Abstract:
AIM:A high-fat diet (HFD) can lead to obesity and related metabolic disorders. This study evaluated the preventive efficacy of myricetin derivative-rich fraction (MD) from Syzygium malaccense leaf extract against HFD-induced obesity, hyperglycaemia, and oxidative stress in C57BL/6J mice. METHODS:HFD-fed mice were administered MD (50 mg/kg, 100 mg/kg, and 150 mg/kg) or 2 mg/kg metformin (positive control) orally for 16 weeks. Normal diet and HFD-fed control groups received normal saline. RESULTS:MD dose of 50 mg/kg was better than 100 mg/kg and 150 mg/kg in significantly reducing weight-gain, glucose intolerance, insulin resistance, lipid accumulation in liver and kidney, and improving the serum lipid profile. Lowered protein carbonyls and lipid hydroperoxides in urine and tissue homogenates and elevated reduced glutathione, ferric reducing antioxidant power (FRAP), and Trolox equivalent antioxidant capacity (TEAC) levels in tissue homogenates indicated amelioration of oxidative stress. CONCLUSION:MD has therapeutic value in the prevention and management of obesity, hyperglycaemia, and oxidative stress.
journal_name
Arch Physiol Biochemjournal_title
Archives of physiology and biochemistryauthors
Nallappan D,Ong KC,Palanisamy UD,Chua KH,Kuppusamy URdoi
10.1080/13813455.2020.1808019subject
Has Abstractpub_date
2020-08-19 00:00:00pages
1-12eissn
1381-3455issn
1744-4160pub_type
杂志文章abstract:AIMS AND BACKGROUND:Obesity is recognised as a significant public health burden worldwide. Recently the cross-talk between gut microbiota and obesity has attracted much attention. To that end, Akkermansia muciniphila has been proposed as a promising microbe to manage obesity. In the present systematic review, we evalua...
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