Molecular targets for steroids in airway vascular smooth muscle.

Abstract:

:The actions of norepinephrine (NE) released from airway sympathetic nerves are partially terminated by the extraneuronal catecholamine uptake. Because various steroid hormones inhibit extraneuronal uptake, it could be responsible for the airway vasoconstriction caused by inhaled glucocorticosteroids (GSs) in vivo. Using bronchial arteries obtained from donor lungs rejected for transplantation, we showed that a plasma membrane-associated transporter is responsible for NE uptake by airway vascular smooth muscle. We identified this transporter, namely the extraneuronal monoamine transporter (EMT), by demonstrating its function and mRNA expression. Furthermore, we showed that the rapid, nongenomic inhibitory GS effect on EMT is likely mediated through the activation of specific K+ channels in the plasma membrane. We believe that our studies identified new molecular targets for GSs in modulating noradrenergic control of airway vascular tone.

journal_name

Arch Physiol Biochem

authors

Horvath G,Wanner A

doi

10.3109/13813450312331337559

subject

Has Abstract

pub_date

2003-10-01 00:00:00

pages

341-4

issue

4

eissn

1381-3455

issn

1744-4160

pii

NBNWEX1XTMEJCCJA

journal_volume

111

pub_type

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