...

journal_title：Molecular microbiology

authors： Klaasen P,de Graaf FK

更新日期：1990-10-01 00:00:00

abstract：:SsrA is a tmRNA involved in tagging polypeptides on stalled ribosomes. The resulting fusion proteins are then degraded. We purified endogenous SsrA-tagged proteins by means of a genetically engineered SsrA and identified some of them. Analysis of the proteins suggested that they are tagged at their C-terminal extremit...

journal_title：Molecular microbiology

authors： Collier J,Binet E,Bouloc P

更新日期：2002-08-01 00:00:00

abstract：:Two so-called Ter sites, which bind the Escherichia coli Tus protein, are located near the replication origin of plasmid R1. Inactivation of the tus gene caused a large decrease in the stability of maintenance of the R1 mini-derivative pOU47 despite the presence of a functional partition system on the plasmid. Deletio...

journal_title：Molecular microbiology

authors： Krabbe M,Zabielski J,Bernander R,Nordström K

更新日期：1997-05-01 00:00:00

abstract：:The complete nucleotide sequence of the gene for a cell-surface protein antigen (PAc) of Streptococcus mutans MT8148 (serotype c) was determined. The pac gene consisted of 4695 bp and coded for a 170773D protein. The pac gene product contained a putative 38 amino acid signal peptide, resulting in a 166817D mature prot...

journal_title：Molecular microbiology

authors： Okahashi N,Sasakawa C,Yoshikawa M,Hamada S,Koga T

更新日期：1989-05-01 00:00:00

abstract：:The TonB system of Escherichia coli (TonB/ExbB/ExbD) transduces the protonmotive force (pmf) of the cytoplasmic membrane to drive active transport by high-affinity outer membrane transporters. In this study, chromosomally encoded ExbD formed formaldehyde-linked complexes with TonB, ExbB and itself (homodimers) in vivo...

journal_title：Molecular microbiology

authors： Ollis AA,Manning M,Held KG,Postle K

更新日期：2009-08-01 00:00:00

abstract：:Protein degradation is required for homeostasis of all living organisms. Self-compartmentalized ATP-dependent proteases are required for virulence of several pathogenic bacteria. Among the proteases implicated are ClpP and Lon, as well as the more recently identified bacterial proteasome. It is generally assumed that ...

journal_title：Molecular microbiology

authors： Butler SM,Festa RA,Pearce MJ,Darwin KH

更新日期：2006-05-01 00:00:00

abstract：:Acetyl-coenzyme A synthetase (Acs) activates acetate into acetyl-coenzyme A (Ac-CoA) in most cells. In Salmonella enterica, acs expression and Acs activity are controlled. It is unclear why the sirtuin-dependent protein acylation/deacylation system (SDPADS) controls the activity of Acs. Here we show that, during growt...

journal_title：Molecular microbiology

authors： Chan CH,Garrity J,Crosby HA,Escalante-Semerena JC

更新日期：2011-04-01 00:00:00

abstract：:NADPH oxidases (Nox) produce reactive oxygen species (ROS) in multicellular eukaryotic organisms. They trigger defense reactions ('oxidative burst') - in phagocytes and plant cells -, and are involved in a broad range of differentiation processes. Fungal Nox-complexes play a central role in vegetative, sexual and path...

journal_title：Molecular microbiology

authors： Marschall R,Tudzynski P

更新日期：2016-07-01 00:00:00

abstract：:Vegetative replication and partitioning of many plasmids and some chromosomes of alphaproteobacteria are directed by their repABC operons. RepA and RepB proteins direct the partitioning of replicons to daughter cells, while RepC proteins are replication initiators, although they do not resemble any characterized repli...

journal_title：Molecular microbiology

authors： Pinto UM,Flores-Mireles AL,Costa ED,Winans SC

更新日期：2011-09-01 00:00:00

abstract：:Lipids are essential structural constituents of bacterial cell membranes and walls, and their biosynthetic pathways are stringently regulated at both biochemical and genetic levels. The recent surge of new information about transcriptional regulation of bacterial lipid metabolism is highlighted by two studies in this ...

journal_title：Molecular microbiology

authors： Zhang YM,Rock CO

更新日期：2010-10-01 00:00:00

abstract：:Understanding the basis of bacterial persistence in latent infections is critical for eradication of tuberculosis. Analysis of Mycobacterium tuberculosis mRNA expression in an in vitro model of non-replicating persistence indicated that the bacilli require electron transport chain components and ATP synthesis for surv...

journal_title：Molecular microbiology

authors： Dhiman RK,Mahapatra S,Slayden RA,Boyne ME,Lenaerts A,Hinshaw JC,Angala SK,Chatterjee D,Biswas K,Narayanasamy P,Kurosu M,Crick DC

更新日期：2009-04-01 00:00:00

abstract：:Pneumococcus has been shown to bind to epithelial cells of the nasopharynx and lung, and to endothelial cells of the peripheral vasculature. To characterize bacterial elements required for attachment to these cell types, a library of genetically altered pneumococci with defects in exported proteins was screened for th...

journal_title：Molecular microbiology

authors： Spellerberg B,Cundell DR,Sandros J,Pearce BJ,Idanpaan-Heikkila I,Rosenow C,Masure HR

更新日期：1996-02-01 00:00:00

abstract：:Cells require a sensory system and a motility structure to achieve directed movement. Bacteria and archaea possess rotating filamentous motility structures that work in concert with the sensory chemotaxis system. This allows microorganisms to move along chemical gradients. The central response regulator protein CheY c...

journal_title：Molecular microbiology

authors： Li Z,Rodriguez-Franco M,Albers SV,Quax TEF

更新日期：2020-09-01 00:00:00

abstract：:The gene cbhA from the cellulolytic bacterium Cellulomonas fimi encodes a protein of 872 amino acids designated cellobiohydrolase A (CbhA). Mature CbhA contains 832 amino acid residues and has a predicted molecular mass of 85,349 Da. It is composed of five domains: an N-terminal catalytic domain, three repeated sequen...

journal_title：Molecular microbiology

authors： Meinke A,Gilkes NR,Kwan E,Kilburn DG,Warren RA,Miller RC Jr

更新日期：1994-05-01 00:00:00

abstract：:Fungi defend their ecological niche against antagonists by producing antibiosis molecules. Some of these molecules are only produced upon confrontation with the antagonist. The basidiomycete Coprinopsis cinerea induces the expression of the sesquiterpene synthase-encoding gene cop6 and its two neighboring genes coding...

journal_title：Molecular microbiology

authors： Stöckli M,Morinaka BI,Lackner G,Kombrink A,Sieber R,Margot C,Stanley CE,deMello AJ,Piel J,Künzler M

更新日期：2019-08-01 00:00:00

abstract：:Era is a low-molecular-weight GTPase essential for Escherichia coli viability. The gene encoding Era is found in the rnc operon, and the synthesis of both RNase III and Era increases with growth rate. Mutants that are partially defective in Era GTPase activity or that are reduced in the synthesis of wild-type Era beco...

journal_title：Molecular microbiology

authors： Britton RA,Powell BS,Dasgupta S,Sun Q,Margolin W,Lupski JR,Court DL

更新日期：1998-02-01 00:00:00

abstract：:The serine-threonine kinase TOR, the Target of Rapamycin, is an important regulator of nutrient, energy and stress signaling in eukaryotes. Sch9, a Ser/Thr kinase of AGC family (the cAMP-dependent PKA, cGMP- dependent protein kinase G and phospholipid-dependent protein kinase C family), is a substrate of TOR. Here, we...

journal_title：Molecular microbiology

authors： Alves de Castro P,Dos Reis TF,Dolan SK,Oliveira Manfiolli A,Brown NA,Jones GW,Doyle S,Riaño-Pachón DM,Squina FM,Caldana C,Singh A,Del Poeta M,Hagiwara D,Silva-Rocha R,Goldman GH

更新日期：2016-11-01 00:00:00