Interactions of Neisseria meningitidis with cells of the human meninges.

abstract：:Alternative sigma (σ) factors govern expression of bacterial genes in response to diverse environmental signals. In Pseudomonas aeruginosa σPvdS directs expression of genes for production of a siderophore, pyoverdine, as well as a toxin and a protease. σFpvI directs expression of a receptor for ferripyoverdine import....

journal_title：Molecular microbiology

authors： Edgar RJ,Hampton GE,Garcia GPC,Maher MJ,Perugini MA,Ackerley DF,Lamont IL

更新日期：2017-12-01 00:00:00

abstract：:The 9.5 kb virB operon is the largest of the six major operons in the Ti plasmid vir region. This operon contains eleven genes, the largest of which is virB4. This gene encodes an 84 kDa protein whose function has not been identified. Its roles in conferring virulence on Agrobacterium tumefaciens and in the T-DNA tran...

journal_title：Molecular microbiology

authors： Shirasu K,Koukolíková-Nicola Z,Hohn B,Kado CI

更新日期：1994-02-01 00:00:00

abstract：:In the intracellular pathogen Brucella abortus, the general stress response (GSR) signalling system determines survival under acute stress conditions in vitro, and is required for long-term residence in a mammalian host. To date, the identity of the Brucella sensor kinase(s) that function to perceive stress and direct...

journal_title：Molecular microbiology

authors： Kim HS,Willett JW,Jain-Gupta N,Fiebig A,Crosson S

更新日期：2014-11-01 00:00:00

abstract：:The Escherichia coli urinary tract isolate C1212 contains two pyelonephritis-associated pili (pap) DNA sequences designated here as pap-17 and pap-21. Each of these pap sequences encodes antigenically-distinct pilin monomers, pilin-17 and pilin-21, respectively. Most individual strain C1212 cells isolated from a singl...

journal_title：Molecular microbiology

authors： Low D,Robinson EN Jr,McGee ZA,Falkow S

更新日期：1987-11-01 00:00:00

abstract：:Sequence-inherent targeting information directs polypeptides synthesized in the cytosol to their respective cellular compartment. Some proteins use ambiguous sorting signals or specific folding properties to be dually distributed between the cytosol and mitochondria. A study published in this issue of Molecular Microb...

journal_title：Molecular microbiology

authors： Herrmann JM

更新日期：2009-04-01 00:00:00

abstract：:This review assembles data from three bodies of literature (bacterial genetics, plastid biogenesis and parasitology) that seldom have much direct cross-talk. After overcoming terminological complications to sort out microbial nifS from sufS genes, we connect a bacterial operon, recently found to be involved in iron me...

journal_title：Molecular microbiology

authors： Ellis KE,Clough B,Saldanha JW,Wilson RJ

更新日期：2001-09-01 00:00:00

abstract：:Peptidoglycan (PG), the major component of the bacterial cell wall, is one large macromolecule. To allow for the different curvatures of PG at cell poles and division sites, there must be local differences in PG architecture and eventually also chemistry. Here we report such local differences in the Gram-positive rod-...

journal_title：Molecular microbiology

authors： Morales Angeles D,Liu Y,Hartman AM,Borisova M,de Sousa Borges A,de Kok N,Beilharz K,Veening JW,Mayer C,Hirsch AK,Scheffers DJ

更新日期：2017-04-01 00:00:00

abstract：:MisL is an autotransporter protein encoded by Salmonella pathogenicity island 3 (SPI3). To investigate the role of MisL in Salmonella enterica serotype Typhimurium (S. Typhimurium) pathogenesis, we characterized its function during infection of mice and identified a host receptor for this adhesin. In a mouse model of ...

journal_title：Molecular microbiology

authors： Dorsey CW,Laarakker MC,Humphries AD,Weening EH,Bäumler AJ

更新日期：2005-07-01 00:00:00

abstract：:A new class of Bacillus thuringiensis delta-endotoxins, or insecticidal control proteins (ICPs), is defined by an apparently cryptic protein with a unique primary structure and novel entomocidal specificity for certain coleopteran and lepidopteran species. The discovery of a new group of ICPs will extend the use of th...

journal_title：Molecular microbiology

authors： Tailor R,Tippett J,Gibb G,Pells S,Pike D,Jordan L,Ely S

更新日期：1992-05-01 00:00:00

abstract：:LamB glycoporin has an important general role in carbohydrate uptake during growth at low extracellular sugar concentrations. lamB and mal regulon induction during glucose starvation and glucose-limited continuous culture was investigated using lacZ fusions. A low-level burst of lamB induction occurred upon entry into...

journal_title：Molecular microbiology

authors： Notley L,Ferenci T

更新日期：1995-04-01 00:00:00

abstract：:Carbapenems such as meropenem are being investigated for their potential therapeutic utility against highly drug-resistant tuberculosis. These β-lactams target the transpeptidases that introduce interpeptide cross-links into bacterial peptidoglycan thereby controlling rigidity of the bacterial envelope. Treatment of M...

journal_title：Molecular microbiology

authors： Kumar P,Arora K,Lloyd JR,Lee IY,Nair V,Fischer E,Boshoff HI,Barry CE 3rd

更新日期：2012-10-01 00:00:00

abstract：:In contrast to many antimicrobial peptides, members of the proline-rich group of antimicrobial peptides inactivate Gram-negative bacteria by a non-lytic mechanism. Several lines of evidence indicate that they are internalized into bacteria and their activity mediated by interaction with unknown cellular components. Wi...

journal_title：Molecular microbiology

authors： Mattiuzzo M,Bandiera A,Gennaro R,Benincasa M,Pacor S,Antcheva N,Scocchi M

更新日期：2007-10-01 00:00:00

abstract：:The Vipp1 protein is essential in cyanobacteria and chloroplasts for the maintenance of photosynthetic function and thylakoid membrane architecture. To investigate its mode of action we generated strains of the cyanobacteria Synechocystis sp. PCC6803 and Synechococcus sp. PCC7942 in which Vipp1 was tagged with green f...

journal_title：Molecular microbiology

authors： Bryan SJ,Burroughs NJ,Shevela D,Yu J,Rupprecht E,Liu LN,Mastroianni G,Xue Q,Llorente-Garcia I,Leake MC,Eichacker LA,Schneider D,Nixon PJ,Mullineaux CW

更新日期：2014-10-13 00:00:00

abstract：:Having no known environmental reservoir, Streptococcus pyogenes, a bacterium responsible for a wider variety of human diseases than any other bacterial species, must rely on its host for metabolic substrates. Although a streptococcal aldolase, LacD.1, has been adapted to virulence gene regulation, both LacD.1 and a pa...

journal_title：Molecular microbiology

authors： Loughman JA,Caparon MG

更新日期：2007-04-01 00:00:00

abstract：:A collection of 20 strains of Helicobacter pylori from several regions of the world was studied to better understand the population genetic structure and diversity of this species. Sequences of fragments from seven housekeeping genes (atpA, efp, mutY, ppa, trpC, ureI, yphC ) and two virulence-associated genes (cagA, v...

journal_title：Molecular microbiology

authors： Achtman M,Azuma T,Berg DE,Ito Y,Morelli G,Pan ZJ,Suerbaum S,Thompson SA,van der Ende A,van Doorn LJ

更新日期：1999-05-01 00:00:00

abstract：:Urinary tract infection (UTI) is a very common extraintestinal infection, and Escherichia coli is by far the most common causative organism. Uropathogenic E. coli possess traits that distinguish them from commensal strains of E. coli, such as secretion systems that allow virulence factors to be targeted to extracytopl...

journal_title：Molecular microbiology

authors： Guyer DM,Henderson IR,Nataro JP,Mobley HL

更新日期：2000-10-01 00:00:00

abstract：:The Salmonella enterica serotype Typhimurium (S. typhimurium) genome contains a large repertoire of putative fimbrial operons that remain poorly characterized because they are not expressed in vitro. In this study, insertions that induced expression of the putative stdABCD fimbrial operon were identified from a random...

journal_title：Molecular microbiology

authors： Chessa D,Winter MG,Nuccio SP,Tükel C,Bäumler AJ

更新日期：2008-05-01 00:00:00

abstract：:Transposon Tn 1546 confers resistance to glycopeptide antibiotics in enterococci and encodes two D,D-peptidases (VanX and VanY) in addition to the enzymes for the synthesis of D-alanyl-D-lactate (D-Ala-D-Lac). VanY was produced in the baculovirus expression system and purified as a proteolytic fragment that lacked the...

journal_title：Molecular microbiology

authors： Arthur M,Depardieu F,Cabanié L,Reynolds P,Courvalin P

更新日期：1998-11-01 00:00:00

abstract：:Amino acid sequence analyses have indicated that the amino-terminal part of bacteriophage PRD1 structural protein P7 carries a conserved transglycosylase domain. We analysed wild-type PRD1 and different mutant particles in zymograms and found a glycolytic activity that was associated with protein P7. This is the first...

journal_title：Molecular microbiology

authors： Rydman PS,Bamford DH

更新日期：2000-07-01 00:00:00

abstract：:Reversible protein acetylation is established as a modification of major regulatory significance. In particular, histone acetylation regulates access to genetic information in eukaryotes. For example, class I and class II histone deacetylases are regulatory components of corepressor complexes involved in cell cycle pr...

journal_title：Molecular microbiology

authors： Ingram AK,Horn D

更新日期：2002-07-01 00:00:00

abstract：:Survival and replication inside host cells by Brucella spp. requires a type IV secretion system (T4SS), encoded by the virB locus. However, the identity of the molecules secreted by the T4SS has remained elusive. We hypothesized that proteins translocated by the T4SS would be co-regulated with the virB operon. The Lux...

journal_title：Molecular microbiology

authors： de Jong MF,Sun YH,den Hartigh AB,van Dijl JM,Tsolis RM

更新日期：2008-12-01 00:00:00

abstract：:A number of strains of the widespread aerobic soil bacterium, Bacillus sphaericus, possess crystalline inclusions of a toxin lethal to a variety of insect (larvae) which are vectors of major tropical diseases. Partial amino acid sequence data from one strain, B. sphaericus 2362 have permitted us to design oligonucleot...

journal_title：Molecular microbiology

authors： Hindley J,Berry C

更新日期：1987-09-01 00:00:00

abstract：:Chemoreceptors play a central role in chemotaxis, allowing bacteria to detect chemical gradients and bias their swimming behavior in order to navigate toward favorable environments. The genome of the kiwifruit pathogen, Pseudomonas syringae pv. actinidiae (Psa) strain NZ-V13 encodes 43 predicted chemoreceptors, none o...

journal_title：Molecular microbiology

authors： McKellar JL,Minnell JJ,Gerth ML

更新日期：2015-05-01 00:00:00

abstract：:Development of penicillin resistance in Streptococcus pneumoniae is due to successive mutations in penicillin-binding proteins (PBPs) which reduce their affinity for beta-lactam antibiotics. PBP2x is one of the high-Mr PBPs which appears to be altered both in resistant clinical isolates, and in cefotaxime-resistant la...

journal_title：Molecular microbiology

authors： Laible G,Hakenbeck R,Sicard MA,Joris B,Ghuysen JM

更新日期：1989-10-01 00:00:00

abstract：:Of the four Plasmodium species that routinely cause malaria in humans, Plasmodium falciparum is responsible for the majority of malaria mortality and consequently gets most of the headlines. Outside Africa, however, more malaria cases are caused by its distant cousin Plasmodium vivax, resulting in a daunting morbidity...

journal_title：Molecular microbiology

authors： Rayner J

更新日期：2005-03-01 00:00:00

abstract：:Coli surface antigen 6 (CS6) is a widely expressed enterotoxigenic Escherichia coli (ETEC) colonization factor that mediates bacterial attachment to the small intestinal epithelium. CS6 is a polymer of two protein subunits CssA and CssB, which are secreted and assembled on the cell surface via the CssC/CssD chaperone ...

journal_title：Molecular microbiology

authors： Roy SP,Rahman MM,Yu XD,Tuittila M,Knight SD,Zavialov AV

更新日期：2012-12-01 00:00:00

abstract：:In this study we uncover two genes in Lactobacillus brevis ATCC 367, tstT and tstR, encoding for a rhodanese and a transcriptional regulator involved in cyanide detoxification. TstT (LVIS_0852) belongs to a new class of thiosulphate:cyanide sulphurtransferases. We found that TstR (LVIS_0853) modulates both the express...

journal_title：Molecular microbiology

authors： Pagliai FA,Murdoch CC,Brown SM,Gonzalez CF,Lorca GL

更新日期：2014-05-01 00:00:00

abstract：:The prnA gene codes for a transcriptional activator that mediates proline induction of four other genes involved in proline utilization as a nitrogen and/or carbon source in Aspergillus nidulans. In this paper, we present the genomic and cDNA sequence and the transcript map of prnA. The PrnA protein belongs to the Zn ...

journal_title：Molecular microbiology

authors： Cazelle B,Pokorska A,Hull E,Green PM,Stanway G,Scazzocchio C

更新日期：1998-04-01 00:00:00

abstract：:The cGvpE protein of Halobacterium salinarum PHH4 has been identified as transcriptional activator for the promoter of the c-gvpA gene encoding the major gas vesicle structural protein cGvpA. Molecular modelling of the carboxy-terminal region of cGvpE suggests that this protein resembles a basic leucine-zipper protein...

journal_title：Molecular microbiology

authors： Plösser P,Pfeifer F

更新日期：2002-07-01 00:00:00

abstract：:We present structural and biochemical evidence for a redox switch in the archaeal transcriptional regulator SurR of Pyrococcus furiosus, a hyperthermophilic anaerobe. P. furiosus produces H(2) during fermentation, but undergoes a metabolic shift to produce H(2) S when elemental sulfur (S(0) ) becomes available. Change...

journal_title：Molecular microbiology

authors： Yang H,Lipscomb GL,Keese AM,Schut GJ,Thomm M,Adams MW,Wang BC,Scott RA

更新日期：2010-09-01 00:00:00