Characterization of Helicobacter pylori HP0231 (DsbK): role in disulfide bond formation, redox homeostasis and production of Helicobacter cystein-rich protein HcpE.

abstract：:Because the ferric uptake regulator (fur) appears to be an essential gene in Pseudomonas aeruginosa, resistance to manganese was used as an enrichment to isolate strains carrying point mutations in the fur gene in order to assess its role in the co-ordinate expression of siderophores and exotoxin A (ETA). This report ...

journal_title：Molecular microbiology

authors： Barton HA,Johnson Z,Cox CD,Vasil AI,Vasil ML

更新日期：1996-09-01 00:00:00

abstract：:The FNR protein in Escherichia coli is an O(2) sensor that modifies global gene expression to adapt the cell to anaerobic growth. Regulation of FNR involves continuous cycling of the protein between its active and inactive states under aerobic conditions without apparent function. This raises the question of what bene...

journal_title：Molecular microbiology

authors： Tolla DA,Savageau MA

更新日期：2011-01-01 00:00:00

abstract：:Accumulation of stalled ribosomes at the 3' end of mRNA without a stop codon (non-stop mRNA) is supposed to be toxic to bacterial cells. Escherichia coli has at least two distinct systems to rescue such stalled ribosomes: SsrA-dependent trans-translation and ArfA-dependent ribosome rescue. Combination of the ssrA and ...

journal_title：Molecular microbiology

authors： Chadani Y,Ono K,Kutsukake K,Abo T

更新日期：2011-05-01 00:00:00

abstract：:polY, a transcriptional regulatory gene in the polyoxin biosynthetic cluster of Streptomyces cacaoi, was analysed, and its deduced product (PolY) showed amino acid sequence homology to AfsR from Streptomyces coelicolor A3(2). PolY contains an OmpR-like DNA binding domain at its N-terminal and an ATPase domain in the m...

journal_title：Molecular microbiology

authors： Li R,Liu G,Xie Z,He X,Chen W,Deng Z,Tan H

更新日期：2010-01-01 00:00:00

abstract：:The porin oprE gene of Pseudomonas aeruginosa PAO1 was isolated. Its nucleotide sequence indicated that the structural gene of 1383 nucleotide residues encodes a precursor consisting of 460 amino acid residues with a signal peptide of 29 amino acid residues, which was confirmed by the N-terminal 23-amino-acid sequence...

journal_title：Molecular microbiology

authors： Yamano Y,Nishikawa T,Komatsu Y

更新日期：1993-05-01 00:00:00

abstract：:The genes ftsE and ftsX are organized in one operon together with ftsY. FtsY codes for the receptor of the signal recognition particle (SRP) that functions in targeting a subset of inner membrane proteins. We have found no indications for a structural relationship between FtsE/X and FtsY. Evidence is presented that Ft...

journal_title：Molecular microbiology

authors： de Leeuw E,Graham B,Phillips GJ,ten Hagen-Jongman CM,Oudega B,Luirink J

更新日期：1999-02-01 00:00:00

abstract：:The Helicobacter pylori vacuolating cytotoxin (VacA) induces degenerative vacuolation of sensitive mammalian cell lines. Although evidence is accumulating that VacA enters cells and functions from an intracellular site of action, the biochemical mechanism by which VacA mediates cellular vacuolation has not been establ...

journal_title：Molecular microbiology

authors： Ye D,Blanke SR

更新日期：2002-03-01 00:00:00

abstract：:Soupene et al. [J. Bacteriol. (2003) 185 5611-5626] made the unexpected observation that the presence of a mutation, in the gene for the N-acetylglucosamine repressor, nagC, increased the growth rate of Escherichia coli MG1655 on galactose, an unrelated sugar. We have found that NagC, binds to a single, high-affinity ...

journal_title：Molecular microbiology

authors： El Qaidi S,Allemand F,Oberto J,Plumbridge J

更新日期：2009-01-01 00:00:00

abstract：:Many physiological adjustments to nutrient changes involve ppGpp. Recent attempts to deduce ppGpp regulatory effects using proteomics or gene profiling can rigorously identify proteins or transcripts, but the functional significance is often unclear. Using a random screen for synthetic lethals we found a ppGpp-depende...

journal_title：Molecular microbiology

authors： Harinarayanan R,Murphy H,Cashel M

更新日期：2008-08-01 00:00:00

abstract：:Peptide transport in microorganisms is important for nutrition of the cell and various signalling processes including regulation of gene expression, sporulation, chemotaxis, competence and virulence development. Peptide transport is mediated via different combinations of ion-linked and ATP-binding cassette (ABC) trans...

journal_title：Molecular microbiology

authors： Doeven MK,Kok J,Poolman B

更新日期：2005-08-01 00:00:00

abstract：:Streptococcus pneumoniae is one of the most important model organisms for studies on natural genetic transformation in bacteria. The prevalence of this gene exchange mechanism in the genus Streptococcus has not been subjected to systematic investigations, but it has been known for decades that only a few streptococcal...

journal_title：Molecular microbiology

authors： Håvarstein LS

更新日期：2010-11-01 00:00:00

abstract：:The human fungal pathogen Candida albicans switches its morphology from yeast to hyphal forms. The morphological transition may render C. albicans virulent. Several signaling cascades, including those of the cyclic AMP-protein kinase A and mitogen-activated protein kinase pathways, are responsible for morphogenesis. I...

journal_title：Molecular microbiology

authors： Kim SW,Joo YJ,Chun YJ,Park YK,Kim J

更新日期：2019-09-01 00:00:00

abstract：:Messenger RNA decay in Bacillus subtilis is accomplished by a combination of exoribonucleases and endoribonucleases. Intermediates in the decay process have not been readily detectable, and previous studies on mRNA decay have used a handful of highly expressed transcripts as models. Here, we use RNA-Seq analysis to pr...

journal_title：Molecular microbiology

authors： Liu B,Deikus G,Bree A,Durand S,Kearns DB,Bechhofer DH

更新日期：2014-10-01 00:00:00

abstract：:Several Fusarium species produce the polyketide mycotoxin zearalenone (ZEA), a causative agent of hyperestrogenic syndrome in animals that is often found in F. graminearum-infected cereals in temperate regions. The ZEA biosynthetic cluster genes PKS4, PKS13, ZEB1 and ZEB2 encode a reducing polyketide synthase, a non-r...

journal_title：Molecular microbiology

authors： Park AR,Son H,Min K,Park J,Goo JH,Rhee S,Chae SK,Lee YW

更新日期：2015-09-01 00:00:00

abstract：:Cell-cell communication via the production and detection of chemical signal molecules has been the focus of a great deal of research over the past decade. One class of chemical signals widely used by proteobacteria consists of N-acyl-homoserine lactones, which are synthesized by proteins related to LuxI of Vibrio fisc...

journal_title：Molecular microbiology

authors： Pappas KM,Weingart CL,Winans SC

更新日期：2004-08-01 00:00:00

abstract：:Early diverged extant organisms, which may serve as convenient laboratory models to look for and study evolutionary ancient features of eukaryotic cell biology, are rare. The diplomonad Giardia intestinalis, a protozoan parasite known to cause diarrhoeal disease, has become an increasingly popular object of basic rese...

journal_title：Molecular microbiology

authors： Hehl AB,Marti M

更新日期：2004-07-01 00:00:00

abstract：:Streptomyces lividans has a novel DNA modification, which sensitises its DNA to degradation during electrophoresis (the Dnd phenotype). The entire gene cluster (dnd) involved in this modification was localized on an 8 kb DNA fragment and was expressed in a S. lividans deletion mutant (dnd) and in several heterologous ...

journal_title：Molecular microbiology

authors： Zhou X,He X,Liang J,Li A,Xu T,Kieser T,Helmann JD,Deng Z

更新日期：2005-09-01 00:00:00

abstract：:All 21 of the Nudix hydrolase genes from the radiation-resistant organism Deinococcus radiodurans have been cloned into vectors under the control of T7 promoters and expressed as soluble proteins in Escherichia coli. Their sizes range from 9.8 kDa (91 amino acids) to 59 kDa (548 amino acids). Two novel proteins were i...

journal_title：Molecular microbiology

authors： Xu W,Shen J,Dunn CA,Desai S,Bessman MJ

更新日期：2001-01-01 00:00:00

abstract：:In the past, ultrastructural investigations of Leishmania mexicana amastigotes revealed structures that were tentatively identified as autophagosomes. This study has now provided definitive data that autophagy occurs in the parasite during differentiation both to metacyclic promastigotes and to amastigotes, autophagos...

journal_title：Molecular microbiology

authors： Williams RA,Tetley L,Mottram JC,Coombs GH

更新日期：2006-08-01 00:00:00

abstract：:Aspergillus fumigatus, an important human nosocomial pathogen, is resistant to sordarin derivatives, a new family of antifungals that inhibit protein synthesis by interaction with the EF-2-ribosomal stalk complex. To explore the role of the A. fumigatus ribosome in the resistance mechanism, the fungal stalk proteins w...

journal_title：Molecular microbiology

authors： Santos C,Ballesta JP

更新日期：2002-01-01 00:00:00

abstract：:The psaBCA locus of Streptococcus pneumoniae encodes a putative ABC Mn2+-permease complex. Downstream of the operon is psaD, which may be co-transcribed and encodes a thiol peroxidase. Previously, there has been discordance concerning the phenotypic impact of mutations in the psa locus, resolution of which has been co...

journal_title：Molecular microbiology

authors： McAllister LJ,Tseng HJ,Ogunniyi AD,Jennings MP,McEwan AG,Paton JC

更新日期：2004-08-01 00:00:00

abstract：:The DNA damage and stress response pathways interact to regulate cellular responses to genotoxins and environmental stresses. How these pathways interact in Schizosaccharomyces pombe is not well understood. We demonstrate that osmotic stress suppresses the DNA damage sensitivity of checkpoint mutants, and that this oc...

journal_title：Molecular microbiology

authors： Alao JP,Huis In 't Veld PJ,Buhse F,Sunnerhagen P

更新日期：2010-07-01 00:00:00

abstract：:Protein kinase C constitutes a family of serine-threonine kinases found in all eukaryotes and implicated in a wide range of cellular functions, including regulation of cell growth, cellular differentiation and immunity. Here, we present three independent lines of evidence which indicate that protein kinase C is essent...

journal_title：Molecular microbiology

authors： Penn TJ,Wood ME,Soanes DM,Csukai M,Corran AJ,Talbot NJ

更新日期：2015-10-01 00:00:00

abstract：:The analysis of completed archaeal genome sequences led to the identification of a set of approximately 10-20 genes whose protein products were inferred to be involved in chromosomal DNA replication. Until recently, however, little was known of the biochemical properties of these proteins. Here, I review recent progre...

journal_title：Molecular microbiology

authors： MacNeill SA

更新日期：2001-05-01 00:00:00

abstract：:Having no known environmental reservoir, Streptococcus pyogenes, a bacterium responsible for a wider variety of human diseases than any other bacterial species, must rely on its host for metabolic substrates. Although a streptococcal aldolase, LacD.1, has been adapted to virulence gene regulation, both LacD.1 and a pa...

journal_title：Molecular microbiology

authors： Loughman JA,Caparon MG

更新日期：2007-04-01 00:00:00

abstract：:Temperate phage P2 has the capacity to function as a helper for the defective, unrelated, satellite phage P4. In the absence of a helper, P4 can either lysogenize its host or establish itself as a plasmid. For lytic growth, P4 requires the structural genes, packaging and lysis functions of the helper. P4 can get acces...

journal_title：Molecular microbiology

authors： Liu T,Renberg SK,Haggård-Ljungquist E

更新日期：1998-12-01 00:00:00

abstract：:A biochemical approach to identify proteins with high affinity for choline-containing pneumococcal cell walls has allowed the localization, cloning and sequencing of a gene (lytC ) coding for a protein that degrades the cell walls of Streptococcus pneumoniae. The lytC gene is 1506 bp long and encodes a protein (LytC) ...

journal_title：Molecular microbiology

authors： García P,Paz González M,García E,García JL,López R

更新日期：1999-07-01 00:00:00

abstract：:Cell division in most bacteria is directed by FtsZ, a conserved tubulin-like GTPase that assembles forming the cytokinetic Z-ring and constitutes a target for the discovery of new antibiotics. The developmental regulator MciZ, a 40-amino acid peptide endogenously produced during Bacillus subtilis sporulation, halts cy...

journal_title：Molecular microbiology

authors： Araújo-Bazán L,Huecas S,Valle J,Andreu D,Andreu JM

更新日期：2019-04-01 00:00:00

abstract：:The Helicobacter pylori genome contains a gene (hp1338 or nikR) that encodes a nickel-dependent regulator that is homologous to the Escherichia coli nickel-responsive regulator, NikR. The H. pylori nikR product acts as a pleiotropic metal-dependent regulator. We constructed a non-polar isogenic mutant deleted for the ...

journal_title：Molecular microbiology

authors： Contreras M,Thiberge JM,Mandrand-Berthelot MA,Labigne A

更新日期：2003-08-01 00:00:00

abstract：:Gene expression in the Leishmania is controlled post-transcriptionally, and is likely to be impacted by both 5' and 3' untranslated regions (UTRs). We have investigated the effects of trinucleotides in the AUG-proximal region (APR) (i.e. positions -3 to -1 upstream of an AUG) on two reporter genes in the context of an...

journal_title：Molecular microbiology

authors： Stanton JD,Mensa-Wilmot K

更新日期：2006-08-01 00:00:00