Abstract:
:Arecoline is known to cause endocrine dysfunction. In the current article role of arecoline on pineal-testis activity was investigated in hypothyroid rats induced by propylthiouracil (PTU). PTU treatment caused thyroid dysfunction ultrastructurally with a fall in T3 and T4 levels followed by a rise of thyroid stimulating hormone (TSH) level. Pineal activity was impaired by PTU treatment, as evident from degenerated synaptic ribbons and mitochondria of the pinealocytes with depletion of pineal and serum N-acetyl serotonin and melatonin levels. Leydig cell function was suppressed, evident from reduced smooth endoplasmic reticulum and depletion of testosterone level. Sex accessories function was impaired by showing scanty rough endoplasmic reticulum with depletion of fructose and sialic acid levels. Arecoline treatment that caused pineal dysfunction and testicular stimulation in control rats, suppressed both pineal and testis functions after PTU treatment. The findings suggest that arecoline inhibits pineal-testis function in experimentally induced hypothyroid rats.
journal_name
Arch Physiol Biochemjournal_title
Archives of physiology and biochemistryauthors
Saha I,Chakraborty SB,Chatterjee A,Pradhan D,Chatterji U,Maiti BRdoi
10.1080/13813455.2018.1486428subject
Has Abstractpub_date
2020-02-01 00:00:00pages
7-16issue
1eissn
1381-3455issn
1744-4160journal_volume
126pub_type
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