Inactivation of the replication-termination system affects the replication mode and causes unstable maintenance of plasmid R1.

abstract：:In response to recommendations from the Steering Committees responsible for co-ordination of World Health Organization programmes for research on the immunology of leprosy (IMMLEP) and tuberculosis (IMMTUB), a list was prepared summarizing the properties of mycobacterial proteins currently under investigation with res...

journal_title：Molecular microbiology

authors： Young DB,Kaufmann SH,Hermans PW,Thole JE

更新日期：1992-01-01 00:00:00

abstract：:We cloned the CaYFH1 gene that encodes the yeast frataxin homologue in Candida albicans. CaYFH1 was expressed in Deltayfh1 Saccharomyces cerevisiae cells, where it compensated for all the phenotypes tested except for the lack of cytochromes. Double DeltaCayfh1/DeltaCayfh1 mutant had severe defective growth, accumulate...

journal_title：Molecular microbiology

authors： Santos R,Buisson N,Knight SA,Dancis A,Camadro JM,Lesuisse E

更新日期：2004-10-01 00:00:00

abstract：:Silent information regulator 2 (Sir2)-related proteins or sirtuins function as NAD(+)-dependent deacetylases or ADP ribosylases that target a range of substrates, thereby influencing chromatin structure and a diverse range of other biological functions. Genes encoding three Sir2-related proteins (SIR2rp1-3) have been ...

journal_title：Molecular microbiology

authors： Alsford S,Kawahara T,Isamah C,Horn D

更新日期：2007-02-01 00:00:00

abstract：:We have systematically examined the mRNA profiles of 36 two-component deletion mutants, which include all two-component regulatory systems of Escherichia coli, under a single growth condition. DNA microarray results revealed that the mutants belong to one of three groups based on their gene expression profiles in Luri...

journal_title：Molecular microbiology

authors： Oshima T,Aiba H,Masuda Y,Kanaya S,Sugiura M,Wanner BL,Mori H,Mizuno T

更新日期：2002-10-01 00:00:00

abstract：:Cell wall lipids of Mycobacterium tuberculosis containing multiple methylbranched fatty acids play critical roles in pathogenesis and thus offer targets for new antimycobacterial drugs. Mycocerosicacid synthase gene (mas) encodes the enzyme that produces one class of such acids. Seven mas-like genes (msls) were identi...

journal_title：Molecular microbiology

authors： Dubey VS,Sirakova TD,Kolattukudy PE

更新日期：2002-09-01 00:00:00

abstract：:Carbapenems such as meropenem are being investigated for their potential therapeutic utility against highly drug-resistant tuberculosis. These β-lactams target the transpeptidases that introduce interpeptide cross-links into bacterial peptidoglycan thereby controlling rigidity of the bacterial envelope. Treatment of M...

journal_title：Molecular microbiology

authors： Kumar P,Arora K,Lloyd JR,Lee IY,Nair V,Fischer E,Boshoff HI,Barry CE 3rd

更新日期：2012-10-01 00:00:00

abstract：:In Methanobacterium thermoautotrophicum, the fmdECB operon encoding the molybdenum formyl-methanofuran dehydrogenase is directly preceded by an open reading frame tfx predicted to encode a DNA binding protein. The 16.1 kDa protein has an N-terminal basic domain with a helix-turn-helix motif for DNA binding and a C-ter...

journal_title：Molecular microbiology

authors： Hochheimer A,Hedderich R,Thauer RK

更新日期：1999-01-01 00:00:00

abstract：:Protein kinase C constitutes a family of serine-threonine kinases found in all eukaryotes and implicated in a wide range of cellular functions, including regulation of cell growth, cellular differentiation and immunity. Here, we present three independent lines of evidence which indicate that protein kinase C is essent...

journal_title：Molecular microbiology

authors： Penn TJ,Wood ME,Soanes DM,Csukai M,Corran AJ,Talbot NJ

更新日期：2015-10-01 00:00:00

abstract：:The monocistronic transcript of rpsO undergoes an endonucleolytic cleavage downstream of the coding sequence, which removes the hairpin of the transcription terminator and initiates the rapid degradation of the message. We demonstrate here that the two rne-dependent cleavages, on both sides of the transcription termin...

journal_title：Molecular microbiology

authors： Braun F,Hajnsdorf E,Régnier P

更新日期：1996-03-01 00:00:00

abstract：:In this study we show for the first time the intracellular distribution of a K39 kinesin homologue in Leishmania donovani, a medically important parasite of humans. Further, we demonstrated that this motor protein is expressed in both the insect and mammalian developmental forms (i.e. promastigote and amastigotes) of ...

journal_title：Molecular microbiology

authors： Gerald NJ,Coppens I,Dwyer DM

更新日期：2007-02-01 00:00:00

abstract：:In this work we present the localization and characterization of the repl promoter (Prepl) and show aspects of the regulation. Comparison of Prepl with other autoregulated replication protein gene promoters revealed similarities, but Prepl differs from some of these characterized promoters in not being regulated by th...

journal_title：Molecular microbiology

authors： Gammie AE,Crosa JH

更新日期：1991-12-01 00:00:00

abstract：:Protection against maternal malaria has been associated with the acquisition of a specific antibody response that prevents adhesion of Plasmodium falciparum-infected erythrocytes to the glycosaminoglycan chondroitin-4-sulphate (CSA), which is present in the placental intervillous space. These antibodies are directed a...

journal_title：Molecular microbiology

authors： Andrews KT,Pirrit LA,Przyborski JM,Sanchez CP,Sterkers Y,Ricken S,Wickert H,Lépolard C,Avril M,Scherf A,Gysin J,Lanzer M

更新日期：2003-08-01 00:00:00

abstract：:The DnaA protein, which initiates chromosomal replication in Escherichia coli, is negatively regulated by both the sliding clamp of DNA polymerase III holoenzyme and the IdaB protein. We have found that, when the amount of minichromosome is limited in an in vitro replication system, minichromosomal replication-stimula...

journal_title：Molecular microbiology

authors： Su'etsugu M,Kawakami H,Kurokawa K,Kubota T,Takata M,Katayama T

更新日期：2001-04-01 00:00:00

abstract：:The human oral bacterium Streptococcus gordonii expresses, on the cell surface, two antigenically related high-molecular-mass polypeptides denoted CshA and CshB, encoded by genes at separate chromosomal loci. The precursor form of CshA is composed of four distinct segments: (i) a 41-amino-acid residue leader peptide, ...

journal_title：Molecular microbiology

authors： McNab R,Jenkinson HF,Loach DM,Tannock GW

更新日期：1994-11-01 00:00:00

abstract：:Gram-negative bacteria, mitochondria, and chloroplasts all possess an outer membrane populated with a host of β-barrel outer-membrane proteins (βOMPs). These βOMPs play crucial roles in maintaining viability of their hosts, and therefore, it is essential to understand the biogenesis of this class of membrane proteins....

journal_title：Molecular microbiology

authors： Lundquist K,Billings E,Bi M,Wellnitz J,Noinaj N

更新日期：2020-12-13 00:00:00

abstract：:Bacteria co-ordinate their social behaviour in a density-dependent manner by production of diffusible signal molecules by a process known as quorum sensing (QS). It is generally assumed that in homogenous environments and at high cell density, QS synchronizes cells in the population to perform collective social tasks ...

journal_title：Molecular microbiology

authors： Pradhan BB,Chatterjee S

更新日期：2014-05-01 00:00:00

abstract：:The S box transcription termination control system regulates expression of genes involved in methionine metabolism. Expression of the S box regulon, comprised of 11 transcriptional units in Bacillus subtilis, is induced in response to starvation for methionine. We previously demonstrated that S-adenosylmethionine (SAM...

journal_title：Molecular microbiology

authors： McDaniel BA,Grundy FJ,Henkin TM

更新日期：2005-08-01 00:00:00

abstract：:Protein translocation across the bacterial cytoplasmic membrane has been studied extensively in Escherichia coli. The identification of the components involved and subsequent reconstitution of the purified translocation reaction have defined the minimal constituents that allowed extensive biochemical characterization ...

journal_title：Molecular microbiology

authors： Manting EH,Driessen AJ

更新日期：2000-07-01 00:00:00

abstract：:Toxin-antitoxin (TA) systems on the chromosomes of free-living bacteria appear to facilitate cell survival during intervals of stress by inducing a state of reversible growth arrest. However, upon prolonged stress, TA toxin action leads to cell death. They have been implicated in several clinically important phenomena...

journal_title：Molecular microbiology

authors： Prysak MH,Mozdzierz CJ,Cook AM,Zhu L,Zhang Y,Inouye M,Woychik NA

更新日期：2009-03-01 00:00:00

abstract：:In their natural habitats, microorganisms are often exposed to osmolality changes in the environment. The osmotic stress must be sensed and converted into an activity change of specific enzymes and transport proteins and/or it must trigger their synthesis such that the osmotic imbalance can be rapidly restored. On the...

journal_title：Molecular microbiology

authors： Poolman B,Glaasker E

更新日期：1998-07-01 00:00:00

abstract：:Many bacteria colonize surfaces and transition to a sessile mode of growth. The plant pathogen Agrobacterium tumefaciens produces a unipolar polysaccharide (UPP) adhesin at single cell poles that contact surfaces. Here we report that elevated levels of the intracellular signal cyclic diguanosine monophosphate (c-di-GM...

journal_title：Molecular microbiology

authors： Xu J,Kim J,Koestler BJ,Choi JH,Waters CM,Fuqua C

更新日期：2013-09-01 00:00:00

abstract：:The essential proteins DnaB, DnaD and DnaI of Bacillus subtilis are required for initiation, but not elongation, of DNA replication, and for replication restart at stalled forks. The interactions and functions of these proteins have largely been determined in vitro based on their roles in replication restart. During r...

journal_title：Molecular microbiology

authors： Smits WK,Goranov AI,Grossman AD

更新日期：2010-01-01 00:00:00

abstract：:The chromosomal DpnII gene cassette of Streptococcus pneumoniae encodes two methyltransferases and an endonuclease. One methyltransferase acts on double-stranded and the other on single-stranded DNA. Two mRNAs are transcribed from the cassette. One, a SigA promoter transcript, includes all three genes; the other inclu...

journal_title：Molecular microbiology

authors： Lacks SA,Ayalew S,de la Campa AG,Greenberg B

更新日期：2000-03-01 00:00:00

abstract：:The Vipp1 protein is essential in cyanobacteria and chloroplasts for the maintenance of photosynthetic function and thylakoid membrane architecture. To investigate its mode of action we generated strains of the cyanobacteria Synechocystis sp. PCC6803 and Synechococcus sp. PCC7942 in which Vipp1 was tagged with green f...

journal_title：Molecular microbiology

authors： Bryan SJ,Burroughs NJ,Shevela D,Yu J,Rupprecht E,Liu LN,Mastroianni G,Xue Q,Llorente-Garcia I,Leake MC,Eichacker LA,Schneider D,Nixon PJ,Mullineaux CW

更新日期：2014-10-13 00:00:00

abstract：:The [NiFe]hydrogenase of the photosynthetic bacterium Rhodobacter capsulatus is encoded by the structural hupSLC operon, the expression of which is induced by H2. H2 activation was no longer observable in chromosomal hupR mutants, an indication that HupR is implicated directly in the activation by H2 of hupS gene expr...

journal_title：Molecular microbiology

authors： Toussaint B,de Sury d'Aspremont R,Delic-Attree I,Berchet V,Elsen S,Colbeau A,Dischert W,Lazzaroni Y,Vignais PM

更新日期：1997-12-01 00:00:00

abstract：:Of the four Plasmodium species that routinely cause malaria in humans, Plasmodium falciparum is responsible for the majority of malaria mortality and consequently gets most of the headlines. Outside Africa, however, more malaria cases are caused by its distant cousin Plasmodium vivax, resulting in a daunting morbidity...

journal_title：Molecular microbiology

authors： Rayner J

更新日期：2005-03-01 00:00:00

abstract：:Genotoxic agents from endogenous and exogenous sources cause double-strand breaks (DSBs) in chromosomal DNA. Given the threat these lesions pose to viability, it is not surprising that multiple, conserved mechanisms exist for their detection, processing and repair. Previous studies have established both functional non...

journal_title：Molecular microbiology

authors： Warner DF,Mizrahi V

更新日期：2011-01-01 00:00:00

abstract：:Plasmodium parasites possess a single pyruvate dehydrogenase (PDH) enzyme complex that is localized to the plastid-like organelle known as the apicoplast. Unlike most eukaryotes, Plasmodium parasites lack a mitochondrial PDH. The PDH complex catalyses the conversion of pyruvate to acetyl-CoA, an important precursor fo...

journal_title：Molecular microbiology

authors： Pei Y,Tarun AS,Vaughan AM,Herman RW,Soliman JM,Erickson-Wayman A,Kappe SH

更新日期：2010-02-01 00:00:00

abstract：:Comparison of the Leishmania infantum genome with Leishmania braziliensis and Leishmania major genomes has identified 25 L. infantum species-specific genes that are absent or pseudogenes in L. major and L. braziliensis. To determine whether these L. infantum species-specific genes are involved in visceral Leishmania i...

journal_title：Molecular microbiology

authors： Zhang WW,Matlashewski G

更新日期：2010-07-01 00:00:00

abstract：:The prnA gene codes for a transcriptional activator that mediates proline induction of four other genes involved in proline utilization as a nitrogen and/or carbon source in Aspergillus nidulans. In this paper, we present the genomic and cDNA sequence and the transcript map of prnA. The PrnA protein belongs to the Zn ...

journal_title：Molecular microbiology

authors： Cazelle B,Pokorska A,Hull E,Green PM,Stanway G,Scazzocchio C

更新日期：1998-04-01 00:00:00