Localization of the sporulation protein SpoIIE in Bacillus subtilis is dependent upon the cell division protein FtsZ.

abstract：:The pathogenic fungus Candida albicans commonly causes mucosal surface infections. In immunocompromised patients, C. albicans may penetrate into deeper tissue, enter the bloodstream and disseminate within the host causing life-threatening systemic infections. In order to elucidate how C. albicans responds to the chall...

journal_title：Molecular microbiology

authors： Fradin C,Kretschmar M,Nichterlein T,Gaillardin C,d'Enfert C,Hube B

更新日期：2003-03-01 00:00:00

abstract：:NADPH oxidases (Nox) produce reactive oxygen species (ROS) in multicellular eukaryotic organisms. They trigger defense reactions ('oxidative burst') - in phagocytes and plant cells -, and are involved in a broad range of differentiation processes. Fungal Nox-complexes play a central role in vegetative, sexual and path...

journal_title：Molecular microbiology

authors： Marschall R,Tudzynski P

更新日期：2016-07-01 00:00:00

abstract：:The Ca(2+)-dependent protein phosphatase calcineurin is an important regulator of ion transporters from many organisms, including the Saccharomyces cerevisiae vacuolar Ca(2+)/H(+) exchanger Vcx1p. In yeast and plants, cation/H(+) exchangers are important in shaping cytosolic Ca(2+) levels involved in signal transducti...

journal_title：Molecular microbiology

authors： Pittman JK,Cheng NH,Shigaki T,Kunta M,Hirschi KD

更新日期：2004-11-01 00:00:00

abstract：:Formation of the asymmetrically located septum divides sporulating bacilli into two distinct cells: the mother cell and the prespore. The rigidifying wall material in the septum is subsequently removed by autolysis. Examination of published electron micrographs indicates that the two septal membranes then fuse to form...

journal_title：Molecular microbiology

authors： Higgins ML,Piggot PJ

更新日期：1992-09-01 00:00:00

abstract：:Acetyl-coenzyme A synthetase (Acs) activates acetate into acetyl-coenzyme A (Ac-CoA) in most cells. In Salmonella enterica, acs expression and Acs activity are controlled. It is unclear why the sirtuin-dependent protein acylation/deacylation system (SDPADS) controls the activity of Acs. Here we show that, during growt...

journal_title：Molecular microbiology

authors： Chan CH,Garrity J,Crosby HA,Escalante-Semerena JC

更新日期：2011-04-01 00:00:00

abstract：:Differential gene expression is a key strategy adopted by the Lyme disease spirochaete, Borrelia burgdorferi, for adaptation and survival in the mammalian host and the tick vector. Many B. burgdorferi surface lipoproteins fall into two distinct groups according to their expression patterns: one group primarily express...

journal_title：Molecular microbiology

authors： Wang P,Dadhwal P,Cheng Z,Zianni MR,Rikihisa Y,Liang FT,Li X

更新日期：2013-09-01 00:00:00

abstract：:Capsular polysaccharides are well-established virulence factors of pathogenic bacteria. Their biosynthesis and export are regulated within the transmembrane polysaccharide assembly machinery by the autophosphorylation of atypical tyrosine-kinases, named BY-kinases. However, the accurate functioning of these tyrosine-k...

journal_title：Molecular microbiology

authors： Bechet E,Gruszczyk J,Terreux R,Gueguen-Chaignon V,Vigouroux A,Obadia B,Cozzone AJ,Nessler S,Grangeasse C

更新日期：2010-09-01 00:00:00

abstract：:Fourteen Rhodobacter capsulatus mutants unable to grow with xanthine as sole nitrogen source were isolated by random Tn5 mutagenesis. Five of these Tn5 insertions were mapped within two adjacent chromosomal EcoRI fragments hybridizing to oligonucleotides synthesized according to conserved amino acid sequences of eukar...

journal_title：Molecular microbiology

authors： Leimkühler S,Kern M,Solomon PS,McEwan AG,Schwarz G,Mendel RR,Klipp W

更新日期：1998-02-01 00:00:00

abstract：:The mechanisms of transcription repression and derepression in vivo are not fully understood. We have obtained evidence that begins to clarify the minimum requirements for counteracting nucleosomal repression in vivo. Location of the TATA element near the nucleosome dyad does not block RNA polymerase II transcription ...

journal_title：Molecular microbiology

authors： Moss DR,Laybourn PJ

更新日期：2000-06-01 00:00:00

abstract：:Bacteria of the genera Bacillus and Clostridium form highly resistant spores, which in the case of some pathogens act as the infectious agents. An exosporium forms the outermost layer of some spores; it plays roles in protection, adhesion, dissemination, host targeting in pathogens and germination control. The exospor...

journal_title：Molecular microbiology

authors： Terry C,Jiang S,Radford DS,Wan Q,Tzokov S,Moir A,Bullough PA

更新日期：2017-05-01 00:00:00

abstract：:Glutaredoxins and thioredoxins are small heat-stable oxidoreductases that have been conserved throughout evolution. The yeast Saccharomyces cerevisiae contains two gene pairs encoding cytoplasmic glutaredoxins (GRX1, GRX2) and thioredoxins (TRX1, TRX2). We report here that the quadruple trx1 trx2 grx1 grx2 mutant is i...

journal_title：Molecular microbiology

authors： Draculic T,Dawes IW,Grant CM

更新日期：2000-06-01 00:00:00

abstract：:P66 is a Borrelia burgdorferi surface protein with β₃ integrin binding and channel forming activities. In this study, the role of P66 in mammalian and tick infection was examined. B. burgdorferiΔp66 strains were not infectious in wild-type, TLR2⁻/⁻- or MyD88⁻/⁻-deficient mice. Strains with p66 restored to the chromoso...

journal_title：Molecular microbiology

authors： Ristow LC,Miller HE,Padmore LJ,Chettri R,Salzman N,Caimano MJ,Rosa PA,Coburn J

更新日期：2012-09-01 00:00:00

abstract：:The marine Gram-negative bacteria Rhodopirellula baltica and Oceanicaulis alexandrii have, in contrast to Escherichia coli, membrane insertases with extended positively charged C-terminal regions similar to the YidC homologues in mitochondria and Gram-positive bacteria. We have found that chimeric forms of E. coli Yid...

journal_title：Molecular microbiology

authors： Seitl I,Wickles S,Beckmann R,Kuhn A,Kiefer D

更新日期：2014-01-01 00:00:00

abstract：:We investigated the function and transcriptional regulation of ywcG. The protein is essential for Bacillus subtilis. Biochemical characterization of the protein revealed that it is an FMN-containing NADPH oxidase. ywcG is transcribed throughout the whole life cycle of B. subtilis. The start point of transcription is p...

journal_title：Molecular microbiology

authors： Moch C,Schrögel O,Allmansberger R

更新日期：1998-03-01 00:00:00

abstract：:RbpA is an RNA polymerase-binding protein that occurs in the actinomycete family of bacteria and is regulated by the disulphide stress-response sigma factor, sigma(R), in Streptomyces coelicolor. Here we demonstrate that rbpA null mutants exhibit a slow-growth phenotype and are particularly sensitive to the transcript...

journal_title：Molecular microbiology

authors： Newell KV,Thomas DP,Brekasis D,Paget MS

更新日期：2006-05-01 00:00:00

abstract：:The heterotrimeric G-protein pathway is a ubiquitous eukaryotic signalling module that is known to regulate growth and differentiation in many plant pathogens. We previously identified Pigpa1, a gene encoding a G-protein alpha subunit from the potato late blight pathogen Phytophthora infestans. P. infestans belongs to...

journal_title：Molecular microbiology

authors： Latijnhouwers M,Ligterink W,Vleeshouwers VG,van West P,Govers F

更新日期：2004-02-01 00:00:00

abstract：:The non-essential RGD1 gene from Saccharomyces cerevisiae encodes a protein that has been characterized in vitro as a Rho GTPase activating protein (RhoGAP) for the Rho3 and Rho4 proteins. Rgd1p, which displays a conserved FCH-coiled coil-Rho-GAP domain organization, showed a patch-like distribution in the cell, inclu...

journal_title：Molecular microbiology

authors： Roumanie O,Peypouquet MF,Bonneu M,Thoraval D,Doignon F,Crouzet M

更新日期：2000-06-01 00:00:00

abstract：:Bacterial protein secretion is catalysed by the SecYEG protein-conducting channel complexed with the SecA ATPase motor. To gain insight into the SecA-SecYEG interaction we used peptide arrays, thermodynamic quantification, mutagenesis and functional assays. Our data reveal that: (i) SecA binds with low affinity on sev...

journal_title：Molecular microbiology

authors： Karamanou S,Bariami V,Papanikou E,Kalodimos CG,Economou A

更新日期：2008-10-01 00:00:00

abstract：:In contrast to many type II restriction enzymes, dimeric proteins that cleave DNA at individual recognition sites 4-6 bp long, the SfiI endonuclease is a tetrameric protein that binds to two copies of an elongated sequence before cutting the DNA at both sites. The mode of action of the SfiI endonuclease thus seems mor...

journal_title：Molecular microbiology

authors： Bilcock DT,Halford SE

更新日期：1999-02-01 00:00:00

abstract：:We show in this work that disruption of the hfq gene in Escherichia coli causes a large increase in IS10 transposition when IS10 is present on a multi-copy plasmid. Hfq is an RNA-binding protein that regulates the expression of a large number of genes at the post-transcriptional level by promoting the pairing of mRNAs...

journal_title：Molecular microbiology

authors： Ross JA,Wardle SJ,Haniford DB

更新日期：2010-11-01 00:00:00

abstract：:Most of the genes required for the conjugative transfer of DNA are encoded by the 33 kb transfer (tra) operon of F-like conjugative plasmids. Transcription of the tra operon is positively regulated by the TraJ transcriptional activator which, in turn, is negatively regulated by the FinOP fertility inhibition system. T...

journal_title：Molecular microbiology

authors： van Biesen T,Frost LS

更新日期：1994-11-01 00:00:00

abstract：:Cloning and sequencing of the IgA1 protease gene (iga) from Neisseria meningitidis strain HF13 showed an overall structure equivalent to iga genes from Neisseria gonorrhoeae and Haemophilus influenzae, although no region corresponding to the gonococcal alpha-peptide was evident. An additional 18 N. meningitidis and 3 ...

journal_title：Molecular microbiology

authors： Lomholt H,Poulsen K,Kilian M

更新日期：1995-02-01 00:00:00

abstract：:We have identified a phosphate transporter (TcPho91) localized to the bladder of the contractile vacuole complex (CVC) of Trypanosoma cruzi, the etiologic agent of Chagas disease. TcPho91 has 12 transmembrane domains, an N-terminal regulatory SPX (named after SYG1, Pho81 and XPR1) domain and an anion permease domain. ...

journal_title：Molecular microbiology

authors： Jimenez V,Docampo R

更新日期：2015-09-01 00:00:00

abstract：:Malaria transmission requires that the parasites differentiate into gametocytes prior to ingestion by a mosquito during a blood meal. Once in the mosquito midgut the gametocytes emerge from red blood cells (RBCs), fertilize, develop into ookinetes and finally infectious sporozoites. Gamete surface antigen, Pfs230, is ...

journal_title：Molecular microbiology

authors： Eksi S,Czesny B,van Gemert GJ,Sauerwein RW,Eling W,Williamson KC

更新日期：2006-08-01 00:00:00

abstract：:Ethylenediaminetetraacetate (EDTA) is currently the most abundant organic pollutant due to its recalcitrance and extensive use. Only a few bacteria can degrade it, using EDTA monooxygenase (EmoA) to initiate the degradation. EmoA is an FMNH2 -dependent monooxygenase that requires an NADH:FMN oxidoreductase (EmoB) to p...

journal_title：Molecular microbiology

authors： Jun SY,Lewis KM,Youn B,Xun L,Kang C

更新日期：2016-06-01 00:00:00

abstract：:Each year, several million tons of dimethylsulfoniopropionate (DMSP) are produced by marine phytoplankton and bacteria as an important osmolyte to regulate their cellular osmosis. Microbial breakdown of DMSP to the volatile gas dimethylsulfide (DMS) plays an important role in global biogeochemical cycles of the sulphu...

journal_title：Molecular microbiology

authors： Chen Y,Schäfer H

更新日期：2019-06-01 00:00:00

abstract：:In the multicellular bacterium Streptomyces coelicolor, functions of developmental (bald) genes are required for the biosynthesis of SapB, a hydrophobic peptidic morphogen that facilitates aerial hyphae formation. Here, we show that aerial hyphal growth and SapB biosynthesis could be activated independently from the n...

journal_title：Molecular microbiology

authors： Nguyen KT,Willey JM,Nguyen LD,Nguyen LT,Viollier PH,Thompson CJ

更新日期：2002-12-01 00:00:00

abstract：:Gene expression in the Leishmania is controlled post-transcriptionally, and is likely to be impacted by both 5' and 3' untranslated regions (UTRs). We have investigated the effects of trinucleotides in the AUG-proximal region (APR) (i.e. positions -3 to -1 upstream of an AUG) on two reporter genes in the context of an...

journal_title：Molecular microbiology

authors： Stanton JD,Mensa-Wilmot K

更新日期：2006-08-01 00:00:00

abstract：:IS231 constitutes a family of insertion sequences widespread among Bacillus thuringiensis subspecies. Three new IS231 variants have been isolated from B. thuringiensis subspecies finitimus (IS231 D and E) and israelensis (IS231F). Like the previously described IS231A, B and C, these 1.7 kb elements display single open...

journal_title：Molecular microbiology

authors： Rezsöhazy R,Hallet B,Delcour J

更新日期：1992-07-01 00:00:00

abstract：:Proteins with LytM (Peptidase_M23) domains are broadly distributed in bacteria and have been implicated in a variety of important processes, including cell division and cell-shape determination. Most LytM-like proteins that have been structurally and/or biochemically characterized are metallo-endopeptidases that cleav...

journal_title：Molecular microbiology

authors： Peters NT,Morlot C,Yang DC,Uehara T,Vernet T,Bernhardt TG

更新日期：2013-08-01 00:00:00